Clinical trials: Periprosthetic Joint Infection
Peri-Prosthetic Joint Infection
IP-coated Revision Hip Implants
The primary aim of the clinical investigation is to demonstrate the efficacy of a silver-based antimicrobial coating on hip implants in the reduction of periprosthetic infections in revision hip arthroplasty due to periprosthetic…
- Trial name
- HIPrevision (NCT06737809)
- Testing
- IP Plasmafit® Revision cup (and stem) system
- Where
- 2 sites in Germany, Poland
- Volunteers
- 268 people
- Sponsor
- Aesculap AG
Prosthetic Joint Infections of Hip, Bacteriophage Therapy
Bacteriophage Therapy for Staphylococcus Lugdunensis Prosthetic Joint Infection
This is a single-patient, phase I/II clinical trial that aims to evaluate the potential of a bacteriophage drug product to treat and prevent the recurrence of a Staphylococcus lugdunensis prosthetic joint infection of the hip.
- Trial name
- NCT07461337
- Testing
- Five phage anti-Staphylococcus aureus bacteriophage cocktail
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- University of Calgary
Periprosthetic Joint Infection (PJI)
A Phase 1/2 Study to Evaluate the Safety, PK and Efficacy of TNP-2092 Administered Via IA Injection in PJI Participants
This is a Phase 1/2, randomized, controlled, open-label, proof-of-concept study to evaluate the safety and tolerability, local and systemic PK profiles of TNP-2092 administered via IA injection on the basis of vancomycin IV and…
- Trial name
- NCT06889701
- Testing
- TNP-2092 for injection, Vancomycin Hydrochloride for Injection (IA), Vancomycin Hydrochloride for Injection (IV)
- Where
- China
- Volunteers
- 33 people
- Sponsor
- TenNor Therapeutics Inc.
Arthropathy of Hip, Arthropathy of Knee
Diagnosis of Periprosthetic Joint Infection and the Common Pathogens, Durg-resistance in Periprosthetic Joint Infection
This retrospective study aims to improve the diagnosis of PJI as well as to identify microorganisms causing periprosthetic joint infection (PJI) and the drug-resistant spectrum
- Trial name
- NCT03365323
- Testing
- Periprosthetic Joint Infection, Non-Periprosthetic Joint Infection
- Volunteers
- 160 people
- Sponsor
- Peking University People's Hospital
Prosthetic Joint Infection
Abbreviated Protocol for Two-Stage Exchange
Study Type: A multi-site, parallel group, randomized trial. Study Objectives: The objective is to evaluate safety and determine preliminary efficacy of VT-X7 (Vancomycin and Tobramycin Exchanged over 7 Days).
- Trial name
- APEX (NCT04662632)
- Testing
- VT-X7 Treatment System with Tobramycin Sulfate, Standard of Care, Two-stage exchange arthroplasty
- Where
- 17 sites in United States
- Volunteers
- 76 people
- Sponsor
- Osteal Therapeutics, Inc.
Prosthetic Joint Infection
Integrated Microfluidic Systems for Diagnosis of Periprosthetic Joint Infection
Diagnosing periprosthetic joint infection (PJI) remains a major clinical challenge. The diagnosis of PJI is based on a composition of clinical judgment, serologic test from peripheral blood, synovial fluid cytology and…
- Trial name
- NCT04056780
- Testing
- Sample collection study
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- Chang Gung Memorial Hospital
Joint Infection, Periprosthetic Left Knee Joint Infection
Microbiological Structure of Pathogens of Periprosthetic Infection of Large Joints in the Post-Covid Period
Background. Infection is the most common complication of complications after joint arthroplasty. During the COVID-19 pandemic increased used antibacterial drugs by adults, this could change the spectrum of infectious agents and…
- Trial name
- NCT06267287
- Testing
- Microbiological examination of the patient's biological material and determination of antibiotic resistance
- Where
- Russia
- Volunteers
- 342 people
- Sponsor
- Federal State Budgetary Organization, Federal Center for Traumatology, Orthopedics and Arthroplasty
Prosthetic-joint Infection, Knee Infection
Real-component vs All-cement Articulating Spacers for Periprosthetic Knee Infection
In the US, if an infection in an artificial knee joint doesn't heal with antibiotics alone, the standard treatment is a two-stage revision of the artificial knee.
- Conditions
- Prosthetic-joint Infection, Knee Infection, Arthroplasty Complications, Joint Infection
- Trial name
- NCT06293352
- Testing
- All-cement articulating spacer, Durable, real-component articulating spacer, Rigid Spacer
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- Northwestern University
Wound Heal, Periprosthetic Joint Infection
Closed Incisional Negative Pressure Wound Therapy in Post-surgical Wound Care of Patients With Periprosthetic Joint Infection
In the proposed study, we will apply Prevena on the surgical wound right after closure of the wound in the operating theater. Prevena will be used for 7 days, unless there is ongoing infection or much wound drainage that requires…
- Trial name
- NCT05357287
- Testing
- PREVENA incision management system
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- Chang Gung Memorial Hospital
Periprosthetic Joint Infections
Multicenter Trial of Antibiotic Eluting Graft for Promoting New Bone Growth in/Near Infected Bone Cavities
This is a pivotal, prospective, multi-center, randomized, concurrent control, patient and assessor-blinded study with two arms: a treatment arm (where subjects will be treated with the EP Granules + Tobramycin (EP G + T)…
- Trial name
- MAGIC (NCT05361941)
- Testing
- EP Granules with Tobramycin, empty voids
- Where
- 16 sites in United States
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Elute, Inc.
Prosthetic Joint Infection
The Utility of Next-generation Sequencing for the Diagnosis of Periprosthetic Joint Infection
This is a prospective multicenter study. All patients presenting for revision hip or knee arthroplasty for all indications under the respective surgeon's care may be eligible.
- Trial name
- NCT03200470
- Testing
- No intervention: sample collection study
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Rothman Institute Orthopaedics
Periprosthetic Joint Infection
Phage Therapy for the Treatment of a Chronic Enterococcus Faecium Periprosthetic Joint Infection
This purpose of this clinical trial is to evaluate the safety, tolerability and efficacy of a bacteriophage therapy in a patient with a methicillin-susceptible Enterococcus faecium (E.
- Trial name
- NCT06942624
- Testing
- Phage Therapy
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- Orthopaedic Innovation Centre