Clinical trials: Persistent Pain
Pain, Advanced Cancer
Sativex® for Relieving Persistent Pain in Participants With Advanced Cancer
This 9-week study aimed to determine the efficacy, safety and tolerability of nabiximols (Sativex®) as an adjunctive treatment, compared with placebo in relieving uncontrolled persistent chronic pain in participants with advanced…
- Trial name
- NCT01262651
- Testing
- Nabiximols
- Where
- 72 sites in United States, Belgium and 10 more
- Volunteers
- 397 people
- Sponsor
- GW Pharmaceuticals Ltd
Spine Fusion
The Role of Bone SPECT/CT in Evaluation of Persistent or Recurrent Back Pain Following Spine Surgery
To evaluate the role of SPECT/CT in assessment of the osteoblastic activity in patients with persistent or recurrent back pain after spine surgery with inconclusive CT/MRI findings.
- Trial name
- NCT04803136
- Testing
- spine surgeries
- Volunteers
- 4 people
- Sponsor
- Assiut University
Type 2 Diabetes, Persistent Pain
Cognitive Bias Modification for Interpretation (CBM-I) in People With Type 2 Diabetes and Persistent Pain
The goal of this clinical trial is to examine the efficacy of cognitive bias modification for interpretation (CBM-I) in people with Type 2 Diabetes and persistent pain.
- Trial name
- NCT06908486
- Testing
- Cognitive Bias Modification for Interpretation
- Where
- Australia
- Volunteers
- 319 people
- Sponsor
- University of Sydney
Breakthrough Pain
An Observational, Non-Interventional Trial to Assess Patient Satisfaction and Safety of Subsys™ Spray.
Chronic pain patients who experience breakthrough pain in the background of controlled persistent pain with opioids will be followed for 3 months in order to assess the safety and titration trends in the clinical practice setting…
- Trial name
- NCT01901718
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- International Clinical Research Institute
Persistent Post Operative Opioid Use, Post-surgical Pain
Personalized Post-Operative Pain Management
The main questions this study aims to answer are: Does perioperative PGx personalized opiate therapy reduce persistent post-operative opioid use dependency, improve pain management and reduce opiate related adverse events in…
- Trial name
- NCT06669650
- Testing
- PGx guided personalized post-operative pain management, Oxycodone, Hydromorphone
- Where
- United States
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- University of Tennessee Graduate School of Medicine
Opioid Use, Post Operative Pain
Assessment of the Development of Postoperative Persistent Postoperative Pain
During the postoperative period, it is possible to observe the development of acute pain, which lasts no longer than a week after surgery.
- Conditions
- Opioid Use, Post Operative Pain, Chronic Pain
- Trial name
- NCT05370924
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Chronic Pain, Acute Pain
Pilot Study on the Effects of Low-Level Laser Therapy Treatment for Acute and Persistent Discomfort
This study will examine the effectiveness of Low-Level Laser Therapy (LLLT) for the management of pain in various locations of the body.
- Trial name
- NCT04774783
- Testing
- Low-Level Laser Therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Arkansas Colleges of Health Education
Pain, Neuropathic Pain
Nerveblocks for Persistent Pain After Breast Cancer Surgery
Persistent pain after breast cancer surgery (PPBCS) affects 25-60% of breast cancer survivors and nerve damage has been implicated as the cause of this neuropathic pain condition.
- Conditions
- Pain, Neuropathic Pain, Breast Cancer
- Trial name
- NCT02336529
- Testing
- Bupivacaine, NaCl
- Volunteers
- 48 people
- Sponsor
- Kenneth Geving Andersen
Spinal Cord Stimulation, Chronic Pain
Epigenetic Mechanisms and Symptom Clusters Associated with Resolution of Pain Following Spinal Cord Stimulation
Spinal cord stimulation (SCS) is indicated for selected patients with chronic pain who have not responded to conventional medical management.
- Trial name
- NCT04960592
- Testing
- Spinal Cord Stimulation
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- University of Arkansas
Pain, Postoperative
Personalized Prediction of Persistent Postsurgical Pain
P5 is planned as a prospective observational study, collecting evidence-based perioperative data on patient history and demographics, physical function, cognitive measures, psychological, and biological markers associated with…
- Trial name
- P5 (NCT04864275)
- Where
- United States
- Volunteers
- 2,500 people
- Sponsor
- Washington University School of Medicine
Breast Cancer
Regional Anesthesia for Breast Surgery
Patients scheduled for mastecotmy will be randomized to receive either an ultrasound-guided double space paravertebral block or a PECSII + parasternal block.
- Trial name
- NCT03941223
- Testing
- PECSII and paravertebral blocks
- Where
- Italy
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Persistent Idiopathic Facial Pain (PIFP)
Deciphering Persistent Orofacial Pain - PIFP
Persistent non-dental orofacial pain is common yet poorly characterised, and its pathophysiology remains largely unknown. Two clinically similar entities are distinguished: post-traumatic trigeminal neuropathic pain (PTNP), in…
- Trial name
- NCT07791004
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Chronic Non-Malignant Pain
Efficacy and Safety of Hydromorphone Hydrochloride Extended-Release Compared to Placebo in Subjects With Persistent Pain
The objective of this study is to assess the efficacy and safety of 8 mg Hydromorphone Hydrochloride Extended-Release.
- Trial name
- NCT00365898
- Testing
- Hydromorphone Hydrochloride Extended-Release
- Where
- 14 sites in United States
- Volunteers
- 380 people
- Sponsor
- Purdue Pharma LP
Chronic Pain, Persistent Pain
Physiotherapy Intervention Program for Chronic Pain Associated With Depressive Disorder
This prospective longitudinal pre-post intervention study aims to evaluate the effects of an 8-week physiotherapy program combining face-to-face and asynchronous tele-rehabilitation sessions in individuals with chronic persistent…
- Conditions
- Chronic Pain, Persistent Pain, Depressive Disorder
- Trial name
- NCT07764848
- Testing
- Hybrid Physiotherapy Program
- Where
- Spain
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Sanitaria Aragón