Clinical trials: Phantom Limb Pain After Amputation, open to volunteers
Phantom Limb Pain After Amputation
Preventing Chronification of Phantom Limb Pain Through Mirror Therapy in Conjunction With tDCS
Background: Most amputees experience phantom limb pain (PLP), for years after amputation. Virtually all PLP research to date has focused on the mechanisms of chronic PLP, ignoring the mechanisms of chronification.
- Trial name
- NCT07139483
- Testing
- Trans Direct-Cranial Stimulation (tDCS), Mirror therapy
- Where
- 3 sites in Israel
- Volunteers
- 108 people
- Sponsor
- University of Haifa
Phantom Limb Pain After Amputation
Prophylactic TBR on Phantom Limb Pain
This prospective study seeks to evaluate the effectiveness of prophylactic Targeted Brain Rehabilitation (TBR) in preventing or reducing Phantom Limb Pain (PLP).
- Trial name
- NCT06956508
- Testing
- Targeted Brain Rehabilitation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- OrthoCarolina Research Institute, Inc.
Limb Pain, Phantom, Residual Limbs Pain
Pain and Disability Outcomes in Post Amputation Patients
The objective of this study is to evaluate efficacy of varied medical and procedural therapies used to treat pain after surgical amputation of a limb.
- Conditions
- Limb Pain, Phantom, Residual Limbs Pain, Disability Physical
- Trial name
- NCT05716321
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Milton S. Hershey Medical Center
Phantom Pain Following Amputation of Lower Limb, Amputation
Efficacy and Mechanisms of Virtual Reality Treatment of Phantom Leg Pain.Home-Based Treatment
After amputation of an arm or leg, up to 90% of subjects experience a "phantom limb", a phenomenon characterized by persistent feelings of the missing limb.
- Trial name
- PLP Home-Based (NCT07044323)
- Testing
- Active Virtual Reality Treatment
- Where
- 3 sites in United States
- Volunteers
- 44 people
- Sponsor
- Albert Einstein Healthcare Network
Residual Limb Pain, Stump Pain
Post-Amputation Stump Infection as a Predictor of Persistent Residual Limb Pain: A Prospective Cohort Study
Persistent residual limb pain is common after traumatic amputation and significantly impairs rehabilitation and prosthetic use. Postoperative stump infection may contribute to peripheral nerve sensitization, scar fibrosis, and…
- Conditions
- Residual Limb Pain, Stump Pain, Post-Amputation Pain, Surgical Site Infection
- Trial name
- INF-STUMP-PAIN (NCT07438795)
- Volunteers
- 150 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Phantom Limb Pain After Amputation, Lower Limb Amputation Above Knee
Clinical Application Observation on the Evaluation of Phantom Limb Pain With the Suralis System
This study tests whether a vibration-based feedback device (Suralis) can reduce phantom limb pain in people with lower-leg amputations over 3 weeks.
- Conditions
- Phantom Limb Pain After Amputation, Lower Limb Amputation Above Knee, Lower Limb Amputation Below Knee, Lower Limb Amputation Knee
- Trial name
- NCT07324109
- Testing
- Vibrotactile sensory feedback
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Median
Pain Management, Pain
Silencing Neuroma Pain-Botulinum Toxin Versus Local Anesthetic Injection
Neuroma-related pain is a frequent and disabling condition after limb trauma and amputation. Available treatments often provide short-lasting or insufficient analgesia.
- Conditions
- Pain Management, Pain, Phantom Limb Pain, Phantom Limb Pain After Amputation
- Trial name
- SILENCE-NEUROM (NCT07431944)
- Testing
- Botulinium toxin type A injection, Local Anesthesia
- Where
- Ukraine
- Volunteers
- 100 people
- Sponsor
- Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)
Lower Limb Surgery, Pain
Role of Perineural Catheter in Pain Control and Opioid Consumption After Major Amputation of Lower Limb
The goal of this randomized controlled clinical trial is to evaluate the effectiveness of postoperative bupivacaine infusion through a perineural catheter in managing postoperative pain and to determine the opioid consumption…
- Conditions
- Lower Limb Surgery, Pain, Phantom Limb Pain After Amputation, Stump Pain
- Trial name
- NCT07896798
- Testing
- Bubpivacaine, Tramadol, Saline
- Volunteers
- 96 people
- Sponsor
- Aga Khan University
Amputation, Amputation of Lower Limb
Cryo NerVe Block Extremity AmputatioN RegIStry for Post Operative and pHantom Limb Pain
The goal of this Registry is to see how the device is used when freezing nerves during an amputation procedure.
- Conditions
- Amputation, Amputation of Lower Limb, Amputation of Upper Limb, Amputation, Limb Loss
- Trial name
- VANISH (NCT06908538)
- Testing
- cryoablation
- Where
- 9 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- AtriCure, Inc.
Symptomatic Neuroma, Phantom Limb Pain After Amputation
Evaluation of RPNI for Symptomatic Neuromas in Lower Limb Amputees
This prospective, observational cohort study evaluates the long-term outcomes of Regenerative Peripheral Nerve Interface (RPNI) surgery in patients with major lower extremity amputations suffering from symptomatic neuromas.
- Conditions
- Symptomatic Neuroma, Phantom Limb Pain After Amputation, Residual Limb Pain, Neuropathic Pain
- Trial name
- RPNI-AMPUTEE (NCT07420192)
- Testing
- Regenerative Peripheral Nerve Interface (RPNI) Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Saglik Bilimleri Universitesi
VTE (Venous Thromboembolism), Phantom Limb Pain After Amputation
Venous Thromboembolism and Chronic Pain After Major Limb Trauma
Major limb trauma is associated with a high risk of venous thromboembolism (VTE) due to systemic inflammation, endothelial injury, immobilization, and hypercoagulability.
- Conditions
- VTE (Venous Thromboembolism), Phantom Limb Pain After Amputation, Chronic Pain, Chronic Pain Due to Injury
- Trial name
- THROMBO-PAIN (NCT07475910)
- Where
- Ukraine
- Volunteers
- 150 people
- Sponsor
- Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)
Amputation, Surgical, Pain Management
Early Postoperative Pain Following a Limb Amputation
The primary aim of this study is to characterize the trajectory of pain and functional recovery in the first post-operative period following a limb amputation.
- Conditions
- Amputation, Surgical, Pain Management, Rehabilitation
- Trial name
- Pain-Amp (NCT07393139)
- Testing
- Pain assessment
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Istituto Ortopedico Rizzoli