Clinical trials: Peripheral Neuropathic Pain
Complex Regional Pain Syndromes
Feasibility Study of Combined Peripheral Nerve Block and Physiotherapy for CRPS
Chronic pain is a debilitating condition affecting 1 in 5 Canadians with a yearly economic cost of over $40 billion in healthcare spending and loss of productivity.
- Trial name
- NCT05589259
- Testing
- Axillary Brachial Plexus Block plus Physiotherapy, Physiotherapy alone
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tracy Cupido
Neuropathic Pain
Cyclization of Motor Cortex Stimulation
Motor cortex stimulation (MCS) is a form of brain stimulation for patients with neuropathic pain not responsive to medication. An electrode is placed on the surface of the brain and connected to a programmable battery in the…
- Trial name
- NCT02465918
- Testing
- motor cortex stimulation (Change of Stimulation Timing)
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- University of British Columbia
Postherpetic Neuralgia
Evaluation of Civamide Patch in Treatment of Postherpetic Neuralgia and Post-Incisional Neuralgia
This proof of concept study is designed to evaluate the safety and efficacy of topically administered Civamide Patch for the treatment of moderate to severe daily pain associated with postherpetic neuralgia localized to the…
- Trial name
- NCT00845923
- Testing
- Civamide Patch
- Where
- 4 sites in United States, Canada
- Volunteers
- 22 people
- Sponsor
- Winston Laboratories
Chemotherapy-Induced Peripheral Neuropathy, Hematopoietic and Lymphoid System Neoplasm
Assessing Effect of Spinal Cord Stimulation on Pain and Quality of Life With Chemotherapy-Induced Peripheral Neuropathy
This study examines how spinal cord stimulation (SCS) affects pain level and quality of life in patients experiencing chemotherapy-induced peripheral neuropathy (CIPN).
- Conditions
- Chemotherapy-Induced Peripheral Neuropathy, Hematopoietic and Lymphoid System Neoplasm, Malignant Solid Neoplasm
- Trial name
- NCT05411523
- Testing
- Quality-of-Life Assessment, Questionnaire Administration, Spinal Cord Stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Carpal Tunnel Syndrome (CTS), Peloidotherapy
Efficacy of Paraffin Bath and Peloidotherapy in Carpal Tunnel Syndrome
Patients diagnosed with mild and moderate idiopathic CTS will be randomly divided into three groups. Patients who received 15 sessions of peloid therapy along with a home exercise program will constitute the first group.
- Conditions
- Carpal Tunnel Syndrome (CTS), Peloidotherapy, Paraffin Bath, Exercise
- Trial name
- NCT06986668
- Testing
- Peloidotherapy, paraffin bath, home exersize
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Konya Beyhekim Training and Research Hospital
Breast Cancer, Chemotherapy-induced Peripheral Neuropathy (CIPN)
Chinese Medicinal Component Relieves CIPN and Mitochondria Function
A randomized controlled trial was designed and conducted to confirm whether oral administration of the herb Moutan Cortex, which contains paeonol, can alleviate peripheral neuropathy in paclitaxel-treated cancer patients.
- Trial name
- NCT07693374
- Testing
- Moutan cortex
- Where
- Taiwan
- Sponsor
- Taiwan Municipal An-Nan Hospital-China Medical University
Neuralgia, Postherpetic
Safety and Effectiveness of Repeated Administration of QUTENZA Patches for Treatment of Pain Caused by Nerve Damage
In this study all patients will be treated with the same medicine, the QUTENZA patch. Subjects will receive up to 6 QUTENZA patch applications over 12 months.
- Trial name
- STRIDE (NCT01252160)
- Testing
- QUTENZA
- Where
- 64 sites in Austria, Belgium and 14 more
- Volunteers
- 306 people
- Sponsor
- Astellas Pharma Inc
Head and Neck Cancer (H&N)
Evaluating Avive+ Soft Tissue Matrix for Prevention of Superficial Radial Nerve Morbidity Following Radial Forearm Free Flap Harvest
Radial forearm free flap (RFFF) reconstruction is commonly used for head and neck defects but is associated with donor-site morbidity, including neuropathic pain and sensory disturbance.
- Trial name
- NCT07558096
- Testing
- Standard Closure (Control), Avive+ Intervention
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Alabama at Birmingham
Diabetic Neuropathy With Neurologic Complication
Observational Study of the the Use of a Trigeminal Vagal Nerve Stimulator in the Routine Care of Native Americans With Diabetic Neuropathy Pain. Pain Scores, Drug Use and Glucose Measurements Will be Assessed
This is an observational study that will follow patients in the course of routine care and measure pain levels, glucose assessments and drug utilization for native American patients with diabetic neuropathy
- Trial name
- NCT07025356
- Testing
- Implantation of a trigeminal Vagus cervical nerve stimulator system, Implantation of a neurostimulator system for trigeminal vagal cervical nerve stimulation
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Vagus Nerve Society
Complex Regional Pain Syndrome, Type I
Study to Evaluate the Efficacy and Safety of Lenalidomide in the Treatment of Complex Regional Pain Syndrome Type 1
The purpose of this multicenter, double-blind, placebo-controlled study is to evaluate the efficacy and safety of Lenalidomide in adult subjects with Complex Regional Pain Syndrome (CRPS) Type 1.
- Trial name
- CRPS-002 (NCT00109772)
- Testing
- lenalidomide
- Where
- 27 sites in United States
- Volunteers
- 184 people
- Sponsor
- Celgene Corporation
Back Pain, Failed Back Surgery Syndrome
Epidural Pulsed Radiofrequency Treatment in Failed Back Surgery Syndrome
Low back pain can persist in some patients with history of back surgery. In some cases, an increase in pain may even occur, and chronic pain may make treatment more difficult.
- Conditions
- Back Pain, Failed Back Surgery Syndrome, Neuropathic Pain
- Trial name
- NCT06239857
- Testing
- Epidural pulsed radiofrequency
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Chronic Pain, Neuralgia
Acupuncture Versus Conventional Treatment for Chronic Pain in Patients With Chronic Kidney Disease
This study evaluated acupuncture plus optimized conventional pharmacological treatment compared with optimized conventional pharmacological treatment alone for chronic pain in adults with chronic kidney disease receiving…
- Conditions
- Chronic Pain, Neuralgia, Renal Insufficiency,Chronic
- Trial name
- NCT07891819
- Testing
- Acupuncture, Optimized conventional pharmacological treatment
- Where
- Brazil
- Volunteers
- 110 people
- Sponsor
- Federal University of São Paulo
Tarsal Tunnel Syndrome
Tarsal Tunnel Syndrome and Fibromyalgia
Widespread pain is observed in patients diagnosed with fibromyalgia, and lower extremity and foot pain are also common. In our study, we aimed to evaluate the relationship between foot pain and tarsal tunnel syndrome in female…
- Trial name
- NCT05135572
- Testing
- Fibromiyalgia and foot pain
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Kutahya Health Sciences University
Radiculopathy, Musculoskeletal Diseases
Clinical Effectiveness of High-Intensity Laser Therapy in Patients With Cervical Radiculopathy:
This investigation aims to investigate the effect of high intensity laser therapy on radicular symptoms, neuropathic pain, cervical range of motion and quality of life in patients with cervical radiculopathy compared to cervical…
- Conditions
- Radiculopathy, Musculoskeletal Diseases, Cervical Pain, Cervical Radicular Pain
- Trial name
- NCT04734977
- Testing
- High-intensity laser therapy (HILT), Therapeutic Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Afyonkarahisar Health Sciences University
Neck Pain, Radiculopathy, Cervical
Repeated Transforaminal Anesthetic Injections With or Without Glucocorticoid in Patients With Cervical Radiculopathy
The main objective is to evaluate pain and muscle strength in the upper extremities after treatment with cervical transforaminal injection of glucocorticoid vs.
- Conditions
- Neck Pain, Radiculopathy, Cervical, Cervical Foraminal Stenosis, Cervical Disc Disease
- Trial name
- NCT03541681
- Testing
- Glucocorticoid Injections, Anesthetic Injections
- Sponsor
- Region Skane
Cervical Radiculopathy
Efficacy Of Gross Myofascial Release With Neural Mobilization Versus Neural Mobilization Alone On Pain, Functional Limitations, And Cervical Range Of Motion In Cervical Radiculopathy
This is a randomized control trial aims to evaluate the efficacy of gross myofascial release with neural mobilization versus neural mobilization alone on pain, functional limitations, and cervical range of motion in cervical…
- Trial name
- NCT07808476
- Testing
- Gross Myofascial Release + Neural Mobilization, Neural Mobilization
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- Ibadat International University, Islamabad
Neuropathic Pain
Intravenous Immunoglobulin (IVIG) for Resistant Neuropathic Pain
This project addresses a vexing problem that has alluded the best efforts of the medical/scientific community: treatment of resistant neuropathic pain.
- Trial name
- NCT00850005
- Testing
- Intravenous immunoglobulin, Normal Saline
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of Calgary
Neuropathic Pain, Neuralgia
Study to Evaluate the Efficacy of Lithium Carbonate in Spinal Cord Injury Patients With Neuropathic Pain
To investigate the efficacy of lithium carbonate in the treatment of neuropathic pain of patients with spinal cord injury.
- Conditions
- Neuropathic Pain, Neuralgia, Spinal Cord Injuries
- Trial name
- NCT01855594
- Testing
- Lithium Carbonate
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- China Spinal Cord Injury Network
Diabetic Neuropathies
tSCS and AR on Pain and Balance in Diabetic Peripheral Neuropathy
tSCS and AR-based training have individually shown benefits in neuromotor rehabilitation; no study to date has evaluated their combined effects on pain, balance, lower-limb strength, retention, and vibration sense in diabetic…
- Trial name
- NCT07619794
- Testing
- transcutaneous spinal cord stimulation, Augmented Reality
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Acute Sciatica
A Comparative Effectiveness Randomised Placebo Controlled Pilot Trial of the Management of Acute Lumbar Radicular Pain
Aim: In subjects with acute sciatica (≤ 4 weeks duration), this is a pilot comparative effectiveness study to evaluate feasibility and to determine final sample size for a future adequately powered randomised controlled trial of…
- Trial name
- SCIATICA (NCT03240783)
- Testing
- Betamethasone OR Dexamethasone Injectable, Normal Saline Flush, 0.9% Injectable Solution, Dexamethasone Oral Tablet
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- St George Hospital, Australia