Clinical trials: Platelet Aggregation
Coronary Artery Disease
Smoking Cessation in Patients After Coronary Angiography
OBJECTIVES The goal of this study is to evaluate the self-achieved smoking cessation supported with cytisine smoking cessation and its' on platelet aggregation and prothrombotic state in patients after coronary angiography and…
- Trial name
- NCT04784702
- Volunteers
- 122 people
- Sponsor
- Centre of Postgraduate Medical Education
Acute Myocardial Infarction
Study of Platelet Function After Administration of Aspirin Versus Lysine Acetylsalicylate in STEMI Patients
Prasugrel and ticagrelor, new P2Y12-ADP receptor antagonists, are associated with greater pharmacodynamic inhibition and reduction of cardiovascular events in patients with an acute coronary syndrome.
- Trial name
- ECCLIPSE-STEMI (NCT02929888)
- Testing
- Lysine Acetilsalicilate, Aspirin
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Fundacion Investigacion Interhospitalaria Cardiovascular
Sickle Cell Anemia
Study of Beet Juice for Patients With Sickle Cell Anemia
The investigators hypothesize that increasing plasma nitrite using dietary nitrate will improve platelet function and red cell deformability and decrease MCHC in patients with sickle cell disease.
- Trial name
- NCT02162225
- Testing
- beet juice (Unbeetable)
- Where
- United States
- Sponsor
- Wake Forest University Health Sciences
Colorectal Cancer
Acetylsalicylic Acid and Colorectal Cancer Prevention: Exploring the Platelet Function of Its Mechanism of Action
In a preliminary study in healthy subjects, the investigators determined the pharmacokinetic and pharmacodynamic of enteric-coated acetylsalicylic acid (ASA) (Adiro 100 mg, Bayer), and the variability (coefficient of variation)…
- Trial name
- NCT02125409
- Testing
- Acetylsalicylic acid, Screening colonoscopy
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Aragon Institute of Health Sciences
Sleep Apnea, Cardiovascular Diseases
Platelet Activation and Circadian Rhythms of Clotting-Fibrinolysis Factors in Patients With Sleep Apnea Syndrome
The objective of the study is to define and compare clotting- fibrinolysis patterns, platelet function markers and endothelial dysfunction in patients with SAHS before and after treatment and normal controls age and weight…
- Trial name
- NCT00456287
- Testing
- CPAP (Continuous Positive Airway Pressure)
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Sociedad Española de Neumología y Cirugía Torácica
Coronary Artery Disease
Effect of Prasugrel Versus Clopidogrel on Platelet Function After Bivalirudin Cessation
Early stent thrombosis has been noted with increased frequency in acute coronary syndrome (ACS) patients undergoing percutaneous coronary intervention (PCI) who are treated with bivalirudin and clopidogrel.
- Trial name
- NCT01789814
- Testing
- Prasugrel, Clopidogrel
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Tufts Medical Center
Healthy
Pharmacodynamics of CGT 2168 Compared With Plavix®
CG106 is a Phase I open-label, randomized, multiple-dose, two-way crossover study to characterize the pharmacodynamics and pharmacokinetics of the investigational fixed-dose combination product CGT 2168 (clopidogrel, 75 mg and…
- Trial name
- NCT00620802
- Testing
- CGT-2168, Plavix
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cogentus Pharmaceuticals
Platelet Aggregation, Spontaneous, Coronary Artery Disease
Effect of Low Dose of Colchicine on Platelet Reactivity
Inflammation plays an important role in atherosclerosis and the occurrence of ischemic events. Statins, in addition to their lipid-lowering effect, have also documented anti-inflammatory effect that may partly explain their…
- Trial name
- NCT05956145
- Testing
- Colchicine 0.5 MG
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- University of Sao Paulo
End-stage Renal Disease, Thrombocytopathy
Cohort Study Comparing Short Daily Hemodialysis (HD) With Conventional HD
This study is examining the effects of short daily hemodialysis on platelet function, fluid volume control, arterial stiffness and patient quality of life, as compared to conventional hemodialysis.
- Conditions
- End-stage Renal Disease, Thrombocytopathy, Cardiovascular Diseases
- Trial name
- NCT00182156
- Where
- Canada
- Sponsor
- McMaster University
Platelet Dysfunction
Evaluation of Platelet Function After Statin Loading Dose in Patients Before Percutaneous Coronary Intervention
The purpose of this study is to evaluate the effect of a loading dose of two different statins on platelet reactivity (atorvastatin, metabolized by CYP3A4, and rosuvastatin, which is rather independent of this enzyme)in patients…
- Trial name
- STATIPLAT (NCT01526460)
- Testing
- Atorvastatin, Rosuvastatin
- Where
- Italy
- Volunteers
- 146 people
- Sponsor
- IRCCS San Raffaele
Healthy
The Effects of DLBS1033 on Haemostasis Parameters in Healthy Volunteers
DLBS1033 is bioactive protein fraction which extracted from Lumbricus rubellus earthworm. This earthworm comes from Pengalengan, West Java, Indonesia.
- Trial name
- NCT01694537
- Testing
- DLBS1033
- Where
- Indonesia
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Atrial Fibrillations, Heart Valve Prostheses
What is the Optimal antiplatElet and Anticoagulant Therapy in Patients With Oral Anticoagulation Undergoing revasculariSaTion 2.
The optimal antithrombotic therapy for patients with atrial fibrillation (AF) with a CHA2DS2-VASc score ≥1 with concomitant acute coronary syndrome (ACS) or revascularisation by percutaneous coronary intervention (PCI) with…
- Conditions
- Atrial Fibrillations, Heart Valve Prostheses, Acute Coronary Syndromes, Coronary Artery Diseases
- Trial name
- WOEST 2 (NCT02635230)
- Testing
- Combination of chronic oral anticoagulation and a P2Y12 inhibitor with or without aspirin.
- Where
- 9 sites in Belgium, Netherlands
- Volunteers
- 2,200 people
- Sponsor
- R&D Cardiologie
Coronary Artery Disease, Dyslipidemia
The Impact of Tredaptive on Flow-Mediated Dilation in Cardiac Patients
Laropiprant (LRP; Merck \& Co., Inc, Whitehouse Station, NJ, USA) is a potent, once-daily, highly selective PGD2-receptor (DP1) antagonist.
- Trial name
- NCT01052311
- Testing
- Tredaptive (1 g extended release niacin+ 20 mg laropiprant), Tredaptive
- Where
- Israel
- Volunteers
- 8 people
- Sponsor
- Sheba Medical Center
Congenital Heart Defect, Blood Coagulation Disorder
Bedside Evaluation of Coagulation in Children With Congenital Heart Disease
The purpose of this study is to assess coagulation and platelet function in children with congenital heart disease, measured with a bedside device (thromboelastometry and impedance aggregometry).
- Trial name
- POCHEMO (NCT02387944)
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Blood Coagulation Disorders
Dental Extractions in Patients Under Dual Antiplatelet Therapy
The purpose of this study is to compare two hemostatic agents in patients under dual antiplatelet therapy using the intraoral bleeding time after dental extractions.
- Trial name
- DUALex (NCT02918045)
- Testing
- HemCon Dental Dressing, Oxidized Cellulose Gauze
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo General Hospital
Coronary Artery Disease
Duration of Platelet Inhibition by Aspirin
The well established importance of regular aspirin administration stands on firm grounds, as large meta-analyses have shown this therapy to significantly reduce the risk of death.
- Trial name
- NCT00671021
- Testing
- Platelet aggregation
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Platelet Aggregation, Acute Myocardial Infarction
Effect of Exercise on Platelet Reactivity After Myocardial Infarction
This project aims to evaluate, in recent post-acute myocardial infarction (AMI) patients on dual antiplatelet therapy, the impact of regular exercise training on platelet aggregability and the correlation between the level of…
- Conditions
- Platelet Aggregation, Acute Myocardial Infarction, Exercise Training
- Trial name
- NCT02958657
- Testing
- Exercise Training
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- University of Sao Paulo General Hospital
Acute Coronary Syndrome, Angioplasty, Transluminal, Percutaneous Coronary
Early Use of Rosuvastatin in Acute Coronary Syndromes: Targeting Platelet-Leukocyte Interactions
The central hypothesis for this work is that platelet - leukocyte interactions play a critical role in the pathogenesis of acute ischemic events.
- Conditions
- Acute Coronary Syndrome, Angioplasty, Transluminal, Percutaneous Coronary, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Blood Platelets
- Trial name
- NCT01241903
- Testing
- rosuvastatin
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Susan Smyth
Platelet Dysfunction
The Effect of Dapagliflozin on Platelet Function testinG Profiles in Diabetic PatiEnts.
Sodium GLucose Transport 2 inhibitors (SGLT2I), including dapagliflozin, reduce the likelihood of hospitalization for heart failure and death in persons with type 2 diabetes, of which the mechanism has not been fully elucidated.
- Trial name
- EDGE (NCT04400760)
- Testing
- DAPA Tx
- Where
- Trinidad and Tobago
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The University of The West Indies
Purpura, Thrombotic Thrombocytopenic, Von Willebrand Disease Type-2b
ARC1779 Injection in Patients With Von Willebrand Factor-Related Platelet Function Disorders
To evaluate the overall safety and tolerability of ARC1779, a therapeutic oligonucleotide ("aptamer") in patients with three types of von Willebrand Factor related platelet disorders.
- Trial name
- NCT00632242
- Testing
- ARC1779
- Where
- Austria
- Volunteers
- 28 people
- Sponsor
- Archemix Corp.