Clinical trials: Persistent Postoperative Pain
Persistent Spinal Pain Syndrome Type II, Failed Back Surgery Syndrome
Persistent Post-Lumbar Surgery Pain Syndrome (PSPS) Type II is a Common Condition Encountered in Pain Units, With Limited Available Therapeutic Options. Epidural Pulsed Radiofrequency (PRF) Administered Via Catheter Has Demonstrated Greater Efficacy Compared to the Transforaminal Approach. This Rand
This study is for people who continue to have low back pain after spinal surgery, a condition called persistent spinal pain syndrome type II. Current treatments, such as epidural injections, often provide only limited relief.
- Conditions
- Persistent Spinal Pain Syndrome Type II, Failed Back Surgery Syndrome, Chronic Low Back Pain, Post-Laminectomy Syndrome
- Trial name
- EPIPUL (NCT07156513)
- Testing
- Epidural Pulsed Radiofrequency, Betamethasone (Epidural Corticosteroid Injection)
- Where
- 4 sites in Spain
- Volunteers
- 131 people
- Sponsor
- Puerta de Hierro University Hospital
Persistent Pain, Postoperative Hyperalgesia
Prevention of Persistent Postsurgical Pain After Thoracotomy
Postthoracotomy acute pain is followed by persistent postsurgical pain in 20-30% of the patients, defined as pain that lasts more than 3-6 months after surgery.
- Trial name
- NCT01243801
- Testing
- Ketamine
- Where
- 2 sites in Spain
- Volunteers
- 104 people
- Sponsor
- Hospital Clinic of Barcelona
Post-operative Tooth Pain, Root Canal Therapy
DPBRN Peri-operative Pain and Root Canal Therapy
The purpose of this study is to identify pre-operative factors that put patients at greater risk of developing severe tooth pain following root canal therapy, thereby providing evidence that will allow dentists to act…
- Trial name
- NCT01201681
- Where
- 8 sites in United States, Denmark
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Dental Practice-Based Research Network
Persistent Post Operative Opioid Use, Post-surgical Pain
Personalized Post-Operative Pain Management
The main questions this study aims to answer are: Does perioperative PGx personalized opiate therapy reduce persistent post-operative opioid use dependency, improve pain management and reduce opiate related adverse events in…
- Trial name
- NCT06669650
- Testing
- PGx guided personalized post-operative pain management, Oxycodone, Hydromorphone
- Where
- United States
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- University of Tennessee Graduate School of Medicine
Pain, Postoperative, Neuropathic Pain
Persistent Pain After Laparoscopic Inguinal Hernia Repair
Describe and characterizes laparoscopic postherniotomy patients with persistent moderate/severe pain affecting every day activities - including detailed quantitative sensory assessment
- Conditions
- Pain, Postoperative, Neuropathic Pain, Postherniotomy Pain
- Trial name
- NCT01085110
- Where
- Denmark
- Volunteers
- 11 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Postoperative Pain
4P: Persistent Postoperative Pediatric Pain
For children, adequate perioperative pain management is a right according to the UN convention on the rights of the child, a law in Sweden since 2020. Despite this, children are still under-treated in many cases.
- Trial name
- 4P (NCT06035042)
- Testing
- Scheduled surgery
- Where
- 4 sites in Sweden
- Volunteers
- 1,000 people
- Sponsor
- Region Halland
Thoracotomy, Hyperalgesia
Central Sensitisation and Postoperative Pain
One out of 10 patients undergoing surgery develops persistent post-surgical pain (PPSP). Unfortunately, available therapies for treating this pain have limited success.
- Conditions
- Thoracotomy, Hyperalgesia, Hyperalgesia, Secondary, Central Sensitisation
- Trial name
- NCT04220697
- Testing
- electroencephalography (EEG), questionnaires, high frequency electrical stimulation of the forearm skin (HFS)
- Where
- 2 sites in Belgium
- Volunteers
- 70 people
- Sponsor
- Université Catholique de Louvain
Post-operative Pain
QSPainRelief-patientCNS : Clinical Biomarkers of Nociception, Sedation and Cognition
QSPainRelief-patientCNS is a monocentric prospective longitudinal study conducted in patients suffering from disabling post-surgical pain for which the treating physician is about to prescribe a given drug combination for the…
- Trial name
- NCT04742790
- Testing
- Scalp electroencephalography (EEG), Laser-evoked potentials (LEPs), Cognitive auditory-evoked potentials (P300)
- Where
- Belgium
- Volunteers
- 180 people
- Sponsor
- Université Catholique de Louvain
Knee Osteoarthritis, Persistent Postsurgical Pain
Comparison of Conventional and Cooled Radiofrequency of the Genicular Nerves in Patients With Chronic Knee Pain
Chronic knee pain remains a disabling disease despite current treatment strategies. There is an increase in the prevalence of osteoarthritis (OA) of the knee in the general population, presently affecting approximately 450,000…
- Conditions
- Knee Osteoarthritis, Persistent Postsurgical Pain, Chronic Knee Pain
- Trial name
- COGENIUS (NCT05407610)
- Testing
- Conventional Radiofrequency ablation of the genicular nerves, Cooled Radiofrequency ablation of the genicular nerves
- Where
- 15 sites in Belgium, Netherlands
- Volunteers
- 400 people
- Sponsor
- Ziekenhuis Oost-Limburg
Failed Back Surgery Syndrome
Spinal Cord Stimulation Combined With Exercise in Persistent Spinal Pain Syndrome
Introduction. At the neurophysiological level, it is possible to observe an increase in the central processing of pain in patients diagnosed with persistent Spinal Pain Syndrome (PSPS-T1/2), potentially stemming from dysfunctions…
- Trial name
- NCT06272539
- Testing
- Exercise, Spinal Cord Stimulation
- Where
- Spain
- Volunteers
- 36 people
- Sponsor
- Fundación Universidad Católica de Valencia San Vicente Mártir
Post-Operative Pain Following Total Knee Arthroplasty
Pilot Study of PEMF Therapy in Treatment of Post-operative Pain Following Total Knee Arthroplasty
The purpose of this study is to investigate whether pulsed electromagnetic energy field (PEMF) therapy is effective in the treatment of persistent pain following total knee arthroplasty (TKA)
- Trial name
- NCT02211534
- Testing
- Pulsed Electromagnetic Field Device (Provant)
- Where
- 14 sites in United States
- Volunteers
- 35 people
- Sponsor
- Regenesis Biomedical, Inc.
Chronic Pain
Incidence and Associated Factors of Persistent Postoperative Incision Scar Pain Following C/s in Mulago Hospital
prospective cohort study of women who underwent caesarean section in mulago hospital. followed up for 2 months and assessed for development of persistent post operative pain at the incision site and its effect on quality of life.
- Trial name
- PPOPinC/S (NCT03269188)
- Volunteers
- 277 people
- Sponsor
- Makerere University
Postoperative Pain
Comparison of the Effects of Erector Spinae Area (ESP) Block and Thoracic Paravertebral Block (TPVB) on Acute Pain, Postoperative Persistent Pain and Neuropathic Pain in Video-Assisted Thoracoscopic Surgery
VATS is a minimally invasive approach that allows the introduction of a video camera and surgical instruments into the thoracic cavity through small incisions made in the chest wall.
- Trial name
- NCT06672848
- Testing
- Numeretic rating scale (NRS), Brief Pain Inventory (BPI), The S-LANSS Pain Score
- Volunteers
- 118 people
- Sponsor
- Aydin Adnan Menderes University
Pain, Surgery
Persistent Pain After Cystectomy for Bladder Cancer
This single-center, cross-sectional survey and sensory examination is conducted to determine the prevalence, sensory characteristics and risk factors of PPSP in patients who underwent cystectomy at Washington…
- Conditions
- Pain, Surgery, Post Operative Pain
- Trial name
- NCT02751346
- Where
- United States
- Volunteers
- 383 people
- Sponsor
- Washington University School of Medicine