Clinical trials: Peripheral Neuropathy Due to Chemotherapy
CIPN - Chemotherapy-Induced Peripheral Neuropathy
Biomarkers in Chemotherapy-Induced Peripheral Neurotoxicity
This pilot study will attempt to establish the feasibility of using tissue oxygen measurements and the protein, neurofilament light chain (NF-L), as potential biomarkers for chemotherapy-induced peripheral neuropathy (CIPN).
- Trial name
- CIPN (NCT03348956)
- Testing
- EPR Oximetry
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Chemotherapy-induced Peripheral Neuropathy, Breast Cancer
Symptoms Associated with Chemotherapy-Induced Peripheral Neuropathy
Breast cancer remains the most frequent type of cancer globally. Nevertheless, the increased rate of disease-free survival of breast cancer brought the specific need of managing of short and long-term side effects of multimodal…
- Conditions
- Chemotherapy-induced Peripheral Neuropathy, Breast Cancer, Breast Cancer Female
- Trial name
- NCT06352567
- Testing
- European Organization for Research and Treatment of Cancer-Chemotherapy Induced Peripheral Neuropathy (EORTC-CIPN20) questionnaire
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people
- Sponsor
- Izmir Bakircay University
Chemotherapy-induced Peripheral Neuropathy, Pediatric Cancer
Preventing Sensory and Motor Dysfunctions in Children Receiving Neurotoxic Chemotherapy
The investigators would like to conduct a prospective, multicenter, two-armed trial (RCT with follow-up). Patients will be recruited from 7 centers (CH/D).
- Trial name
- PrepAIR (NCT05606588)
- Testing
- Playful sensorimotor training
- Where
- 2 sites in Switzerland
- Volunteers
- 131 people
- Sponsor
- University of Basel
Chemotherapy-Induced Peripheral Neuropathy, Radiation Toxicity
Patients Referred to the Chronic Pain Unit for Palliative Treatment With Ozone Therapy Between 2026 and 2029.
The main objective of this study is to analyze the impact on the health-related quality of life of patients with refractory symptoms who have been referred to the Dr.
- Conditions
- Chemotherapy-Induced Peripheral Neuropathy, Radiation Toxicity, Chronic Pain, Delayed Wound Healing
- Trial name
- EPOOzo-2 (NCT07325851)
- Testing
- Ozone Therapy
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Bernardino Clavo, MD, PhD
Chemotherapy Induced Peripheral Neuropathy (CIPN), Cancer
Effect of GMI With and Without NM on LE in Cancer Patients With CIPN
The goal of this interventional study is to learn if graded motor imagery with or without added neural mobilization can treat chemotherapy induced nerve related symptoms in lower limbs of cancer patients.
- Trial name
- CIPN (NCT07712302)
- Testing
- Graded Motor Imagery, Neural Mobilization
- Where
- Pakistan
- Volunteers
- 48 people
- Sponsor
- University of Faisalabad
Chemotherapy Induced Peripheral Neuropathy
Acupuncture for Chemotherapy-induced Peripheral Neuropathy
In this study, a 24-week, single blinded, randomized controlled clinical trial will be conducted to examine the efficacy and safety of acupuncture for Chemotherapy Induced Peripheral Neuropathy (CIPN) in colorectal cancer…
- Trial name
- NCT03582423
- Testing
- electro-acupuncture
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- Hong Kong Baptist University
CIPN - Chemotherapy-Induced Peripheral Neuropathy, Age Over 18
Sensory Rehabilitation in Chemo Induced Peripheral Neuropathy
This study is a cross-over RCT evaluating the effectiveness of 3 sessions a week apart of explicit sensory retraining to the lower extremities in individuals with CIPN versus usual care.
- Conditions
- CIPN - Chemotherapy-Induced Peripheral Neuropathy, Age Over 18, Chemotherapy-induced Peripheral Neuropathy
- Trial name
- NCT06724861
- Testing
- Explicit Sensory Retraining for the lower extremities, no treatment
- Where
- Israel
- Volunteers
- 27 people
- Sponsor
- Assaf-Harofeh Medical Center
Chemotherapy Induced Peripheral Neuropathy (CIPN), Neuropathic Pain
Evaluation of Effectiveness of Closed-loop Spinal Cord Stimulation (CL-SCS) Therapy for Treatment of Chemotherapy Induced Peripheral Neuropathy
The goal of this observational study is to learn about the effectiveness of closed-loop spinal cord stimulation (CL-SCS) therapy for treatment of painful chemotherapy induced peripheral neuropathy.
- Trial name
- CIPRESS (NCT07304401)
- Where
- 5 sites in Netherlands
- Volunteers
- 20 people
- Sponsor
- Rijnstate Hospital
Peripheral Nervous System Diseases
Pre-study to Evaluate IENFD Induction in Patients With Taxane-induced CIPN
This is a non-interventional study examining IENFD levels in patients with CIPN after taxane chemotherapy and in age-matched healthy subjects.
- Trial name
- NCT05133947
- Testing
- Non interventional
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Beijing 3E-Regenacy Pharmaceuticals Co., Ltd.
Chemotherapy-induced Peripheral Neuropathy (CIPN), Healthy
Relationship Between Great Toe Strength And Symptoms of Chemotherapy-Induced Peripheral Neuropathy (CIPN)
Great Toe Strength (GTS) is a potential clinical biomarker that has been associated with functional mobility and health; Additionally, GTS has been identified in the literature as one of the early symptoms of chemotherapy-induced…
- Trial name
- NCT07009717
- Testing
- No intervention (observational study)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Florida
Cancer Survivors, Peripheral Neuropathic Pain
Evaluating Laser Photobiomodulation for the Treatment of Neuropathic Pain in Chemotherapy-induced Peripheral Neuropathy in Cancer Patients
Chemotherapy-induced peripheral neuropathy (CIPN) (including taxanes, platinum, al pervenche from Madagascar alkaloids...), is a frequent secondary effect of treatments: 68% at 1-month post-chemotherapy, 60% at 3 months and 30%…
- Trial name
- NEUROdoux (NCT06834685)
- Testing
- Photobiomodulation sessions
- Where
- 2 sites in France
- Volunteers
- 70 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Chemotherapy Induced Peripheral Neuropathy (CIPN)
The Effect of Aerobic and Resistance Training With and Without Neurodynamic Exercises on Chemotherapy-induced Peripheral Neuropathy Symptoms and Associated Neuro-immune Mechanisms
Chemotherapy-induced peripheral neuropathy (CIPN) is a common and potentially persistent side effect of neurotoxic chemotherapy, characterized by symptoms such as numbness, tingling, pain, and sensory dysfunction in the hands and…
- Trial name
- CIPN-NEXT (NCT07913958)
- Testing
- Exercise program 1: aerobic + resistance training, Exercise program 2: aerobic + resistance training combined with neurodynamic exercises
- Where
- 2 sites in Belgium
- Volunteers
- 87 people
- Sponsor
- Universiteit Antwerpen
Chemotherapy-induced Peripheral Neuropathy, Nerve Pain
The Effect of Yoga on Nerve Pain Caused by Chemotherapy (Chemotherapy-Induced Peripheral Neuropathy)
The purpose of this study is to test whether yoga can reduce nerve pain caused by cancer treatment (chemotherapy-induced peripheral neuropathy, or CIPN).
- Conditions
- Chemotherapy-induced Peripheral Neuropathy, Nerve Pain, Neuropathy, Neuropathy, Painful
- Trial name
- YCT (NCT05121558)
- Testing
- Yoga, Education control, Usual care
- Where
- 8 sites in United States
- Volunteers
- 227 people
- Sponsor
- Dana-Farber Cancer Institute
Chemotherapy-Induced Peripheral Neuropathy, Malignant Neoplasm
Transcranial Direct Current Stimulation in Reducing Pain in Cancer Patients With Chemotherapy Induced Peripheral Neuropathy
This early phase I trial studies how well transcranial direct current stimulation works in reducing pain in cancer patients with chemotherapy induced peripheral neuropathy.
- Trial name
- NCT04135326
- Testing
- Quality-of-Life Assessment, Questionnaire Administration, Transcranial Direct Current Stimulation
- Where
- United States
- Sponsor
- M.D. Anderson Cancer Center
Qutenza, Duloxetine
Qutenza Versus Duloxetine in Chemotherapy-induced Peripheral Neuropathy (CIPN)
The primary objective is to determine whether in patients with CIPN pain, treatment with Qutenza has the same effect as treatment with duloxetine 60 mg daily.
- Conditions
- Qutenza, Duloxetine, Chemotherapy-induced Peripheral Neuropathy, CIPN - Chemotherapy-Induced Peripheral Neuropathy
- Trial name
- QULOX (NCT05560516)
- Testing
- Qutenza, Duloxetine
- Where
- Netherlands
- Volunteers
- 102 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Cancer, Chemotherapy-induced Peripheral Neuropathy
Combined Qigong and Acupressure for Improving Chemotherapy-induced Peripheral Neuropathy
The objective of the study is to investigate the effects of a 16-week combined qigong and acupressure intervention on reducing self-reported chemotherapy-induced peripheral neuropathy (CIPN) severity, objective measures of CIPN…
- Trial name
- NCT05764447
- Testing
- Combined qigong Baduanjin and self-administered acupressure, Wait-list Control
- Where
- Hong Kong
- Volunteers
- 110 people
- Sponsor
- The University of Hong Kong
Cancer, Neuropathy
Nutritional Supplement for Treating Chemotherapy Induced Neuropathy
Administration of a nutritional supplement containing palmitoyethanolamide, alpha lipoic acid, vitamin B12, vitamin B6 , vitamin B1, nicotinamide, magnesium, zinc, vitamin E, and superoxide of dismutase in individuals receiving…
- Conditions
- Cancer, Neuropathy, Chemotherapy Induced Pain Neuropathy, Chemotherapy-Induced Peripheral Neuropathy
- Trial name
- NCT07022938
- Testing
- Epineuron
- Where
- Greece
- Volunteers
- 71 people
- Sponsor
- Aristotle University Of Thessaloniki