Clinical trials: Pleural Effusion
Dengue Fever, Pleural Effusion
Ketotifen as a Treatment for Vascular Leakage During Dengue Fever
Rationale and Aims: Infection by dengue virus (DENV) causes major morbidity and mortality throughout the world. In 2012, an estimated 3.6 billion people live in areas at risk for DENV infection, including Singapore.
- Trial name
- KETODEN (NCT02673840)
- Testing
- Ketotifen
- Where
- 2 sites in Singapore
- Volunteers
- 110 people
- Sponsor
- National University Hospital, Singapore
Pleural Effusion Recurrence, Pulmonary Resection
Evaluation of Fluid Output Threshold for Safe Chest Tube Removal - A Potential Way to Decrease Length of Stay in Hospital and to Improve Postoperative Care After Lung Surgery?
Previous studies have shown that the removal of the chest tube after lung surgery significantly improves pain symptoms and lung function.
- Conditions
- Pleural Effusion Recurrence, Pulmonary Resection, Chest Tube Management
- Trial name
- NCT03093610
- Testing
- Traditional, Test
- Where
- Switzerland
- Volunteers
- 337 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Pleural Effusion
Effect of Bubble Positive Expiratory Pressure and Segmental Breathing Versus Incentive Spirometry in Pleural Effusion
Conducted as a randomized clinical trial, this study will include 40 pediatric participants aged 5-16, recruited from Gulab Devi Chest Hospital and Children's Hospital, Lahore.
- Trial name
- NCT07248774
- Testing
- Bubble PEP, Incentive Spirometery
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Riphah International University
NSCLC
Safety and Efficacy of NK510 to Treat NSCLC
This study assesses the safety and efficacy of NK510 combined with PD-(L)1 inhibitors for relapsed/refractory advanced NSCLC, with two administration routes: intravenous infusion and intrapleural perfusion for malignant pleural…
- Trial name
- NCT06097962
- Testing
- NK510, Tislelizumab，atezolizumab or sugemalimab, systemic therapy as selected by the investigator
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Base Therapeutics (Shanghai) Co., Ltd.
Advanced Solid Tumors, Malignant Pleural Effusions
WSK-IM02 in Advanced Solid Tumors With Malignant Effusions (Phase I)
This is a prospective, single-center, interventional, phase I, dose-escalation, single-arm study designed to evaluate the safety, tolerability, and preliminary efficacy of intrapleural/intraperitoneal infusion of WSK-IM02 in…
- Conditions
- Advanced Solid Tumors, Malignant Pleural Effusions, Malignant Ascites
- Trial name
- NCT07615894
- Testing
- WSK-IM02
- Where
- China
- Volunteers
- 9 people
- Sponsor
- WestVac Biopharma Co., Ltd.
Pleural Effusion, Tuberculosis, Pleural
TBP Survey Among Respiratory Physicians
Tuberculosis is a major infectious disease with a high mortality burden in the Asia-Pacific region and worldwide. Among various types of extrapulmonary tuberculosis, tuberculous pleuritis (TBP) is amongst the most common…
- Trial name
- NCT06390969
- Testing
- Survey
- Where
- Hong Kong
- Volunteers
- 418 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Tuberculosis, Pleural
Diagnostic Utility of Mycobacterium Tuberculosis Cell-free DNA
Tuberculosis (TB) is one of the major global health threats and is the second leading infectious cause of death after COVID-19 in 2022.
- Trial name
- MYDNITE-2 (NCT06439810)
- Testing
- Mycobacterium tuberculosis (MTB) cell-free DNA (cfDNA)
- Where
- Hong Kong
- Volunteers
- 400 people
- Sponsor
- Chinese University of Hong Kong
Invasive Aspergillosis, Pleural Effusion
Diagnostic Accuracy of Pleural Effusion Aspergillosis Biomarker Testing
Diagnostic accuracy of biomarker testing (galactomannan (GM), (1
- Conditions
- Invasive Aspergillosis, Pleural Effusion, Immunosuppression
- Trial name
- EFFU-ASP (NCT02104479)
- Where
- 2 sites in Germany
- Volunteers
- 200 people
- Sponsor
- Heidelberg University
Chylothorax
Chylothorax Following Heart Surgery
The purpose of this study is to determine at risk populations for certain congenital heart defects or certain operative procedures and to define the associated morbidity secondary to chylothorax - prolonged chest tube drainage…
- Trial name
- NCT00215098
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Children's Healthcare of Atlanta
Thoracocentesis of Pleural Effusion
Pleural Manometry in Thoracocentesis
The study aiming to measure the pleural pressure during thoracocentesis in patients with pleural effusion and the value of their measurement in both diagnostic and therapeutic decisions.
- Trial name
- NCT04420663
- Testing
- Pleural Manometry
- Where
- Egypt
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Aly Sherif Hassaballa
Lung Neoplasms
Rational Approach to a Unilateral Pleural Effusion2
Recurrent unilateral, non-infectious pleural exudate is suspicious for primary or secondary pleural malignancy. Both conditions are associated with 5-year survival of 10%.
- Trial name
- REPEAT (NCT02834455)
- Testing
- Contrast-enhanced CT, PET-CT
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Simon Reuter
Pleural Diseases
Optimal Number of Pleural Biopsies During Pleuroscopy
A single-center, non-randomized, prospective observational, pilot study designed to determine what is the optimal number of pleural biopsies to take during pleuroscopy.
- Trial name
- OPTIBIOP (NCT06897878)
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Chylous Pleural Effusion Following Cardiothoracic Surgery
Fortified Skimmed Mother's Milk in the Management of Chylothorax
The purpose of this study is to determine if the use of fortified skimmed mother's milk is a safe alternative to specialized formula in the treatment of chylothorax following cardiothoracic surgery.
- Trial name
- NCT01673165
- Testing
- Skimmed mother's milk, Specialized Formula
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Oregon Health and Science University
Lung Cancer, Small Cell Lung Cancer
QUILT-2.013: First-Line Treatment for Extensive Stage Small Cell Lung Cancer
This trial is titled "A Phase 1b/2 trial of AMG 479 or AMG 102 with Platinum-Based Chemotherapy as First-Line Treatment for Extensive Stage Small-Cell Lung Cancer (SCLC)." Part 1, the phase 1b portion of this study, is a…
- Conditions
- Lung Cancer, Small Cell Lung Cancer, Solid Tumors, Extensive-stage Small Cell Lung Cancer
- Trial name
- SCLC (NCT00791154)
- Testing
- AMG 479, Etoposide, AMG 102
- Volunteers
- 213 people
- Sponsor
- NantCell, Inc.
Adenocarcinoma of the Lung, Adenosquamous Cell Lung Cancer
Docetaxel With Either Cetuximab or Bortezomib as First-Line Therapy in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer
This randomized phase II trial is studying how well giving docetaxel together with either cetuximab or bortezomib works as first-line therapy in treating patients with stage III or stage IV non-small cell lung cancer.
- Conditions
- Adenocarcinoma of the Lung, Adenosquamous Cell Lung Cancer, Large Cell Lung Cancer, Malignant Pleural Effusion
- Trial name
- NCT00118183
- Testing
- docetaxel, cetuximab, bortezomib
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- National Cancer Institute (NCI)
Pleural Effusion, Pleural Diseases
Talc Outpatient Pleurodesis With Indwelling Catheter
This study will be a prospective, randomized trial comparing a new protocol to the standard of care. The investigators protocol and the standard of care involves a previously established procedure that will be completed in the…
- Conditions
- Pleural Effusion, Pleural Diseases, Malignant Pleural Effusion
- Trial name
- TOPIC (NCT03973957)
- Testing
- Indwelling pleural catheter placement, Fentanyl Citrate, Talc Slurry
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- The Cooper Health System
Complicated Pleural Effusion/ Empyema
Effectiveness and Safety of Sodium Bicarbonate Pleural Lavage in the Treatment of Complex Pleural Effusion
The goal of this clinical trial is to evaluate the safety and efficacy of sodium bicarbonate pleural lavage in treating complex pleural effusion in adult.
- Trial name
- SAPLIC (NCT06734481)
- Testing
- Sodium bicarbonate pleural lavage, Saline pleural lavage
- Where
- China
- Volunteers
- 260 people
- Sponsor
- First Affiliated Hospital of Ningbo University
Pleural Effusions
iSTAT Comparison Study, IRB3785
Pleural fluid glucose levels measured with bed-side point of care methods such as finger stick glucometers and I-STAT device correlate with the traditional in-lab testing methods.
- Trial name
- NCT02208895
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Oklahoma
Pleural Effusion
Impact of Pleural Manometry on Chest Discomfort After Therapeutic Thoracentesis
This randomized controlled trial attempts to determine whether the measurement of pleural pressures during therapeutic thoracentesis affects the development of chest discomfort after the procedure.
- Trial name
- NCT02677883
- Testing
- Manometry-guided thoracentesis, Symptom-guided thoracentesis
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Malignant Pleural Effusion
A Phase I Study Evaluating SCB-313(Recombinant Human TRAIL-Trimer Fusion Protein) for the Treatment of Malignant Pleural Effusion
To evaluate the safety and tolerability of single dose of SCB-313 by intrapleural injection.To evaluate the safety and tolerability of repeated dose of SCB-313 by intrapleural injection once a day for 3 days, and to determine the…
- Trial name
- NCT04123886
- Testing
- SCB-313
- Where
- China
- Volunteers
- 14 people
- Sponsor
- Sichuan Clover Biopharmaceuticals, Inc.