Clinical trials: Platelet Function Tests
Coronary Artery Disease (CAD)
Impact of CYP2C19 Genotype-guided Clopidogrel and Ticagrelor Treatment on Platelet Function Test and Metabolomics Profile
Several studies have shown that pharmacodynamic (PD) response varies between patients treated with clopidogrel and that individuals with reduced response have an increased risk of recurrent ischemic events, particularly in…
- Trial name
- NCT05516784
- Testing
- Clopidogrel, Ticagrelor
- Where
- Malaysia
- Volunteers
- 80 people
- Sponsor
- Universiti Sains Malaysia
Platelet Function Tests, Thrombin Generation Tests
Point-of-care Assessment of Thrombin Generation and Platelet Function in Children Requiring Cardiopulmonary Bypass
Coagulopathy after cardiopulmonary bypass (CPB) is associated with increased morbidity and mortality. Clot formation and clot stability are important factors in coagulation and hemostasis.
- Conditions
- Platelet Function Tests, Thrombin Generation Tests, Perioperative Coagulopathy
- Trial name
- NCT02833025
- Testing
- Thrombin generation and Platelet Function Testing
- Where
- Canada
- Volunteers
- 130 people
- Sponsor
- The Hospital for Sick Children
Acute Myocardial Infarction
Safety and Efficacy of Three Different Loading Doses of Clopidogrel, in Patients With Acute Myocardial Infarction
The aim of this study is to determine both safety and effectiveness of three different loading dose regimens of clopidogrel in patients with acute myocardial infarction undergoing primary angioplasty.
- Trial name
- Load & Go (NCT00882739)
- Testing
- Clopidogrel 300 mg, Clopidogrel 600 mg, Clopidogrel 900 mg
- Where
- Italy
- Volunteers
- 168 people
- Sponsor
- Ospedale San Donato
Platelet Function and Reactivity Tests
Comparison of Antiplatelet Effects of Sotagliflozin to FDA-approved Antiplatelet Drugs
This study will identify the potential benefits of regulating platelet activation with sotagliflozin compared to other FDA-approved drugs known to limit platelet activation.
- Trial name
- NCT06933056
- Testing
- Sotagliflozin (SOTA) followed by 3 drugs in a random order, Aspirin followed by 3 drugs in a random order, Clopidogrel followed by 3 drugs in a random order
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Pharmacodynamics
Clopidogrel And Ticagrelor in Healthy Subjects
To evaluate the pharmacodynamics of a lower Ticagrelor dose in healthy Korean volunteers compared with standard Clopidogrel agent.
- Trial name
- NCT02086903
- Testing
- Ticagrelor 90 mg, Clopidogrel 600 mg
- Where
- South Korea
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Dong-A University
Aortic Valve Disease
Transcranial Doppler (TCD) Assessment During Early Anti-thrombotic Therapy After Bioprosthetic Aortic Valve Replacement
The purpose of this study is to determine if there is any difference in the counts of cerebral emboli and platelet function between two prophylactic treatments of thrombosis currently used at University of Ottawa Heart Institute…
- Trial name
- Tissue-Valve (NCT00465218)
- Testing
- Prophylaxis of Thrombosis after aortic valve replacement
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Acute Coronary Syndrome
Testing Responsiveness to Platelet Inhibition on Chronic Antiplatelet Treatment For Acute Coronary Syndromes Trial
This study investigates whether a platelet function testing guided approach with a short-term (1 week) prasugrel treatment and a switch over to clopidogrel treatment in adequate responders to clopidogrel is non-inferior regarding…
- Trial name
- TROPICAL-ACS (NCT01959451)
- Testing
- Prasugrel, Clopidogrel
- Where
- 33 sites in Austria, Germany and 2 more
- Volunteers
- 2,600 people
- Sponsor
- LMU Klinikum
Clot Formation and Platelet Aggregation in Point of Care Testing
Effect of New Oral Anticoagulants Dabigatran and Rivaroxaban on Point of Care Coagulation Testing - an Ex-Vivo Study
The purpose of this study is determine whether point of care coagulation testing is able to map the anticoagulatory effects of new oral anticoagulants dabigatran and rivaroxaban.
- Trial name
- NCT01704053
- Where
- Germany
- Volunteers
- 34 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Coronary Heart Disease
Intracoronary Stenting and Antithrombotic Regimen: ADjusting Antiplatelet Treatment in PatienTs Based on Platelet Function Testing
Clopidogrel low response is associated with a significantly higher risk for ischemic complications after percutaneous coronary intervention.
- Trial name
- ISAR ADAPT PF (NCT01456364)
- Testing
- Ticagrelor, Prasugrel
- Where
- 3 sites in Germany, Hungary
- Volunteers
- 70 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Perioperative Bleeding
Platelet Function Testing Help and Intraoperative Bleeding Risk for Patients Who Are on Plavix Prior to Surgery
A large number of patients are currently on Antiplatelet inhibition using aspirin or Plavix therapy (A Thieno pyridine - ADP mediated platelet inhibitor).
- Trial name
- NCT00653900
- Where
- United States
- Sponsor
- Cedars-Sinai Medical Center
Test the Efficacy of Antiplatelet Regimes in Acute Stroke
Dose-Dependent Effect of Early Antiplatelet Therapy in Acute Ischemic Stroke
The aim of this study is to evaluate the low-response prevalence of early antiplatelet therapy and to test the influence of different aspirin dosages in patients with acute ischemic strokes (AIS).
- Trial name
- NCT01273935
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- Ruhr University of Bochum
Thrombocytopenia, Postpartum Haemorrhage (PPH)
Prediction of Platelet Function Using Viscoelastic Test (ROTEM® Sigma) in Obstetric Anesthesia.
This prospective observational, non-interventional, single-center study aims to evaluate whether the viscoelastic parameter PLTEM, derived from ROTEM® sigma testing (EXTEM-A5 minus FIBTEM-A5), can accurately estimate platelet…
- Trial name
- NCT07616349
- Testing
- No Intervention: Observational Cohort
- Where
- Spain
- Volunteers
- 85 people
- Sponsor
- Nicolas Brogly
Healthy Subjects
Effects of Recombinant Human Erythropoietin on Platelet Function in Healthy Subjects
The purpose of this study is to see if a naturally-occurring hormone called erythropoietin changes the action of platelets in the blood.
- Trial name
- NCT00368238
- Testing
- Recombinant human erythropoietin alfa (drug), Aspirin (drug), Clopidogrel (drug)
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Yale University
Eclampsia Preeclampsia
Magnesium and Platelet Function Testing
Magnesium has built up the reputation of a 'natural calcium antagonist'. However, the exact effect of magnesium on coagulation and more specifically on platelet function is still disputed.
- Trial name
- MgCedVD (NCT03143647)
- Testing
- Collect a study-specific blood sample of healthy subjects
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ziekenhuis Oost-Limburg
Stable Angina Pectoris
Evaluation and Comparison of Several Point-of-care Platelet Function Tests in Predicting Clinical Outcomes in Clopidogrel Pre-treated Patients Undergoing Elective PCI.
The purpose of this study is to investigate whether the level of Platelet Inhibition as assessed with five point-of-care platelet function assays correlates with clinical (periprocedural) outcomes such as Acute Myocardial…
- Trial name
- NCT00352014
- Where
- Netherlands
- Volunteers
- 1,000 people
- Sponsor
- R&D Cardiologie
Infarction, Myocardial Infarction
Which Platelet Function Test Best Reflects the In Vivo Plasma Concentrations of Ticagrelor and Its Active Metabolite?
Ticagrelor is a direct-acting, reversible platelet P2Y12 receptor inhibitor recommended by the recent European Society of Cardiology guidelines in patients with acute coronary syndromes (ACS) (class of recommendation I, level of…
- Conditions
- Infarction, Myocardial Infarction, Cardiovascular Diseases, Heart Diseases
- Trial name
- HARMONIC (NCT02690454)
- Where
- Poland
- Volunteers
- 45 people
- Sponsor
- Collegium Medicum w Bydgoszczy
Myocardial Infarction
Ticagrelor Pharmacokinetics in NSTEMI
Patients with myocardial infarction, which does not include all layers of the heart's muscle wall are common and they often receive pharmacological treatment with the platelet inhibiting drug ticagrelor.
- Trial name
- NCT02292277
- Testing
- Ticagrelor
- Where
- Sweden
- Volunteers
- 63 people
- Sponsor
- Karolinska University Hospital
Comatose
Ticagrelor for the Comatose
The study will investigate the effect of the oral antiplatelet agent ticagrelor (Brilique) when it is administrated through a nasogastric tube in comatose patients.
- Trial name
- TICOMA (NCT02175875)
- Where
- Denmark
- Volunteers
- 47 people
- Sponsor
- Lene Holmvang
Extrahepatic Portal Vein Obstruction (EHPVO), Thrombophilia
Hematological Disorders in EHPVO Patients
This study focuses on patients who have a condition called extrahepatic portal vein obstruction (EHPVO), where a blood clot blocks the portal vein outside the liver.
- Conditions
- Extrahepatic Portal Vein Obstruction (EHPVO), Thrombophilia, Myeloproliferative Neoplasms (MPN), Antiphospholipid Syndrome (APS)
- Trial name
- EHPVO-HEM (NCT07108023)
- Testing
- No intervention (Observational Study)
- Volunteers
- 115 people
- Sponsor
- Rahab Nady
Healthy
In-Vivo Bleeding Volume Test for Platelet-Aspirin Interaction
Purpose of the present research project is to study a new in-vivo test for abnormal platelet function and to study the effect of certain drugs on clinical bleeding.
- Trial name
- Aspirin-BVT (NCT01047722)
- Testing
- Aspirin ingestion followed by doing a Bleeding Volume Test
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Klein, Jeffrey A., M.D.