Clinical trials: Pneumopathy
Non Small Cell Lung Cancer
Phase 2 Study of AUY922 in NSCLC Patients With Exon 20 Insertion Mutations in EGFR
This research study is a Phase II clinical trial, which tests the safety and effectiveness of an investigational drug to learn whether the drug works in treating a specific cancer.
- Trial name
- NCT01854034
- Testing
- AUY922
- Where
- 4 sites in United States
- Volunteers
- 29 people
- Sponsor
- Massachusetts General Hospital
Asthma, Lung Diseases
Intervention to Improve Asthma Management/Prevention
To implement and evaluate a comprehensive asthma education and prevention program in all 54 public elementary schools in the predominantly minority Birmingham, Alabama school system.
- Trial name
- NCT00005734
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Carcinoma, Non-Small-Cell Lung
Study to Evaluate Using Nelfinavir With Chemoradiation for Non-small Cell Lung Cancer
This study combines nelfinavir (NFV) with radiation therapy and chemotherapy as a treatment for non-small cell lung cancer (NSCLC) who are considered candidates for pre-operative treatment.
- Trial name
- NCT00791336
- Testing
- Nelfinavir
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Iowa
COPD, COPD Exacerbation
Supported Rescue Packs Post-discharge in Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a chronic lung disease affecting approximately 10% of the adult population globally.
- Trial name
- RAPID (NCT06347536)
- Testing
- Supported rescue pack
- Where
- 34 sites in United Kingdom
- Volunteers
- 1,400 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Aspiration Pneumonia
Early Stop(Ruling) of the Antibiotic Treatment During Pneumopathies d' Inhalation
The two most common consequences resulting from aspiration are chemical pneumonitis and bacterial aspiration pneumonia. Both entities present with comparable clinical signs and symptoms.
- Trial name
- APAPI (NCT03763799)
- Testing
- PCR-based microbiological diagnosis strategy, Standard microbiological diagnosis strategy
- Where
- 2 sites in France
- Volunteers
- 266 people
- Sponsor
- University Hospital, Lille
Asthma
Reversibility of Methacholine Induced Bronchoconstriction
The study will compare salbutamol reversibility of methacholine induced bronchoconstriction between a pressurized metered dose inhaler with a spacer versus nebulizer administration using a vibrating mesh nebulizer.
- Trial name
- NCT05977699
- Testing
- salbutamol aqueous solution, salbutamol pressurized metered dose inhaler
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- University of Saskatchewan
Lung Neoplasms
Deep Inspiration Breath Hold as Primary Strategy for Locally Advanced Lung Cancer Radiotherapy
Despite considerable advances in cancer treatment, patients with locally advanced lung cancer still face a poor chance of survival and a high risk of experiencing serious, life threatening treatment-related side-effects.
- Trial name
- INHALE (NCT02540499)
- Testing
- DIBH VMAT
- Where
- Denmark
- Volunteers
- 88 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Prognosis
Epigenetic Tools as Prognostic Predictors in Covid19
The necessity for early detection and hence improving the outcome of treatment of pneumonia is critical especially SARS-CoV-2 induced cases.
- Trial name
- NCT04411563
- Testing
- Taking biological samples
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Radiation Pneumonitis
Risk Factors of Radiation Pneumonitis
A prospective observational study to evaluate clinical, dosimetrical, functional, and biological factors in predicting radiation pneumonitis.
- Trial name
- NCT00155909
- Where
- Taiwan
- Volunteers
- 53 people
- Sponsor
- National Taiwan University Hospital
Chronic Obstructive Pulmonary Disease
Cardiovascular Risk and Chronic Obstructive Pulmonary Disease
The principal objective of the study is to measure parameters of inflammation, oxidative stress, and vascular, respiratory, and peripheral muscle function parameters, and identify parameters indicative of evolving cardiovascular…
- Trial name
- ECO-COPD (NCT03014609)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Grenoble
Non-Small Cell Lung Cancer
A Study to Assess Safety, Tolerability, and Pharmacokinetics of ABSK112 in Patients With Non-Small Cell Lung Cancer
This is a first-in-human (FIH), multicenter, non-randomized, openlabel, phase 1 study of ABSK112 in patients with NSCLC to evaluate the safety, tolerability, PK, and preliminary antitumor efficacy.
- Trial name
- NCT06225804
- Testing
- ABSK112
- Where
- 14 sites in United States, China
- Volunteers
- 164 people
- Sponsor
- Abbisko Therapeutics Co, Ltd
SARS-CoV-2
Post-marketing Surveillance (PMS) Use-Result Surveillance With SPIKEVAX BIVALENT, SPIKEVAX X Injection, SPIKEVAX JN Injection and SPIKEVAX IN PRE-FILLED SYRINGE
The main objective of the surveillance is to evaluate the incidence of the adverse events (AEs), and other safety-related information in South-Korean population.
- Trial name
- NCT06333704
- Testing
- SPIKEVAX Bivalent BA.1, SPIKEVAX Bivalent BA.4/5, SPIKEVAX XBB.1.5
- Where
- 26 sites in South Korea
- Volunteers
- 4,207 people, healthy volunteers welcome
- Sponsor
- ModernaTX, Inc.
Breast Cancer, Lung Cancer
Blood Sample Collection to Evaluate Biomarkers in Subjects With Untreated Solid Tumors
The primary objective of this study is to obtain de-identified, clinically characterized, whole blood specimens to evaluate biomarkers associated with cancer for diagnostic assay development.
- Conditions
- Breast Cancer, Lung Cancer, Colorectal Cancer, Prostate Cancer
- Trial name
- NCT03662204
- Testing
- Blood Sample Collection
- Where
- 119 sites in United States
- Volunteers
- 5,133 people
- Sponsor
- Exact Sciences Corporation
Asthma
The Asthma Breathing Record Study
The study involves a new device, called 'N-Tidal C', which uses a method that has the potential to predict when asthma attacks are about to happen. The device works by accurately measuring an individual's exhaled CO2 waveform.
- Trial name
- ABRS (NCT04504838)
- Where
- United Kingdom
- Volunteers
- 124 people
- Sponsor
- TidalSense
COVID-19
International Survey of Acute Coronavirus Syndromes-COVID-19
In response to the COVID-19 crisis, ISACS-TC has promoted a new registry of the existing and further centers of the same geographic areas to support clinical research to prevent, and treat the COVID-19 illness.
- Trial name
- ISACS-COVID-19 (NCT05188612)
- Testing
- Observational (registry)
- Where
- 2 sites in Italy, Spain
- Volunteers
- 10,000 people
- Sponsor
- University of Bologna
COVID-19
Safety and Immunogenicity Study of AdCLD-CoV19: A COVID-19 Preventive Vaccine in Healthy Volunteers
This is a Phase 1/2a clinical trial to assess the safety and immunogenicity of AdCLD-CoV19 in healthy adults.
- Trial name
- NCT04666012
- Testing
- AdCLD-CoV19
- Where
- 5 sites in South Korea
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Cellid Co., Ltd.
Respiratory Distress Syndrome, Adult, Acute Hypoxemic Respiratory Failure
Weaning From Nasal High Flow Therapy
Nasal high flow is widely used in critically ill patients admitted to the intensive care unit (ICU) for acute hypoxemic respiratory failure.
- Conditions
- Respiratory Distress Syndrome, Adult, Acute Hypoxemic Respiratory Failure, Acute Respiratory Distress Syndrome, Weaning Failure
- Trial name
- NCT05210881
- Where
- France
- Volunteers
- 62 people
- Sponsor
- Hôpital Louis Mourier
Bronchial Asthma
A Study of Step-up in Bronchial Asthma as a New End Point in Asthma Control (SURFE)
The goal of this observational study is to learn about the frequency needed for stepping-up treatment in patients with mild and moderate bronchial asthma.
- Trial name
- SURFE (NCT05632081)
- Where
- Saudi Arabia
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
COVID-19, SARS-CoV-2 Infection
Whole-Virion Inactivated SARS-CoV-2 Vaccine (BBV152) for COVID-19 in Healthy Volunteers
Double blind, Multi-Centre study to evaluate the safety, reactogenicity, tolerability, and immunogenicity of three investigational vaccine groups and one placebo group in healthy volunteers who receive two intramuscular doses of…
- Trial name
- BBV152 (NCT04471519)
- Testing
- BBV152A - Phase I, BBV152B - Phase I, BBV152C - Phase I
- Where
- 12 sites in India
- Volunteers
- 755 people, healthy volunteers welcome
- Sponsor
- Bharat Biotech International Limited
Neuroendocrine Carcinoma, Non-small Cell Lung Cancer
Neuroendocrine Transformation in RB1/TP53 Inactivated NSCLC
Histology transformation from non-small cell lung cancer (NSCLC) to neuroendocrine carcinomas (NEC), especially from epidermal growth factor receptor (EGFR) mutant lung adenocarcinoma (LADC) to small cell lung cancer (SCLC), is…
- Conditions
- Neuroendocrine Carcinoma, Non-small Cell Lung Cancer, Histology Transformation
- Trial name
- NCT06369181
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Fudan University