Clinical trials: Persistent Atrial Fibrillation
Non-valvular Paroxysmal, Persistent, or Permanent Atrial Fibrillation, LAA Anatomy Amenable to Treatment by Percutaneous Technique
Coherex WAVECREST I Left Atrial Appendage Occlusion Study
Purpose To establish the safety and efficacy of the Coherex WaveCrest Left Atrial Appendage Occlusion System for left atrial appendage (LAA) closure during treatment of non-valvular atrial fibrillation in patients who are at…
- Conditions
- Non-valvular Paroxysmal, Persistent, or Permanent Atrial Fibrillation, LAA Anatomy Amenable to Treatment by Percutaneous Technique, Anticoagulation Indication for Potential Thrombus Formation in the Left Atrium
- Trial name
- NCT02239887
- Testing
- WaveCrest LAA occlusion device
- Volunteers
- 155 people
- Sponsor
- Coherex Medical
Persistent Atrial Fibrillation
Ranolazine in Atrial Fibrillation Following An ELectricaL CardiOversion
Dose-ranging Phase II study testing the efficacy and safety of 3 doses of Ranolazine (low, intermediate and high, given BID) versus placebo in maintaining sinus rhythm after successful electrical cardioversion in patients with…
- Trial name
- RAFFAELLO (NCT01534962)
- Testing
- Ranolazine
- Where
- 4 sites in Germany, Italy and 2 more
- Volunteers
- 241 people
- Sponsor
- Menarini Group
Persistent Atrial Fibrillation, Paroxysmal Atrial Fibrillation
Evaluating the Efficacy and Feasibility of a Novel Wireless ECG Recording System in Monitoring Patients After Atrial Fibrillation Ablation Procedure
The investigators goal in this study is to examine the feasibility and efficacy of AliveCor iphone case monitoring device in monitoring patients after AF ablation by comparing transmissions using Alive Cor with transmissions from…
- Trial name
- iTransmit (NCT01912911)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The Cleveland Clinic
Persistent Atrial Fibrillation
Persistent Atrial Fibrillation Cryoballoon Ablation
Patients with persistent irregular heartbeats also called persistent atrial fibrillation usually have a lower probability of curing their arrhythmia with ablation with heat called radiofrequency then those with paroxysmal atrial…
- Trial name
- PAFCA (NCT02166723)
- Testing
- Cryoballoon Ablation
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Staten Island University Hospital
Persistent Atrial Fibrillation
Comparison of Reverse Remodeling and PVI Versus CFAE and/or Linear Lesions and PVI for Persistent AF
The hypothesis of this study is that by facilitating reverse atrial remodeling with maintenance of sinus rhythm in the weeks preceding ablation makes it feasible to perform a simple pulmonary vein isolation (PVI) with results…
- Trial name
- NCT01877473
- Testing
- Ablation
- Where
- United States
- Sponsor
- Valley Health System
Persistent Atrial Fibrillation
Left Atrial Appendage Electrical Isolation and Occlusion to Treat Persistent Atrial Fibrillation: A Safety and Feasibility Study
Atrial fibrillation (AF) affects as many as 1 in 16 people over the age of 65 and reduces the quality of life of large numbers of people in the UK and around the world.
- Trial name
- LEIO-AF (NCT02028130)
- Testing
- LAA electrical isolation + occlusion
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Persistent Atrial Fibrillation
Efficacy and Safety Study of the Estech COBRA® Surgical System to Treat Patients With a History of Irregular Heart Beats
The purpose of this study is to demonstrate that the Estech COBRA Surgical System is an effective treatment for patients with irregular heart beats who are undergoing heart surgery.
- Trial name
- NCT01683045
- Testing
- The Estech COBRA® Surgical System
- Where
- 13 sites in United States
- Volunteers
- 6 people
- Sponsor
- Endoscopic Technologies, Inc
Persistent Atrial Fibrillation
Acupuncture in Persistent Atrial Fibrillation
The aim of this trial is to evaluate the effect of acupuncture on prevention of atrial fibrillation (AF) recurrence after electrical cardioversion (EC) for persistent AF patients resistant to the antiarrhythmic drugs (AADs).
- Trial name
- NCT02110537
- Testing
- Active Acupuncture, flecainide
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Kyunghee University Medical Center
Persistent Atrial Fibrillation
Ganglionated Plexi Ablation Combined With Pulmonary Vein Isolation
The investigators have conducted a prospective, double-blind, randomized study to assess the comparative safety and efficacy of two different ablation strategies, PVI plus linear lesions (LL) versus PVI plus GP ablation, in…
- Trial name
- NCT01703247
- Testing
- Pulmonary vein isolation, Ganglionated plexi ablation, Linear Lesion Ablation
- Where
- Russia
- Volunteers
- 264 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Persistent or Permanent Non-valvular Atrial Fibrillation
Atrial Fibrillation (AF) Patients Not Taking Vitamin-K Antagonist (VKA)
The purpose of this study is to assess the safety and tolerability of AZD0837 in patients with atrial fibrillation who are unable or unwilling to take vitamin K antagonist therapy for up to 3 months.
- Trial name
- NCT00623779
- Testing
- AZD0837, Aspirin
- Where
- 38 sites in Denmark, Norway and 4 more
- Volunteers
- 128 people
- Sponsor
- AstraZeneca
Persistent or Permanent Nonvalvular Atrial Fibrillation
Long-term Safety in Atrial Fibrillation Patients
The purpose of this study is to provide safety and tolerability data for AZD0837 during long-term treatment (5 years) in patients with non-valvular atrial fibrillation (AF) and one or more additional risk factors for stroke and…
- Trial name
- NCT00645853
- Testing
- AZD0837, VKA INR 2-3
- Volunteers
- 523 people
- Sponsor
- AstraZeneca
Persistent Atrial Fibrillation
Catheter Versus Thoracoscopic Surgical Ablation Strategy in Persistent Atrial Fibrillation
Atrial fibrillation(AF)is the commonest arrhythmia worldwide and can lead to significant morbidity and mortality, posing an increasing public health burden.
- Trial name
- CASA-AF (NCT01385358)
- Testing
- Thoracoscopically Assisted Surgical Ablation, Catheter Ablation
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Persistent Atrial Fibrillation, Catheter Ablation
Clinical Value of Left Atrial Appendage Flow for Prediction of Successful Catheter Ablation for Persistent Atrial Fibrillation
The purpose of this study was to determine whether left atrial appendage flow velocity, as determined using trans esophageal echocardiography (TEE), predicts the outcome after catheter ablation of persistent Atrial fibrillation…
- Trial name
- CLAAAF (NCT01144858)
- Testing
- a complete transesophageal echocardiography
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Clinique Pasteur
Persistent Atrial Fibrillation
Node and Atrial Fibrillation Ablation for Persistent Atrial Fibrillation
The purpose of the study is to assess combining AF ablation, with AV node ablation and pacemaker implantation for patients suffering with 'irregular heartbeats' or atrial fibrillation. The study will last 13 months.
- Trial name
- NAFAPAF (NCT01057485)
- Testing
- AF ablation and AV node ablation, AV node ablation
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- East Sussex Healthcare NHS Trust
Persistent Atrial Fibrillation
RAte Control Efficacy in Permanent Atrial Fibrillation
The investigators hypothesis is that in patients with permanent AF lenient rate control is not inferior to strict rate control in terms of cardiovascular mortality, morbidity, neurohormonal activation, NYHA class for heart…
- Trial name
- NCT00392613
- Testing
- Strict versus lenient rate control
- Where
- Netherlands
- Volunteers
- 500 people
- Sponsor
- University Medical Center Groningen
Persistent Atrial Fibrillation
Withdrawal Versus Continuation of Amiodarone in Successfully Treated Patients With Persistent Atrial Fibrillation
Amiodarone is considered to be the most effective antiarrhythmic drug in the prevention of persistent atrial fibrillation. It can however cause many adverse events, both cardiac and non-cardiac.
- Trial name
- WISDOM (NCT00845780)
- Testing
- withdrawal or continuation of amiodarone therapy
- Where
- Netherlands
- Volunteers
- 37 people
- Sponsor
- University Medical Center Groningen
Persistent Atrial Fibrillation
Irbesartan and Adhesion Molecules in AF
Experimental data suggest that angiotensin II-antagonists reduce the atrial expression of prothrombotic adhesion molecules and oxidative stress parameters.
- Trial name
- CREATIVE-AF (NCT00613496)
- Testing
- irbesartan
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University of Magdeburg