Clinical trials: Peripheral Diabetic Neuropathy, open to volunteers
Chronic Kidney Disease Stage 3 and 4, Diabetes
Prediction of Peripheral Neuropathy With Functional Testing
Diabetes and chronic kidney disease (CKD) are two distinct pathologies. The former is defined as an impairment in insulin production and/or utilization, while the latter refers to structural or functional abnormalities of the…
- Trial name
- PredictNP (NCT06933108)
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Université catholique de l'Ouest
Diabetic Peripheral Neuropathic Pain
Evaluation of Efficacy and Safety of VX-993 for Pain Associated With Diabetic Peripheral Neuropathy
The purpose of this study is to evaluate the efficacy, safety, and tolerability of VX-993 in participants with pain associated with Diabetic Peripheral Neuropathy (DPN)
- Trial name
- NCT06619860
- Testing
- VX-993, Pregabalin
- Where
- 47 sites in United States, Canada and 4 more
- Volunteers
- 300 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Diabetes Mellitus, Diabetic Foot Ulcer (DFU)
Risk Perception Intervention for High-Risk Diabetic Foot
This study aims to evaluate the effect of health education based on information framing effects on foot ulcer risk perception in patients at high risk of diabetic foot.
- Conditions
- Diabetes Mellitus, Diabetic Foot Ulcer (DFU), Risk Perception, Peripheral Neuropathy With Type 2 Diabetes
- Trial name
- NCT07581262
- Testing
- Gain-Framed, Loss-Framed, Routine Care
- Volunteers
- 90 people
- Sponsor
- The Third Affiliated Hospital of Soochow University
Painful Diabetic Neuropathy (PDN), Diabetic Neuropathy
Efficacy and Feasibility of BurstDR SCS in Painful Diabetic Neuropathy
This prospective, single-arm clinical study evaluates the therapeutic efficacy and feasibility of BurstDR spinal cord stimulation (SCS) using Abbott's Proclaim XR and Eterna systems in patients with painful diabetic neuropathy…
- Conditions
- Painful Diabetic Neuropathy (PDN), Diabetic Neuropathy, Neuropathic Pain, Chronic Pain
- Trial name
- ABBT DPN (NCT07250828)
- Testing
- BurstDR Spinal Cord Stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- TriCity Research Center
Diabetes Mellitus, Type 2, Diabetic Foot
Non-invasive Imaging for In-vivo Quantification of Skin Composition and Structure
The goal of this clinical investigation is to explore a non-invasive technology for measuring the microcirculatory structure, composition and function in patients from a primary care population. The main aims are: 1.
- Conditions
- Diabetes Mellitus, Type 2, Diabetic Foot, Peripheral Arterial Disease, Skin Cancer
- Trial name
- Spectrum1 (NCT06976073)
- Where
- 3 sites in Sweden
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- HJN Sverige AB/Neko Health
Diabetic Peripheral Neuropathy
Adaptive Gamified Sensory Training on Sensory Function and Limb-Specific Functional Performance in Patients With Diabetic Peripheral Neuropathy
Diabetic peripheral neuropathy (DPN) will be considered a clinically important complication of diabetes mellitus that may impair sensory function and interfere with the performance of daily activities involving the hands and…
- Trial name
- NCT07907289
- Testing
- Adaptive Gamified Sensory Training, Conventional Physical Therapy Group
- Volunteers
- 40 people
- Sponsor
- Al-Zaytoonah University of Jordan
Diabetic Foot Ulcer
Placental Cells for Diabetic Foot Ulcers
The purpose of this research study is to test the safety of placental stem cells to treat non-healing diabetic foot ulcers.
- Trial name
- NCT07686094
- Testing
- Placenta Stem Cells
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Wake Forest University Health Sciences
Diabetic Neuropathy
Effect of Reiki on Neuropathic Pain Severity and Sleep Quality in Patients With Diabetic Neuropathy
The study is planned to be conducted in a mixed research design with quantitative and qualitative types. The quantitative phase of the study was planned as a single-blind, randomized controlled study with Reiki group, Sham Reiki…
- Trial name
- NCT06668623
- Testing
- Reiki Group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- TC Erciyes University
Type 2 Diabetes Mellitus, Diabetic Neuropathy
GlucoBites Cookies (Gynura Procumbens) for Glycemic Control and Prevention of Diabetic Foot Ulcer Risk in Type 2 Diabetes
The goal of this randomized controlled trial is to learn if GlucoBites functional cookies containing Gynura procumbens can help improve blood sugar control and lower the risk of diabetic foot ulcers in adults with type 2…
- Trial name
- GlucoBites (NCT07151833)
- Testing
- GlucoBites (with Gynura procumbens), Control Cookies (without Gynura procumbens)
- Where
- Indonesia
- Volunteers
- 126 people
- Sponsor
- Andina Setyawati
Painful Diabetic Neuropathy (PDN), Diabetic Nephropathies
Modality Choice Before and After Failure for the Treatment of Painful Diabetic Neuropathy
The research team will perform a comparative-effectiveness sequential, multiple assignment, randomized trial in painful diabetic neuropathy (PDN) patients for 8 total months, divided into two 4-month stages.
- Trial name
- MCPAIN (NCT07795593)
- Testing
- Cognitive Behavioral Therapy (CBT), Oral Medication, Topical Medication
- Where
- 23 sites in United States
- Volunteers
- 600 people
- Sponsor
- University of Michigan
Diabetes Mellitus, Claudication, Intermittent
Additional Hyperbaric Oxygen After Lower Extremity Amputation
This study evaluates the effect of additional hyperbaric oxygen therapy after lower extremity amputation. The patients will be randomized after amputation to either a treatment group receiving hyperbaric oxygen therapy, or…
- Conditions
- Diabetes Mellitus, Claudication, Intermittent, Critical Limb Ischemia, Osteomyelitis
- Trial name
- AHOLEA (NCT03594344)
- Testing
- Hyperbaric oxygen therapy
- Where
- 2 sites in Norway
- Volunteers
- 120 people
- Sponsor
- Oslo University Hospital
Diabetic Peripheral Neuropathy
Spinal Cord Stimulation and Small Fiber Peripheral Neuropathy
This is a prospective randomized control trial. Participants enrolled into the study will be randomized into one of three groups, two of which are treatment groups and the third is a control group.
- Trial name
- NCT06287736
- Testing
- Spinal Cord Stimulator Implantation (SCS)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Ohio State University
Diabetic Polyneuropathy
Effect of Feldenkrais Method in Enhancing Postural Control for Patients with Diabetic Polyneuropathy
Background: Postural Control is a major complication of polyneuropathy, affecting patients suffering from diabetes mellitus. Purpose: To examine the effect of the Feldenkrais Method on dynamic balance, limits of stability and…
- Trial name
- FeM (NCT06904417)
- Testing
- The Feldenkrais-based intervention, conventional balance training program
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Cairo University
Neurologic Disorders, Nervous System Diseases
Neurologic Stem Cell Treatment Study
This is a human clinical study involving the isolation of autologous bone marrow derived stem cells (BMSC) and transfer to the vascular system and inferior 1/3 of the nasal passages in order to determine if such a treatment will…
- Conditions
- Neurologic Disorders, Nervous System Diseases, Neurodegenerative Diseases, Neurological Disorders
- Trial name
- NEST (NCT02795052)
- Testing
- Intravenous and Intranasal BMSC
- Where
- 3 sites in United States, United Arab Emirates
- Volunteers
- 500 people
- Sponsor
- MD Stem Cells
Diabetic Peripheral Neuropathy (DPN)
Ultrasound Assessment of Sciatic Nerve and Inferior Gluteal Artery in Diabetic Peripheral Neuropathy(DPN): Association With a Target Gene
Diabetic peripheral neuropathy (DPN) is a common and serious complication of diabetes that causes numbness, pain, and weakness, often starting in the feet.
- Trial name
- NCT07595887
- Testing
- No intervention (observational study)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Second Hospital of Shanxi Medical University
Diabetic Peripheral Neuropathy
Effects of Perturbation-Based Versus Conventional Balance Training on Reactive Stepping Ability in Patients With Diabetic Peripheral Neuropathy
This study will compare perturbation-based balance training (PBBT) with conventional balance training in patients with diabetic peripheral neuropathy to assess reactive stepping ability, dynamic balance, and functional balance.
- Trial name
- NCT07902297
- Testing
- Perturbation-Based Balance Training (PBBT), Conventional Balance Training (CBT)
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Diabetic Foot Ulcer (DFU)
Evaluating the Efficacy of FoundationDRS Solo in Addition to Standard of Care for the Treatment of Non-healing Diabetic Foot Ulcers
The goal of this clinical trial is to learn if using FoundationDRS Solo improves healing of chronic, non-healing foot ulcers in diabetic patients.
- Trial name
- NCT07290673
- Testing
- FoundationDRS Solo, Standard of Care
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Samaritan Biologics
Diabetic Nephropathy Type 2
Vitamin D in Diabetic Neuropathy
Introduction Diabetic peripheral neuropathy (DPN) is among the most common chronic complications of diabetes mellitus and represents a major cause of morbidity, impaired quality of life, sleep disturbance, chronic pain, and…
- Trial name
- NCT07644520
- Testing
- Vitamin D
- Volunteers
- 150 people
- Sponsor
- Tanta University
Diabetic Peripheral Neuropathy, Diabetes Mellitus
Innovative Multi-Variable Biofeedback for Improving Gait Performance in Individuals With Diabetic Peripheral Neuropathy
This study aims to collect data to improve gait function in individuals with Diabetic Peripheral Neuropathy (DPN). The primary goals are to evaluate: Biomechanical mechanisms contributing to abnormal plantar pressure and…
- Trial name
- NCT06591780
- Testing
- Clinical Evaluation, Plantar Pressure Biofeedback Gait Training, Propulsion Biofeedback Gait Training
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Florida Institute for Human and Machine Cognition
Chronic Limb-Threatening Ischemia, Diabetic Foot Ulcer
Seltoplasmid Plus Revascularization for Diabetic Infrapopliteal Chronic Limb-Threatening Ischemia
The goal of this clinical trial is to learn whether Seltoplasmid Injection can improve outcomes after lower-extremity revascularization. Revascularization is a procedure used to restore blood flow to the leg.
- Conditions
- Chronic Limb-Threatening Ischemia, Diabetic Foot Ulcer, Infrapopliteal Arterial Occlusive Disease
- Trial name
- NCT07827521
- Testing
- Lower-Extremity Revascularization, Donaperminogene Seltoplasmid
- Where
- 6 sites in China
- Volunteers
- 180 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University