Clinical trials: Polymorphism, Single Nucleotide
Weight Management, Diet Conditions
A to Z Study Follow-up: Collection of DNA Data From Buccal Swabs
The goal of this study is to determine the association between genotypes and diet. The weight and weight loss data are already available from the previously completed study called: A to Z Study - Benefits and Risks of Alternative…
- Conditions
- Weight Management, Diet Conditions, Dietary Recommendations, Overweight Management
- Trial name
- NCT00866151
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Interleukin Genetics, Inc.
Macular Degeneration
Genetic Factors in Age-Related Macular Degeneration
This study will examine whether certain polymorphisms (small gene variances) predispose people to develop age-related macular degeneration (AMD).
- Trial name
- NCT00058695
- Where
- United States
- Volunteers
- 477 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
DAO Genetic Variants
Prevalence of DAO (diamino Oxidase) Deficiency in Newborns
Observational study to estimate the prevalence of genetic DAO deficiency in the population.
- Trial name
- DAO-NEO-2022 (NCT06710366)
- Where
- Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- AB Biotek
Dyslipidemias, Single Nucleotide Polymorphism
VDR SNPs & 25OHD Correlated With Dyslipidemia
The project was aimed to explore the associations of single nucleotide polymorphisms (SNPs) of vitamin D receptor gene with specific circulating lipids in adult Chinese.
- Trial name
- NCT04707612
- Testing
- No intervention.
- Where
- China
- Volunteers
- 1,987 people, healthy volunteers welcome
- Sponsor
- Shenzhen Center for Chronic Disease Control
Phantom Limb
Study to Identify the Genetic Variations Associated With Phantom Limb Pain
The purpose of this study is to determine if there is a genetic component to phantom limb pain. DNA will be analyzed for single nucleotide polymorphisms (SNPs) between the control and phantom limb pain group.
- Trial name
- NCT01462448
- Testing
- Blood Draw
- Where
- United States
- Volunteers
- 726 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Acne Vulgaris
Profiles Analysis of Genome Wide Association Study (GWAS) in Acne Vulgaris in Indonesia.
This study is a series of descriptive-analytic studies on genomic variants in the facial skin of patients with AV at the Dermatology and Venereology Polyclinic by determining the genetic profile by GWAS examination in AVB and…
- Trial name
- NCT06501560
- Testing
- GWAS
- Where
- Indonesia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Dr.dr.Irma Bernadette, SpKK (K)
Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Polymorphism, Single Nucleotide
The Association Between TNFSF4 Polymorphism and CD
The goal of this observational study is to investigate the associations between tumor necrosis factor superfamily member 4 (TNFSF4) gene polymorphisms and the risk of Crohn's disease (CD), and to elucidate the impact of TNFSF4…
- Conditions
- Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Polymorphism, Single Nucleotide, Ustekinumab
- Trial name
- NCT07263464
- Testing
- Ustekinumab - Standard Dosage
- Where
- China
- Volunteers
- 818 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Skin Cancer
TLR4 Polymorphisms and Risk of Skin Cancer
Toll-like receptors (TLRs) play a key role in the innate immune system. Toll-like receptor-4 (TLR4) in particular, appears to play a role in susceptibility to cancer.
- Trial name
- NCT03122366
- Testing
- Detection of single nucleotide polymorphisms (SNP)
- Where
- United States
- Volunteers
- 392 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Delivery, Obstetric
The Occurrence of Single Nucleotide Polymorphism Among Women Who Experienced Obstetric Anal Sphincter Injury
Single-nucleotide polymorphisms (SNP's) in connective tissue components are associated with increased risk of pelvic organ prolapse (POP).
- Trial name
- NCT04047433
- Testing
- screening for single nucleotide polymorphism, whole exome sequencing
- Where
- Israel
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
Asthma in Children, Genetic Disease
Association Between Genetic Polymorphisms and Type 2 Asthma in Children
To further understand the role of gene single nucleotide polymorphism (SNP) in the occurrence of type 2 inflammation-related asthma in children by analyzing the gene single nucleotide polymorphism (SNP), lung function and type 2…
- Conditions
- Asthma in Children, Genetic Disease, Inflammation
- Trial name
- SNP (NCT06840717)
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Guangzhou Institute of Respiratory Disease
Healthy, Metabolism
Personalized Dietary Program and Markers of Wellness
The objective of this study is to determine the impact of an integrated personalized dietary and wellness program which includes dietary advice, meals, and counseling on health and wellness.
- Trial name
- NCT03424395
- Testing
- Personalized dietary and wellness program
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Habit, LLC
Healthy
The Impact of Genotype on Pharmacokinetics and Antiplatelet Effects of Ticagrelor in Healthy Chinese
This study is a open and single center clinical trial in healthy Chinese.The objective of the study is to clarify the pharmacokinetics characteristics and antiplatelet effects of ticagrelor in Chinese and to investigate the…
- Trial name
- IGPPT (NCT03092076)
- Testing
- Ticagrelor
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Guangdong Provincial People's Hospital
ST Elevation Myocardial Infarction
SNPs in the DNase 1 Gene Impair Its Activity and Are Increased in a STE-ACS Patient Cohort Compared to Healthy Controls
Neutrophil extracellular traps (NETs) and deoxyribonuclease (DNase) activity determine outcome in ST elevation acute coronary syndrome (STE-ACS). DNase single nucleotide polymorphisms (SNPs) were increased in a japanese cohort.
- Trial name
- NCT02615015
- Testing
- Blood draw
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Gout, Hyperuricemia
Research and Development of a New Technology for Detection of Abnormal Excretion of Intestinal Uric Acid Involved in the Incidence of Gout
To evaluate differences in specific SNPs and intestinal microflora between patients with gout and hyperuricemia and healthy controls.
- Conditions
- Gout, Hyperuricemia, Gut Microbiota, Uric Acid
- Trial name
- NCT04953533
- Testing
- no intervention
- Where
- China
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Tuberculosis
The Impact of Vitamin D on Tuberculosis Among Koreans
Vitamin D has been regarded to be beneficial to tuberculosis (TB) patients. The aim of this study is to elucidate the role of vitamin D deficiency in development and treatment outcomes among Korean TB patients.
- Trial name
- NCT01137370
- Where
- South Korea
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Premature Birth
Three Interacting Single Nucleotide Polymorphisms (SNPs) and the Risk of Preterm Birth in Black Families
A multilocus interaction of three pro-inflammatory cytokine single nucleotide polymorphisms (SNPs), -3448 Tumor Necrosis Factor-α, -7227 Interleukin 6, and 33314 Interleukin 6R was reported by Menon and associates in 2006.
- Trial name
- NCT00675753
- Testing
- Blood spot specimens will be drawn
- Where
- 2 sites in United States
- Volunteers
- 258 people, healthy volunteers welcome
- Sponsor
- University of Miami
Anovulation, Hyperandrogenism
Whole Genome Analysis for the Detection of Key Genes in the Polycystic Ovary Syndrome
Background: Infertility affects up to 15% of married couples. About half are attributable to female factors, among which anovulation is the leading cause.
- Conditions
- Anovulation, Hyperandrogenism, Polycystic Ovary Syndrome, Single Nucleotide Polymorphism
- Trial name
- NCT00665171
- Where
- Israel
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Maaynei Hayesha Medical Center
Immune Thrombocytopenic Purpura
" Effect of Single-nucleotide Polymorphism of CD40 Gene rs1883832 C/T on the Risk of Immune Thrombocytopenic Purpura "
Immune thrombocytopenia is an acquired autoimmune disease, in which platelets are opsonized by auto-antibodies and destroyed by phagocytic cells .Genetic polymorphisms in the immune mediators have been suggested to play a pivotal…
- Trial name
- NCT05585944
- Testing
- Genotyping of rs1883832C/T related single-nucleotide polymorphism
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sohag University
Non-alcoholic Fatty Liver Disease
Utilizing Non-Invasive Fibroscan® Technology to Identify Genetic Markers for Fatty Liver Progression
Non-alcoholic fatty liver disease (NAFLD) is a common disorder, affecting ~30% of people in the general population and up to 96% of obese individuals.
- Trial name
- NCT02267148
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- UNC Nutrition Research Institute
Type 2 Diabetes Mellitus
Vitamin D Receptor Polymorphisms and Efficacy of Vitamin D-Fortified Yogurt Drink in Patients With Type 2 Diabetes
Study is a 12-week Double blind,controlled experiments designed to examine the possible effects of vitamin D receptor gene polymorphisms on the metabolic, inflammatory and oxidative stress markers in type 2 diabetic patients to…
- Trial name
- NCT01236846
- Testing
- Fortified Yogurt Drink, Plain Yogurt Drink
- Where
- 4 sites in Iran
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Tirang R. Neyestani