Clinical trials: Plasma
Depression
Peripheral Plasma Micro-RNA and Proteomics Mapping in Depressive Patients, Treated With SSRI Medications
A pilot study of mapping the peripheral plasma micro-RNA and proteomics patterns in depressive patients, treated with SSRI medications. It is an observational clinical bio-markers laboratory controlled research with no device.
- Trial name
- MIRPROT (NCT01681407)
- Where
- Israel
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
Hemophilia A
Dose-Response Study of Recombinant Factor VIII Manufactured Protein-Free (rAHF-PFM) in Patients With Hemophilia A
The purpose of this study is to determine the effect of 3 doses of ADVATE rAHF-PFM on initial recovery (% increase [IU/dL] per IU/kg infused) and major single-infusion pharmacokinetic parameters.
- Trial name
- NCT00289536
- Testing
- Antihemophilic factor, recombinant, manufactured protein-free
- Where
- 8 sites in United States
- Volunteers
- 38 people
- Sponsor
- Baxalta now part of Shire
Multiple Myeloma
PRospective Multiple Myeloma Impact Study
This will be a prospective, case-only, study to measure the impact of MMprofiler on treatment intention decisions in Multiple Myeloma patients.
- Trial name
- PROMMIS (NCT02911571)
- Testing
- MMprofiler SKY92 gene signature
- Where
- 9 sites in United States
- Volunteers
- 250 people
- Sponsor
- SkylineDx
Pregnancy Related
Human Anti-D (rh) Immunoglobulin (Rhesoglobin) Efficacy, Safety and Some Pharmacokinetics Parameters in Pregnant Women
Rhesus conflict between mother and fetus is due to the different antigenic composition of erythrocytes. During the first pregnancy, sensitization of the mother to fetal erythrocytes rhesus D (RhD) antigens is formed.
- Trial name
- NCT05245734
- Testing
- Human Anti-D (rh) immunoglobulin
- Where
- 16 sites in Ukraine
- Volunteers
- 281 people
- Sponsor
- Biopharma Plasma LLC
Acute Leukemia
Prospective Study on the Feasibility of Plasma FLT3-Ligand Assay to Achieve a First Estimate of Its Prognostic Value on the Outcome of Patients Treated Intensively for Acute Leukemia
Despite advances in their classification and treatment, acute leukemia remain incurable disease for the majority of patients. It is necessary to identify new prognostic markers of survival and new therapeutic targets to improve…
- Trial name
- FLAM/FLAL (NCT02693899)
- Testing
- Non Interventional study
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Nantes University Hospital
Multiple Myeloma, Renal Insufficiency
Study in Patients With Untreated Multiple Myeloma and Renal Insufficiency
The study will evaluate the effects of BHQ880 in patients with previously untreated multiple myeloma and renal insufficiency who are not considered candidates for bisphosphonate therapy.
- Trial name
- NCT01337752
- Testing
- BHQ880, bortezomib, dexamethasone
- Where
- 8 sites in United States, Spain and 1 more
- Volunteers
- 9 people
- Sponsor
- Novartis Pharmaceuticals
Multiple Myeloma
Efficacy and Safety Study of bb2121 in Subjects With Relapsed and Refractory Multiple Myeloma
This is an open label, single-arm, multicenter, Phase 2 study to evaluate the efficacy and safety of bb2121 in subjects with relapsed and refractory multiple myeloma.
- Trial name
- KarMMa (NCT03361748)
- Testing
- bb2121
- Where
- 48 sites in United States, Belgium and 6 more
- Volunteers
- 149 people
- Sponsor
- Celgene
Advanced Gastric Adenocarcinoma, Immunotherapy
Prospectively Predict the Efficacy of Treatment of Gastrointestinal Tumors Based on Peripheral Multi-omics Liquid Biopsy
To vertify the function of EV-score on predicting \& monitoring immunotherapeutic outcomes of GC
- Trial name
- NCT04993378
- Testing
- EV-array
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shen Lin
Subdermal Skin Tightening
Renuvion/J-Plasma for Subdermal Skin Tightening and Contouring of the Upper Arms: Dissection Technique Comparison
The Renuvion/J-plasma cold atmospheric plasma device has been in clinical use in aesthetics since its approval by the FDA in 2012, but no rigorous clinical trials have been published to quantify the effect of the skin tightening…
- Trial name
- NCT04902599
- Testing
- Renuvion/j-Plasma procedure using blunt dissection technique, Renuvion/j-Plasma procedure using ultrasound-guided dissection technique
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Utah
Plasma Volume, Micronutrients
Cyclic Variation in Micronutrient Concentrations and Plasma Volume
The overall goal of this study is to examine the influence of the menstrual cycle on micronutrient concentrations and plasma volume in healthy, reproductive-age women with regular cycles.
- Conditions
- Plasma Volume, Micronutrients, Menstrual Cycle
- Trial name
- NCT03422809
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Alison Gernand
Acne Vulgaris
Fractional CO2 Laser Delivery of Topical Insulin Versus Platelet Rich Plasma in Treatment of Atrophic Post Acne Scars
compare the efficacy and safety of treating atrophic post acne scars with topical insulin versus Platelet rich Plasma PRP combined with fractional ablative Co2 laser
- Trial name
- NCT06590909
- Testing
- Fractional CO2 laser assisted PDT
- Volunteers
- 22 people
- Sponsor
- Assiut University
Multiple Myeloma
First Autologous Transplant on Minimal Residual Disease Markers in Previously Untreated Myeloma Undergoing Initial Treatment With Velcade
The purpose of this study is to study the MRD status after VELCADE based induction therapy (VELCADE, lenalidomide, dexamethasone or VELCADE, liposomal doxorubicin, dexamethasone) in patients with previously untreated multiple…
- Trial name
- NCT01215344
- Testing
- VELCADE, Lenalidomide, Dexamethasone
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Multiple Myeloma
Observational Registry Study of Chinese Patients Treated With Revlimid (Lenalidomide)
The primary objective of this study is to document efficacy and safety data in a real-world setting of Chinese multiple myeloma patients who have received at least one prior therapy treated with REVLIMID (lenalidomide).
- Trial name
- NCT01947309
- Testing
- Revlimid (lenalidomide)
- Where
- 17 sites in China
- Volunteers
- 176 people
- Sponsor
- Celgene
Plasma Cell Dyscrasia, Monoclonal Gammopathy
A Diagnostic Screening Trial Seeking AL Amyloidosis Very Early
This protocol seeks to enroll smoldering multiple myeloma (SMM) and monoclonal gammopathy of undetermined significant (MGUS) patients with λ light chain (LC) involvement, a group of patients for whom standard of care is…
- Trial name
- SAVE (NCT02741999)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Tufts Medical Center
Non-Small Cell Lung Carcinoma, Small Cell Lung Cancer
Detection of Plasma DNA in Non Small Cell and Small Cell Lung Cancer Patients
The majority of lung cancer patients have a tumor-derived genetic alteration in circulating plasma DNA that could be exploited as a diagnostic tool.
- Trial name
- NCT00213798
- Testing
- Biopsy samples
- Where
- 4 sites in France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Strasbourg, France
Locally Advanced Cervical Cancer
Study on the Relationship Between Plasma MRD and cfDNA HPV and the Efficacy and Prognosis of Locally Advanced Cervical Cancer After Concurrent Chemoradiotherapy
Cervical cancer CC is the most common malignant tumor in the female reproductive system, seriously endangering women's health and life, and is one of the leading causes of death for women worldwide.Globally, HPV causes about 85%…
- Trial name
- NCT05950087
- Testing
- Concurrent chemoradiotherapy
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Guizhou Provincial People's Hospital
Tendinopathy
Treatment of Acute and Chronic Ligament and Tendon Injuries With Platelet Rich Plasma
Platelet rich plasma has been used in previous studies to stimulate faster healing of torn ligaments and tendons in order to help reduce pain and restore normal function.
- Trial name
- NCT01406821
- Testing
- Ultrasound-guided platelet-rich-plasma (PRP) injection, Ultrasound-guided dry needling
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Stanford University
Obesity, Bone Metabolism
Acute Effects of Dairy and Meat Proteins on Bone Metabolism and Metabolic Profile
The purpose of this randomized, controlled, cross over single meal study is to investigate the metabolic effects of a breakfast rich in dairy proteins and to determine biomarkers for their intake.
- Trial name
- MEDA (NCT01773304)
- Testing
- Dietary meal intervention
- Where
- Denmark
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Multiple Myeloma, Peripheral Neuropathy
Evaluation of Bortezomib Induced Peripheral Neuropathy of Multiple Myeloma (MM) Patients
In the present study we are planning to study electrophysiological changes related to the dose and time of bortezomib administration in newly diagnosed patients with MM, during the first months of treatment and 6 months after…
- Trial name
- NCT00872352
- Testing
- EMG
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Wolfson Medical Center
COVID-19
Efficacy of the Infusion of Donor Plasma in COVID-19 Infection
Objectives Primary objectives To assess the superiority or not of the infusion of anti-COVID immune plasma infusion versus a placebo (non-immune plasma) to patients over 65 years of age recently infected with the SARS-CoV-2…
- Trial name
- NCT05247307
- Testing
- convalescent plasma infusion covid 19
- Where
- Spain
- Volunteers
- 93 people
- Sponsor
- Hospital Galdakao-Usansolo