Clinical trials: Phenylephrine
Veisalgia
Study to Evaluate the Pharmacokinetics and Pharmacodynamics of JMI-001
This will be a double-blind, placebo-controlled study with a 4-way crossover design with subjects administered study drug (JMI-001), placebo, fexofenadine alone and naproxen alone on different study days, in conjunction with a…
- Trial name
- NCT03183297
- Testing
- JMI-001, Naproxen, Fexofenadine
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Sen-Jam Pharmaceutical
CBD Pharmacokinetics, Healthy Participants
A Pharmacokinetic Study to Compare CBD-NE to Epidyolex in Healthy Adult Volunteers Under Both Fed and Fasted Conditions
Cannabidiol (CBD), derived from the Cannabis sativa plant, is being investigated for its potential health benefit without the psychoactive properties and adverse reactions that arise from the use of delta-9-tetrahydrocannabinol…
- Trial name
- NCT06578455
- Testing
- Cannabidiol (CBD) Powder, Cannabidiol 100 MG/ML [Epidiolex]
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- dsm-firmenich Switzerland AG
Adverse Effect
ED90 of Norepinephrine and Phenylephrine Boluses Under Intensive Treatment
The objective of this study is to investigate the ED90 of norepinephrine and phenylephrine boluses for treating postspinal anesthesia hypotension under intensive treatment during cesarean section
- Trial name
- NCT06158009
- Testing
- Norepinephrine, Phenylephrine
- Volunteers
- 80 people
- Sponsor
- General Hospital of Ningxia Medical University
Type 2 Diabetes
Study of Comparing the Different Effect of DPP-4 Inhibitors and Sulfonylurea by Using "Biphase-Hyperglycemic Clamp"
The objective of this study is to demonstrate the different effects of two DPP-4 inhibitors(Sitagliptin, Saxagliptin)and the insulin secretagogue: glimepiride on first and second phase insulin secretion by using a…
- Trial name
- NCT01660386
- Testing
- Sitagliptin, Saxagliptin, Glimepiride
- Where
- China
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Transient Insomnia
SM-1 vs 2 Comparators and Placebo in Participants With a History of Transient Insomnia.
The purpose of this study is to investigate the effectiveness, safety and tolerability of a combination drug product (SM-1) containing diphenhydramine, zolpidem and lorazepam, in adult participants who sometimes have difficulty…
- Trial name
- NCT03331042
- Testing
- SM-1, D+Z, D+L
- Where
- 2 sites in United States
- Volunteers
- 85 people
- Sponsor
- Sequential Medicine Ltd
Healthy
Relative Bioavailability of Telmisartan and Dipyridamole After Co-administration Compared to the Bioavailability of Telmisartan or Dipyridamole Alone in Healthy Female and Male Subjects
To investigate the relative bioavailability of telmisartan respectively of dipyridamole after concomitant administration of 80 mg telmisartan in Micardis® and 25 mg acetylsalicylic acid (ASA)/200 mg extended release (ER)…
- Trial name
- NCT02262793
- Testing
- telmisartan, ASA/ER-DP
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Healthy Male Volunteers
A Single-centre, Randomised, Double-blind, Placebo-controlled, Four Way Crossover Phase I Study to Investigate the Effect on QT/QTc Interval of Ceftazidime NXL104 or Ceftaroline Fosamil NXL104, Compared With Placebo, Using Moxifloxacin (Avelox®) as a Positive Control, in Healthy Male Volunteers
This is a single dose study in healthy male volunteers to investigate the effect of high doses of ceftazidime NXL104 (CAZ104) or ceftaroline fosamil NXL104 (CXL104) on the QT interval
- Trial name
- NCT01290900
- Testing
- NXL104, Ceftaroline, Ceftazidime
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Pfizer
Caesarean Section
Optimization of Hemodynamic Conditions During Caesarean Section Under Spinal Anaesthesia
The purpose of this study is to determine wether intravenous Phenylephrine, administered as start bolus and following continuous infusion (specific dosage per weight), or optimal lower limb bandaging is more effective in…
- Trial name
- NCT01278238
- Testing
- Phenylephrine, Lower limb compression
- Where
- Norway
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Anestesiavdelingen Baerum Sykehus
Pulmonary Disease, Chronic Obstructive
Safety Study Using GSK573719 And Tiotropium In Patients With Chronic Obstructive Pulmonary Disease
GSK573719 is a high-affinity specific muscarinic receptor (mAChR) antagonist which is being developed for once daily treatment of chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT00515502
- Testing
- GSK573719, Tiotropium
- Where
- 3 sites in Germany
- Volunteers
- 24 people
- Sponsor
- GlaxoSmithKline
Hypotension, Anesthesia
Intramuscular Phenylephrine HCL for Prevention of Spinal Anesthesia Induced Hypotension
Background: Spinal anesthesia (SA) is preferred over general anesthesia in Cesarean section (CS) due to its better safety profile but SA induced hypotension remains a big challenge for the clinical Anesthetist.
- Trial name
- NCT05348980
- Testing
- Phenylephrine Hydrochloride 4 mg, Phenylephrine Hydrochloride 8 mg
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rehman Medical Institute - RMI
Asthma
A Study to Evaluate the Effect of Two Different Repeat Doses of GSK2190915 on the QTc Interval.
This study is a randomized, placebo controlled, four way crossover, in which the the effect of GSK2190915 on the QTc interval is assessed.
- Trial name
- NCT01721135
- Testing
- GSK2190915 100mg, GSK2190915 200mg, moxifloxacin 400mg
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Prolonged QTc Interval, Pharmacokinetic
Effect of a Multiple-dose Oral Administration of CG5503 PR on the Electrical Activity of the Heart in 48 Healthy Men and Women
The effect of multiple oral administration of two doses of CG5503 PR (prolonged release) compared to placebo on the electrical activity of the heart were investigated.
- Trial name
- NCT03951402
- Testing
- 100 mg CG5503 (tapentadol hydrochloride) PR tablet, 400 mg Moxifloxacin tablet (overencapsulated)
- Where
- Germany
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Grünenthal GmbH
Healthy
Bioavailability of Four Oral Prototype Extended Release Formulations With BI 11634 in Healthy Male Volunteers
To compare the oral bioavailability and rate of absorption of four prototype extended-release (ER) formulations with BI 11634 (single doses) to immediate-release (IR) tablets in healthy male volunteers.
- Trial name
- NCT02214953
- Testing
- BI 11634 ER formulation A, BI 11634 ER formulation B, BI 11634 ER formulation M
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Asthma
A Four-way Crossover, Single and Repeat Dose Study to Determine the Dose Proportionality and Absolute Bioavailability of Fluticasone Furoate Inhalation Powder Administered by Novel Dry Powder Inhaler (NDPI)
The purpose of this study is to demonstrate dose proportionality of the FF (50 microgram (mcg), 100 mcg or 200 mcg), when administered as a single and repeat dose from the NDPI containing FF formulated with lactose.
- Trial name
- NCT01669070
- Testing
- FF, 50 mcg, FF, 100 mcg, FF, 200 mcg
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Septic Shock
Phenylephrine in Septic Shock
The present study was conducted as a prospective, randomized, controlled study to compare: the effects of norepinephrine and phenylephrine on systemic and regional hemodynamics in patients with catecholamine-dependent septic…
- Trial name
- NCT00639015
- Testing
- Phenylephrine, Norepinephrine
- Where
- Italy
- Volunteers
- 32 people
- Sponsor
- University of Roma La Sapienza
Healthy
A Study to Assess the Bioavailability of ASP015K
The objective of the study is to assess the bioavailability of ASP015K within the gastrointestinal tract.
- Trial name
- NCT01430078
- Testing
- ASP015K
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Inc
Healthy Volunteers
Food Effect and Bioequivalence Study of Simufilam Tablets in Healthy Volunteers
This study will compare the pharmacokinetics of the Phase 3 simufilam 100 mg oral tablet when taken fasted versus following a high-fat or low-fat meal.
- Trial name
- NCT04932655
- Testing
- simufilam
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cassava Sciences, Inc.
Gastroesophageal Reflux Disease
A Study to Estimate Effect of 4 Different Doses of AZD3355 on Reflux Episodes, Which Patients With Gastroesophageal Reflux Disease (GERD) May Experience
The purpose of the study is to estimate what effect 4 different doses of AZD3355 will have on the number of reflux episodes, in patients who have GERD and still experience symptoms despite proton pump inhibitor (PPI) treatment.
- Trial name
- NCT01043185
- Testing
- AZD3355
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- AstraZeneca
Asthma
Pilot Pharmacokinetic Clenil Study With AeroChamber Plus™ or Volumatic™ Spacer Devices
The purpose of this study is to evaluate, at steady-state, the systemic exposure and the lung deposition of B17MP (active metabolite of BDP) as AUC0-12h,ss and Cmax,ss, after inhalation of BDP (Clenil® Modulite®) with the…
- Trial name
- NCT01370031
- Testing
- Clenil® Modulite® via AeroChamber Plus™, Clenil® Modulite® via Volumatic™ spacer, Clenil® Modulite® via AeroChamber Plus™ plus charcoal block
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Drug Overdose
Bioavailability of Nasal Naloxone and Injected Naloxone Compared
Opioid overdoses have in the last decade counted for about 230 untimely deaths annually in Norway. The government is currently implementing a strategy for combating this epidemic.
- Trial name
- OPI-15-002 (NCT02598856)
- Testing
- Intranasal (IN) naloxone 1x, Intranasal (IN) naloxone 2, Intravenous (IV) naloxone
- Where
- Norway
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology