Clinical trials: Pleural Effusion
Malignant Pericardial Effusion, Malignant Pleural Effusion
Genetic Sequencing-Informed Targeted Therapy in Treating Patients With Stage IIIB-IV Non-small Cell Lung Cancer
This randomized clinical trial studies how well genetic sequencing-informed targeted therapy works in treating patients with stage IIIB-IV non-small cell lung cancer.
- Conditions
- Malignant Pericardial Effusion, Malignant Pleural Effusion, Recurrent Non-small Cell Lung Cancer, Stage IIIB Non-small Cell Lung Cancer
- Trial name
- NCT02132884
- Testing
- cytology specimen collection procedure, therapeutic procedure, targeted therapy
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Fox Chase Cancer Center
Disorder of Pleura and Pleural Cavity
Thoracoscopic Pleural Lavage and Brushing in Undiagnosed Pleural Effusion
1. To evaluate the diagnostic yield and safety of thoracoscopic pleural lavage and pleural brushing in cases of undiagnosed exudative pleural effusion.
- Trial name
- NCT06066398
- Testing
- medical thoracoscope, Forceps biopsy and pleural brush histopathology, pleural lavage cytology
- Volunteers
- 60 people
- Sponsor
- Assiut University
Pleural Effusion
Use of Procalcitonin in the Diagnosis of Pleural Effusion
Among several markers of inflammation and sepsis, procalcitonin (PCT) markers is being studied to investigate their accuracy for the diagnosis of bacterial infections.
- Trial name
- NCT00172835
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Advanced Cancer, Pleural Effusion
Intrapleural Catheter Daily Versus Three Times a Week Drainage
The goal of this clinical research study is to learn if draining the IPC every day is better at than draining it 3 times a week.
- Trial name
- NCT00761618
- Testing
- Intrapleural catheter (IPC) drained, IPC Placement, Chest X-Ray
- Where
- United States
- Volunteers
- 257 people
- Sponsor
- M.D. Anderson Cancer Center
Splenomegaly, Pleural Effusion
Evaluation of a Pocket-Sized Ultrasound Device As an Aid to the Physical Examination
The 40 resident study subjects will be randomized to either receive a training session on use of a pocket-sized ultrasound or to receive training on physical exam skills.
- Trial name
- NCT01948076
- Testing
- resident with GE vscan
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Pleural Effusion
Use of the Triggering Receptor Expressed on Myeloid Cells-1 (TREM-1) in the Diagnosis of Pleural Effusion
The aim of this trial is to evaluate the level of TREM-1 in different kinds of pleural effusion.
- Trial name
- NCT00166894
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Atrial Fibrillation, Pericardial Effusion
Active Clearance of Chest Tubes After Cardiac Surgery: A Prospective Randomized Controlled Study
The purpose of this study is to assess the effectiveness of the PleuraFlow® Active Tube Clearance (ATC) technology in reducing the rate of postoperative atrial fibrillation (POAF) among post cardiac surgery patients and to…
- Conditions
- Atrial Fibrillation, Pericardial Effusion, Pleural Effusion, Hemothorax
- Trial name
- NCT02808897
- Testing
- Standard drainage, Active Tube Clearance drainage
- Where
- 2 sites in Canada
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- Montreal Heart Institute
Malignant Pleural Effusions (Mpe), Non Small Cell Lung Cancer
First-in-Human Expanded Cohort Study of Intrapleural Administration of TolueneSulfonamide in Patients With Malignant Pleural Effusion
This study aims to evaluate the safety of intrapleural injection of TolueneSulfonamide in patients with malignant pleural effusion and to explore its potential effectiveness.
- Trial name
- NCT07332858
- Testing
- Intrapleural administration of TolueneSulfonamide, Intrapleural administration of normal saline injection
- Where
- China
- Volunteers
- 105 people
- Sponsor
- Gang Hou
Malignant Pleural Effusion, Non Small Cell Lung Cancer
Zometa Adjuvant Treatment of Malignant Pleural Effusion Due To Non-Small Cell Lung Cancer
The purpose of this study is to evaluate whether the addition of the bisphosphonate Zometa (zoledronic acid) used along with standard regimens of chemotherapy, will help to control the need for palliative intervention of…
- Trial name
- ZAP (NCT01004510)
- Testing
- zoledronic acid
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Peter Bushunow MD
Pleural Effusion, Malignant
Relationship Between Pleural Elastance and Effectiveness of Pleurodesis on Recurrent Malignant Pleural Effusion
The objective of this study is to analyze the correlation between pleural elastance and the radiological effectiveness (measured by chest tomography) of pleurodesis performed via catheters in patients with RMPE.
- Trial name
- NCT01819363
- Testing
- Pleural elastance
- Where
- Brazil
- Volunteers
- 140 people
- Sponsor
- Grupo de Pesquisa em Pleura e Oncologia Toracica
Lung Cancer, Metastatic Cancer
Photodynamic Therapy in Treating Patients With Resectable Non-Small Cell Lung Cancer That Has Spread to the Pleura
RATIONALE: Photodynamic therapy uses a drug, such as porfimer sodium, that is absorbed by tumor cells. The drug becomes active when it is exposed to light. When the drug is active, tumor cells are killed.
- Trial name
- NCT00601848
- Testing
- chemotherapy, porfimer sodium, immunohistochemistry staining method
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Cancer
Trastuzumab Plus R115777 in Treating Patients With Advanced or Metastatic Cancer
Phase I trial to study the effectiveness of trastuzumab plus R115777 in treating patients who have advanced or metastatic cancer.
- Trial name
- NCT00005842
- Testing
- trastuzumab, tipifarnib
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- National Cancer Institute (NCI)
Malignant Pleural Effusion
Malignant Pleural Effusion: Pleur-X vs. Chemical Pleurodesis in VATS
This is a prospective randomized study whose aim is to compare the efficacy of the permanent thoracic catheter (Pleur-X) versus chemical pleurodesis in videothoracoscopy (VATS) in the treatment of malignant pleural effusion at…
- Trial name
- Pleur-X (NCT03518788)
- Testing
- Pleur-X, Pleurodesis
- Where
- Switzerland
- Volunteers
- 234 people
- Sponsor
- Rolf Inderbitzi
Non Small Cell Lung Cancer
Intrapleural Administration of Bevacizumab Versus Endostar for Pleural Effusions in NSCLC
Malignant pleural effusion (MPE) is a common complication of advanced non-small cell lung cancer (NSCLC). Bevacizumab, a humanized monoclonal antibody against vascular endothelial growth factor (VEGF), has been shown to be…
- Trial name
- NCT02005120
- Testing
- Bevacizumab, recombinant human endostatin
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- Zhejiang University