Clinical trials: Platelet Activation
Weight Loss
The Effects of Capsinoids on Brown Adipose Tissue Activation in Obesity
This research study is being done to determine whether taking a dietary supplement called capsinoids, derived from sweet peppers, can activate brown fat that is already present or even generate new brown fat in individuals with…
- Trial name
- BATCAP (NCT03110809)
- Testing
- Capsinoid
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Arterial Occlusive Diseases, Coronary Artery Disease
Safety of PZ-128 in Subjects Undergoing Non-Emergent Percutaneous Coronary Intervention
The object of the study is to determine whether different doses of PZ-128, when added to standard medical care in persons undergoing cardiac catheterization/percutaneous coronary intervention, will increase the risk of bleeding.
- Conditions
- Arterial Occlusive Diseases, Coronary Artery Disease, Coronary Disease, Arteriosclerosis
- Trial name
- TRIP-PCI (NCT02561000)
- Testing
- PZ-128
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- Tufts Medical Center
Healthy Volunteers, Sepsis
The Role of the P2Y12 Receptor in Tissue Factor Induced Coagulation
Severe sepsis still carries a high mortality rate despite advantages in intensive care medicine and antimicrobial therapy. The inflammatory and procoagulant host response to infection are intricately linked and interactions…
- Trial name
- NCT01099566
- Testing
- Prasugrel
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Coronary Artery Disease
Effects of Low Dose Aspirin Pre-treatment on Platelet Activation Undergoing Off-pump Coronary Artery Bypass Surgery
Platelet activation after off pump coronary artery bypass (OPCAB) surgery may affect thrombus formation. The purpose of this study is to assess the effects of preoperative continuation of aspirin on platelet activation after off…
- Trial name
- NCT02209909
- Testing
- aspirin continuation, aspirin discontinuation
- Where
- South Korea
- Volunteers
- 48 people
- Sponsor
- Seoul National University Hospital
Hemolytic Uremic Syndrome
Study of 'Vascular Competence' Profile and Endothelial Activation in the Hemolytic Uremic Syndrome in Children and Adults
The Hemolytic Uremic Syndrome (HUS) is a rare thrombotic microangiopathy (TMA), affecting both children and adults. HUS is characterized by the abnormal occurrence of diffuse thrombosis in the microcirculation resulting in the…
- Trial name
- SHU (NCT02904863)
- Testing
- Extra blood draw samples
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Acute Myocardial Infarction
Effect of N-acetylcystein in Myocardial Infarction
We designed this study to evaluate the effect of N-acetylcystein on biomarkers of platelet activation , cardiac necrosis and coronary reperfusion in patients undergoing percutaneous coronary intervention.
- Trial name
- NCT01741207
- Testing
- N-acetylcystein
- Where
- Iran
- Volunteers
- 100 people
- Sponsor
- Tehran University of Medical Sciences
Ischemia
ALBION "Assessment of the Best Loading Dose of Clopidogrel to Blunt Platelet Activation, Inflammation and Ongoing Necrosis"
To compare the Kinetics of inhibition of platelet aggregation (aggregometry) and platelet activation (flow cytometry) with different loading doses of clopidogrel To evaluate the effect on various parameters of inflammation and…
- Trial name
- NCT00360386
- Testing
- Clopidogrel
- Volunteers
- 110 people
- Sponsor
- Sanofi
Bacterial Sepsis
Study and Role of Inflammasome in Platelet Activation During Bacterial And/or Viral Sepsis
: Sepsis, now defined as life-threatening organ dysfunction due to a dysregulated host response to infection, is an important global health problem representing about a fifth of all global deaths.
- Trial name
- PLAQSEPSIS (NCT06657781)
- Where
- Guadeloupe
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Liver Regeneration
Platelets in Liver Regeneration
The most relevant factor predicting morbidity and mortality after liver resections is the ability of the remnant liver to regenerate.
- Trial name
- NCT02113059
- Where
- 2 sites in Austria
- Volunteers
- 40 people
- Sponsor
- Medical University of Vienna
Primary Immune Thrombocytopenia, Warm Autoimmune Hemolytic Anemia
Study of Ianalumab in Adults With Primary Immune Thrombocytopenia (ITP) and Warm-antibody Autoimmune Hemolytic Anemia (wAIHA) Who Have Previously Benefited From Ianalumab
This study is intended to explore the efficacy and safety of a second course of ianalumab after experiencing treatment failure in the pivotal Primary Immune Thrombocytopenia (ITP) trials (CVAY736I12301, CVAY736Q12301) and after…
- Trial name
- VAY RE-HIT (NCT07039422)
- Testing
- Ianalumab
- Sponsor
- Novartis Pharmaceuticals
Acute Ischemic Stroke, Transient Ischemic Attack
sCLEC-2 in Stroke Study
Any platelet function tests have not been widely used in the clinical practice of acute cerebrovascular disease because of the concerns in repeatability, economic performance, and simplicity.
- Trial name
- CLECSTRO (NCT05579405)
- Where
- 9 sites in Japan
- Volunteers
- 600 people
- Sponsor
- University of Yamanashi
Hematopoietic/Lymphoid Cancer, Accelerated Phase Chronic Myelogenous Leukemia
Infection Prophylaxis and Management in Treating Cytomegalovirus (CMV) Infection in Patients With Hematologic Malignancies Previously Treated With Donor Stem Cell Transplant
RATIONALE: Infection prophylaxis and management may help prevent cytomegalovirus (CMV) infection caused by a stem cell transplant.
- Conditions
- Hematopoietic/Lymphoid Cancer, Accelerated Phase Chronic Myelogenous Leukemia, Acute Undifferentiated Leukemia, Adult Acute Lymphoblastic Leukemia in Remission
- Trial name
- NCT01199562
- Testing
- infection prophylaxis and management, laboratory biomarker analysis, flow cytometry
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- City of Hope Medical Center
Endothelial Function, Platelet Aggregation
Effect of Passive Smoking on Platelet Function and Endothelial Function
Passive smoking is associated with an increased risk for cardiovascular events. However, the exact mechanisms by which passive smoking affects cardiovascular health are not entirely understood.
- Trial name
- NCT00923988
- Testing
- secondhand smoke exposure
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kantonsspital Graubünden
Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders
Opioid Titration Order Sheet or Standard Care in Treating Patients With Cancer Pain
RATIONALE: An Opioid Titration Order Sheet that allows healthcare providers to adjust the dose and schedule of pain medication may help improve pain treatment for patients with cancer.
- Conditions
- Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders, Leukemia, Lymphoma
- Trial name
- NCT00666211
- Testing
- educational intervention, Titrated pain management, questionnaire administration
- Where
- 11 sites in United States
- Volunteers
- 98 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
HIV
Tenofovir Abacavir Platelet Activation Study
Some but not all observational studies have found that current exposure to abacavir is associated with increased risk of cardiovascular events such as myocardial infarction, stroke and cardiovascular death.
- Trial name
- TAPAS (NCT02093585)
- Testing
- abacavir (600 mg QD), tenofovir (245 mg QD)
- Where
- Denmark
- Volunteers
- 43 people
- Sponsor
- Jan Gerstoft
Cardiovascular Disease
Conjugated Linoleic Acid Supplementation Study
Cardiovascular disease is a major cause of mortality worldwide resulting in one out of three global deaths. One of the main characteristics of cardiovascular disease is impaired blood flow and increased formation of clots.
- Trial name
- CLASS (NCT01234636)
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Cardiovascular Disease
Dark Chocolate and Platelet Function in Humans
Cardiovascular disease is a major cause of mortality worldwide and responsible for one out of three global deaths. A main characteristic of cardiovascular disease is impaired blood flow and formation of blood clots.
- Trial name
- NCT01099150
- Testing
- Dark chocolate enriched in flavan-3-ols and procyanidins, Standard dark chocolate, White chocolate
- Where
- United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders
3'-Deoxy-3'-[18F] Fluorothymidine PET Imaging in Patients With Cancer
RATIONALE: Diagnostic procedures, such as 3'-deoxy-3'-[18F] fluorothymidine (FLT) PET imaging, may help find and diagnose cancer.
- Conditions
- Brain and Central Nervous System Tumors, Chronic Myeloproliferative Disorders, Leukemia, Lymphoma
- Trial name
- NCT00935090
- Testing
- 3'-deoxy-3'-[18F]fluorothymidine
- Where
- United States
- Sponsor
- Barbara Ann Karmanos Cancer Institute
Atrial Fibrillation, Metabolic Syndrome
Atherosclerosis in Atrial Fibrillation
The prevalence of metabolic syndrome in patients suffering from non valvular atrial fibrillation is derived from studies regarding recurrences of atrial fibrillation after catheter ablation.
- Conditions
- Atrial Fibrillation, Metabolic Syndrome, Oxidative Stress, Atherosclerosis
- Trial name
- NCT01882114
- Where
- Italy
- Volunteers
- 3,000 people
- Sponsor
- University of Roma La Sapienza
Knee Osteoarthritis
Autologous Adipose Stem Cells and Platelet Rich Plasma Therapy for Patients With Knee Osteoarthritis
Adipose stem cells and platelet rich plasma can regenerate the injured cartilage.
- Trial name
- NCT02142842
- Testing
- Autologous adipose tissue stromal vascular fraction and platelet rich plasma
- Where
- 3 sites in Vietnam
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Science Ho Chi Minh City