Clinical trials: Persistent Depressive Disorder
Anxiety Depression (Mild or Not Persistent), Major Depressive Disorder, Single Episode, Unspecified
Self-Management for Anxiety, Depression and Somatoform Disorders
Anxiety, Depression and Somatoform disorders are highly prevalent in primary care. Very often these conditions remain undiscovered and/or untreated.
- Conditions
- Anxiety Depression (Mild or Not Persistent), Major Depressive Disorder, Single Episode, Unspecified, Neurotic, Stress-related and Somatoform Disorders
- Trial name
- SMADS (NCT01726387)
- Testing
- Psychosocial Counseling, Usual Care
- Where
- Germany
- Volunteers
- 364 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Persistent Depressive Disorder
Feasibility and Effectiveness of a Personalized Inpatient Program for Persistent Depressive Disorder
The major objective of this study is to evaluate a new conceptualized personalized concept of Cognitive Behavioral Analysis System of Psychotherapy (CBASPersonalized) in the treatment of patients with persistent depressive…
- Trial name
- PePsy (NCT03616665)
- Testing
- CBASPersonalized
- Where
- 2 sites in Germany
- Volunteers
- 100 people
- Sponsor
- Philipps University Marburg
Anxiety, Anxiety Depression (Mild or Not Persistent)
The Effect of Patient-Family Communication Via Audio Recording
The study was conducted as a randomized controlled blinded study. The sample consisted of 55 patient relatives (27 in the experimental group and 28 in the control group).
- Conditions
- Anxiety, Anxiety Depression (Mild or Not Persistent), Satisfaction With Care
- Trial name
- NCT06627725
- Testing
- Patient-Family Communication
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Yasemin Kalkan Uğurlu
Major Depressive Disorder, Persistent Depressive Disorder
Personalized Indications for CBT and Antidepressants in Treating Depression
Depression currently affects close to 2 million Canadians and is the leading cause of disability worldwide. Pharmacological treatments (antidepressant medication) and psychological treatments such as cognitive-behavioural therapy…
- Trial name
- CANBIND6 (NCT02752542)
- Testing
- Cognitive Behavioral Therapy, Pharmacotherapy
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Nova Scotia Health Authority
Psychosis
Immune Mechanisms of Antipsychotic Treatment Response
The aim of this study is to investigate the role of the immune system in psychotic symptoms and their response to treatment. The investigators will collect blood and cerebrospinal fluid samples from participants with psychosis…
- Trial name
- IMAT (NCT06687694)
- Where
- United Kingdom
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- King's College London
Depressive Symptoms, Anxiety Disorders
SFGT for Persistent Anxiety and Depression
Rationale: Although there are effective treatments available for anxiety and depression, there is a large group of clients that does not benefit sufficiently from first-choice treatment.
- Conditions
- Depressive Symptoms, Anxiety Disorders, Persistent, Anxiety Depression
- Trial name
- NCT05942495
- Testing
- short-term schema focused group therapy
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- GGZ Noord-Holland-Noord
Depression, Major Depressive Disorder
Individualized (fMRI-guided) TMS Treatment for Depression
The purpose of this study is to investigate the responses of the brain region known as the subgenual anterior cingulate cortex (sgACC) during transcranial magnetic stimulation (TMS) in individuals with depression.
- Conditions
- Depression, Major Depressive Disorder, Persistent Depressive Disorder
- Trial name
- NCT06266390
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Pennsylvania
Major Depressive Disorder
SPD489 in Adults With Persistent Executive Function Impairments (EFI) and Partial or Full Remission of Recurrent Major Depressive Disorder
To evaluate the efficacy of SPD489 for the treatment of executive function impairments (EFI) when used as an adjunct to stable, standard therapy in the setting of partial or full remission from recurrent Major Depressive Disorder…
- Trial name
- NCT00985725
- Testing
- SPD489 (Lisdexamfetamine dimesylate)
- Where
- 33 sites in United States
- Volunteers
- 143 people
- Sponsor
- Shire
Insomnia, Major Depressive Disorder
Using Sleep Wearables to Adapt Cognitive-behavioral Therapy for Insomnia in the Context of Depression (CBTiA)
This study aims to better adapt cognitive behavioral therapy for insomnia (CBTi) for people with comorbid depression by using objective sleep measures to tailor the behavioral interventions components of CBTi.
- Conditions
- Insomnia, Major Depressive Disorder, Persistent Depressive Disorder
- Trial name
- CBTiA (NCT05990855)
- Testing
- eCBTi-obj, eCBTi-subj
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- University of Ottawa
Depression, Cost Benefit Analysis
Dysthymia: Associated Costs, Treatment and Change Process
The study evaluates cost and effect of inpatient versus outpatient treatment of dysthymia, as well as investigates the processes through which psychotherapy works in treating dysthymia.
- Conditions
- Depression, Cost Benefit Analysis, Psychotherapeutic Processes
- Trial name
- DFront (NCT04911829)
- Testing
- Psychotherapy
- Where
- Norway
- Volunteers
- 80 people
- Sponsor
- Modum Bad
Insomnia, Depression
Acupuncture for Persistent Insomnia Associated With Major Depressive Disorder
The purpose of this study is to evaluate the clinical effectiveness of acupuncture treatment on residual insomnia in major depressive patients.
- Trial name
- NCT01707706
- Testing
- Acupuncture
- Where
- Hong Kong
- Volunteers
- 150 people
- Sponsor
- The University of Hong Kong
Mood Disorders, Major Depressive Disorder
Unobtrusive Monitoring of Affective Symptoms and Cognition Using Keyboard Dynamics (UnMASCK)
Mood disorders are associated with significant financial and health costs for the United States, partially due to cognitive problems in these patients that can worsen disease course and impair treatment response.
- Conditions
- Mood Disorders, Major Depressive Disorder, Bipolar Disorder I, Bipolar Disorder II
- Trial name
- UnMASCK (NCT04358900)
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Chicago
Depression, Postpartum
Integrated Psychological Program for Management of Postnatal Depression and Persistent Postpartum Pain After Childbirth
The integrated psychological program (IPP) is based on evidence from the local population showing that the interventional components (mindfulness training, music listening, video counselling) are amenable to implementation in the…
- Trial name
- CODEPAD-II (NCT05285215)
- Testing
- Integrated psychological program (IPP)
- Where
- Singapore
- Volunteers
- 1,716 people
- Sponsor
- KK Women's and Children's Hospital
Anxiety Depression (Mild or Not Persistent)
Life Satisfaction and Psychopathology in Institutionalized Elderly People
The present study attempted to test the benefits of a Mindfulness-Based Stress Reduction (MBSR) program in Portuguese institutionalized elderly people, as a way to improve life satisfaction and reduce psychopathology.
- Trial name
- NCT02774018
- Testing
- Mindfulness-Based Stress Reduction (MBSR) program
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Irmandade da Misericórdia de Albergaria-a-Velha
Depression, Major Depressive Disorder (MDD)
Individualized fMRI-guided TMS for Depression
The goal of this clinical trial is to learn how transcranial magnetic stimulation (TMS) affects brain circuits involving the subgenual anterior cingulate cortex (sgACC) in adults with depression.
- Conditions
- Depression, Major Depressive Disorder (MDD), Depression - Major Depressive Disorder, Persistent Depressive Disorder
- Trial name
- R33 MDD (NCT07804459)
- Testing
- Active Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Pennsylvania
Depression, Postpartum, Analgesia, Obstetrical
CODEPAD (Collaborative Outcomes of DEpression and Pain Associated With Delivery)
Postnatal depression affects about 10-15% of women after childbirth. Approximately 3-5% of women experience a moderate-to-severe depression that requires medical attention.
- Conditions
- Depression, Postpartum, Analgesia, Obstetrical, Anesthesia, Obstetrical
- Trial name
- CODEPAD (NCT03167905)
- Testing
- Epidural delivery system, Entonox, Meperidine
- Where
- Singapore
- Volunteers
- 881 people
- Sponsor
- KK Women's and Children's Hospital
Social Isolation or Loneliness, Anxiety
Health Surveillance at University of Applied Science Hamburg (HAW)
The aim of Health Surveillance 2025 is to analyze and describe the state of health of employees at University of Applied Science Hamburg, key influencing factors and individual resources.
- Conditions
- Social Isolation or Loneliness, Anxiety, Anxiety Acute, Anxiety Depression
- Trial name
- HAW_HS2025 (NCT07089914)
- Where
- Germany
- Volunteers
- 679 people, healthy volunteers welcome
- Sponsor
- Jacobs University Bremen gGmbH
Major Depressive Episode (MDE), Major Depressive Disorder (MDD)
LHC-CIDI-5 in Hong Kong
The World Health Organization Composite International Diagnostic Interview-5th (CIDI-5) is a standardized diagnostic tool used to assess the prevalence of mental and substance use disorders over varying time frames (30 days, 12…
- Conditions
- Major Depressive Episode (MDE), Major Depressive Disorder (MDD), Persistent Depressive Disorder (PDD), Suicidal Ideation
- Trial name
- NCT06804525
- Testing
- CIDI-5, LHC-CIDI-5
- Where
- Hong Kong
- Volunteers
- 2,500 people
- Sponsor
- The University of Hong Kong
Anxiety Disorders, Generalized Anxiety Disorder
Mindful Self-compassion for Anxiety and Depression: Impact of Delivery Method
The study will compare the delivery of an 8-week Mindful Self-Compassion training, in-person against video-conference, on anxiety and depression symptom severity in patients with diagnosed anxiety disorders (generalized anxiety…
- Conditions
- Anxiety Disorders, Generalized Anxiety Disorder, Social Anxiety Disorder, Panic Disorder
- Trial name
- NCT07028216
- Testing
- Mindful Self-Compassion
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Georgetown University
Psychotic Disorders
A Study Based on the French National Health Insurance Database in Participants With Psychotic Disorders
The primary purpose of the study is to compare therapy with antipsychotic medication (antipsychotic monotherapy or antipsychotic combination) versus no antipsychotic medication, and antipsychotic monotherapy versus antipsychotic…
- Trial name
- NCT05633108
- Testing
- No Intervention
- Where
- United Kingdom
- Volunteers
- 579,728 people
- Sponsor
- Eisai Co., Ltd.