Clinical trials: Pituitary Diseases
Pituitary Adenoma
Comparison of The Effects of Sevoflurane, Desflurane and Total Intravenous Anaesthesia on Pulmonary Function Tests
This study will compare the effects of sevoflurane, desflurane and total intravenous anaesthesia on pulmonary function tests in patients undergoing endoscopic endonasal transsphenoidal surgery of pituitary gland.
- Trial name
- NCT02709863
- Testing
- Sevoflurane, Desflurane, Propofol
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Hypogonadotropic Hypogonadism
Low Energy Availability and Pituitary Function (LEAP Study)
The purpose of this study is to learn more about reproductive hormones and if they change in response to 5-days eating an individualized, standardized diet at two levels: energy balance and low energy intake.
- Trial name
- LEAP (NCT05808647)
- Testing
- 5-day controlled metabolic dietary intake
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Psychological Stress, Hemostatic Disorder
Copeptin and Psychological Stress of Medic During COVID-19 Pandemic
Psychological stress (PSS) is one of the most common problems among healthcare providers during COVID-19 pandemic. PSS influences the homeostatic equilibrium of the body, involving activation of the sympathetic nervous system and…
- Trial name
- COVID-19 (NCT04757285)
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Pleuropulmonary Blastoma, Cystic Nephroma
Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome
Pleuropulmonary Blastoma (PPB) is a rare lung tumor which develops in childhood. The underlying genetic factors which contribute to the development and progression of PPB are not defined.
- Conditions
- Pleuropulmonary Blastoma, Cystic Nephroma, Sertoli-Leydig Cell Tumor of Ovary, Medulloepithelioma
- Trial name
- PPB (NCT00565903)
- Where
- United States
- Volunteers
- 1,247 people, healthy volunteers welcome
- Sponsor
- Ashley Hill
Ovarian Stimulation, Infertility
Pharmacokinetics of FSH and hCG Following Multiple Dose of Gonadotropins-IBSA.
Pharmacokinetics of FSH and hCG after multiple subcutaneous injection of Gonadotropins-IBSA.
- Trial name
- NCT06659692
- Testing
- Gonadotropins Subcutaneous
- Where
- 2 sites in Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- IBSA Institut Biochimique SA
Growth Hormone Deficiency, Growth Hormone Treatment
Effects of Growth Hormone and IGF-1 on Anabolic Signals and Stem Cell Recruitment in Human Skeletal Muscle
12 adult hypopituitary patients with newly diagnosed Growth hormone (GH)-deficiency will be studied two times. The first examinations will be performed shortly after time of diagnose before initiation of exogenous GH treatment…
- Trial name
- NCT03878992
- Testing
- Genotropin miniquick 0.5 mg, injection
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Fatigue Syndrome, Chronic, Healthy
Study of the Hypothalmic-Pituitary-Adrenal (HPA) Axis and Its Role in Major Depression
Major depression represents a major public health problem worldwide and in the U.S. Fifteen percent of the U.S. population has depression at some point in life (40 million individuals).
- Conditions
- Fatigue Syndrome, Chronic, Healthy, Mood Disorders
- Trial name
- NCT00001479
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Endocrine Diseases
Evaluation of Adults With Endocrine and Metabolic-Related Conditions
Background: There are many endocrine and metabolic-related conditions. Two well-known disorders include diabetes and thyroid disease. Some of these diseases are caused by a change in genes.
- Trial name
- NCT02830308
- Where
- United States
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Panhypopituitarism
Baseline Sexual Function, Cognitive Function, Body Composition and Muscle Parameters and Pharmacokinetics of Transdermal Testosterone Gel in Women With Hypopituitarism
The purpose of this study is to determine the blood levels of testosterone gel administered for a week to women with hypopituitarism and determine if this leads to testosterone replacement in a normal range for women.
- Trial name
- NCT00144404
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Charles Drew University of Medicine and Science
Growth Hormone Deficiency, Attention Deficit Disorder
The Impact of the Use of Recombinant Human Growth Hormone on ADHD Characteristics in Children and Adolescents
Analysis of the short-and long-term impact of recombinant growth hormone on attention deficit and hyperactivity charachteristics in children and adolescents.
- Conditions
- Growth Hormone Deficiency, Attention Deficit Disorder, Idiopathic Short Stature
- Trial name
- NCT02973061
- Testing
- Questionnaires
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Cognitive Therapy, Control
Efficacy of Cognitive Behavioral Therapy and Hair Cortisol Concentration
Stress is considered as a risk factor for physical and mental health. For this reason, interventional programs focused on stress management have been developed.
- Trial name
- NCT03476200
- Testing
- Cognitive Behavioral Therapy
- Where
- Spain
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Growth Hormone Disorder, Adult Growth Hormone Deficiency
A Single Dose Trial in Healthy Caucasians and Japanese Subjects Investigating the Pharmacokinetics of Somatropin
This trial was conducted in the United States of America (USA). The aim of this clinical trial was to investigate the pharmacokinetics of somatropin in healthy Japanese and Caucasian subjects, and to identify somatostatin-related…
- Conditions
- Growth Hormone Disorder, Adult Growth Hormone Deficiency, Healthy
- Trial name
- NCT00931476
- Testing
- somatropin
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Pituitary Adenomas
Genome-wide Association Study of Pituitary Tumors
Pituitary adenomas is a very common disease, but the cause and genetics hasn't been identified. The investigators are going to use genome-wide association study to identify genes that may be related to pituitary adenomas.
- Trial name
- NCT01442220
- Where
- China
- Volunteers
- 12,500 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
GH Deficiency (GHD), Growth Retardation
Evaluation of Pharmacokinetic and Pharmacodynamic Parameters of Somatropin Produced by Laboratory Blausiegel Indústria e Comércio Ltda., Compared to Saizen® From Laboratory Merck Serono S.A.
The primary objective of this study is to compare the pharmacokinetic and pharmacodynamic effect between two preparations of somatropin (T and C) after a single administration of 5 mg in healthy subjects by altering serum…
- Trial name
- NCT01494779
- Testing
- Somatropin
- Where
- Brazil
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Azidus Brasil
Vertigo, Peripheral, Vertigo, Brain Stem
Copeptin and the S-100b Protein in Stroke
This study evaluated the value of using copetin and protein S 100 b to eliminate the diagnosis of stroke in patients presenting with vertigo in emergency departments.
- Conditions
- Vertigo, Peripheral, Vertigo, Brain Stem, Vertigo; Central, Vertigo; Cerebral
- Trial name
- NCT03974464
- Testing
- copeptin, PS100
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Social Psychology
Vasopressin and the Social Brain
It has long been established that interpersonal relationships can have a profound impact on health and well-being. Yet, the investigators are still learning about the complex biological processes that contribute to positive…
- Trial name
- NCT02394054
- Testing
- Intranasal vasopressin
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Acromegaly
Cardiac (CMRI) Assessment of Acromegaly
In this study, the investigators will evaluate the cardiac structure and function, focusing on the myocardial water content and interstitial fibrosis, in patients with active acromegaly in comparison with 1) healthy volunteers…
- Trial name
- ACROCOEUR (NCT02948322)
- Testing
- CMRI, Gadolinium, OGTT
- Where
- France
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pituitary Neoplasms
Clinical Evaluation of [68Ga]Ga-NOTA-RF PET Imaging Targeting RFVT3 in Patients With Pituitary Tumors
This study aims to evaluate the clinical application value of [68Ga]Ga-NOTA-RF, a novel PET molecular probe targeting riboflavin transporter 3 (RFVT3), in patients with pituitary adenomas.
- Trial name
- NCT07254104
- Testing
- [68Ga]Ga-NOTA-RF
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Healhty
Oromucosal Oxytocin and Vasopressin Modulation of Emotional Face Attention
The goal of this clinical trial is to learn how 24 IU oxytocin (OT) and 24 IU arginine vasopressin (AVP), administered through the oral mucosa, affect attention to emotional faces and related brain activity in healthy adults.
- Trial name
- NCT07838493
- Testing
- Oxytocin (OT), Arginine Vasopressin (AVP)
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Acromegaly
Oral Glucose Tolerance Testing (OGTT) on Patients Taking Somatostatin Analogs
The purpose of this study is to test the effect of long-acting somatostatin analog medications, taken by patients with acromegaly or carcinoid syndrome, on growth hormone in comparison to healthy controls who are not receiving…
- Trial name
- NCT01371045
- Testing
- Oral Glucose Tolerance Test (OGTT)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center