Clinical trials: Persistent Atrial Fibrillation
Atrial Fibrillation, Persistent
Optimal Pacing Rate for Cardiac Resynchronization Therapy
This is a prospective, randomized crossover study. The objective of the study is to determine if a pacing rate of 80 beats per minute (bpm) improves exercise tolerance during the 6-minute walk test.
- Trial name
- OPT-RATE AF (NCT06445439)
- Testing
- Pacing rate of 80 bpm, Pacing rate of 60 bpm
- Where
- 5 sites in United States
- Volunteers
- 60 people
- Sponsor
- Medstar Health Research Institute
Atrial Fibrillation
SCAR Burden of Left Atrium Guided cathEter Ablation sTrategy for Persistent Atrial Fibrillation
This is a multicenter, randomized controlled trial to compare the recurrence of 1-year atrial arrhythmia after catheter ablation of atrial fibrillation (AF) between pulmonary vein isolation (PVI) and PVI with additional left…
- Trial name
- SCARLET-AF (NCT05794386)
- Testing
- LVA-guided LA substrate modification
- Where
- South Korea
- Volunteers
- 204 people
- Sponsor
- Seoul National University Hospital
Persistent Atrial Fibrillation, Pulsed-field Ablation
Pulsed-field Ablation in Patients With Persistent Atrial Fibrillation
Since a new method called pulsed-field ablation (PFA) has emerged, allowing significantly simpler, safer, and faster creation of ablative lesions in paroxysmal AF and PsAF (13), redefining the "optimal" ablation approach started…
- Trial name
- PIVCO (NCT05922917)
- Testing
- pulsed-field ablation
- Where
- 3 sites in Czechia
- Volunteers
- 300 people
- Sponsor
- České Budějovice Hospital
Atrial Fibrillation (AF), Persistant Atrial Fibrillation
A Global Study Comparing Pulsed Field Ablation With Electrographic Flow Mapping Versus Posterior Wall Ablation for Persistent Atrial Fibrillation
The purpose of this study is to establish the safety of the pulsed field ablation (PFA) therapy of Pulmonary Veins and Electrographic Flow (EGF) identified extra-PV sources of atrial fibrillation (PVI + EGF ablation of sources)…
- Trial name
- OPTIMIZE (NCT07187115)
- Testing
- FARAPOINT Pulsed Field Ablation System, OptiMap System (non-ablative), FARAPULSE Pulsed Field Ablation (PFA) System and Opal HDx Mapping System
- Where
- 15 sites in United States, Belgium and 2 more
- Volunteers
- 699 people
- Sponsor
- Boston Scientific Corporation
Persistent Atrial Fibrillation
CONVERGE - Epi/Endo Ablation For Treatment of Persistent Atrial Fibrillation(AF)
This is a multi-center, open label, randomized pivotal study evaluating the safety and efficacy of the EPi-Sense-AF Guided Coagulation System for the treatment of persistent AF patients, refractory or intolerant to at least one…
- Trial name
- CONVERGE (NCT01984346)
- Testing
- AtriCure EPi-Sense-AF Guided Coagulation System with VisiTrax, Endocardial RF Catheter ablation using Open Irrigated-tip RF Abaltion Catheter with unidirectional or bidirectional steering
- Where
- 27 sites in United States, United Kingdom
- Volunteers
- 170 people
- Sponsor
- AtriCure, Inc.
Atrial Fibrillation, Persistent
Rate Control Self-adjustment in Patients With Permanent or Persistent Atrial Fibrillation Using Device Home Monitoring
Patients with permanent or persistent atrial fibrillation require rate control medication to prevent excessive tachycardia. Since too much medication leads to a lower than expected heart rate (low output and symptoms) and too…
- Trial name
- NCT05066971
- Testing
- Self-adjustment of medication
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Université de Sherbrooke
Atrial Fibrillation, Persistent
Adjunctive Right Atrial Ablation for Persistent Atrial Fibrillation
Persistent atrial fibrillation (PerAF) can induce right atrial (RA) enlargement. Our previous study demonstrated patients with PerAF and RA enlargment may benefit from adjunctive RA ablation.
- Trial name
- NCT05883722
- Testing
- Catheter ablation
- Volunteers
- 200 people
- Sponsor
- Xu Liu
Persistent Atrial Fibrillation
Study Comparing Pulmonary Vein Isolation With the Cryoballoon and Radiofrequency Energy(Contact Force) in the Treatment of Persistent Atrial Fibrillation (AF) (Cryo Vs CF in PerAF)
The purpose of this study is to perform a prospective, randomised study investigating the safety and efficacy of cryoballoon catheter ablation compared with radiofrequency ablation(contact force), in the treatment of persistent…
- Trial name
- NCT03053570
- Testing
- Cryoballoon, Radiofrequency Energy(Contact Force)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- China Cardiometabolic Registries
Persistent Atrial Fibrillation
Liner Ablation Using Contact-force in Atrial Fibrillation
Linear ablation is frequently used in the procedure for persistent atrial fibrillation. However, it has a limitation because of technical difficulty. Incomplete block is common and an important cause of atrial tachycardia.
- Trial name
- LIBCAAF (NCT03091972)
- Testing
- Pulmonary vein isolation, Contact force assisted left atrial linear ablation, left atrial linear ablation without contact force monitoring
- Where
- South Korea
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Korea University Anam Hospital
Atrial Fibrillation
Line Versus Spot Ablation in Persistent Atrial Fibrillation
In this randomized study dealing with the ablative treatment of persistent atrial fibrillation, two ablation strategies are compared: a more anatomically guided linear ablation scheme versus an electrophysiological guided focal…
- Trial name
- NCT00196157
- Testing
- linear anatomically oriented ablations, focal electrophysiological oriented ablations
- Where
- Germany
- Volunteers
- 116 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Atrial Fibrillation, Paroxysmal or Persistent
Reversal of Atrial Substrate to Prevent Atrial Fibrillation Cohort Study
Atrial fibrillation (AF) is a major health problem, with a prevalence of 0.4-1% of the population. It results in high healthcare costs and significant morbidity, especially for patients with severe symptoms.
- Trial name
- RASTA-Cohort (NCT06249269)
- Where
- 7 sites in Canada
- Volunteers
- 198 people
- Sponsor
- Ratika Parkash
Atrial Fibrillation (AF)
Comparative Efficacy and Safety of Extensive Electro-Anatomical Guided Pulsed Field Ablation Versus Radiofrequency Ablation in Persistent Atrial Fibrillation
This multicenter, randomized controlled trial aims to compare the efficacy and safety of extensive electro-anatomical guided pulsed field ablation (EXT-PFA) with traditional radiofrequency ablation (RF) in treating persistent…
- Trial name
- NCT06745167
- Testing
- Pulsed field ablation, Radiofrequency ablation alone
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Shanghai Chest Hospital
Persistent Atrial Fibrillation, Longstanding Persistent Atrial Fibrillation
Electrographic Flow Mapping Validation in Patients With Persistent Atrial Fibrillation (EVAL AF)
This is a prospective, observational, single center pilot trial to find out if a new computerized technology for analysis of the electrical activity recorded during atrial fibrillation can identify the electrical source of this…
- Trial name
- NCT05093868
- Testing
- Electrographic Flow Mapping
- Where
- United States
- Sponsor
- Corewell Health East
Atrial Fibrillation, Persistent, Atrial Fibrillation
AF-FLOW Registry to Evaluate Electrographic Flow Mapping in Patients Undergoing Ablation for Atrial Fibrillation
This post-market global registry will evaluate the ability of Electrographic Flow (EGF™) mapping to identify atrial fibrillation (AF) sources and guide ablation therapy in patients with atrial fibrillation in real-world setting.
- Conditions
- Atrial Fibrillation, Persistent, Atrial Fibrillation, Arrhythmias, Cardiac, Heart Diseases
- Trial name
- NCT05481359
- Testing
- Electrographic Flow™ (EGF) mapping and ablation
- Where
- 5 sites in United States, Netherlands and 1 more
- Volunteers
- 25 people
- Sponsor
- Ablacon, Inc.
Persistent Atrial Fibrillation, Atrial Fibrillation Ablation
Oesophageal Pacing to Check Left Atrial Posterior Wall Isolation
Patients undergoing hybrid AF ablation second stage catheter ablation have the posterior left atrium mapped to see it if is electrically isolated.
- Trial name
- NCT05086861
- Testing
- Oesophageal pacing after left atrial posterior wall isolation
- Where
- United Kingdom
- Volunteers
- 52 people
- Sponsor
- University Hospital Plymouth NHS Trust
Scar-related Atrial Tachycardia, Persistent Atrial Fibrillation
A Study of Intracardiac Ultrasound With the NUVISION NAV Ultrasound Catheter
The purpose of this study is to assess the performance and safety of using the investigational catheter.
- Conditions
- Scar-related Atrial Tachycardia, Persistent Atrial Fibrillation, Paroxysmal Atrial Fibrillation, Ventricular Tachycardia
- Trial name
- NCT05970120
- Testing
- NUVISION NAV Ultrasound Catheter
- Where
- 3 sites in Croatia, Israel and 1 more
- Volunteers
- 30 people
- Sponsor
- Biosense Webster, Inc.
Atrial Fibrillation
Early Versus Late DC-cardioversion of Persistent Atrial Fibrillation. Effect on Atrial Remodeling,Inflammatory and Neurohumoral Markers and Recurrence of Atrial Fibrillation
Atrial fibrillation (AF) is the most common arrhythmia present in 1% of population under 60 years of age and reaching up to 15% at 80 years.
- Trial name
- NCT01593150
- Testing
- Pradaxa, TEE, Compare TEE guided cardioversion to Dabigatran + DC cardioversion
- Where
- Denmark
- Volunteers
- 141 people
- Sponsor
- Odense University Hospital
Atrial Fibrillation
Shock Energy for Electrical Cardioversion of Persistent Atrial Fibrillation
The goal of this clinical trial is to compare the efficacy of a maximum output shock for cardioverting atrial fibrillation between two commonly used defibrillators in New Zealand .
- Trial name
- NCT05903170
- Testing
- 360J LifePak Monitor/Defibrillator, 200J Philips HeartStart MRx Monitor/Defibrillator
- Where
- New Zealand
- Volunteers
- 100 people
- Sponsor
- Wellington Hospital
Persistent Atrial Fibrillation
Catgut Embedding in Acupoints on Treating Persistent Atrial Fibrillation After Catheter Ablation
This is a multi-center, 2-arm, assessor and statistician blinded, pilot randomized controlled trial, to evaluate the effect of catgut embedding in acupoints of Neiguan and Zusanli in reducing early recurrence and improving…
- Trial name
- NCT05125042
- Testing
- Amiodarone hydrochloride tablet + acupoint catgut embedding, Amiodarone hydrochloride tablet
- Volunteers
- 120 people
- Sponsor
- Shanghai Chest Hospital
Atrial Fibrillation, Left Atrial Appendage
Left Atrial Appendage Electrical Isolation in Persistent Atrial Fibrillation
This project intends to enroll patients with persistent atrial fibrillation who are planning to undergo catheter ablation of atrial fibrillation.
- Conditions
- Atrial Fibrillation, Left Atrial Appendage, Left Atrial Appendage Occlusion, Catheter Ablation
- Trial name
- NCT04897204
- Testing
- Catheter ablation and left atrial appendage occlusion, Additional left atrial appendage electrical isolation combined with catheter ablation and left atrial appendage occlusion
- Volunteers
- 120 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine