Clinical trials: Pollution; Exposure
Exposure to Environmental Pollution, Non-occupational
Epigenetic Effect Modifications With Ozone Exposure on Healthy Volunteers
The purpose of this protocol is to assess whether epigenetic factors in healthy individuals make a person more or less responsive to lung inflammation following ozone exposures.
- Trial name
- Geminoz (NCT02469428)
- Testing
- Clean air, Ozone
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Environmental Protection Agency (EPA)
PreDiabetes
Cleaner Air for Lower Cardiometabolic Risk
The purpose of this interventional sham-controlled pilot study is to study the effects of using portable air cleaners (PACs) in outpatient adults with prediabetes.
- Trial name
- NCT05994937
- Testing
- PAC with HEPA filter intact, PAC with HEPA filter removed
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- NYU Langone Health
Pollution; Exposure
Effects of Transportation Choices on Commuter Health
The primary project objective is to investigate how an individual's choices influence personal exposures to traffic-related air pollutants (TRAPs) and the corresponding acute health effects.
- Trial name
- ETCH (NCT05758714)
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- UConn Health
Sleep Quality
Mitigation of Health Effects in Pregnant Women by Reducing Exposure to Heat and Air Pollution
The goal of this clinical trial is to assess the effectiveness of an intervention (combination of behavioural recommendations and technical measures) in reducing personal exposure to heat and air pollution and related health…
- Trial name
- ISMED CLIM PW (NCT07609433)
- Testing
- Heat intervention, Heat and air pollution mitigation intervention
- Where
- 3 sites in Cyprus, Italy
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Cyprus
Lung Cancer, High-Risk Cancer
Taiwan Real-world LDCT Screening Behavior and Outcome Research for High Risk Subjects Based on Health Promotion Administration
Lung cancer is the leading cause of mortality in the world, and also in Taiwan.Despite the researches and availability in new therapies, it causes the highest mortality and is one of the most preventable cancers as well.
- Conditions
- Lung Cancer, High-Risk Cancer, Smoking, Pollution; Exposure
- Trial name
- TRIO (NCT05557487)
- Testing
- Low dose computed tomography
- Where
- 7 sites in Taiwan
- Volunteers
- 6,618 people, healthy volunteers welcome
- Sponsor
- Gee-Chen Chang
Interstitial Lung Disease Due to Systemic Disease (Disorder), Interstitial Lung Disease Due to Systemic Disease (Telomere Biology Disorder)
Occupational and Environmental Exposures Analysis in Interstitial Lung Diseases.
The OCEAN-ILD study is designed to prospectively evaluate the prevalence and clinical relevance of environmental and occupational exposures in a large Italian cohort of patients affected by any ILD, using a standardised exposure…
- Conditions
- Interstitial Lung Disease Due to Systemic Disease (Disorder), Interstitial Lung Disease Due to Systemic Disease (Telomere Biology Disorder), Exposure Occupational, Occupational Exposure
- Trial name
- OCEAN-ILD (NCT07577115)
- Testing
- standard interview
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- Istituto Clinico Humanitas
Heart Failure
Project 4: ACHIEVE PATHFINDER
ACHIEVE-P4: PATHFINDER is a randomized, blinded clinical trial of portable air cleaners (PAC) provided at the time of hospital discharge to Heart Failure (HF) patients. It will be carried out at Henry Ford Hospitals.
- Trial name
- PATHFINDER (NCT06070428)
- Testing
- PAC provision at hospital discharge, Control non-intervention; PAC without filter
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Henry Ford Health System
Water-Related Diseases, Enteric Pathogens
Rural Appalachia Pilot Water Treatment Trial
Consumption of unsafe drinking water is associated with a substantial burden of disease globally. In the USA, the burden of disease associated with consumption of contaminated drinking water from non-regulated private wells and…
- Conditions
- Water-Related Diseases, Enteric Pathogens, Exposure to Chemical Pollution
- Trial name
- NCT06120985
- Testing
- Countertop pitcher water filter
- Where
- 2 sites in United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Asthma, Chronic Obstructive Pulmonary Disease (COPD)
Lungs on Fire: Wildfire Smoke, Incident Diseases, Susceptible Populations, and Community Values in Canada
Wildfire smoke (WFS) is the leading climate-related risk in Canada and the main source of harmful air pollution. While short-term breathing problems caused by smoke are well known, there is limited knowledge on how repeated…
- Conditions
- Asthma, Chronic Obstructive Pulmonary Disease (COPD), Lung Cancer
- Trial name
- LoF (NCT07536178)
- Testing
- Woodsmoke (Lodgepole Pine) exposure, Filtered air exposure
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Risk Factors for Respiratory and Cardiovascular Disease
Influence of Indoor Air Filtration Strategies on Occupant Health Indicators
The purpose of this study is to evaluate whether two different central air purification technologies reduce air pollutant exposure and beneficially influence health as evaluated with a suite of biological markers related to…
- Trial name
- NCT02769208
- Testing
- Central air handling unit air purification technologies
- Where
- China
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Feng Li
Healthy, Exposure to Pollution
Sympathetic Nerve Response Incited by Biodiesel Exhaust Exposure
The adverse effects of current ambient air pollution on cardiovascular and respiratory health have been demonstrated in an extensive series of epidemiological, observational and experimental studies.
- Trial name
- NCT03698344
- Testing
- Biodiesel exhaust exposure
- Where
- Sweden
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Umeå University
Tobacco Use, Pollution; Exposure
FRESHAIR4Life: Building the Case for Action
The goal of this observational study is to understand the burden and determinants of tobacco use and air pollution (AP) exposure among mid- to late adolescents in Greece, the Kyrgyz Republic, Pakistan, Romania, and Uganda.
- Conditions
- Tobacco Use, Pollution; Exposure, Non-communicable Disease
- Trial name
- NCT06074939
- Volunteers
- 1,750 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Cardiovascular Diseases
Cleaner Air for Better Cardiac Biomarkers
This pilot project is a randomized, double-blind, sham-controlled trial investigating whether in-home air pollution reductions using portable air cleaners (PACs) can decrease circulating concentrations of biomarkers of…
- Trial name
- NCT05379400
- Testing
- Portable air cleaner (PAC)
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- NYU Langone Health
Pollution; Exposure, HTN
The Effect of Personal Protective Aids on Hypertension and Diabetes in People Exposed to High Levels of Air Pollution
This is a randomized controlled trial to evaluate personal protective aids (air purifier and N95) as a therapeutic measure in people with hypertension and diabetes exposed to high levels of PM2.5 in India.
- Conditions
- Pollution; Exposure, HTN, Diabetes Mellitus
- Trial name
- NCT04854187
- Where
- India
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Medstar Health Research Institute
Premature Birth, Fetal Growth Retardation
NACER II: Reducing Prenatal Exposures to Household Air Pollution in Rural Guatemala Through a Gas Stove/Behavior Intervention to Improve Neonatal Health
Greater efforts are needed to bring affordable, clean stoves and adaptive behavioral strategies to the millions of households worldwide that continue to burn solid cooking fuels using inefficient stoves.
- Conditions
- Premature Birth, Fetal Growth Retardation, Infections, Respiratory, Exposure to Environmental Pollution, Non-occupational
- Trial name
- NCT02812914
- Testing
- Low-cost gas stove, Peer education classes, Resource-intensive behavioral intervention approach
- Where
- Guatemala
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Tobacco Smoke Pollution, Maternal Exposure During Pregnancy
Prenatal Tobacco Exposure and Newborn Outcomes: A Maternal Urinary Cotinine Study
Prenatal exposure to tobacco smoke, through either active maternal smoking or secondhand exposure, has been associated with impaired fetal oxygenation, metabolic stress, and adverse early neonatal outcomes.
- Conditions
- Tobacco Smoke Pollution, Maternal Exposure During Pregnancy, Infant, Newborn, Carbon Monoxide Poisoning
- Trial name
- NCT07201181
- Testing
- Maternal Urinary Cotinine Assessment
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Haseki Training and Research Hospital
Healthy Participants
Wildfire Related Air Pollution Exposure and Cognitive Function Pilot Study
This study will examine how breathing wildfire-related air pollution (WRAP) for one hour affects healthy adults. The main question the study will answer if the effect of WRAP exposure on p-tau, a blood marker of cognitive…
- Trial name
- WRAP (NCT07151235)
- Testing
- Simulated wildfire smoke exposure, Clean Air exposure
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Lung; Premature, Pollution; Exposure
Ultrafine Particles and Fetal Contamination
The objective of this study is to evaluate the transplacental passage of fine and ultrafine particles (nanoparticles) inhaled by the mother.
- Trial name
- FOETOPUF (NCT04068389)
- Testing
- Pulmonary Tissue Collection
- Volunteers
- 62 people
- Sponsor
- University Hospital, Bordeaux
Exposure to Environmental Pollution, Non-occupational
The Interaction of Social Factors With Air Pollution
Purpose: The purpose of this protocol is to understand how social factors such as psychosocial stress may modify how people respond to air pollution.
- Trial name
- SOZIAL (NCT02206750)
- Testing
- Clean Air, Ozone
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Environmental Protection Agency (EPA)
Airway Inflammation, Systemic Inflammation
HIPWOODS - Health Effects Related to Exposure to Particle Pollution From Woodburning Stoves
The study intends to focus on health effects and symptoms related to particle exposure from wood burning stoves The objective is to determine whether moderate exposure to particles from wood smoke in a real life situation causes…
- Trial name
- HIPWOODS (NCT00673907)
- Testing
- Wood smoke particles
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Aarhus