Clinical trials: Polygenic Score
Hypertension (HTN), Cardiometabolic Diseases
Genetic Architecture of Natriuretic Peptides and Blood Pressure Response
Natriuretic peptides (NPs) are hormones produced by the heart and play an important role in maintaining cardiovascular health and have favorable metabolic benefits.
- Trial name
- NCT07118592
- Testing
- Low Salt Diet, High Salt Diet, Saline Infusion
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Polygenic Score
Polygenic Embryo Selection
This study will evaluate whether IVF success rates after PRS-based embryo selection differ from those after morphology-based embryo selection, and whether polygenic disease risk correlates with embryo morphology.
- Trial name
- NCT07841769
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Nucleus Genomics Inc.
Ovarian Cancer, BRCA Mutation
Polygenic Risk Scores and Multi-cancer Early Detection for Ovarian Cancer
The overall goal of the Polygenic Risk Scores and Multi-cancer Early Detection for Ovarian Cancer (PROMISE) study is to better understand how women may incorporate both polygenic risk score (PRS) and novel early detection…
- Trial name
- PROMISE (NCT06436248)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Abramson Cancer Center at Penn Medicine
Wearable Electronic Devices, Polygenic Risk Score
DELphi Procedure for Developing Recommendations for the Implementation of Wearable Devices and Polygenic Risk Scores
DEL-DIP is a prospective observational study employing a Delphi methodology (at least two online rounds) to elicit and consolidate the views of an expert panel within the INNOPREV project.
- Conditions
- Wearable Electronic Devices, Polygenic Risk Score, CVD - Cardiovascular Disease, Primary Prevention
- Trial name
- DEL-DIP (NCT07358481)
- Where
- Italy
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Prostate Cancer
The i4i PRODICT® Study: Evaluation of the i4i PRODICT® Test in Different Ethnic Groups (The i4i PRODICT® Study).
The i4i PRODICT® study has been developed to investigate the uptake and acceptability of the i4i PRODICT® test which combines both common and rare genetic changes (genetic variants) into one saliva-based DNA test to estimate a…
- Trial name
- NCT06636526
- Testing
- The i4i PRODICT® test., Prostate cancer screening, MRI Scan
- Where
- 3 sites in United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Institute of Cancer Research, United Kingdom