Clinical trials: Platelet Transfusion
Platelet Aggregation, Blood Transfusion
Validation of a Red Blood Cell Transfusion Prediction Model in a Low Transfusion Rate Population.
The transfusion risk and clinical knowledge (TRACK) allogeneic blood transfusion prediction model was developed more than ten years ago and demonstrated good discriminative ability in patients with increased risk for allogeneic…
- Trial name
- TRACK-TCT (NCT05581238)
- Testing
- TRACK-TCT
- Where
- Netherlands
- Volunteers
- 6,428 people, healthy volunteers welcome
- Sponsor
- Medisch Spectrum Twente
Coronary Artery Disease, Coronary Artery Bypass Graft
Tranexamic Acid in On-pump CABG With Premature Clopidogrel Cessation
The use of platelet aggregation inhibitors, including aspirin and clopidogrel, has become a standard management strategy for patients with acute coronary syndrome.
- Trial name
- NCT01596738
- Testing
- Tranexamic Acid, Saline
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Li Lihuan
Platelet Refractoriness, Hematologic Malignancy
A Pilot Trial Using Isatuximab to Overcome Platelet Transfusion Refractoriness in Human Leukocyte Antigen Allo-Immunized Patients (SuppCare 001)
Some of the treatments for cancer can cause platelets (the part of the blood that helps with clotting) to decrease. If they are too low, then clinicians may recommend a transfusion (getting platelets from another person added to…
- Trial name
- NCT05284032
- Testing
- isatuximab 10 mg/kg
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Firas El Chaer, MD
Chronic Periodontitis (Disorder), Periodontitis
i-PRF & Root Surface Biomodification
This study is designed to evaluate a new method to improve healing in patients with gum disease (periodontitis). A total of 42 adults with gum pockets deeper than 5 millimeters will take part.
- Trial name
- iPRF-Perio (NCT07207668)
- Testing
- Open Flap Debridement (OFD), 24% EDTA Root Conditioning, Injectable Platelet-Rich Fibrin (i-PRF)
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Halil Ata BIÇAKÇIOGLU
Dengue, Dengue Fever
Risk Factors for Hospitalization and Transfusion Criteria in Patients With Dengue Virus Infection
This 3-year prospective observational study aims to identify clinical and laboratory risk factors associated with hospitalization in patients with confirmed dengue virus infection.
- Conditions
- Dengue, Dengue Fever, Dengue Fever With Warning Signs
- Trial name
- DENGUE-FACT (NCT07007585)
- Where
- Mexico
- Volunteers
- 100 people
- Sponsor
- Jose Ivan Rodriguez de Molina Serrano
Sepsis, Thrombocytopenia
Platelet Transfusion in Sepsis Trial
Platelets are important mediators of an inflammatory response and a key component of the innate immune system to defend the human body against invading pathogens.
- Trial name
- NCT03968484
- Testing
- platelet transfusion
- Sponsor
- University Hospital Tuebingen
Healthy, Transfusion Reactions
Effects of Antibodies to White Blood Cells on Platelet Transfusion Patients
This study will determine if transfusion of platelets containing HLA antibodies (certain antibodies to white blood cells) are more likely to cause transfusion reactions than transfusion of platelets that do not contain HLA…
- Trial name
- NCT00460122
- Where
- United States
- Volunteers
- 135 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Perioperative Bleeding
Platelet Function Testing Help and Intraoperative Bleeding Risk for Patients Who Are on Plavix Prior to Surgery
A large number of patients are currently on Antiplatelet inhibition using aspirin or Plavix therapy (A Thieno pyridine - ADP mediated platelet inhibitor).
- Trial name
- NCT00653900
- Where
- United States
- Sponsor
- Cedars-Sinai Medical Center
Thrombocytopenia
Transfusing Neonates Based on Platelet Mass
Thrombocytopenia (low platelet count) is common in the neonatal intensive care unit. Commonly, the decision of when to transfuse platelets is based on platelet number.
- Trial name
- NCT00759980
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- Christiana Care Health Services
Sepsis, Thrombocytopenia
The INFUSE Trial - Intervening With Platelet Transfusions in Sepsis
Sepsis is life-threatening and dysregulated response to infection that results in endothelial activation and dysfunction that leads to systemic microvascular leak and multiple-organ failure.
- Trial name
- INFUSE (NCT03090919)
- Testing
- Platelet transfusion, Saline
- Where
- United States
- Sponsor
- Susan Smyth
Reversal of Platelet Aggregation Inhibitors
Reversal of Aspirin Antiplatelet Therapy With Cold Stored Platelets
Purpose of this study is to compare the reversal responses of 4°C cold stored platelets (CSP) versus 7 day, 22°C room temperature stored platelets (RTP) when given to healthy adult subjects who have received a loading dose of…
- Trial name
- RASP (NCT05111028)
- Testing
- Autologous Room Temperature stored Platelet transfusion, Autologous Cold Stored Platelet transfusion
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Bloodworks
Bleeding, Platelets
Autologous Cold-stored Apheresis Platelets
The Auto-PLTS Study is a single-centre trial performed at Toronto General Hospital (TGH) that uses a randomized, patient preference design.
- Conditions
- Bleeding, Platelets, Cardiopulmonary Bypass, Cardiac Surgery
- Trial name
- Auto-PLTS (NCT07064954)
- Testing
- Autologous Cold-Stored Platelets, Allogeneic Room Temperature-Stored Platelets (Standard of Care)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Thrombocytopaenia, Haematological Malignancies
Clinical Efficacy of Platelet Transfusion
The aim of this study is to analyze the effect of the storage time of platelet concentrates on the occurrence of bleeding events during prophylactic platelet transfusions in patients with hematological malignancies.
- Trial name
- ECLAT (NCT06805097)
- Testing
- Self-assessment of bleeding events
- Where
- France
- Volunteers
- 343 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Hematological Malignancies, Platelet Transfusion Refractoriness (PTR)
Acalabrutinib Maleate and Bortezomib for Patients With HLA Antibodies
Platelet transfusion refractoriness (PTR) is a common complication in patients with hematological malignancies. It not only prolongs the duration of platelet transfusion dependence and significantly increases the risk of…
- Conditions
- Hematological Malignancies, Platelet Transfusion Refractoriness (PTR), HLA Antibodies
- Trial name
- AB-HLA-2026 (NCT07635511)
- Testing
- Acalabrutinib maleate, bortezomib, HLA-matched or crossmatched irradiated platelets
- Volunteers
- 42 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Myeloid Leukemia
A Trial Comparing a Prophylactic With a Therapeutic Platelet Transfusion Strategy in Two Groups
The purpose of this study is to show that a therapeutic platelet transfusion strategy (i.e. platelet transfusion only in case of bleeding) needs minimally a quarter less of transfusions compared to the standard prophylactic…
- Trial name
- NCT00521664
- Testing
- Prophylactic platelet transfusion, Therapeutic platelet transfusion
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- Technische Universität Dresden
Dengue Fever, Dengue Hemorrhagic Fever
Efficacy of Fresh Frozen Plasma (FFP) in Treating Thrombocytopenia in Dengue Patients
This clinical trial seeks to assess the effectiveness of fresh frozen plasma (FFP) in the treatment of thrombocytopenia in individuals with dengue.
- Conditions
- Dengue Fever, Dengue Hemorrhagic Fever, Dengue Shock Syndrome
- Trial name
- EFFP-TDP (NCT06642493)
- Testing
- Fresh frozen plasma
- Where
- Bangladesh
- Volunteers
- 300 people
- Sponsor
- Sheikh Hasina National Institute of Burn and Plastic Surgery
Healthy
Assessment of Whole Blood Cold Stored Platelets
The purpose of this study is to determine the life span and functional characteristics of platelets derived from whole blood that has been stored in a refrigerator for up to 21 days.
- Trial name
- Brrr (NCT02006368)
- Testing
- Blood Collection and autologous re-infusion
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Bloodworks
Diabetic Wounds, Platelet Rich Plasma
Allogeneic vs Autologous PRP for Diabetic Wounds in Renal Dysfunction: a Randomized Controlled Trial
Diabetic wounds are difficult to heal. Autologous platelets in diabetic patients with renal insufficiency have poor function. Allogeneic platelet plasma has a promising application prospect.
- Conditions
- Diabetic Wounds, Platelet Rich Plasma, Allogeneic Blood Transfusions, Renal Dysfunction
- Trial name
- NCT07020559
- Testing
- allogeneic platelet plasma, autologous platelet plasma
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Peking University Third Hospital
Myelodysplastic Syndrome, Thrombocytopenia
Safety Study of Eltrombopag Combined With Azacitidine to Treat Myelodysplastic Syndrome (MDS)
Patients with Myelodysplastic Syndromes (MDS) often suffer from low platelet levels which may lead to bleeding complications. Treatment with cytotoxic agents can decrease the platelet levels further.
- Trial name
- NMDSG10A (NCT01481220)
- Testing
- Eltrombopag
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- Nordic MDS Group
Autologous Blood Transfusion
Autologous Platelet-rich Plasma (aPRP) for Complex Aortic Arch Surgerymacrovascular Operation
Perioperative blood loss continues to be a serious problem in complex aortic arch surgery using deep hypothermic circulatory arrest (DHCA). Major blood loss causes increased morbidity and mortality [1].
- Trial name
- NCT02572440
- Testing
- Sorin XTRA/Sorin Group,
- Where
- China
- Sponsor
- Beijing Anzhen Hospital