Clinical trials: Persistent Post-surgical Pain
Opioid Consumption, Postoperative
Precision Pain Management - A Randomized Clinical Trial Assessing the Efficacy of Suzetrigine on Postoperative Analgesia Among Surgical Patients at Higher Risk for Persistent Postoperative Opioid Use (POU)
The purpose of the study is to investigate the efficacy of suzetrigine for treatment of acute postoperative pain among surgical patients identified as high risk for persistent postoperative opioid use (POU).
- Trial name
- NCT07672015
- Testing
- Suzetrigine, Standard Care (in control arm)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, San Diego
Breast Cancer, Chronic Pain
Evaluation And Risk Assessment For Persistent Postsurgical Pain After Breast Surgery
Pre-existing pain and severe postoperative pain are predictors of persistent pain after surgery, but a complete understanding on the development of persistent pain is still lacking.
- Conditions
- Breast Cancer, Chronic Pain, Acute Pain, Depression, Anxiety
- Trial name
- B-CAPP (NCT03408717)
- Testing
- Questionnaires, Mechanical Temporal Summation assessment, Pain threshold assessment
- Where
- 2 sites in United States, Singapore
- Volunteers
- 220 people
- Sponsor
- KK Women's and Children's Hospital
Persistent Spinal Pain Syndrome Type 2 (PSPS-T) Lower Spine, Chronic Low Back Pain
SPINE-RISK VE: Multimodal Predictive Model for Failed Back Surgery Syndrome in Venezuelan Surgical Patients
SPINE-RISK VE is a prospective multicenter cohort study designed to develop and internally validate a multimodal preoperative predictive model for Failed Back Surgery Syndrome (FBSS), now classified as Persistent Spinal Pain…
- Conditions
- Persistent Spinal Pain Syndrome Type 2 (PSPS-T) Lower Spine, Chronic Low Back Pain, Postoperative Pain, Lumbar Spine Surgery
- Trial name
- SPINE-RISK VE (NCT07693517)
- Testing
- SPINE-RISK VE multimodal preoperative assessment
- Where
- Venezuela
- Volunteers
- 150 people
- Sponsor
- juan jose valero quintero,MD
Neuropathic Pain, Thoracic Surgery, Video Assisted
Chronic Pain After Thoracotomy (Video Assisted Thoracic Surgery - VATS)
This is an explorative study investigating potential nerve injury after VATS.
- Conditions
- Neuropathic Pain, Thoracic Surgery, Video Assisted, Chronic Pain
- Trial name
- NCT01068457
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Hydromorphone Use, Acute Postoperative Pain
Methadone and Hydromorphone For Spinal Surgery
Patients undergoing major spinal surgery continue to experience moderate-to-severe pain during the first 2-3 days following the operative procedure.
- Conditions
- Hydromorphone Use, Acute Postoperative Pain, Patient Satisfaction, Chronic Persistent Surgical Pain
- Trial name
- NCT02107339
- Testing
- Methadone, Hydromorphone
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Persistent Post-surgical Pain, Veterans
Telephone Cognitive Behavioral Therapy for Veterans Undergoing Surgery
The study team propose to investigate the feasibility and pilot a Telephone Cognitive Behavioral Therapy intervention for those identified to be at risk for chronic pain following surgery.
- Trial name
- NCT03351309
- Testing
- Telephone-based Cognitive Behavioral Therapy (CBT)
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Iowa City Veterans Affairs Medical Center
Obesity, Chronic Pain
Chronic Abdominal Pain After Laparoscopic Sleeve Gastrectomy
The study aims to evaluate the prevalence of postoperative chronic pain, defined as the persistence of abdominal pain for more than 3 months after laparoscopic sleeve gastrectomy.
- Conditions
- Obesity, Chronic Pain, Abdominal Pain
- Trial name
- Chron Pain LSG (NCT06686875)
- Testing
- Questionnaire
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Medical University of Warsaw
Inguinal Hernia, Chronic Pain
A National Center for Persistent Severe Pain After Groin Hernia Repair
This prospective, consecutive cohort study presents nationwide 5-year outcome data on patients with severe persistent pain after groin hernia repair (SPG).
- Trial name
- Q5Y (NCT03713047)
- Volunteers
- 222 people
- Sponsor
- University of Copenhagen
Pain, Chronic Postsurgical, Knee Osteoarthritis
Central Sensitization in Total Knee Arthroplasty Patients with Persistent Pain
Persistent post-surgical pain is a significant adverse effect after total knee arthroplasty, present in around 20% of the patients. Central sensitization may contribute to developing and maintaining pain.
- Conditions
- Pain, Chronic Postsurgical, Knee Osteoarthritis, Sensitization, Central
- Trial name
- NCT05575310
- Testing
- Total Knee Arthroplasty
- Where
- Spain
- Volunteers
- 117 people
- Sponsor
- University of Barcelona
Coping Skills Training for Persistent Post-Surgical Pain, General Health Education
Well-Being After Breast Cancer Surgery
The purpose of this study is to compare the benefits of skills training and health education interventions designed specifically to increase the well-being of people with persistent pain after breast surgery for lobular carcinoma…
- Trial name
- WB ABCs (NCT04225585)
- Testing
- CST-PSP, General health education
- Where
- 2 sites in United States
- Volunteers
- 316 people
- Sponsor
- Duke University
Postsurgical Pain, Abdominal Pain
The Analgesic Efficacy of Δ9-THC (Namisol®) in Patients With Persistent Postsurgical Abdominal Pain
Persistent postsurgical abdominal pain (PPAP) is a very difficult to treat pain. This pain can persist for months or even years and significantly diminishes quality of life.
- Conditions
- Postsurgical Pain, Abdominal Pain, Chronic Pain
- Trial name
- NCT01562483
- Testing
- Tetrahydrocannabinol
- Where
- Netherlands
- Volunteers
- 36 people
- Sponsor
- Radboud University Medical Center
Persistent Postsurgical Pain
Investigate and Predict Aortic & Thoracic Surgery Persistenet Postsurgical Pain
This is an observational clinical study aiming to further the wider understanding of patients who develop persistent pain after Thoracoabdominal Aorta surgery, a surgical cohort who are disproportionately affected.
- Trial name
- ImPARTonPPP (NCT05369130)
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Queen Mary University of London
Pain, Neuropathic Pain
Nerveblocks for Persistent Pain After Breast Cancer Surgery
Persistent pain after breast cancer surgery (PPBCS) affects 25-60% of breast cancer survivors and nerve damage has been implicated as the cause of this neuropathic pain condition.
- Conditions
- Pain, Neuropathic Pain, Breast Cancer
- Trial name
- NCT02336529
- Testing
- Bupivacaine, NaCl
- Volunteers
- 48 people
- Sponsor
- Kenneth Geving Andersen
Pain, Postoperative
Prediction of Persistent Postsurgical Pain After Video-assisted Thoracic Surgery (VATS)
Prospective cohort study of factors predisposing to persistent post surgical pain after video-assisted thoracic surgery
- Trial name
- NCT01300195
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Chronic Pain, Knee Pain Chronic
Perioperative Vitamin C to Reduce Persistent Pain After Total Knee Arthroplasty
Phase II Multicentre, pilot, parallel-group, blinded, 1:1 randomized controlled trial to determine the feasibility of conducting a larger definitive trail of using vitamin C to reduce persistent pain in patients undergoing total…
- Conditions
- Chronic Pain, Knee Pain Chronic, Post Operative Pain
- Trial name
- PROVISION (NCT06123715)
- Testing
- Vitamin C
- Where
- 3 sites in Canada
- Volunteers
- 400 people
- Sponsor
- University Health Network, Toronto
Persistent Postsurgical Pain, Breast Cancer Female
Preventing Persistent Pain and Reducing Depressive and Anxious Symptoms Following Mastectomy and Lumpectomy
The proposed study will be a pilot randomized controlled trial comparing treatment as usual (TAU) to treatment as usual plus a brief Acceptance and Commitment Therapy (ACT) intervention (TAU + ACT) with mastectomy and lumpectomy…
- Conditions
- Persistent Postsurgical Pain, Breast Cancer Female, Ductal Carcinoma in Situ
- Trial name
- NCT03430765
- Testing
- Acceptance and Commitment Therapy
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Katherine Hadlandsmyth
Neuropathic Pain
Cryoneurolysis for Cutaneous Neuropathic Pain
Feasibility study with 25 patients investigating the effect of cryoneurolysis on persistent cutaneous neuropathic pain after surgery and trauma. All patients receive active treatment (cryoneurolysis).
- Trial name
- NCT04911569
- Testing
- Cryoneurolysis
- Where
- Denmark
- Volunteers
- 25 people
- Sponsor
- Aarhus University Hospital
Knee Arthropathy
Persistent Post Surgical Pain After Total Knee Arthroplasty
Patients undergone total knee replacement are randomized to receive a "fast track" regional anesthesia protocol or a "traditional" regional anesthesia continuous infusion by both a femoral and sciatic catheter to assess if this…
- Trial name
- NCT06182059
- Testing
- continuous peripheral nerve block
- Where
- Italy
- Volunteers
- 436 people
- Sponsor
- Policlinico di Monza SpA
Persistent Postsurgical Pain
Risk Factors and Mechanisms for Persistent Postsurgical Pain After Total Knee Replacement
Osteoarthritis (OA) is the single most common cause of disability in mid and late life. About 27 million people in the United States suffer from this incurable process and 10 million have OA of the knee.
- Trial name
- PPP-TKA (NCT01320150)
- Where
- United States
- Volunteers
- 311 people
- Sponsor
- Rush University Medical Center
Pain, Postoperative
Persistent Postoperative Pain Incidence With Gabapentin Used
The study's objective will be to evaluate the gabapentine efficiency in orally and long term used after painfully surgeries.
- Trial name
- PPP (NCT02693821)
- Testing
- Gabapentin
- Where
- Argentina
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Hospital Italiano de Buenos Aires