Clinical trials: Placental Insufficiency
Ophthalmic Artery, Labor and Delivery
The Ophthalmic Artery Doppler Evaluation Prior to Labor Induction and Adverse Intrapartum Fetal Outcomes
The ophthalmic artery Doppler has been recently proposed as a potential "soft marker" for placental insufficiency in retrospective and observational studies, with similar clinical significance with respect to Uterine Artery (UA)…
- Conditions
- Ophthalmic Artery, Labor and Delivery, Induction of Labor, Intrapartum Fetal Distress
- Trial name
- OPHELIA (NCT07846137)
- Testing
- Ophthalmic Artery Doppler
- Where
- Italy
- Volunteers
- 1,477 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Placental Insufficiency
Aspirin for the Enhancement of Trophoblastic Invasion in Women With Abnormal Uterine Artery Doppler at 11-14 Weeks of Gestation
To establish wether a prophylactic intervention from first trimester with low-dose of aspirin improves trophoblastic invasion evaluated at third trimester in women defined as high-risk by abnormal uterine artery Doppler at first…
- Trial name
- ASAP (NCT01616615)
- Testing
- Aspirin
- Where
- 3 sites in Spain
- Volunteers
- 190 people
- Sponsor
- Sara Varea
Pre-eclampsia
Oxford Luteal Dysfunction and Placental Insufficiency Study
High blood pressure (BP) affects approximately 1 in 10 pregnancies. About half of women with high blood pressure in pregnancy develop a serious complication called preeclampsia, which kills over 70,000 women and 500,000 babies…
- Trial name
- OxLuPIn (NCT07072052)
- Testing
- No intervention planned
- Where
- United Kingdom
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Pregnancy Related, Fetal Growth Retardation
Pregnancy Repository
An essential part of clinical research is the availability and accessibility of human biospecimens for the identification of biomarkers, new treatments and measurement of response to therapy.
- Conditions
- Pregnancy Related, Fetal Growth Retardation, Placental Insufficiency, Preeclampsia
- Trial name
- PR (NCT06339606)
- Testing
- Biospecimen collection
- Volunteers
- 7,000 people
- Sponsor
- Sunnybrook Health Sciences Centre
Stillbirth
Revealed Versus Concealed Cerebroplacental Ratio
The purpose of this study is to evaluate the role of an integrated strategy at selecting fetuses for delivery at term based on a combination of fetal biometry and cerebroplacental ratio (CPR) to reduce stillbirth rate and adverse…
- Trial name
- NCT02907242
- Testing
- Revealment
- Where
- 9 sites in Chile, Czechia and 4 more
- Volunteers
- 11,582 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Pre-eclampsia
Early Placental Insufficiency Screening
To assess the role of uterine artery and maternal serum PlGf and sflt-1 and their combination in screening for pre-eclampsia and small -for-gestational age (SGA) fetuses at 12-14 weeks of gestation
- Trial name
- BIODOP-T1 (NCT01348711)
- Where
- 4 sites in France
- Volunteers
- 226 people
- Sponsor
- University Hospital, Tours
Severe Intra-uterine Growth Restriction, Preterm Birth
Impact of Early and Severe Fetal Growth Restriction on Neurodevelopmental Outcomes in Preterm Infants
Very early onset intra uterine growth restriction (IUGR) affects 5-10% of pregnancies and is the second leading cause of perinatal mortality.
- Conditions
- Severe Intra-uterine Growth Restriction, Preterm Birth, Neurodevelopmental Disorders, Placental Insufficiency
- Trial name
- NCT05381272
- Volunteers
- 20 people
- Sponsor
- Central Hospital, Nancy, France
High Risk Pregnant Women, Placental Insufficiency
Low Weight Heparin prOphylaxis for Placental-Mediated Complications of PrEgnancy
This is a Multicenter, randomized, open-label, parallel groups study to test the hypothesis that prophylactic low molecular weight heparin (LMWH) (enoxaparin) initiated before 14 weeks of gestation could improve maternal and…
- Conditions
- High Risk Pregnant Women, Placental Insufficiency, Preeclampsia
- Trial name
- HOPPE (NCT01388322)
- Testing
- Enoxaparin
- Where
- 4 sites in Spain
- Volunteers
- 361 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Chronic Kidney Diseases
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Intravenous Infusion for CKD
This trial will study the safety and efficacy of intravenous infusion of cultured allogeneic adult umbilical cord derived mesenchymal stem cells for the treatment of Chronic Kidney Disease.
- Trial name
- NCT05018845
- Testing
- AlloRx
- Where
- Antigua and Barbuda
- Volunteers
- 20 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Placental Insufficiency, Enoxaparin
Enoxaparin in the Prevention of Placental Insufficiency in Pregnant Women
Assessment of the effectiveness of Enoxaparin, at a preventive dose, combined with Aspirin treatment versus Aspirin only treatment in reducing placental insufficiency in pregnant women.
- Trial name
- PRESANCE (NCT03528967)
- Testing
- Enoxaparin 40 mg / 0.4 mL Prefilled Syringe, Aspirin 100 mg Oral Tablet, Enteric Coated
- Where
- Tunisia
- Volunteers
- 89 people
- Sponsor
- Les Laboratoires des Médicaments Stériles
Placental Insufficiency, Preterm Infant
Impact of Umbilical Cord Milking in Preterm Neonates With Placental Insufficiency
To investigate the effect of umbilical cord milking (UCM) on peripheral hematologic parameters including hematopoietic progenitor cells in premature infants ≤ 34 weeks gestational age with placental insufficiency.
- Trial name
- NCT03731611
- Testing
- Umbilical Cord Milking
- Where
- 2 sites in Egypt
- Volunteers
- 90 people
- Sponsor
- Mansoura University Children Hospital
Pregnancy, Venous Thrombosis
Free DNA and Nucleosome Concentrations in Pathological Pregnancies
The primary objective of this study is to demonstrate that plasma concentrations of nucleosomes and free DNA differ between three groups: 1.
- Conditions
- Pregnancy, Venous Thrombosis, Pulmonary Embolism, Hypertension, Pregnancy-Induced
- Trial name
- NCT01736826
- Testing
- Bloodwork, baseline, Blood work, Months 1 & 2, Bloodwork, Months -1 to -6
- Where
- France
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Preeclampsia and Intrauterine Growth Restriction
Placental Insufficiency Microcirculation Quantification by Ultrafast Doppler (MICRODOPPLER PLACENTA)
To identify fetuses small for their gestational-age who have reached their appropriate growth potential from growth-restricted fetuses due to placental insufficiency is uneasy.
- Trial name
- NCT03860103
- Where
- France
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital