Clinical trials: Peripheral Nervous System Diseases
Diabetes, Peripheral Neuropathy
WIREDUP: Wearable Insoles for Recurrent Diabetic Ulcer Prevention
The primary aim of this study is to demonstrate the impact of the Orpyx® Sensory Insoles (Orpyx Medical Technologies Inc., Calgary AB, Canada) ("Orpyx" or "the Company") as an adjunct to the standard of care (SOC), as compared to…
- Conditions
- Diabetes, Peripheral Neuropathy, Diabetic Foot, Diabetic Foot Ulcer
- Trial name
- WIREDUP (NCT05950659)
- Testing
- Orpyx Sensory Insole System
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Johns Hopkins University
Diabetes, Peripheral Neuropathy
Wearable Insoles for Recurrent Diabetic Ulcer Prevention
The primary objective of the study is to demonstrate the clinical advantages of using the Orpyx SI Sensory Insole (SI) system as an adjunct to standard of care in reducing plantar ulceration in high-risk individuals.
- Conditions
- Diabetes, Peripheral Neuropathy, Diabetic Foot Ulcer
- Trial name
- WIREDUP (NCT07674420)
- Testing
- Orpyx Sensory Insole System
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Johns Hopkins University
Neuropathic Pain, Distal Sensory Polyneuropathy
Effects of LY3848575 Versus Placebo in Participants With Painful Distal Sensory Polyneuropathy
The purpose of this study is to evaluate how safe and how well a treatment works compared to placebo for people with nerve pain that begins in their feet and moves up the leg to just below the knee.
- Trial name
- NCT06568042
- Testing
- LY3848575
- Where
- 76 sites in United States, Canada and 5 more
- Volunteers
- 558 people
- Sponsor
- Eli Lilly and Company
HIV Infections
Effects of TENS and Mindfulness Meditation in Persons With HIV-related Neuropathy
This study is to explore the effects of transcutaneous nerve stimulation (TENS) and mindfulness meditation in persons living with HIV (PLHIV) and painful neuropathy in the feet.
- Trial name
- NCT04868123
- Testing
- Transcutaneous Nerve Stimulation (TENS), Mindfulness Meditation
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Rutgers University
Peripheral Neuropathy
Innovative Treatment of Chemotherapy-Induced Painful Peripheral Neuropathy in Adolescents and Young Adults With Cancer: A Two Arm Pilot Study
To evaluate the efficacy and safety of Scrambler therapy (ST) for chemotherapy-induced painful peripheral neuropathy (CIPN), and the impact of ST on physical functioning and quality of life (QoL) in adolescents and young adults…
- Trial name
- NCT05357469
- Testing
- Immediate St (Scrambler Therapy), Waitlist ST (Scrambler Therapy)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- M.D. Anderson Cancer Center
Peripheral Neuropathy, Neuro-Degenerative Disease
A Prospective Natural History and Outcome Measure Discovery Study of Charcot-Marie-Tooth Disease, Type 4J
This is a multicenter, longitudinal, prospective observational natural history study of subjects with a molecularly confirmed diagnosis of CMT4J.
- Conditions
- Peripheral Neuropathy, Neuro-Degenerative Disease, Neuromuscular Diseases
- Trial name
- CMT4J (NCT06151600)
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Elpida Therapeutics SPC
Multi-drug Resistant Tuberculosis, Extensively Drug Resistant Tuberculosis
TBTC Study 30: Safety and Tolerability of Low Dose Linezolid in MDR TB
This study evaluated the safety and tolerability of low-dose linezolid (600 mg once daily) administered for 16 weeks as part of an optimized background regimen for the treatment of multidrug-resistant tuberculosis (MDR-TB).
- Trial name
- LiMiT (NCT00664313)
- Testing
- Linezolid
- Where
- South Africa
- Volunteers
- 36 people
- Sponsor
- Centers for Disease Control and Prevention
Chemotherapy Induced Peripheral Neuropathy
Randomized Clinical Investigation of Photobiomodulation (PBM) for the Management of Early Peripheral Neuropathy Related to Medical Oncologic Therapy
Chemotherapy-induced peripheral neuropathy (CIPN) is one of the common complications of cancer treatment and involves paresthesia, numbness and/or burning pain in distal limbs.
- Trial name
- ENL (NCT07681921)
- Testing
- Photobiomodulation
- Where
- Belgium
- Volunteers
- 98 people
- Sponsor
- Jules Bordet Institute
Chemotherapy Induced Peripheral Neuropathy
Self-applied taVNS for CIPN
The purpose of this study is to determine the feasibility of using a portable device at home to self-administer transcutaneous auricular vagus nerve stimulation (taVNS).
- Trial name
- NCT07596030
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Miami
Peripheral Neuropathy With Type 2 Diabetes, Peripheral Neuropathy Grade 2 or Greater
Wearable Sensory Prosthesis to Improve Coordination, Walking, and Physical Activity
The goal of this clinical trial is to investigate whether sensory stimulations from a neuroprosthesis device (Walkasins®) can increase physical activity and improve gait quality in persons with peripheral neuropathy (PN).
- Conditions
- Peripheral Neuropathy With Type 2 Diabetes, Peripheral Neuropathy Grade 2 or Greater, Balance, Balance Impairment, Gait Disorders, Fatigue
- Trial name
- NCT07554443
- Testing
- External, lower limb sensory prosthesis
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- RxFunction Inc.
Bladder Cancer, Metastatic Urothelial Carcinoma
Sacituzumab Tirumotecan vs MMAE-ADCs in Advanced Urothelial Carcinoma (FUSCC-SPARE-UC-01)
The main goal of this clinical trial is to learn if a new targeted cancer drug called sacituzumab tirumotecan (sac-TMT) works to treat cancer while causing less nerve damage in patients with advanced urothelial carcinoma who have…
- Conditions
- Bladder Cancer, Metastatic Urothelial Carcinoma, Urothelial Carcinoma, Peripheral Neuropathy
- Trial name
- SPARE-UC-01 (NCT07662863)
- Testing
- Sacituzumab Tirumotecan, MMAE-based ADC, Sacituzumab Tirumotecan (Observational Cohort)
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Fudan University
Electroacupuncture, Chemotherapy
Electroacupuncture for Preventing Chemotherapy-Induced Peripheral Neuropathy in Patients With Early-stage Cancer
This randomized controlled clinical trial aims to clarify the clinical efficacy and safety of electroacupuncture combined with thumbtack needle for the prevention of chemotherapy-induced peripheral neuropathy(CIPN), and to…
- Conditions
- Electroacupuncture, Chemotherapy, Peripheral Neuropathy, Early Stage Cancer
- Trial name
- NCT07663396
- Testing
- True electroacupuncture, True thumbtack needle
- Where
- China
- Volunteers
- 278 people
- Sponsor
- Affiliated Hospital of Qinghai University
Anti MAG Neuropathy
This Study Aims to Investigate the Efficacy of Photobiomodulation in the Treatment of Anti-MAG-induced Peripheral Neuropathy (LASER-MAG)
Patients treated in the hematology department of the Quimper/Cornouaille Hospital Center for IgM monoclonal gammopathy with anti-MAG and symptomatic peripheral neuropathy often reach a therapeutic impasse.
- Trial name
- LASER-MAG (NCT07661667)
- Testing
- photobiomodulation
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier de Cornouaille
Carpal Tunnel Syndrome
Combined Manual Therapy and Percutaneous Neuromodulation for Moderate Carpal Tunnel Syndrome
Carpal tunnel syndrome (CTS) is the most common peripheral entrapment neuropathy and can cause pain, numbness, tingling, and functional impairment of the hand.
- Trial name
- MANUCTS (NCT07654621)
- Testing
- Combined Manual Therapy and Ultrasound-Guided Percutaneous Neuromodulation, Postsurgical Rehabilitation
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Universidad Europea de Valencia
Childhood Cancer
Patients At Risk for Sensory Screening (HPARSS) to Enhance Sensory Deficit Screening in Childhood Cancer Survivors
The overall goal of this study is to attempt to overcome the organizational barriers that impede prompt screening for at-risk sensory deficits in childhood cancer survivors (CCS).
- Trial name
- NCT05582551
- Testing
- Highlighting Patients at Risk for Sensory Screening (HPARSS)
- Where
- United States
- Volunteers
- 146 people
- Sponsor
- Washington University School of Medicine
Ankylosing Spondylitis, Peripheral Neuropathies
Assessment of Peripheral Neuropathy in Ankylosing Spondylitis
investigators hypothesized that peripheral neuropathy in ankylosing spondylitis is associated with higher disease activity, greater central sensitization, worse functional impairment, and poorer quality of life.
- Trial name
- NCT07641920
- Testing
- Nerve conduction study
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Assiut University
Electroacupuncture, Chemotherapy
Electroacupuncture for Preventing Chemotherapy-Induced Peripheral Neuropathy in Patients With Advanced Cancer
This randomized controlled clinical trial aims to clarify the clinical efficacy and safety of electroacupuncture combined with thumbtack needle for the prevention of chemotherapy-induced peripheral neuropathy(CIPN), and to…
- Conditions
- Electroacupuncture, Chemotherapy, Advanced Cancer, Peripheral Neuropathy
- Trial name
- NCT07644533
- Testing
- True electroacupuncture, True thumbtack needle
- Where
- China
- Volunteers
- 264 people
- Sponsor
- Affiliated Hospital of Qinghai University
Urothelial Carcinoma (UC), Peripheral Nerve Disease
Study of Peripheral Neuropathy in Patients With Advanced Urothelial Cancer Treated With Enfortumab Vedotin and Pembrolizumab With Supportive Neuridase (ENDEAVOR)
his prospective exploratory study aims to describe the course of peripheral neuropathy in patients with locally advanced or metastatic urothelial carcinoma treated with enfortumab vedotin in combination with pembrolizumab and…
- Trial name
- ENDEAVOR (NCT07629700)
- Testing
- enfortumab vedotin (EV), PEMBROLIZUMAB (alone or when added to a regimen above), Neuridase
- Volunteers
- 40 people
- Sponsor
- University of Florence
Chemotherapy-induced Peripheral Neuropathy (CIPN)
Trial of a Virtual Exercise-based Rehabilitation Program to Treat Persistent Chemotherapy-Induced Peripheral Neuropathy (CIPN)
The purpose of this study is to determine the effectiveness of the EX-CIPN program in reducing the strength of CIPN symptoms and CIPN-related disability and improving the ability to complete everyday activities.
- Trial name
- EX-CIPN (NCT07481149)
- Testing
- EX-CIPN
- Where
- Canada
- Volunteers
- 240 people
- Sponsor
- University Health Network, Toronto
Chemotherapy-induced Peripheral Neuropathy
Exercise-based Rehabilitation to Treat Persistent Chemotherapy Induced Peripheral Neuropathy (CIPN)
The goal of this clinical trial is to learn if the EX-CIPN exercise-based intervention is feasible, acceptable, and safe in participants with persistent chemotherapy-induced peripheral neuropathy (CIPN).
- Trial name
- EX-CIPN (NCT06405542)
- Testing
- EX-CIPN
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto