Clinical trials: Personality
Borderline Personality Disorder
PET Imaging and Olanzapine Treatment in Borderline Personality Disorder
The overall design of the study is to perform both a PET and MRI scan on objectively identified borderline personality disorder patients, to treat them with olanzapine for 8 weeks, and to then re-scan the patients with PET.
- Trial name
- NCT00275301
- Testing
- olanzapine
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Borderline Personality Disorder
Study to Test the Efficacy and Safety of Vafidemstat in Adult Borderline Personality Disorder Population
PORTICO is a Phase IIb study to evaluate the efficacy and safety of vafidemstat in an adult borderline personality disorder (BPD) population.
- Trial name
- NCT04932291
- Testing
- vafidemstat
- Where
- 21 sites in United States, Bulgaria and 3 more
- Volunteers
- 211 people
- Sponsor
- Oryzon Genomics S.A.
Borderline Personality Disorder
Treating Suicidal Behavior and Self-Mutilation in People With Borderline Personality Disorder
This study will determine whether dialectical behavior therapy and fluoxetine are more effective combined or alone in treating people with borderline personality disorder.
- Trial name
- NCT00533117
- Testing
- Fluoxetine, Dialectical Behavior Therapy, Supportive psychotherapy
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- New York State Psychiatric Institute
Pulmonary Function; Newborn, Abnormal, Infant Wheeze
Vitamin C to Decrease Effects of Smoking in Pregnancy on Infant Lung Function
Vitamin C supplementation (500 mg per day) given to pregnant women who can not quit smoking will improve the pulmonary function tests in their offspring measured at 3 months of age.
- Conditions
- Pulmonary Function; Newborn, Abnormal, Infant Wheeze, In-utero Nicotine, Second Hand Smoke
- Trial name
- VCSIP (NCT01723696)
- Testing
- Vitamin C +prenatal vitamin
- Where
- 2 sites in United States
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Borderline Personality Disorder
A Study to Test Different Doses of BI 1358894 and Find Out Whether They Reduce Symptoms in People With Borderline Personality Disorder
This study is open to adults with borderline personality disorder. The purpose of this study is to find out whether a medicine called BI 1358894 helps to reduce symptoms in people with borderline personality disorder.
- Trial name
- NCT04566601
- Testing
- BI 1358894
- Where
- 67 sites in United States, Argentina and 13 more
- Volunteers
- 390 people
- Sponsor
- Boehringer Ingelheim
Borderline Personality Disorder
Ketamine in Borderline Personality Disorder
The purpose of this study is to test the potential of the rapid-acting anti-depressant ketamine to decrease suicidality in Borderline Personality Disorder (BPD).
- Trial name
- NCT03395314
- Testing
- Ketamine, Midazolam
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Yale University
Borderline Personality Disorder
A Trial of Brexpiprazole in the Treatment of Borderline Personality Disorder
There are currently no pharmacological treatments approved to treat borderline personality disorder (BPD). This trial will be conducted to evaluate the efficacy and safety of brexpiprazole for the treatment of participants…
- Trial name
- NCT04100096
- Testing
- Brexpiprazole
- Where
- 77 sites in United States, Spain and 1 more
- Volunteers
- 332 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Substance Use, Psychopathy
The Impact of Psychopathic Traits on the Efficacy of a Substance Use Intervention
Substance use among criminal offenders constitutes a major public health problem and is tied to negative consequences for offenders, their families, and their communities.
- Trial name
- NCT01532934
- Testing
- motivational enhancement therapy, standard care
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- University of Rochester
Borderline Personality Disorder
Caplyta in Borderline Personality Disorder
The primary objective of the proposed study is to evaluate the safety and efficacy of Caplyta (lumateperone) in adults with borderline personality disorder (BPD).
- Trial name
- NCT05356013
- Testing
- Caplyta
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Chicago
Antisocial Behavior, Aggression
The Effect of Prefrontal Cortex Stimulation on Antisocial and Aggressive Behavior
This study investigates the effect of upregulating prefrontal cortex activity on antisocial and aggressive behavior and risk factors for such behavior.
- Trial name
- NCT02427672
- Testing
- Transcranial direct current stimulation
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Healthy
Individual Differences in the Response to Drugs
The purpose of this study is to examine whether individual differences in acute responses to drugs co-vary across three drugs from different drug classes: alcohol, amphetamine and delta-9-tetrahydrocannabinol (THC).
- Trial name
- TDS (NCT02485158)
- Testing
- THC, AMP, ALC
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Self-Injurious Behavior, Self Harm
Treating Self Injurious Behavior: A Novel Brain Stimulation Approach
The purpose of this study is to explore the tolerability and effectiveness of transcranial direct current stimulation (tDCS) as a potential treatment for non-suicidal self-injury (NSSI).
- Conditions
- Self-Injurious Behavior, Self Harm, Self-injury, Self-inflicted Injury
- Trial name
- NCT04244786
- Testing
- Transcranial direct current stimulation, No intervention
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- New York State Psychiatric Institute
Borderline Personality Disorder (BPD)
Researching the Effectiveness of a Alivis, a Digital Health Application for Borderline Personality Disorder
This randomized controlled trial (RCT) with 470 patients diagnosed with Borderline Personality Disorder (BPD) aims to investigate the effectiveness of the unguided digital therapeutic alivis for patients with BPD as defined in…
- Trial name
- REVALDI-BPD (NCT06601907)
- Testing
- alivis
- Where
- Germany
- Volunteers
- 286 people
- Sponsor
- Gaia AG
Borderline Personality Disorder
Brexpiprazole in Borderline Personality Disorder
The primary objective of the proposed study is to evaluate the safety and efficacy of Brexpiprazole in adults with borderline personality disorder (BPD).
- Trial name
- NCT03418675
- Testing
- Rexulti
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Chicago
Borderline Personality Disorder
Seroquel Extended Release (XR) for the Management of Borderline Personality Disorder (BPD)
The Primary objective of this study is to evaluate Seroquel XR in the treatment of borderline personality disorder (BPD). As in many initial randomized control trials, the study will be of relatively short duration - 8 weeks - to…
- Trial name
- NCT00880919
- Testing
- quetiapine extended-release
- Where
- 3 sites in United States
- Volunteers
- 95 people
- Sponsor
- University of Minnesota
Anxiety, Depression
Neuromodulation Enhanced Cognitive Restructuring: A Proof of Concept Study
Psychological treatments are effective, but take a long time and can be burdensome. Therefore, avenues to optimize behavioral treatments are needed.
- Conditions
- Anxiety, Depression, Personality Disorders, Trauma and Stress-related Disorders
- Trial name
- NCT02573246
- Testing
- Cognitive Restructuring, rTMS
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- Duke University
Borderline Personality Disorder
Efficacy of Transference-Focused Psychotherapy for Borderline Personality Disorder
The purpose of this study is to find out whether Transference-Focused Psychotherapy (TFP) is effective in the treatment of Borderline Personality Disorder.
- Trial name
- NCT00714311
- Testing
- Transference-Focused Psychotherapy, treatment by experienced community psychotherapists
- Where
- 2 sites in Austria, Germany
- Volunteers
- 104 people
- Sponsor
- University Hospital Muenster
Borderline Personality Disorder, Emotional Problem
Preschooler Emotion Regulation in the Context of Maternal Borderline Personality Disorder
Offspring of mothers with Borderline Personality Disorder (BPD) are at serious risk for developing mental illness at every stage of their life, and yet little is known about how this risk is transmitted.
- Trial name
- NCT03060902
- Testing
- Dialectical Behavior Therapy Skills
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- University of Oregon
Obsessive-compulsive Disorder, Ocd
Riluzole Augmentation in Treatment-refractory Obsessive-compulsive Disorder
Obsessive-compulsive disorder (OCD) affects 2-3% of the population and leads to a great deal of suffering. Many patients benefit from established treatments, the mainstay of which are cognitive behavioral therapy and a group of…
- Trial name
- NCT00523718
- Testing
- riluzole
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Yale University
Borderline Personality Disorder
Mapping Aspects of Psychotherapy in Dialectical Behavior Therapy
Although dialectical behavior therapy (DBT) skills training is effective in the treatment of borderline personality disorder, it contains four skills modules and there is little research to guide their modular application.
- Trial name
- MAP-DBT (NCT04626310)
- Testing
- Dialectical behavior therapy - emotion regulation skills training, Dialectical behavior therapy - interpersonal effectiveness skills training, Interpersonal psychotherapy
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- University of Massachusetts, Amherst