Clinical trials: Plasma Concentration
Hemodiafiltration, Sepsis
Antibiotic Plasma Concentrations During Continuous Renal Replacement Therapy With a High Adsorption Membrane (oXiris®)
Study: Open label, non-randomized, observational, descriptive and prospective pharmacokinetic. Patients: sepsis patients undergoing continuous renal replacement therapy (CRRT) and admitted at the Intensive care unit of Bellvitge…
- Conditions
- Hemodiafiltration, Sepsis, Acute Kidney Injury
- Trial name
- NCT04033029
- Testing
- Continuous venovenous hemodiafiltration with high adsorption membrane (oXiris®), Antibiotics
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Hospital Universitari de Bellvitge
Pain Treatment, Robotic Assisted Laparoscopic Surgery
Bilateral Dual Transversus Abdominis Plane Block for Robotic Assisted Laparoscopic Surgery
To evaluate the effects of bilateral dual transversus abdominis plane block on postoperative pain after robotic assited laparoskopic surgery and measure the plasma-level of ropivacain after the bilateral dual transversus…
- Conditions
- Pain Treatment, Robotic Assisted Laparoscopic Surgery, Bilateral Dual Transversus Abdominis Plane Block
- Trial name
- NCT01760161
- Testing
- Ropivacaine, Isotonic potassium chloride
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Aalborg University Hospital
Cirrhosis Renal
Description of the Evolution of Plasma and Urinary Concentrations of Iohexol in a Cirrhotic Patient Population
Background: It is important to accurately assess the glomerular filtration rate (GFR) of patients with liver diseases, particularly cirrhosis, to deliver care and adjust the drugs' posology.
- Trial name
- DFG HEP (NCT03769597)
- Testing
- Iohexol Inj 300 MG/ML
- Where
- France
- Volunteers
- 13 people
- Sponsor
- University Hospital, Limoges
Healthy
Examine Plasma Concentrations of Buprenorphine Following Reapplication of Buprenorphine Transdermal System (BTDS) After Variable Application Site Rest Periods
The purpose of this study is to determine the pharmacokinetics of BTDS following same-site patch reapplication after rest intervals.
- Trial name
- NCT01259102
- Testing
- Buprenorphine transdermal patch
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Purdue Pharma LP
Gestational Diabetes
Associations of Plasma Vanadium Concentrations With Gestational Diabetes Mellitus
Background: Vanadium compounds have been shown to exert insulin-mimetic effects and thereby control glucose homeostasis. However, studies regarding the levels of vanadium and gestational diabetes mellitus (GDM) are limited and…
- Trial name
- NCT05267457
- Testing
- Plasma vanadium concentration
- Volunteers
- 504 people, healthy volunteers welcome
- Sponsor
- Liegang Liu
Supratentorial Neoplasms
Anaesthesia for Supratentorial Tumor Resection
This is a double center, multidisciplinary, prospective, randomized, double-blind, with a superiority hypothesis, trial including 100 patients scheduled for resection of a supratentorial brain tumour under general anesthesia.
- Trial name
- NCT00389883
- Testing
- Comparison of two anesthetics protocol
- Where
- 2 sites in France
- Volunteers
- 69 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Healthy, Plasma Concentration of YM060
A Study to Compare Oral Absorption of YM060 Between Orally-disintegrating Tablet (Without Water) and Conventional Tablet
A study to compare time-course changes of plasma concentration of YM060 after intake of conventional tablet and orally-disintegrating tablet. Orally-disintegrating tablets will be administered without water.
- Trial name
- NCT01392794
- Testing
- YM060
- Where
- Japan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Inc
Healthy Participants
Bioavailability of Bosutinib Administered as Capsule Contents Mixed With Applesauce or Yogurt Relative to Intact Capsules Under Fed Condition
This study is intended to estimate the relative bioavailability of a single 500 mg dose of bosutinib when administered as capsule contents mixed with applesauce or yogurt to intact capsules under fed condition in adult healthy…
- Trial name
- NCT04916769
- Testing
- Bosutinib capsule
- Where
- Belgium
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy
Pharmacokinetics of Sufentanil Sublingual Microtablet 30 mcg and 15 mcg in Healthy Subjects
The purpose of this study is to establish the single and multiple-dose pharmacokinetics (PK) of sublingual administration of the Sufentanil Sublingual Microtablet (SSM) 30 mcg and compare the pharmacokinetics of a single dose of…
- Trial name
- NCT02082236
- Testing
- Treatment Arm A: Sufenta®, Treatment B: Sufentanil SSM 30 mcg, Treatment C: SSM 15 mcg
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Talphera, Inc
Local Anesthetic Systemic Toxicity, Anesthesia, Local
Ropivacaine Plasma Concentration With or Without Epinephrine for Posterior Quadratus Lumborum Block
Introduction The posterior Quadratus Lumborum Block (pQLB) has been used in postoperative pain management after Cesarean Section (CS).
- Trial name
- NCT04562103
- Testing
- Epinephrine / Ropivacaine, Ropivacaine
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Acne Vulgaris
An Evaluation of the Adrenal Suppression Potential and PK of CB-03-01 Cream in Pediatric Patients With Acne Vulgaris
This study is designed to determine the hypothalamic-pituitary-adrenal (HPA) axis suppression potential and pharmacokinetic (PK) properties of CB-03-01 Cream, 1%, applied every twelve hours for two weeks, in pediatric patients 9…
- Trial name
- NCT02720627
- Testing
- cortexolone 17α-propionate
- Where
- 10 sites in United States, Poland
- Volunteers
- 27 people
- Sponsor
- Cassiopea SpA
Photosensitive Epilepsy
Effect of Valproic Acid Concentration on Photic Response
We are trying to learn if small changes in the amount of a valproate in the blood (given through an IV) will change the way the brain reacts to flashing lights.
- Trial name
- NCT00609245
- Testing
- Valproic Acid
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- Vanderbilt University Medical Center
Tendinopathy, Rheumatic Diseases
Performance-Enhancing Effects of Platelet-Rich Plasma (PRP) Injections
Platelet-Rich Plasma (PRP) has been banned in competitive athletes because some people think it may enhance athletic performance. However, there is very little published research to support or undermine this point of view.
- Trial name
- NCT01200875
- Testing
- Ultrasound-guided platelet-rich-plasma (PRP) injection, Platelet-Rich Plasma (PRP)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Stanford University
Type 2 Diabetes Mellitus
Effect of Moringa Oleifera on Metformin Plasma Level in Type 2 Diabetes Mellitus Patients
Type 2 diabetes mellitus (T2DM) patients from our previous survey tend to co-administer various herbs with their oral hypoglycemic agents (OHA). Some of these herbs are known to possess antidiabetic activities.
- Trial name
- NCT03189407
- Testing
- Moringa oleifera tea
- Volunteers
- 25 people
- Sponsor
- Titilayo O Fakeye
Healthy Men, Raised Fasting Plasma Triacylglycerol Concentrations
Palmitic Acid in the Sn-2 Position of Triacylglycerols and Postprandial Lipemia
The purpose of this study is to determine whether high-fat meals rich in palmitic acid in the sn-2 position decrease lipaemia in men aged 40-70 y with higher than optimal fasting triacylglycerol concentrations.
- Trial name
- NCT01710280
- Testing
- High-fat meal containing native palm olein, High-fat meal containing interesterified palm olein
- Where
- United Kingdom
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- King's College London
Coronary Artery Disease, Cardiopulmonary Bypass
Propofol Pharmacokinetics and Pharmacodynamics During Cardiopulmonary Bypass
Cardiopulmonary bypass (CPB) is known to alter pharmacokinetics (PK) and brain sensitivity to several drugs, including propofol.
- Conditions
- Coronary Artery Disease, Cardiopulmonary Bypass, Coronary Artery Bypass Graft
- Trial name
- NCT00622791
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo
Vascular Diseases, Leukoaraiosis
Concentration of Trimethylamine Oxide (TMAO) in Blood Plasma as a Risk Factor for Vascular Cerebral Damage
The primary aim of the current research project is to answer the question, whether plasma trimethylamine N-oxide (TMAO) level may be used as a marker of ischemic changes in the brain.
- Conditions
- Vascular Diseases, Leukoaraiosis, Ischemia, Cerebral
- Trial name
- NCT03903601
- Testing
- Magnetic Resonance Imaging (MRI), Blood samples collection, Neuropsychological tests
- Where
- Poland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
General Anesthesia
Continuous and Discontinuous Determination of Propofol Concentration in Breathing Gas
This study should compare the propofol concentration in breathing gas and in plasma (before and) after lung passage. Propofol concentrations in breathing gas are continuously measured by a sensor.
- Trial name
- NCT00532402
- Where
- 2 sites in Germany
- Volunteers
- 16 people
- Sponsor
- University of Luebeck
Atrial Fibrillation
Microparticles Circulating Plasma Concentration in Atrial Fibrillation After Percutaneous Occluding of the Left Atrium
The aim of the study is to compare levels of differnts types of microparticles circulating before and after percutaneous occluding of the left atrium by patients with atrial fibrillation and patients control.
- Trial name
- MICROPLUG (NCT03361202)
- Testing
- blood sampling
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Institut Mutualiste Montsouris
Healthy
A Study To Estimate The Time Course Of PF-00241939 Concentration In The Blood Following Dosing By Oral Inhalation From Dry Powder Inhalers.
The purpose of this study is to investigate the time course of PF-00241939 concentration in the blood following dosing by oral inhalation from dry powder inhalers.
- Trial name
- B0871002 (NCT00862667)
- Testing
- Treatment A, Treatment B, Treatment C
- Where
- Singapore
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Pfizer