Clinical trials: Physical Function in Older Adults, open to volunteers
Cognition Disorders
Impact of Glasses for Vision Problems on Cognitive Function in Rural Older Adults
The aim of this project is to explore whether vision correction can effectively slow cognitive decline in older adults. The primary question it seeks to answer is: Can providing free near and/or distance vision correction glasses…
- Trial name
- CLEVER (NCT06836440)
- Testing
- Free Prescription Glasses
- Where
- China
- Volunteers
- 964 people, healthy volunteers welcome
- Sponsor
- Yuju Wu
PTSD and Trauma-related Symptoms, Cognitive Decline in Older Adults
Acute Effects of Estradiol Administration on Brain Function During Fear Learning
The goal of current study is to better understand how fear is processed in the brain and how these processes are influenced by cognition and hormones.
- Conditions
- PTSD and Trauma-related Symptoms, Cognitive Decline in Older Adults, Post Menopausal Women
- Trial name
- EstroFearGen (NCT07737613)
- Testing
- estradiol
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Cognitive Dysfunction, Mobility Limitation
Up-2 Study: Cognitively Engaging Walking Exercise and Neuromodulation to Enhance Brain Function in Older Adults
Declines in cognitive function and walking function are highly intertwined in older adults. A therapeutic approach that combines complex (cognitively engaging) aerobic walking exercise with non-invasive electrical brain…
- Conditions
- Cognitive Dysfunction, Mobility Limitation, Frail Elderly
- Trial name
- NCT05830942
- Testing
- Walking Exercise, Prefrontal Active tDCS
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Florida
Multiple Sclerosis (MS) Secondary Progressive
Senolytics for Secondary Progressive MS
This is a clinical trial to see whether senolytic therapy is safe and feasible for patients with secondary progressive MS and whether treatment improves physical and thinking abilities.
- Trial name
- NCT07270120
- Testing
- Dasatinib and quercetin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Ohio State University
Sedentary Behavior / Physical Inactivity, Aging
Effects of Different Amounts of Plyometric Exercise Without Jumping in Physically Inactive Older Adults
The goal of this clinical trial is to investigate whether different amounts of plyometric exercise without jumping can improve lower-limb muscle strength, power, and muscle and tendon mechanical properties in sedentary and/or…
- Trial name
- NJPT-OLDER (NCT07891000)
- Testing
- High-Volume Non-Jumping Plyometric Training, Low-Volume Non-Jumping Plyometric Training
- Volunteers
- 54 people
- Sponsor
- University of Americas - Chili
Aging, Balance Control in Elderly
Effects of Telerehabilitation-Based Dual-Task Exercises on Balance, Fall Risk, Cognitive Function, and Sleep Quality in Geriatric Individuals
The purpose of this study is to investigate the effects of dual-task exercises-which simultaneously target cognitive and motor functions-delivered via telerehabilitation on fall risk, balance, cognitive functions, and sleep…
- Conditions
- Aging, Balance Control in Elderly, Sleep Disorder (Disorder)
- Trial name
- NCT07472101
- Testing
- Telerehabilitation Based Dual-Task Exercises, Educational Brochure and Phone Follow-Up
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Bulent Ecevit University
Sedentary Behavior, Frailty
Effects of Intermittent Hypoxia-Hyperoxia in Older Adults
The supply of oxygen is essential for energy production, recovery from efforts, and human life. Intermittent Hypoxia-Hyperoxia Exposure (IHHE) is a novel technique in which the subject is exposed to a respiratory environment with…
- Conditions
- Sedentary Behavior, Frailty, Older Adults
- Trial name
- NCT06686316
- Testing
- Device: Hypoxic Gas Mixture
- Volunteers
- 16 people
- Sponsor
- Sierra Varona SL
Insomia Disorder
A Trial to See if Daridorexant Can Help Adults and Elderly People With Insomnia Sleep Better During the Night and Function Better During the Day
The purpose of this clinical trial is to collect more data about the effect of daridorexant in adults and elderly people with insomnia disorder.
- Trial name
- DARI-DREAM (NCT07843329)
- Testing
- Daridorexant
- Where
- 9 sites in United States
- Volunteers
- 344 people
- Sponsor
- Idorsia Pharmaceuticals Ltd.
Sarcopenia
The Krill Ageing Muscle Mechanisms (KAMM) Study
This study aims to determine the mechanisms via which krill oil supplementation increases muscle strength and whether this translates to improvements in gait and functional characteristics in older adults.
- Trial name
- KAMM (NCT06296875)
- Testing
- Vegetable oil, Krill oil
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Cognitive Dysfunction ( MMSE < 24 )
Effects of tDCS on Cognitive Function in Older Adults With Subjective Cognitive Decline: Randomized Sham-Controlled Trial
This randomized, double-blind, sham-controlled clinical trial evaluates the effects of transcranial direct current stimulation (tDCS) using the Sooma Oy device on cognitive function in older adults with Subjective Cognitive…
- Trial name
- TDCSCOGSCDTRIA (NCT07531888)
- Testing
- Transcranial Direct Current Stimulation
- Where
- Mexico
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidad Autónoma del Estado de Hidalgo
Hard-to-Reach Elderly
Impact Assessment of the Jockey Club REACH & Map Program for Hard-to-reach Older Adults
The goal of this study is to evaluate the impact of the Reach-and-Map project on increasing functional capacity to optimize the functional ability of the vulnerable group of "Hard-to-Reach" older adults through increase the…
- Trial name
- NCT07305441
- Testing
- Mapped intervention based on health status
- Where
- Hong Kong
- Volunteers
- 5,500 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Older Adults (65 Years and Older), Fitness Testing
Health-related Physical Fitness and Executive Function in Older Adults: A Prospective Study
This study aims to explore the relationship between health-related physical fitness and behavioural and electrophysiological aspects of cool and hot executive function in older adults through a year prospective study design.
- Conditions
- Older Adults (65 Years and Older), Fitness Testing, Executive Function (Cognition), Prospective Study
- Trial name
- NCT07048561
- Testing
- observation alone
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Taiwan Normal University
Spinal Amyotrophy
SMAdult - Monitoring of Movement on Spinal Muscular Atrophy
Spinal muscular atrophy (SMA) is a rare neuromuscular disease causing progressive muscle weakness related to degeneration of motor neurons.
- Trial name
- SMAdult (NCT07894185)
- Testing
- wearable sensors
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Liege
Brain Health, Longevity
L-serine and Strength Training in the Elderly
This study investigates whether taking the amino acid L-serine, either alone or in combination with targeted strength training, can have a positive effect on mental performance, brain function, and physical fitness in older…
- Conditions
- Brain Health, Longevity, Cognitive Performance, Strength Training Effects
- Trial name
- AAAging (NCT07466290)
- Testing
- Strength training, L-serine supplementation, Control (cornstarch)
- Where
- Austria
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Lung Carcinoma
Telephone-based Physical Activity Coaching or Self Monitored Physical Activity to Improve Physical Function in Older Adults Who Are Undergoing Surgery for Lung Cancer and Their Caregivers
This clinical trial compares telephone-based physical activity coaching to self monitored physical activity for improving physical function in older adults who are undergoing surgery for lung cancer and their caregivers.
- Trial name
- NCT06196008
- Testing
- Educational Intervention, Exercise Intervention, Medical Device Usage and Evaluation
- Where
- 16 sites in United States
- Volunteers
- 382 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Frailty, Dementia
Multicomponent Exercise Program on Physical Function, Cognition and Falls Risk Among Older Adults Living in Nursing Homes (MOVE4CARE)
Can a multicomponent exercise program significantly improve physical and cognitive function and reduce fall rates among nursing home residents? To address this question, the present study aims to compare the effectiveness of a…
- Trial name
- MOVE4CARE (NCT07392944)
- Testing
- Multicomponent exercise intervention, stretching and relaxation program
- Where
- Portugal
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidade do Porto
Cognitive Decline, Aging
Effects of Comprehensive Community Support Programs on Cognitive Function and Quality of Life in Older Adults
This prospective observational study aims to investigate the effects of a multidomain community-based support program on cognitive function and quality of life in older adults attending the Vefahane Life Center in Istanbul…
- Conditions
- Cognitive Decline, Aging, Quality of Life
- Trial name
- NCT07610109
- Testing
- Multidomain Community Support Program
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Istanbul Medipol University Hospital
Cognition Disorders in Old Age, Cognitive and Behavioral Impairment
Evaluation of the Effect of L-Arginine on the Cognitive Function in Geriatric Patients
This study aims to evaluate the effect of L-arginine supplementation on cognitive function in geriatric patients. Eligible participants will receive either L-arginine (6 grams once daily) or placebo, and their cognitive…
- Trial name
- NCT07338682
- Testing
- L-Arginine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- German University in Cairo
Sarcopenic Obesity, Obesity and Obesity-related Medical Conditions
Plant vs Animal-based Protein Sources as an Anabolic and Metabolic-protective Options for SO in Older Adults
This study is testing how different types of protein - from red meat, legumes (like lentils and beans), or a mix of both - affect muscle strength, body composition, and metabolic health in older adults with obesity who are also…
- Conditions
- Sarcopenic Obesity, Obesity and Obesity-related Medical Conditions, Obesity (Body Mass Index >30 kg/m2), Sarcopenia
- Trial name
- NCT07030738
- Testing
- Legume-Based High-Protein Diet + Resistance Training, Meat-Based High-Protein Diet + Resistance Training, Mixed Legume and Meat High-Protein Diet + Resistance Training
- Where
- Israel
- Volunteers
- 180 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Type 2 Diabetes Mellitus (T2DM), Sarcopenia
Multimodal Training Effects in Middle-Aged and Older Adults With Diabetic Sarcopenia
This study aims to investigate the effects of a 12-week multimodal exercise intervention on middle-aged and older adults (aged 45~85 years) with Type 2 Diabetes Mellitus (T2DM).
- Trial name
- NCT07398495
- Testing
- Multimodal Exercise Program
- Where
- Taiwan
- Volunteers
- 128 people
- Sponsor
- yueh chu wu