Clinical trials: Pharmacogenetics
Pain, Postoperative
Evaluation of Pharmacogenetic Factors Affecting Fentanyl Requirements for Postoperative Pain Control
Fentanyl is a widely used opioid analgesic. There are big interindividual variabilities in dose requirements of fentanyl for postoperative pain control.
- Trial name
- NCT00824772
- Where
- South Korea
- Volunteers
- 204 people
- Sponsor
- Inje University
Alcohol Dependence
Pharmacogenetic Response to Naltrexone For Alcohol Dependence
The aims of the study are to test for treatment outcome differences in alcohol dependent subjects randomly assigned to 12 weeks of treatment with NTX (50mg/day) or placebo among those with one or two copies of the Asp40 allele of…
- Trial name
- NCT00831272
- Testing
- naltrexone
- Where
- 4 sites in United States
- Volunteers
- 221 people
- Sponsor
- David Oslin
Depression
Venlafaxine Augmentation in Treatment Resistant Depression
This is an assessment of the efficacy of venlafaxine-HCL augmentation with the neuroleptic quetiapine in treatment resistant depression.
- Trial name
- NCT00253266
- Testing
- Venlafaxine, Quetiapine
- Where
- Germany
- Volunteers
- 126 people
- Sponsor
- Max-Planck-Institute of Psychiatry
Cardiovascular Diseases, Heart Diseases
Genetic Epidemiology of Responses to Antihypertensives
To determine whether measured variation in genes coding for components of vasoconstriction and volume regulating systems predict interindividual differences in blood pressure response to therapy with a thiazide diuretic…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension
- Trial name
- GERA (NCT00005520)
- Testing
- Hydrochlorothiazide, Candesartan
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- Mayo Clinic
Pharmacogenomic Testing
VICE-MPRINT: Maternal and Pediatric Pharmacogenetics Survey
The field of pharmacogenetics has progressed from the discovery of genetic variants that cause variable function of drug metabolism enzymes to a cornerstone of clinical precision medicine.
- Trial name
- MPRINT (NCT05037305)
- Testing
- Educational video
- Where
- 2 sites in United States
- Volunteers
- 798 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Depression, Anxiety
Retrospective Analysis of Outcomes With a Pharmacogenomic Algorithm
Antidepressants are among the most widely prescribed medications, yet only 35-45% of patients achieve remission following an initial antidepressant trial.
- Trial name
- UHS (NCT01632267)
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Assurex Health Inc.
Atrial Fibrillation, Pulmonary Embolism
Comparison of Warfarin Dosing Using Decision Model Versus Pharmacogenetic Algorithm
This is a prospective comparison of clinician dosing and a pharmacogenetic algorithm in diagnosed patients requiring warfarin therapy.
- Conditions
- Atrial Fibrillation, Pulmonary Embolism, Deep Vein Thrombosis
- Trial name
- NCT00511173
- Testing
- Warfarin Dose based on pharmacogenetics
- Volunteers
- 102 people
- Sponsor
- Creighton University
Heart Failure With Reduced Ejection Fraction
Mechanistic Clinical Trial Comparing the Pharmacokinetics/Pharmacodynamics of Metoprolol in Heart Failure With Reduced Ejection Fraction Patients With Low vs. High Polygenic Score
The purpose of this trial is to better understand how the beta-blocker metoprolol works in people with Heart Failure with Reduced Ejection Fraction (HFrEF) according to participants genetics.
- Trial name
- NCT07490067
- Testing
- Metoprolol Succinate, Beta-Blocker Polygenic Score, Illumina Infinium Global Diversity Array with Enhanced Pharmacogenomics (PGx)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Michigan
Fentanyl, Newborn
Pharmacogenetics Analysis of Fentanyl Administered in Newborns
Fentanyl is an opioid drug used as analgesic and anaesthetic also in Neonatal Intensive Care Units (NICU), according to the last national and international recommendations, during invasive life support strategies such as…
- Conditions
- Fentanyl, Newborn, Pharmacogenetics
- Trial name
- NCT05805241
- Where
- Italy
- Volunteers
- 66 people
- Sponsor
- IRCCS Burlo Garofolo
Cancer, Gastrointestinal Cancer
Evaluating Microarray Pharmacogenetic Testing in Cancer Patients
The purpose of this research is to evaluate the impact of a microarray PGx test on prescribing/dosing of drugs and cancer treatments in patients with cancer who are currently eligible for single-gene DPYD testing.
- Trial name
- NCT06489041
- Testing
- Pharmacogenomic Testing with the "Global Diversity Array with Enhanced PGx"
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Wake Forest University Health Sciences
Patients With Head and Neck Cancer (ORL)
Pharmacokinetics and Pharmacogenetics-based Adaptive Dosing of 5-fu (5-Fluorouracile) in Head & Neck Cancer Patient Undergoing Docetaxel, Cisplatin, 5-Fluorouracile (=TPF) Therapy
Docetaxel, Cisplatin, 5-Fluorouracile (=TPF) is a mainstay for treating head and neck cancers, but elderly or fragile patients are often precluded because of the risk of severe toxicities associated with this protocol.
- Trial name
- 5-FU (NCT02484677)
- Testing
- Cisplatin, Docetaxel, 5-Fluorouracile
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Pharmacogenomics and Cardiovascular Events
Pharmacogenomics and Effective Treatment With Clopidogrel
The aim of this biospecimen repository is to evaluate an individual's genotype, identify the variances, and understand how they relate to treatment with clopidogrel.
- Trial name
- NCT01611545
- Testing
- Pharmacogenomics
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Avera McKennan Hospital & University Health Center
Atrial Fibrillation
Evaluation of a Pharmacogenetic-based Warfarin Dosing Algorithm in Patients
Background: Time in therapeutic range (TTR) is a measurement of quality of warfarin therapy and lower TTR values (<50%) are associated with greater risk of thromboembolic and bleeding events.
- Trial name
- NCT02592980
- Testing
- Pharmacogenetic anticoagulation, Traditional anticoagulation
- Where
- Brazil
- Volunteers
- 300 people
- Sponsor
- University of Sao Paulo General Hospital
ALL, Childhood, Pediatric Cancer
Pharmacogenomic Association Study in Indian Children With Acute Lymphoblastic Leukemia
A five-year prospective observational cohort study. The study is focused on observing the relation between static germline variants and therapeutic response in Indian children with acute lymphoblastic leukemia (ALL).
- Conditions
- ALL, Childhood, Pediatric Cancer, Toxicity, Drug, Adverse Drug Event
- Trial name
- MPGx-INDALL (NCT05512169)
- Where
- 2 sites in India
- Volunteers
- 556 people
- Sponsor
- University of Geneva, Switzerland
Major Surgery, Coronary Artery Disease
Vitamins in Nitrous Oxide Study
In this study, we want to find out if laughing gas (nitrous oxide) leads to a higher rate of cardiac complications after surgery in patients with a specific genetic profile (mutations in the MTHFR gene) and if this risk can be…
- Trial name
- VINO (NCT00655980)
- Testing
- Vitamin B12 and folic acid, standard of care
- Where
- United States
- Volunteers
- 687 people
- Sponsor
- Washington University School of Medicine
Carcinoma, Squamous Cell, Mouth Neoplasms
Pharmacogenetic Response to Chemotherapy Induction for ORL Cancers
The purpose of this study is to determine if there is a correlation between tumor response after 3 doses of chemotherapy by induction using Docetaxel, Cisplatine and 5-Fluorouracile for advanced stage epidermoid carcinomas of the…
- Conditions
- Carcinoma, Squamous Cell, Mouth Neoplasms, Oropharyngeal Neoplasms, Laryngeal Neoplasms
- Trial name
- APPROCHE ORL (NCT01104714)
- Where
- 14 sites in France
- Volunteers
- 90 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Type 2 Diabetes
TriMaster: Study of a DPP4 Inhibitor, SGLT2 Inhibitor and Thiazolidinedione as Third Line Therapy in Patients With Type 2 Diabetes.
The aim of this project is to identify subgroups of patients with type 2 diabetes that respond well or poorly to particular drugs based on particular clinical characteristics such as their weight or kidney function, to enable…
- Trial name
- TriMaster (NCT02653209)
- Testing
- Sitagliptin - DPP4i, Canagliflozin - SGLT2i, Pioglitazone - TZD
- Where
- United Kingdom
- Volunteers
- 525 people
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Hypertension
Antihypertensive Response to Losartan and Genetic Polymorphisms
The purpose of this study is to evaluate the antihypertensive response of treatment with losartan with reference to genetic polymorphisms.
- Trial name
- NCT00617877
- Testing
- losartan potassium, Comparator: Hydrochlorothiazide
- Volunteers
- 800 people
- Sponsor
- Merck Sharp & Dohme LLC
Pharmacogenetic Testing
Pilot of Preemptive Pharmacogenetics in Medically Underserved Patients
This is a pragmatic clinical trial of 100 patients who self-identify as black or Latino. Patients with active prescriptions for at least 3 medications and a medication change within the past 6-months will be recruited from the…
- Trial name
- NCT04630093
- Testing
- Panel-based pharmacogenetic genotyping
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Florida
Venous Thromboembolism, Atrial Fibrillation
EUropean Pharmacogenetics of AntiCoagulant Therapy - Warfarin
Rationale: The narrow therapeutic range and wide inter-patient variability in dose requirement make anticoagulation response to coumarin derivatives unpredictable.
- Trial name
- EU-PACT (NCT01119300)
- Testing
- Genotype-guided dosing algorithm, Standard care
- Where
- 3 sites in Sweden, United Kingdom
- Volunteers
- 455 people
- Sponsor
- Utrecht Institute for Pharmaceutical Sciences