Clinical trials: Persistent Postoperative Pain
Lung Cancer
Predictors of Acute and Persistent Postoperative Pain in Lung Cancer Surgery
The aim of this observational study is to investigate if preoperative quantitative sensory testing, anxiety and depression symptoms, and biological markers are associated with the risk of developing acute and chronic…
- Trial name
- NCT05599386
- Testing
- Preoperative test
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Jannie Bisgaard Stæhr
Chronic Post Operative Pain
Prevalence and Risk Factors for Postsurgical Pain After the Open Reduction and Internal Fixation of Lower Limbs.
The objective of this study is to specify the demographic and medical factors that most likely constitute a risk of developing CPSP in the patients with lower limb.
- Trial name
- NCT06136663
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Xuzhou Central Hospital
Chronic Pain
Pain Trajectories in Severe Persistent Inguinal Post-herniorrhaphy Pain
Severe persistent postsurgical pain (PPP) remains a major healthcare challenge. In the third most common surgical procedure in the UK, inguinal herniorrhaphy, including 85,000 surgeries in 2015, an estimated 1,500 to 3,000…
- Trial name
- NCT03881124
- Volunteers
- 95 people
- Sponsor
- University of Copenhagen
Pain, Postoperative, Cognitive Function Abnormal
Perioperative Cognitive Training in Thoracic Surgery
More than 30% of patients undergoing thoracic surgical procedures develop persistent post-surgical pain (PPSP), which results in impaired functioning, diminished quality of life, and increased risk of chronic opioid use.
- Conditions
- Pain, Postoperative, Cognitive Function Abnormal, Lung Cancer
- Trial name
- COFLEX-T (NCT04563234)
- Testing
- COFLEX neurocognitive training, Crossword puzzles
- Sponsor
- Washington University School of Medicine
Persistent Spinal Pain Syndrome Type 2, Failed Back Surgery Syndrome
Open and Closed Loop DTM SCS in Patients With PSPS Type 2: ENDLESS Study
Evaluation of the effectiveness of differential target multiplexed spinal cord stimulation for treatment of Persistent Spinal Pain Syndrome Type II (PSPS-T2).
- Conditions
- Persistent Spinal Pain Syndrome Type 2, Failed Back Surgery Syndrome, Failed Neck Surgery Syndrome
- Trial name
- ENDLESS (NCT07211308)
- Testing
- Spinal Cord Stimulation
- Where
- 5 sites in Belgium, Netherlands
- Volunteers
- 200 people
- Sponsor
- Universitair Ziekenhuis Brussel
Persistent Postsurgical Pain, Arthritis Knee
Weight Change and the Risk of Chronic Pain Following Hip and Knee Arthroplasties
The study is a nationwide, register-based cohort survey study. The objective of this study is to investigate whether weight change is associated with the incidence of persistent postoperative pain following total hip arthroplasty…
- Conditions
- Persistent Postsurgical Pain, Arthritis Knee, Arthropathy of Knee, Arthropathy of Hip
- Trial name
- NCT06024161
- Testing
- Weight gain, Weight loss, Weight unchanged
- Volunteers
- 6,400 people
- Sponsor
- Bispebjerg Hospital
Opioid Use, Post Operative Pain
Assessment of the Development of Postoperative Persistent Postoperative Pain
During the postoperative period, it is possible to observe the development of acute pain, which lasts no longer than a week after surgery.
- Conditions
- Opioid Use, Post Operative Pain, Chronic Pain
- Trial name
- NCT05370924
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Chronic Postsurgical Pain
Vaginal or Laparoscopic Hysterectomy, Persistent Postsurgical Pain
Previous studies have shown that chronic pain after hysterectomy is common. The aim of this study is to investigate the incidence of chronic pain after vaginal or laparoscopic hysterectomy for benign reasons.
- Trial name
- NCT01537731
- Testing
- vaginal or laparoscopic hysterectomy
- Where
- Finland
- Volunteers
- 225 people
- Sponsor
- Tampere University Hospital
Postoperative Pain
4P: Persistent Postoperative Pediatric Pain
For children, adequate perioperative pain management is a right according to the UN convention on the rights of the child, a law in Sweden since 2020. Despite this, children are still under-treated in many cases.
- Trial name
- 4P (NCT06035042)
- Testing
- Scheduled surgery
- Where
- 4 sites in Sweden
- Volunteers
- 1,000 people
- Sponsor
- Region Halland
Chronic Postsurgical Pain, Acute Postoperative Pain
Persistent Pain and Its Impact on Daily Life After Lung Surgery
This study will examine how pain changes over the first six months after lung surgery and how it affects daily life. It will include adults scheduled for surgery to remove part or all of a lung.
- Conditions
- Chronic Postsurgical Pain, Acute Postoperative Pain, Pain-Related Functional Interference
- Trial name
- NCT07853456
- Testing
- Longitudinal Assessment of Pain and Pain-Related Functional Interference
- Volunteers
- 350 people
- Sponsor
- Aerospace Center Hospital
Postoperative Pain
Comparison of the Effects of Erector Spinae Area (ESP) Block and Thoracic Paravertebral Block (TPVB) on Acute Pain, Postoperative Persistent Pain and Neuropathic Pain in Video-Assisted Thoracoscopic Surgery
VATS is a minimally invasive approach that allows the introduction of a video camera and surgical instruments into the thoracic cavity through small incisions made in the chest wall.
- Trial name
- NCT06672848
- Testing
- Numeretic rating scale (NRS), Brief Pain Inventory (BPI), The S-LANSS Pain Score
- Volunteers
- 118 people
- Sponsor
- Aydin Adnan Menderes University
Breast Cancer, Pain
Long Term Follow-up of Persistent Pain, Sensory Disturbances and Lymphedema After Breast Cancer Treatment
Persistent pain, sensory disturbances, lymphedema and functional impairment are frequently occurring late effects of breast cancer treatment.
- Conditions
- Breast Cancer, Pain, Post Operative Pain, Lymphedema
- Trial name
- NCT01543711
- Where
- Denmark
- Volunteers
- 2,411 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Pain, Postoperative, Root Resorption
Evaluation of Different Medicaments in the Management of Necrotic Primary Molars by Lesion Sterilization and Tissue Repair
Management of non-vital primary molars is challenging due to the natural anatomy of primary teeth, patients' young age, and their behavior toward dental treatment.
- Conditions
- Pain, Postoperative, Root Resorption, Persistent Infection, Necrotic Pulp
- Trial name
- NCT06926322
- Testing
- Conventional double antibiotic paste of Metronidazole 500 mg plus Ciprofloxacin 500 mg mixed with propylene glycol, Double antibiotic paste of Metronidazole and Ciprofloxacin loaded chitosan-coated silver nanoparticles, chitosan-coated silver nanoparticles
- Where
- Egypt
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Breast Cancer
Regional Anesthesia for Breast Surgery
Patients scheduled for mastecotmy will be randomized to receive either an ultrasound-guided double space paravertebral block or a PECSII + parasternal block.
- Trial name
- NCT03941223
- Testing
- PECSII and paravertebral blocks
- Where
- Italy
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Failed Back Surgery Syndrome, Persistent Spinal Pain Syndrome Type 2
Differential Target Multiplexed Spinal Cord Stimulation
Evaluation of the effectiveness of differential target multiplexed spinal cord stimulation for treatment of chronic back and leg pain.
- Trial name
- DETECT (NCT05068011)
- Testing
- Spinal Cord Stimulation
- Where
- 14 sites in Belgium
- Volunteers
- 250 people
- Sponsor
- Moens Maarten
Amputation; Lower Extremity, Pain, Persistent Postsurgical
Altius Peripheral Nerve Stimulation in Amputees After TMR/RPNI
This is a single-center, prospective, within-subject study. This study seeks to enroll a total of 32 prospective subjects who will undergo surgical implantation of the FDA-approved Altius® system.
- Trial name
- NCT07571239
- Testing
- Surgical Implantation
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- NYU Langone Health
Persistent Apical Periodontitis
Effect Of Different Sodium Hypochlorite Concentrations On Intracanal Substance P, CGRP And Opiorphin Levels And Postoperative Pain During Root Canal Retreatment
This randomized clinical study aims to evaluate the effect of different sodium hypochlorite concentrations (1%, 2.5%, and 5.25%) used during root canal retreatment on intracanal levels of Substance P, CGRP, and Opiorphin, as well…
- Trial name
- NaOCl-NPP (NCT07453576)
- Testing
- Sodium Hypochlorite 1% Irrigation, Sodium Hypochlorite 2.5% Irrigation, Sodium Hypochlorite 5% Irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- KEZBAN MELTEM ÇOLAK
Persistent Post Operative Opioid Use, Post-surgical Pain
Personalized Post-Operative Pain Management
The main questions this study aims to answer are: Does perioperative PGx personalized opiate therapy reduce persistent post-operative opioid use dependency, improve pain management and reduce opiate related adverse events in…
- Trial name
- NCT06669650
- Testing
- PGx guided personalized post-operative pain management, Oxycodone, Hydromorphone
- Where
- United States
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- University of Tennessee Graduate School of Medicine
Thoracotomy, Chronic Pain
Sensory Changes From Chest Drains
Does chest drains contribute to the post thoracotomy pain syndrome
- Trial name
- NCT01274871
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Pain, Nociceptive Pain
FDG PET/MR Imaging of Peripheral Pain Generators
The purpose of this research is to determine if a PET/MRI scan using FDG can accurately identify the source of chronic pain. Identifying the source of pain may help doctors treat chronic pain more effectively.
- Trial name
- NCT06171659
- Testing
- FDG radiotracer, PET/MRI, PET/CT imaging
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison