Clinical trials: Polypharmacy
Polypharmacy, Insomnia
MIDAS Cluster Randomized Controlled Trial of Implementation Strategies to Optimize Use of Medications in VA Clinical Settings
Scientific advances are constantly leading to better treatments. However, it is quite challenging for healthcare systems, including VA, to ask very busy providers to change the way they practice.
- Conditions
- Polypharmacy, Insomnia, Anticoagulants
- Trial name
- MIDAS cRCT (NCT05065502)
- Testing
- Academic Detailing (AD), LEAP
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- VA Office of Research and Development
Constipation, Diarrhea
Use of Drugs and Constipation in Nursing Homes
The purpose of this study is to study factors (drugs, serum concentration of drugs, nutrition, physical activity, demographics, diseases etc.) related to constipation and diarrhea in nursing homes, and the effect of different…
- Trial name
- NCT00849628
- Where
- Norway
- Volunteers
- 267 people
- Sponsor
- Norwegian University of Science and Technology
Dose Administration Aids, Medication Adherence
Testing a Smart Medication Dispenser (Mobili®) to Help People With Chronic Conditions Take Their Medicine
Medication adherence is one of the biggest challenges faced by healthcare systems, especially among people with multiple chronic diseases who take several medications daily.
- Conditions
- Dose Administration Aids, Medication Adherence, Polypharmacy, Technology in Health
- Trial name
- MobiMAd@PT RCT (NCT07175545)
- Testing
- Independent use of the Mobili® Device by patients, overseen by pharmacists
- Where
- Portugal
- Volunteers
- 96 people
- Sponsor
- Lusofona University
Dementia
Optimal Medication Management in Alzheimer's Disease and Dementia
The study objective is to conduct a pragmatic deprescribing intervention for people with Alzheimer's Disease or Related Dementia with Multiple Chronic Conditions (ADRD-MCC) so that these patients are on 'just right' medication…
- Trial name
- Optimize (NCT03984396)
- Testing
- Educational Materials - Patient & Clinician
- Where
- United States
- Volunteers
- 7,398 people
- Sponsor
- Kaiser Permanente
Medication Non Adherence, Polypharmacy
Tailored Medication Management Intervention
Successful medication management is an essential instrumental activity of daily living (IADL) for older adults with polypharmacy; however, between 40%-70% of older adults fail to take their medications as prescribed.
- Trial name
- NCT04717297
- Testing
- Medication Management Remote Intervention, Waitlist Control, Medication Management In-Person Intervention
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Washington University School of Medicine
Diabetes, Cholesterol
Interprofessional Pharmacogenomics (IPGx) Registry and Repository
This program collects genetic and health information to help doctors choose the right medications for patients.
- Conditions
- Diabetes, Cholesterol, Cancer, Blood Pressure Disorders
- Trial name
- IPGx Registry (NCT06726590)
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- Texas A&M University
Comorbidity, Medication Therapy Management
Team Approach to Polypharmacy Evaluation and Reduction
In an aging population, most seniors suffer from multiple chronic conditions. When the number of medications taken is ≥5 (polypharmacy), the burden of taking so many together can do more harm than good.
- Trial name
- TAPER (NCT02562352)
- Testing
- TAPER program
- Where
- Canada
- Volunteers
- 38 people
- Sponsor
- McMaster University
Type 2 Diabetes
The ADDITION Study. Intensive Treatment in People With Screen Detected Diabetes in Primary Care.
The ADDITION study comprise 2 parts: screening for Type 2 diabetes and intensive treatment compared to standard treatment. 1. In the screening study, the feasibility and results of country specific models to identify undiagnosed…
- Trial name
- ADDTION (NCT00237549)
- Testing
- optimised treatment
- Where
- 4 sites in Denmark, Netherlands and 1 more
- Volunteers
- 3,057 people
- Sponsor
- University of Aarhus
Alzheimer s Disease, Vascular Dementia
Predictors of Emergency Department Use in Frail Patients
When admitted to the emergency department (ED), elderly non-autonomous patients show high risk of adverse health outcomes. The prompt identification of ED use risk factors in such population is hence needed.
- Conditions
- Alzheimer s Disease, Vascular Dementia, Frailty, Elderly
- Trial name
- THE-Spoke 10 (NCT07259499)
- Testing
- Plasma phosphorylated Tau 181
- Where
- Italy
- Volunteers
- 110 people
- Sponsor
- University of Pisa
Deprescriptions, Polypharmacy
Effects of Communication Training to Involve Older People in Decisions to DEPRESCRIBE Cardiometabolic Medication: a Cluster-randomized Trial in Primary Care
The researchers will investigate the effects of a communication training for community pharmacists and general physicians that aims to make it easier for them to stop or lower medication for cardiovascular disease and/or diabetes…
- Conditions
- Deprescriptions, Polypharmacy, Primary Health Care, Community Pharmacy Services
- Trial name
- CO-DEPRESCRIBE (NCT05507177)
- Testing
- communication training programme for healthcare providers
- Where
- Netherlands
- Volunteers
- 310 people
- Sponsor
- University Medical Center Groningen
Polypharmacy, Deprescription
Reducing Post-discharge Potentially Inappropriate Medications Among Older Adults
Potentially inappropriate medications (PIMs) can lead to adverse drug events (ADEs) among older adults and especially those classified as frail. ADEs are responsible for nearly 27,000 hospital admissions in Canada annually.
- Conditions
- Polypharmacy, Deprescription, Aged
- Trial name
- MedSafer (NCT02918058)
- Testing
- MedSafer
- Where
- Canada
- Volunteers
- 924 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Polypharmacy, Inappropriate Prescribing
SPIDER: A Research & QI Collaboration Supporting Practices in Improving Care for Complex Elderly Patients
Elders living with multiple chronic conditions often take many drugs (polypharmacy); some of the drugs may not benefit them or may be harmful.
- Conditions
- Polypharmacy, Inappropriate Prescribing, Aged, Primary Health Care
- Trial name
- SPIDER (NCT03689049)
- Testing
- SPIDER, Usual Care
- Where
- 9 sites in Canada
- Volunteers
- 104 people
- Sponsor
- University of Toronto Practice Based Research Network
Sarcopenia
(De)Prescribing in Hospitalized Sarcopenic Geriatric Patients
The goal of this clinical trial is to compare the effects of a deprescribing pharmacotherapy approach to the STOPP-START approach (usual care) in geriatric patients with sarcopenia and polypharmacy.
- Trial name
- MEDEGESARC (NCT05757765)
- Testing
- deprescribing pharmacotherapy approach (DPA), STOPP-START deprescribing approach (SSA)
- Volunteers
- 160 people
- Sponsor
- Zuyderland Medisch Centrum
Chronic Illness, Opioid Use
Characteristics and Clinical Implications of a Clinical Decision Support System
The investigators propose to study the feasibility, acceptability, usability and outcomes of a new clinical decision support system for clinicians of opioid therapy in the context of specialist palliative care for serious chronic…
- Conditions
- Chronic Illness, Opioid Use, Palliative Care
- Trial name
- NCT03295097
- Testing
- Clinical Decision Support System
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Hospice of Henderson County, Inc.
Open Angle Glaucoma
MIMS® Retrospective Chart Review
This is a post-market clinical follow-up, retrospective chart review of MIMS® surgical procedures conducted during time period between Sep 2023 and April 2025.
- Trial name
- NCT06614218
- Testing
- Minimally Invasive Micro Sclerostomy
- Where
- Armenia
- Volunteers
- 34 people
- Sponsor
- Sanoculis Ltd
Quality of Life
Comprehensive Geriatric Assessment - Can it Improve Quality of Life
Like most developed countries the population of Sweden is getting older and consequently the number of individuals with chronic diseases will be an increasing challenge for its healthcare system.
- Trial name
- NCT01925105
- Testing
- Experimental: Optimization of treatment
- Where
- Sweden
- Volunteers
- 220 people
- Sponsor
- Örebro County Council
Psychotropic Drugs, Psychiatric Drugs
Decreasing Harms and Improving Child Health
The investigators are doing this study because they know from research and talking with caregivers that kids can be on a bunch of medications, and it's hard to keep track of what the medications are for and whether or not they…
- Conditions
- Psychotropic Drugs, Psychiatric Drugs, Children, Shared Decision Making
- Trial name
- NCT07392489
- Testing
- AWARE Shared Decision Making Medication Review
- Where
- 4 sites in United States
- Volunteers
- 31 people
- Sponsor
- Glyn Jones-Elwyn
Medication Therapy Management, Medication Adherence
Polymedication-Check With Insight in Patients' Medication Organisation and Comprehension of Generics
Patients using multiple drugs including generics have found different solutions to manage their medication. During a Polymedication-Check (medication review type 2a service in community pharmacies) additional information about…
- Trial name
- NCT03321058
- Testing
- Assessment
- Where
- Switzerland
- Volunteers
- 125 people
- Sponsor
- University Hospital, Basel, Switzerland
Malnutrition, Aged
Nutritional Status and Medication Treatment in Home-dwelling Older Adults
The project "Nutrition and Medication management in home-dwelling older adults" consist of two separate studies witch are described in the same study protocol. This is the first study in this Project.
- Conditions
- Malnutrition, Aged, Polypharmacy
- Trial name
- NCT04229238
- Where
- Norway
- Volunteers
- 400 people
- Sponsor
- University of Oslo
Multimorbidity, Polypharmacy
Multi-PAP: Improving Prescription in Primary Care Patients With Multimorbidity and Polypharmacy
This study assesses the effectiveness of a complex intervention in young-old patients with multimorbidity and polypharmacy aimed at improving physician drug prescription in primary care, measured by means of the Medication…
- Conditions
- Multimorbidity, Polypharmacy, Other Diagnoses, Comorbidities, and Complications
- Trial name
- Multi-PAP (NCT02866799)
- Testing
- Multi-PAP, Usual care
- Where
- 3 sites in Spain
- Volunteers
- 593 people
- Sponsor
- Instituto Aragones de Ciencias de la Salud