Clinical trials: Polymorphism
Coronary Artery Disease
Role of CYP2C19 Polymorphism in the Drug Interaction Between Clopidogrel and Omeprazole
Clopidogrel, an inhibitor of ADP induced platelet aggregation and activation, is one of the most commonly used drugs in patients with cardiovascular disease.
- Trial name
- NCT01094275
- Testing
- Clopidogrel 75mg, Omeprazole 20mg
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Neil Kleiman, MD
Heart Failure, Levosimendan
Study on the Correlation Between NAT2(N-acetyltransferase2) Gene Polymorphism and CrCl(Creatine Clreance) and the Efficacy and Safety of Levosimendan in Patients With Severe Heart Failure
1. To evaluate the efficacy and safety of levosimendan in the treatment of heart failure ; 2. Guide patients to apply levosimendan individually and establish a dose adjustment program.
- Conditions
- Heart Failure, Levosimendan, Efficacy, Safety
- Trial name
- NCT05913271
- Where
- China
- Volunteers
- 352 people
- Sponsor
- Yi Han
Thalassemia
Demographic, Clinical, Laboratory and Genetical Characteristics of Patients With Beta Thalassemia Intermedia
The definition of Thalassemia Intermedia is not generally accepted and the specific clinical and laboratory characteristics varies between patients.
- Trial name
- NCT01443312
- Testing
- Laboratory analysis.
- Where
- Israel
- Volunteers
- 28 people
- Sponsor
- HaEmek Medical Center, Israel
Macular Degeneration
VEGF Gene Association With Response to Neovascular Age-related Macular Degeneration With Anti-VEGF Agents
The main purpose of this study is to investigate the association between VEGF gene polymorphism and the response to intravitreal drugs in neovascular age-related macular degeneration.
- Trial name
- NCT01655589
- Where
- Brazil
- Volunteers
- 74 people
- Sponsor
- Institute of Vision, Brasil
Anovulation, Disorder Due Cytochrome P450 CYP2D6 Variant
Influence of Pharmacogenetic Factors, Paroxetine and Clarithromycin on Pharmacokinetics of Clomiphene
Aim of the study is the clinical validation of the metabolism and the pharmakokinetic of Clomifen in correlation to CYP2D6 and inhibition of CYP3A4.
- Conditions
- Anovulation, Disorder Due Cytochrome P450 CYP2D6 Variant, Cytochrome P450 CYP3A Enzyme Deficiency
- Trial name
- NCT01289756
- Testing
- Clomiphene, clomiphene and paroxetine, clomiphene and clarithromycin
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Robert Bosch Gesellschaft für Medizinische Forschung mbH (RBMF)
Asthma
Genetic Determinants of the Bronchodilatation Effect of Albuterol ex-Vivo
The role played by ß2AR polymorphisms in determining the bronchial response to ß2AR agonist drugs, has been confirmed by several studies.
- Trial name
- NCT00162422
- Testing
- albuterol
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Hadassah Medical Organization
Cytochrome P450 CYP2D6 Enzyme Deficiency, Poor Metabolizer Due to Cytochrome P450 CYP2D6 Variant
Drug & Gene Interaction Risk Analysis With & Without Genetic Testing Among Patients Undergoing MTM
This randomized controlled trial will evaluate whether the use of pharmacogenetic testing through a Medication Therapy Management (MTM) program has a beneficial impact on drug therapy problems.
- Conditions
- Cytochrome P450 CYP2D6 Enzyme Deficiency, Poor Metabolizer Due to Cytochrome P450 CYP2D6 Variant, Ultrarapid Metabolizer Due to Cytochrome P450 CYP2D6 Variant, Extensive Metabolizer Due to Cytochrome P450 CYP2D6 Variant
- Trial name
- NCT02428660
- Testing
- Pharmacogenetic testing, Software-based drug & gene interaction risk analysis, MTM
- Where
- United States
- Volunteers
- 341 people
- Sponsor
- Genelex Corporation
Pain, CYP2D6 Polymorphism
Precision Medicine Guided Treatment for Cancer Pain
Pain is one of the most burdensome symptoms associated with cancer and its treatment, and opioids are the cornerstone of clinical pain management in cancer patients.
- Trial name
- NCT02664350
- Testing
- CYP2D6, Brief Pain Inventory-Short Form (BPI-SF), M.D. Anderson Symptom Inventory (MDASI)
- Where
- 2 sites in United States
- Volunteers
- 63 people
- Sponsor
- University of Florida
Stage IV Colorectal Cancer, Gastric Cancer
Investigation of Association Between UGT1A1 Polymorphisms and Irinotecan Toxicity in Korean Patients
The purpose of this study is to investigate the association between UGT1A1 polymorphisms and neutropenia and diarrhea in Korean patients with advanced colorectal or gastric cancer treated with FOLFIRI regimen.
- Trial name
- NCT01271582
- Testing
- Irinotecan, 5FU, leucovorin
- Where
- 5 sites in South Korea
- Volunteers
- 1,500 people
- Sponsor
- Asan Medical Center
Skin Cancer
TLR4 Polymorphisms and Risk of Skin Cancer
Toll-like receptors (TLRs) play a key role in the innate immune system. Toll-like receptor-4 (TLR4) in particular, appears to play a role in susceptibility to cancer.
- Trial name
- NCT03122366
- Testing
- Detection of single nucleotide polymorphisms (SNP)
- Where
- United States
- Volunteers
- 392 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Gene Polymorphism, ASCVD
NPC1L1 Gene Polymorphism and the Efficacy and Safety of Hybutimibe
Significant individual differences may lead to differences in patients' responses to drug therapy and lead to an increased incidence of adverse reactions.
- Trial name
- NCT06641661
- Testing
- Hybutimibe 10mg QD
- Volunteers
- 1,000 people
- Sponsor
- Qianfoshan Hospital
Wildtype, Polymorphism Liver FABP
Potential Association of a Common L-FABP Polymorphism With Lipid-induced Hepatic Insulin Resistance
The investigators hypothesise that a common A277G polymorphism of the liver fatty acid binding protein (L-FABP) gene, which leads to an amino acid exchange, may be associated with alterations of lipid-induced hepatic insulin…
- Trial name
- NCT00277342
- Testing
- measurement of lipid-induced hepatic insulin resistance
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- German Institute of Human Nutrition
Genetic Predisposition to Disease
RORC Genetic Polymorphism of Rheumatoid Arthritis
Three candidate single nucleotide polymorphisms in the RORC2 gene, rs9826 A/G, rs3790515 C/T and rs3828057 C/T were examined together with estimation of nuclear hormone retinoic acid receptor-related orphan receptor variant 2…
- Trial name
- NCT03615729
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Assiut University
Polymorphic Ventricular Tachycardia, Heart Failure
Radiofrequency Ablation for Polymorphic Ventricular Tachycardia With Heart Failure (RFCA for PMVT-HF)
This is a prospective, randomized, controlled trial to investigate the efficacy of radiofrequency catheter ablation (RFCA) combined with guideline-directed medical therapy (GDMT) compared to GDMT alone in patients with…
- Trial name
- NCT07130175
- Testing
- Radiofrequency Catheter Ablation, Guideline-Directed Medical Therapy (GDMT)
- Where
- China
- Volunteers
- 118 people
- Sponsor
- Qian Feng
Abortion, Spontaneous
Interleukin-10 Promoter-1082A/G Polymorphism and Idiopathic Recurrent Miscarriage Risk
This study aimed to assess the correlation between the interleukin-10 (IL-10)-1082A/G polymorphism and idiopathic recurrent miscarriage (IRM) of Chinese Han.
- Trial name
- NCT02633475
- Testing
- IL-10 polymorphism
- Where
- 2 sites in China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Fourth Affiliated Hospital of Guangxi Medical University
Pharmacokinetic Study in Healthy Volunteers
Evaluation of Solanidine as an Exogenous Biomarker to Phenotype CYP2D6 Activity in Humans
This study investigates the evaluation of solanidine as an exogenous biomarker to phenotype CYP2D6-activity in humans. Participants will be classified by their CYP2D6 genotype into poor metabolizers (PM), low intermediate…
- Trial name
- SOLA-1 (NCT07817030)
- Testing
- Yohimbine, Consumption of a defined potato-rich meal
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
High Myopia, Gene Mutations
TGFB1 And LAMA1 Gene Polymorphisms in High Myopia
The investigators aimed to investigate TGFB1 and LAMA1 gene polymorphisms in children with high myopia in order to determine the genetic basis of large myopic shifts causing severe visual impairment and complications.
- Trial name
- NCT03451877
- Testing
- TGFB1 AND LAMA1 GENE POLYMORPHISMS
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Ege University
Prostate Cancer
Pharmacogenomics IND Commercial SNP Clinical Study - Abiraterone and Single Nucleotide Polymorphisms
The usual approach group, 300 double blind random group separated PC patients currently used the Combined Chemotherapy on ZYTIGA - abiraterone acetate tablet, film coated plus prednisone tablet plus BICALUTAMIDE tablet, it will…
- Trial name
- Drugs-SNPs (NCT03348670)
- Testing
- Abiraterone - Usual, Abiraterone - Study
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Han Xu, M.D., Ph.D., FAPCR, Sponsor-Investigator, IRB Chair
Atrial Fibrillation, Deep Vein Thrombosis
A Genomic Approach to Warfarin Dose Prescription in Admixed Caribbean Hispanics
Caribbean Hispanics are a population with a disproportionately high prevalence of cardio-metabolic disorders but with a limited expectation of benefits from current pharmacogenetic algorithms derived mainly in subjects of…
- Conditions
- Atrial Fibrillation, Deep Vein Thrombosis, Cardiac Valvular Insufficiency, Coagulopathies
- Trial name
- NCT02345356
- Testing
- Genotype-guided, Standard-of-Care
- Where
- 3 sites in United States, Puerto Rico
- Volunteers
- 200 people
- Sponsor
- University of Puerto Rico
Recurrent Pityriasis Versicolor
Gene Polymorphism in Tinea Versicolor
Blood samples will be taken from cases presenting with recurrent tinea versicolor , after confirmation of diagnosis by wood's light and KOH examination, for the detection of gene polymorphism in IL17 A and IL17 F.
- Trial name
- NCT04769804
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Kasr El Aini Hospital