Clinical trials: Polymorphism, Genetic
Prostate Cancer
Exploring Genomic, Proteomic and Dosimetric Determinants of Late Toxicity After Three Dimensional Conformal Radiotherapy (RT) for Prostate Cancer
Prostate cancer is the most common malignancy in males, and radiotherapy is a commonly chosen treatment option for patients with localized disease.
- Trial name
- NCT00122265
- Where
- Canada
- Volunteers
- 83 people
- Sponsor
- AHS Cancer Control Alberta
Pulmonary Disease, Chronic Obstructive, Generalized Chronic Periodontitis
The Association of SERPINA1 Gene Disturbance in Patients With Lung and Gum Disorders
Chronic obstructive pulmonary disease and periodontitis are chronic inflammatory diseases. The study aims to determine if the genetic polymorphism of SERPINA1 gene in patients with COPD serve as a risk factor for developing…
- Trial name
- SA1PLG (NCT02498938)
- Testing
- SERPINA1 gene
- Where
- India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Diabetes Mellitus, Healthy
Genetic Influence on Susceptibility to Type 1 Diabetes Mellitus
Type 1 diabetes mellitus is an autoimmune disease in which the body's immune cells attack the insulin-producing cells of the pancreas.
- Trial name
- NCT00001985
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Breast Cancer Patients
Study of ABCB1,SLC22A16 Drug Transporter Genes and Doxorubicin and Cyclophosphamide Toxicity in Brest Cancer Patient
polymorphisms of drug transporter genes may influence of Doxorubicin-Cyclophosphamide toxicity in breast cancer patients. the investigators want to evaluate the association between associations between genetic polymorphisms of…
- Trial name
- NCT04654195
- Testing
- polymorphism analysis, Doxorubicin-Cyclophosphamide regimen
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Damanhour University
Hepatitis B, Carcinoma, Hepatocellular
Effect of Polymorphisms in the IL-1 Gene Complex on the Development of Chronic Hepatitis and Hepatocellular Carcinoma
The purpose of this study is to determine the effect of polymorphisms in the IL-1 gene complex on the development of chronic hepatitis and hepatocellular carcinoma.
- Conditions
- Hepatitis B, Carcinoma, Hepatocellular, Polymorphism, Genetic
- Trial name
- NCT00155103
- Where
- Taiwan
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Genotype-related Drug Metabolism
Open Label Study for the Functional Characterization of Drug Metabolism and Transport
Aim of this study is to comprehensively assess in healthy volunteers the metabolic processes and factors that define drug response.
- Trial name
- IKP243 (NCT01788254)
- Testing
- Codeine, Midazolam, pravastatin
- Where
- 2 sites in Germany
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Matthias Schwab
Diabetes, Hypoglycemia Unawareness
The Effect of Antecedent Hypoglycaemia on β2-adrenergic Sensitivity
Hypoglycaemia unawareness is a common complication in patients with type 1 diabetes and with insulin-treated type 2 diabetes of long duration.
- Trial name
- NCT00160056
- Testing
- Hypoglycemia
- Where
- Netherlands
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Kidney Diseases
Chinese Herb Nephropathy Epidemiology and Association With CYP2D6, CYP2C19, PXR, or MDR1 Polymorphism
1. Chinese herb nephropathy (CHN), a kind of kidney failure caused by Chinese herbs, may be related to the a component called aristolochic acid (AA). 2.
- Trial name
- NCT01503645
- Where
- 2 sites in Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Asthma
A Cohort Study of Smoking Prevention and Health Promotion for Middle School Students in Wuhan, China
We propose to add a collection of buccal cells to a school-based cohort of 7th graders in Wuhan, a large industrial city in China.
- Trial name
- NCT00341653
- Where
- China
- Volunteers
- 5,051 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Alzheimer's Disease
Effect of REST in the Alzheimer Disease Continuum
The investigators assume that REST gene polymorphism affects REST protein concentration, and REST protein concentration in peripheral blood is related to cognitive function and hippocampus.
- Trial name
- ERADC (NCT03884023)
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Dongzhimen Hospital, Beijing
Obesity, Metabolically Healthy Obesity
Exercise and Diet Responses in Adult Men With Obesity by MC4R Genotype and Metabolic Health
This study evaluated whether differences in the MC4R rs17782313 gene variant and metabolic health status were associated with different responses to a 12-week exercise and dietary intervention in adult men with obesity.
- Conditions
- Obesity, Metabolically Healthy Obesity, Metabolically Unhealthy Obesity
- Trial name
- NCT07750197
- Testing
- Supervised Aerobic and Resistance Exercise
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Harbin Sport University
Non-alcoholic Fatty Liver Disease
Utilizing Non-Invasive Fibroscan® Technology to Identify Genetic Markers for Fatty Liver Progression
Non-alcoholic fatty liver disease (NAFLD) is a common disorder, affecting ~30% of people in the general population and up to 96% of obese individuals.
- Trial name
- NCT02267148
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- UNC Nutrition Research Institute
Developmental Delays
The Relationship Between Arsenic Methylation Capability and Blood Metals in Children With Developmental Delays
The purpose of this study is to explore the relationship between arsenic methylation and blood metals in children with developmental delays and its correlation with health related quality of life.
- Trial name
- NCT02523989
- Testing
- study group
- Where
- Taiwan
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Autism Spectrum Disorders
Susceptibility Genes in Autism Spectrum Disorders
The main objective of the study is to define, for Autism Spectrum Disorder, the extent of genetic variation in synaptic pathways that may be targeted for therapeutic development.
- Trial name
- NCT02628808
- Where
- 5 sites in France
- Volunteers
- 1,616 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Ventricular Arrythmia
China Inherited Ventricular Arrhythmias Registry
This is an observational, prospective, multi-center registry, aiming at building a risk stratification for malignant inherited ventricular arrhythmias, including Brugada syndrome(Brs)、Long QT syndrome(LQTS)、Short QT…
- Trial name
- NCT03880708
- Where
- China
- Volunteers
- 500 people
- Sponsor
- China National Center for Cardiovascular Diseases
Chronic Myeloid Leukemia
Effect of Pharmacogenetics on Imatinib Plasma Level and Response
Imatinib, the tyrosine kinase inhibitor, is used for treatment of Philadelphia positive chronic myeloid leukemia. Despite its efficacy and favorable pharmacokinetic profile, there is a large inter-individual variability in…
- Trial name
- NCT03262974
- Testing
- PCR, HPLC-UV
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Myocardial Infarction
Effect of Diabetes and Hepatic Enzymes Mutation on Clopidogrel VS Ticagrelor Activity in Myocardial Infarction (MI) Patients Undergoing Primary Percutaneous Coronary Intervention (PCI)
In this study the combined effect of diabetes mellitus and cyp2c19 polymorphism on platelet aggregation inhibitory activity of the highest traditionally used loading dose 600 mg clopidogrel and ticagrelor 180 mg loading dose will…
- Trial name
- NCT03613857
- Testing
- Clopidogrel, Ticagrelor 90mg
- Where
- Egypt
- Volunteers
- 1,022 people
- Sponsor
- Cairo University
Chronic Kidney Disease, End Stage Renal Disease
Klotho Gene Polymorphism in Dialyzed Patients With Hyperphosphatemia
Patients with chronic kidney disease (CKD) and those with end-stage renal disease (ESRD) undergoing renal replacement therapies show elevated serum phosphate levels which predispose them to cardiovascular calcifications and high…
- Conditions
- Chronic Kidney Disease, End Stage Renal Disease, Hyperphosphatemia, Renal Osteodystrophy
- Trial name
- NCT00374712
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Metastatic Colorectal Cancer
Evaluation of VEGF Polymorphism as Predictive Factor in Metastatic Colorectal Cancer Treated With Folfiri Plus Bevacizumab
-1498C/T VEGF polymorphism, as suggested by a recent retrospective analysis, seems to have a role in predicting the efficacy of Bevacizumab plus FOLFIRI in first-line treatment of metastatic colorectal cancer patients.
- Trial name
- PROVETTA (NCT01363739)
- Where
- Italy
- Volunteers
- 265 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
MASLD/MASH (Metabolic Dysfunction-Associated Steatotic Liver Disease / Metabolic Dysfunction-Associated Steatohepatitis)
Study of PNPLA3 Genetic Polymorphisms in Patients With Non-Alcoholic Fatty Liver Disease in an Ultramarine Population (AdipoDROMExpo)
Metabolic Dysfunction Associated Liver Disease (MASLD) is associated with metabolic syndrome, and PNPLA3 variants are known to be implicated in intrahepatic lipid accumulation and linked to lipotoxicity.
- Trial name
- AdipoDROMExpo (NCT07330830)
- Where
- 3 sites in French Guiana, Guadeloupe and 1 more
- Volunteers
- 600 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe