Clinical trials: Platelet Aggregation Inhibitors
Coronary Artery Disease, Myocardial Infarction
Aspirin Response in High Risk Patients With Coronary Artery Disease
Previous studies indicate that patients with cardiovascular disease have a variable response to aspirin. Despite treatment with aspirin a large number of patients suffer a myocardial infarction.
- Conditions
- Coronary Artery Disease, Myocardial Infarction, Diabetes Mellitus, Renal Insufficiency, Chronic
- Trial name
- NCT01383304
- Where
- Denmark
- Volunteers
- 906 people
- Sponsor
- University of Aarhus
Antiplatelet Agents; Endothelial Function; Pleotropic Effects
Ticagrelor and Endothelial Function
To evaluate the effect of ticagrelor on endothelial function as measured by flow mediated dilation of the brachial artery. This will be compared to prasugrel.
- Trial name
- NCT02261922
- Testing
- ticagrelor, prasugrel
- Where
- Lebanon
- Volunteers
- 20 people
- Sponsor
- Hotel Dieu de France Hospital
Acute Coronary Syndrome
Ticagrelor Versus Clopidogrel in Myocardial Salvage in Patients With STEMI Undergoing Primary PCI
Therefore, in this study, we try to evaluate the impact of clopidogrel loading dose 300mg vs. ticagrelor 180 mg on myocardial injury as measured by contrast-enhanced magnetic resonance imaging (CE-MRI) in STEMI patients…
- Trial name
- NCT02792712
- Testing
- Ticagrelor, Clopidogrel
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Drug Resistance
Aspirin and Clopidogrel Resistance Study
Resistance to antiplatelet drugs (aspirin, clopidogrel) is a recognized phenomenon with a prevalence from 17% to 35%. Resistance as detected by in vitro tests such as Multiple Electrode Aggregometry (MEA) has been shown to…
- Trial name
- NCT01039480
- Where
- Switzerland
- Volunteers
- 82 people
- Sponsor
- University Hospital, Basel, Switzerland
Atrial Fibrillation, Atrial Appendage
AntiPlatelet theraPy stratEgy followiNg Left Atrial appenDAGe closurE
The APPENDAGE study is a phase 4 multicentre randomized opened clinical trial comparing 2 different antithrombotic strategies following left atrial appendage closure (LAAC) in patients with non valvular atrial fibrillation (AF).
- Conditions
- Atrial Fibrillation, Atrial Appendage, Anticoagulants, Stroke
- Trial name
- APPENDAGE (NCT04796714)
- Testing
- Double antiplatelet therapy, Aspirin, Brain MRI
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Bordeaux
Vascular Disease, Coronary Artery Disease Risk Factors Multiple
Safety Study of PZ-128 in Subjects With Multiple Coronary Artery Disease Risk Factors
This study is a Phase I, intravenous, single-dose escalation study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of PZ-128 (pepducin inhibitor of PAR1) in subjects with vascular disease or who have 2…
- Trial name
- NCT01806077
- Testing
- PZ-128
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Tufts Medical Center
OGD, Gastric Ulcer Induced by Anti-platelet Agent
Effect of Second-look Endoscopy on Peptic Ulcer Rebleeding in Patients With Early Resumption of Antiplatelet Agents
OBJECTIVES: Up to 15% of patients with peptic ulcer bleeding will develop rebleeding, mainly in those with ulcers of higher-risk stigmata (i.e. Forrest class Ia to IIb).
- Conditions
- OGD, Gastric Ulcer Induced by Anti-platelet Agent, Duodenal Ulcer Induced by Anti-platelet Agent
- Trial name
- NCT02840929
- Testing
- Second-look OGD, Esomeprazole
- Where
- 2 sites in China, Hong Kong
- Volunteers
- 2 people
- Sponsor
- The University of Hong Kong
Chronic Coronary Syndrome, Coronary Artery Bypass Graft CABG
Antiplatelet Strategy for CCS Patients Undergoing CABG
To evaluate the long-term outcomes of different antiplatelet strategies, including DAPT, aspirin monotherapy, and clopidogrel monotherapy, in CCS patients undergoing CABG.
- Trial name
- CABG_DAPT_SAPT (NCT06881901)
- Volunteers
- 29,898 people
- Sponsor
- Samsung Medical Center
Pulmonary Arterial Hypertension
A Study With BPS-314d-MR-PAH-303 in Participants With Pulmonary Arterial Hypertension
This is a multi-center, open-label study for eligible participants who were actively participating in the BPS-314d-MR-PAH-302 double-blind study (NCT01908699) at the time the study was concluded.
- Trial name
- BEAT OLE (NCT03657095)
- Testing
- Esuberaprost
- Where
- 45 sites in United States, Israel
- Volunteers
- 112 people
- Sponsor
- Lung Biotechnology PBC
Coronary Artery Disease
SAfety and EFficacy of Bridging Antithrombotic Therapy During Elective Non-cardiac Surgery
Patients with coronary artery disease, especially after PCI, require long-term oral antiplatelet therapy. However, this patient population may inevitably require non-cardiac surgery for a variety of conditions.
- Trial name
- SAFE (NCT04675801)
- Where
- China
- Volunteers
- 950 people
- Sponsor
- Beijing Anzhen Hospital
Arterial Obstructive Diseases, Coronary Disease
Safety of SCH 530348 in Subjects Undergoing Non-Emergent Percutaneous Coronary Intervention (Study P03573)
The object of the study is to determine whether different doses of SCH 530348, when added to standard medical care in persons undergoing percutaneous coronary intervention, will increase the risk of bleeding.
- Trial name
- NCT00132912
- Testing
- SCH 530348
- Volunteers
- 1,030 people
- Sponsor
- Merck Sharp & Dohme LLC
Cardiovascular Diseases, Acute Coronary Syndrome
Pharmacogenomics of Anti-platelet Intervention-2 (PAPI-2) Study
It is standard treatment to take anti-platelet medication after cardiac catheterization and stent placement to help prevent the formation of blood clots that may cause heart attack or stroke.
- Trial name
- PAPI-2 (NCT01452152)
- Testing
- clopidogrel, prasugrel
- Where
- 5 sites in United States
- Volunteers
- 9 people
- Sponsor
- University of Maryland, Baltimore
Cardiac Arrest, Myocardial Infarction
Monitoring Antiplatelet Drugs in Cardiac Arrest Patients
Dual Antiplatelet Therapy (DAPT) with acetylsalicylic acid (ASA) and oral P2Y12 inhibitor (Clopidogrel, Ticagrelor or Prasugrel) is recommended in STEMI or NSTEMI patients undergoing primary Percutaneous Coronary Intervention…
- Conditions
- Cardiac Arrest, Myocardial Infarction, Extracorporeal Membrane Oxygenation, Platelet Dysfunction
- Trial name
- PLT-ECMO (NCT05730114)
- Testing
- Antiplatelet Drug
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Milano Bicocca
Carotid Stenosis
Platelet Inhibition and Transcranial Doppler (TCD)-Detected Microemboli During and After Carotid Artery Stenting (CAS) in Asymptomatic Patients Prior to Cardiac Surgery
As with coronary artery stenting, activation and embolisation of platelets occurs with carotid artery stenting (CAS). Based on promising data on the use of clopidogrel plus aspirin in coronary stenting this dual antiplatelet…
- Trial name
- IMPACT (NCT01146301)
- Testing
- Clopidogrel
- Where
- Netherlands
- Sponsor
- R&D Cardiologie
Hip Fracture
Hip-Fracture Surgery on Patients in Clopidogrel Therapy
Patients in Clopidogrel therapy alone or in combination with acetylsalicylic acid (Dual Antiplatelet Therapy (DAPT) presenting with a hip-fracture represent the surgeon with the dilemma of putting the patient at risk of a major…
- Trial name
- NCT02391883
- Testing
- Clopidogrel
- Volunteers
- 356 people
- Sponsor
- Hvidovre University Hospital
Non-ST Elevation Myocardial Infarction
Tailored Use of Tirofiban for Non-ST-elevation Acute Coronary Syndrome Patients
Investigators aimed to test the beneficial effect of tirofiban, a GPIIb/IIIa antagonist, for Non-ST-Elevation Acute Coronary Syndrome Patients who has high resistance to clopidogrel.
- Trial name
- NCT03114995
- Testing
- Tirofiban
- Volunteers
- 140 people
- Sponsor
- Seoul National University Bundang Hospital
Antiplatelet Agents, Perioperative Care
Optimal PERioperative Antiplatelet Therapy Investigation ON Abdominal Surgery After Coronary Stent Implantation
The purpose of this study is to evaluate the impact of perioperative aspirin continuation on clinical outcomes in patients with a history of coronary stent implantation who are scheduled for abdominal surgery.
- Trial name
- OPERATION (NCT06723145)
- Testing
- Aspirin, Aspirin interruption
- Where
- Japan
- Volunteers
- 1,200 people
- Sponsor
- Kyoto University
Myocardial Infarction, Angioplasty, Balloon, Coronary
Comparison of Prasugrel and Ticagrelor in the Treatment of Acute Myocardial Infarction
This study evaluates the efficacy of Prasugrel and Ticagrelor in the treatment of acute myocardial infarction.
- Conditions
- Myocardial Infarction, Angioplasty, Balloon, Coronary, Platelet Aggregation Inhibitors
- Trial name
- PRAGUE-18 (NCT02808767)
- Testing
- Prasugrel, Ticagrelor
- Where
- Czechia
- Volunteers
- 1,226 people
- Sponsor
- Faculty Hospital Kralovske Vinohrady
Analgesia, Obstetrical, Coagulation Defect; Postpartum
IV Ketorolac on Platelet Function Post-Cesarean Delivery
Cesarean delivery has become the most common surgical procedure in the US. Non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to improve the quality of post-cesarean analgesia and markedly reduce opioid consumption.
- Conditions
- Analgesia, Obstetrical, Coagulation Defect; Postpartum, Nonsteroidals (NSAIDs)Toxicity, Postpartum Hemorrhage
- Trial name
- KetoPltAgg (NCT03805607)
- Testing
- Ketorolac Tromethamine 30 MG/ML
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Intracerebral Hemorrhage
Platelet Transfusion in Acute Intracerebral Hemorrhage
To prove whether use of antiplatelet agents results into a rapid enlargement of hematoma after onset of acute intracerebral hemorrhage.
- Trial name
- NCT00699621
- Testing
- platelets
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- University of Oulu