Clinical trials: Physiological Strain
Skin Cancer, Heat Tolerance
Title: ICARUS - Psycho-physiological Profiling of Low and High Heat-resilient Individuals
The escalating environmental heat-stress associated with global warming is a societal challenge with large and potential harmful consequences for humans.
- Conditions
- Skin Cancer, Heat Tolerance, Heat-related Illness, Hyperthermia
- Trial name
- ICARUS (NCT07510061)
- Testing
- Controlled Heat and Ultraviolet Radiation Exposure Protocol
- Where
- 2 sites in Denmark, Greece
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Clostridium Difficile Infection
Safety and Clinical Effectiveness of Oral Probiotic MIYA-BM to Prevent Recurrent Clostridium Difficile Infections
Patients with confirmed C. difficile infection (CDI) who meet eligibility requirements will be invited to participate. All study patients must receive treatment for CDI with metronidazole or vancomycin.
- Trial name
- NCT01077245
- Testing
- MIYA-BM Fine Granules (CBM588)
- Sponsor
- Osel, Inc.
Malaria (Plasmodium Falciparum)
Malaria CVD 36000; Gates INV090205
In order to control infections, the investigators must first detect them. Biosensor devices may allow early detection and intervention for infectious diseases, helping the investigators to recognize infections early, and allow…
- Trial name
- NCT07558122
- Testing
- PfSPZ Challenge (NF54), Wearable Biosensor Devices
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Heat Stress, Physiological Stress
Physiological Strain in Young Adults During a Simulated Heat Wave
The likelihood of exposure to overheated indoor environments is increasing as climate change is exacerbating the frequency and severity of hot weather and extreme heat events.
- Trial name
- NCT06618352
- Testing
- Simulated indoor overheating exposure
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Physiological Strain
The Affect of a Ventilated Helmet on Physiological Load
The use of infantry helmets under heavy heat stress conditions, during physical exertion, may hinder the body's ability to effectively dissipate heat from the head area, thereby damaging the soldier's function.
- Trial name
- NCT01595906
- Testing
- Ventilated Helmet
- Where
- Israel
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Medical Corps, Israel Defense Force
Body Temperature Changes, Heat Stress
Ambient Temperature and Thermoregulation During Exercise in Children and Youth
Little is known about how children and youth regulate body temperature during exercise across different environmental temperatures compared with young adults, including whether differences in whole-body heat exchange contribute…
- Conditions
- Body Temperature Changes, Heat Stress, Child Development, Heat
- Trial name
- NCT07781605
- Testing
- Exercise at 22°C, Exercise at 26°C, Exercise at 31°C
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Heat Stress, Physiological Stress
Heat Stress in Individuals With Schizophrenia
Schizophrenia is a severe mental illness affecting approximately 24 million people worldwide and is associated with more than double the all cause mortality risk of the general population.
- Conditions
- Heat Stress, Physiological Stress, Cognitive Change
- Trial name
- NCT07383324
- Testing
- Simulated exposure to indoor overheating
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of Ottawa
Ergonomics
These Studies Assess Surgeons' Physical and Ergonomic Workloads. Study 1 Compares Laparoscopic vs. Hugo RAS Robotic Approaches for Rectal Resection. Study 2 Compares Hugo RAS vs. Da Vinci Xi for Prostatectomy. Both Track Physiological Stress, Surgical Strain Phases, and Exerted Force.
The ERGOROB (ERGOnomics in surgical ROBotics) study is an observational research project focused on the physical well-being of surgeons.Why is this study important?Surgeons perform complex, lengthy procedures that can lead to…
- Trial name
- ERGOROB (NCT07479121)
- Testing
- surgical approach
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Body Temperature Changes, Heat Stress
Consecutive Occupational Heat Exposure With and Without Overnight Cooling
Extreme heat events are becoming more frequent, intense, and prolonged, increasing the risk of heat-related illness among workers exposed to hot environments.
- Conditions
- Body Temperature Changes, Heat Stress, Heat Exposure, Heat Fatigue
- Trial name
- NCT07656519
- Testing
- Simulated occupational heat exposure with recovery at recommended indoor temperature limit, Simulated occupational heat exposure with recovery in an overheated indoor environment
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Heart Failure, Diastolic, Aortic Valve Stenosis
Changes in Cardiac Deformation Following Physiologic Alterations and Inotropic Support.
The investigators want to compare the effects of two drugs, levosimendan and milrinone, on cardiac muscle, both in terms of contractility and relaxation. Half of the participants will be randomized to each drug.
- Conditions
- Heart Failure, Diastolic, Aortic Valve Stenosis, Monitoring, Physiologic, Physiology
- Trial name
- NCT02408003
- Testing
- Levosimendan, Milrinone
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Sahlgrenska University Hospital
Heat Stress, Physiological Stress
Influence of Indoor Humidity on Physiological Strain in Older Adults During a Simulated Heat Wave
Laboratory-based studies show that exposure to high humidity can worsen the effects of heat stress in young and older adults by impeding sweat evaporation - the main mechanism by which the human body cools itself.
- Trial name
- NCT06842953
- Testing
- Simulated indoor overheating
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Body Temperature Changes, Heat Stress
Exercise Intensity and Heat Responses in Children and Youth
Little is known about how children and youth regulate body temperature during exercise in the heat compared with young adults, including whether differences in whole-body heat exchange contribute to their responses.
- Conditions
- Body Temperature Changes, Heat Stress, Child Development, Heat
- Trial name
- NCT07781592
- Testing
- Low-Intensity Exercise in the Heat, Moderate-Intensity Exercise in the Heat, Vigorous-Intensity Exercise in the Heat
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Aging, Heat Stress
Establishing Evidence-based Indoor Temperature Thresholds to Protect Health
An individual's ability to adequately cope with short- or long-term increases in ambient temperature is critical for maintaining health and wellbeing.
- Conditions
- Aging, Heat Stress, Physiological Stress
- Trial name
- HW2 (NCT04348630)
- Testing
- Simulated heatwave exposure
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Body Temperature Regulation
Physiological and Molecular Influences of Astaxanthin Supplementation on Heat Strain in Humans
Exposure to heat stress can compromise the physiological and cognitive function and be life threatening, particularly in a military setting.
- Trial name
- Astaxanthin (NCT02088242)
- Testing
- Astaxanthin
- Where
- Israel
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Coronary Artery Disease Progression, Radial Wall Strain
Natural History of Coronary Atherosclerosis
The present study sought to explore the predictive value of radial wall strain (RWS, derived solely from angiograms) for coronary artery lesion progression compared with lesion vulnerability assessed by optical coherence…
- Conditions
- Coronary Artery Disease Progression, Radial Wall Strain, Atherosclerotic Lesion, Optical Coherence Tomography
- Trial name
- NASCENT (NCT06040073)
- Where
- China
- Volunteers
- 125 people
- Sponsor
- China National Center for Cardiovascular Diseases
Body Temperature Changes, Heat Stress
Initial Stay Times and Heat Mitigation Controls for Uncompensable Occupational Heat Stress - Part III
Occupational heat stress directly threatens workers' ability to live healthy and productive lives. Heat exposed workers are at an elevated risk of experiencing impaired work performance and cognitive function leading to a greater…
- Conditions
- Body Temperature Changes, Heat Stress, Heat Exposure, Heat Fatigue
- Trial name
- NCT06630832
- Testing
- Simulated work in the heat with no cooling during rest breaks, Simulated work in the heat with partial cooling during rest breaks, Simulated work in the heat with full cooling during rest breaks
- Where
- Canada
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Heat Strain, Healthy Volunteer Study
The Kidney's Response to Exercise in Heat, and the Impact of Vitamin B3 on This Response
The goal of this clinical trial is to learn about the processes occurring in the kidneys while under heat stress in healthy volunteers.
- Conditions
- Heat Strain, Healthy Volunteer Study, Kidney Dysfunction
- Trial name
- NCT06983730
- Testing
- Vitamin B3
- Where
- 2 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Heat Tolerance
Heat Stress and Physiological Strain of Permeable vs. Impermeable CB Protective Garment
Current protective clothing of any kind, especially the nuclear-biological-chemical (NBC) protective garments, amplify thermal stress because of the inherent properties of the clothing material.
- Trial name
- NCT01221012
- Where
- Israel
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Medical Corps, Israel Defense Force
Total Hip Arthroplasty (THA), Impaction
Automated V Manual Impactor Study
This study investigates the use of an automated impactor device in total hip arthroplasty versus manual malleting method and the physiological strain on the surgeon.
- Conditions
- Total Hip Arthroplasty (THA), Impaction, Physiological Strain
- Trial name
- NCT06903767
- Testing
- Automated Impaction (HAMMR), Manual Malleting
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics