Clinical trials: Peripheral Neuropathies
Peripheral Diabetic Neuropathy, Cardiovascular Autonomic Neuropathy
The Association Between Cognitive Function and Neuropathy in Individuals With Type 2 Diabetes
The goal of this observational study is to evaluate whether individuals with different types of diabetic neuropathy (peripheral and cardiovascular autonomic neuropathy) are at an increased risk of cognitive impairment and to…
- Conditions
- Peripheral Diabetic Neuropathy, Cardiovascular Autonomic Neuropathy, Cognitive Impairment, Diabetes Type 2
- Trial name
- ASCEND (NCT06857994)
- Where
- Denmark
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Steno Diabetes Center Copenhagen
Diabetic Peripheral Neuropathy (DPN), Pain
Study on Serum Transcriptomics and Metabolomics in Patients With Diabetic Peripheral Neuropathy
This part of the study enrolled 30 sex- and age-matched healthy controls, 30 diabetic patients without peripheral neuropathy, and 30 patients with diabetic peripheral neuropathy (DPN).
- Trial name
- NCT07518433
- Testing
- Not applicable- observational study
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Zhejiang Chinese Medical University
Diabetic Foot, Peripheral Neuropathy With Type 2 Diabetes
The Effects of Different Exercises on Tissue Mechanics, Strength and Neuropathy Symptoms in Type 2 Diabetes Patients
To examine the effects of aerobic exercise and foot exercises in addition to aerobic exercise on lower extremity distal tissue mechanics, muscle strength and neuropathy symptoms in type 2 diabetics with peripheral neuropathy.
- Trial name
- NCT05422235
- Testing
- Routine Medical Treatment, Aerobic Exercise, Aerobic Exercise+ Foot-Related Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Eastern Mediterranean University
Carpal Tunnel Syndrome (CTS), Median Nerve Entrapment
"Ultrasound Measures and Clinical Outcomes in Healthy Individuals, Mild and Moderate Carpal Tunnel Syndrome Patients"
"This study aims to investigate ultrasonographic parameters of the median nerve in healthy individuals and patients with mild and moderate carpal tunnel syndrome (CTS).
- Conditions
- Carpal Tunnel Syndrome (CTS), Median Nerve Entrapment, Electrophysiologic Study, Ultrasound
- Trial name
- NCT07408596
- Testing
- ultrasound
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Istanbul University
CIPN - Chemotherapy-Induced Peripheral Neuropathy, Chemotherapy-Induced Peripheral Neuropathy
The Influence of Chemotherapy on Position Sense
Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most prevalent side-effects of chemotherapy, causing sensory and motor symptoms in patients.
- Conditions
- CIPN - Chemotherapy-Induced Peripheral Neuropathy, Chemotherapy-Induced Peripheral Neuropathy, Chemotherapy-Induced Peripheral Neuropathy in Breast Cancer
- Trial name
- ProprioCIPN (NCT07367711)
- Testing
- Questionnaire - Edinburgh Handedness Assessment, Questionnaire - QuickDash, Questionnaire - EORTC QLQ-CIPN20
- Where
- Belgium
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Peripheral Neuropathies, Environmental Risk Factor
Environmental Factors Associated With Peripheral Neuropathies in French Guiana
Peripheral neuropathies (PN) affect 1% of the global population, particularly the elderly. About 20-30% of cases remain unexplained.
- Conditions
- Peripheral Neuropathies, Environmental Risk Factor, Lead Neuropathy, Mercury Neuropathy
- Trial name
- YANANER (NCT07341997)
- Testing
- Case Group
- Where
- 2 sites in French Guiana
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Admin CIC
Diabetic Peripheral Neuropathy (DPN)
Thymoquinone as an add-on Therapy for the Management of Patients With Diabetic Peripheral Neuropathy
The goal of this clinical trial is to evaluate the efficacy of thymoquinone as an adjuvant treatment with pregabalin in the management of diabetic peripheral neuropathy for both sexes older than 18 years.
- Trial name
- TQDPN (NCT07313111)
- Testing
- stander treatment pregabalin, thymoquinone
- Where
- Iraq
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hawler Medical University
Diabete Mellitus, Peripheral (Sensorimotor) Diabetic Polyneuropathy
Neurophysiological, Autonomic, and Sonographic Assessment of Diabetic Peripheral Neuropathy
Diabetic peripheral neuropathy causes pain, sensory loss, and foot risk; multimodal assessment enables earlier diagnosis and improved patient management.
- Trial name
- NCT07306884
- Testing
- Nerve conduction study, Nerve ultrasound, Autonomic assessment
- Where
- Egypt
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Assiut University
Amyotrophic Lateral Sclerosis (ALS), Peripheral Neuropathies
Translating Single-cell Vulnerability Into Novel ALS Biomarkers and Therapeutic Targets: Towards a Liquid Nerve Biopsy
The progress of ALS research and clinical practice is hampered by lack of effective biomarkers to monitor disease onset and progression.
- Trial name
- TUNEABLE (NCT07268833)
- Where
- 4 sites in Italy
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Diabete Mellitus, Diabete Type 2
A Pilot Study of the Effectiveness of Foot-Ankle and Walking Exercises in Patients With Diabetes Mellitus
This pilot feasibility and exploratory study, conducted to prepare for a definitive Randomized Controlled Trial (RCT), compares a structured foot-ankle exercise program with a walking exercise program in adults with Diabetes…
- Conditions
- Diabete Mellitus, Diabete Type 2, Diabetic Peripheral Neuropathy, Diabetic Foot
- Trial name
- NCT07270328
- Testing
- Foot-ankle exercise group, Walking exercise group, Control group
- Where
- 3 sites in Indonesia
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Guillain Barré Syndrome, Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Our Study Aims to Determine if Nerve Alterations in Acute GBS and CIDP Detectable by Ultrasound Match Electrodiagnostic Findings and if This Method Aids Early Diagnosis, Predict Their Outcomes and Differentiate Between Axonal and Demyelinating Subtypes.
Neuromuscular ultrasound (NMUS) is emerging as a valuable non-invasive diagnostic tool. In GBS, NMUS can detect proximal nerve enlargement early, before neurophysiological changes.
- Conditions
- Guillain Barré Syndrome, Chronic Inflammatory Demyelinating Polyradiculoneuropathy, Peripheral Nerve Disorder, Peripheral Nerves US
- Trial name
- NCT06615622
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Neuropathy;Peripheral
Short Duration Electrical Stimulation to Improve Outcomes After Cubital Tunnel Release (SELECT) Trial
A novel temporary peripheral nerve stimulation system that delivers electrical stimulation therapy in a cubital tunnel release model will be evaluated for feasibility.
- Trial name
- SELECT (NCT05980767)
- Testing
- Temporary Peripheral Nerve Stimulation System
- Where
- 2 sites in Canada
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Epineuron Technologies Inc.
Multiple Sclerosis, Parkinson Disease
Gait and Balance Impairment in Rare and Very Rare Neurological Diseases
Rare and very rare neurological diseases primarily or exclusively affect the nervous system with a prevalence of < 5 out of 10'000 and 100'000 people, respectively.
- Conditions
- Multiple Sclerosis, Parkinson Disease, Peripheral Neuropathy, Rare Diseases
- Trial name
- GALVANISE (NCT06343558)
- Testing
- Questionnaires, clinical scales and instrumental tests
- Where
- 2 sites in Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Chemotherapy-induced Peripheral Neuropathy, Tibial Neuropathy
Tibial Nerve Elastography in Chemotherapy-Induced Neuropathic Pain
This observational study aims to evaluate the tibial nerve stiffness using Shear Wave Elastography (SWE) in patients with chemotherapy-induced peripheral neuropathy (CIPN) compared to healthy volunteers.
- Trial name
- NCT07048431
- Testing
- Shear Wave Elastography Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ankara Etlik City Hospital
Diabetic Peripheral Neuropathy
Corneal Nerves Function and Structure
Peripheral neuropathy affects about 50% of the diabetic population and there is no treatment other than good blood glucose control, which is ineffective in subjects with type 2 diabetes.
- Trial name
- NCT04222660
- Testing
- Blackmores Omega Daily (4 1g capsules per day)
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Chronic Pain, Peripheral Neuropathy
StimRouter Registry Clinical Protocol
This Registry study will prospectively evaluate the long-term effectiveness, safety, and tolerability of the StimRouter Neuromodulation System, along with evaluating the technical performance of StimRouter, surgical outcomes…
- Conditions
- Chronic Pain, Peripheral Neuropathy, Nervous System Diseases, Peripheral Nervous System Diseases
- Trial name
- NCT03913689
- Testing
- StimRouter Neuromodulation System
- Where
- 9 sites in United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Bioness Inc
Peripheral Neuropathy
Pharmacological Modulation of Peripheral Nerve Excitability
The present project is a human experimental study. The aim is to assess the pharmacologically modulated excitability of peripheral sensory nerves with a human experimental model.
- Trial name
- NCT06312254
- Testing
- Topical lidocaine 5%, Topical Phenytoin 10%, Topical Mepyramine 2%
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Peripheral Neuropathy
Multimodal Ultrasound in Peripheral Neuropathy
This study will enforce the role of ultrasound in early diagnosis and screening on peripheral neuropathy in comparison with other modalities.
- Trial name
- NCT06711133
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Chemotherapy-induced Peripheral Neuropathy
Neural and Immune Correlates of CIPN and Possible Analgesic Effect of Non-invasive Motor Cortex Stimulation
Over half of cancer patients receiving common chemotherapy treatments experience painful nerve damage called chemotherapy-induced peripheral neuropathy (CIPN).
- Trial name
- NIBS4CIPN (NCT06522685)
- Testing
- transcranial direct current stimulation Soterix REMOTE 1x1 miniCT
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Morgan State University
Safety, Peripheral Neuropathy
Xanamem™ in Healthy Elderly Subjects
Xanamem™ is being developed as a potential drug for Alzheimer's disease. This study drug has been designed to change the cortisol levels in the brain. Cortisol is a naturally occurring hormone in the body.
- Conditions
- Safety, Peripheral Neuropathy, Cortisol, Central Nervous System
- Trial name
- XanaHES (NCT03830762)
- Testing
- Xanamem
- Where
- Australia
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Actinogen Medical