Clinical trials: Peripheral Diabetic Neuropathy
Diabetic Autonomic Neuropathy, Gastrointestinal Motility Disorder
Gastrointestinal Motility Among Diabetes Patients
Gastrointestinal (GI) symptoms including vomiting, nausea, abdominal pain, constipation or chronic diarrhea affect a large number of patients with diabetes mellitus (DM).
- Conditions
- Diabetic Autonomic Neuropathy, Gastrointestinal Motility Disorder, Diabetes Mellitus, Change of Transit or Circulation
- Trial name
- NCT02573519
- Testing
- 11C Donepezil PET/CT scan, 3D-Transit, 3D-Transit during treatment with Pyridostigmine
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Diabetic Peripheral Neuropathy
Electrical Stimulation for Improving Balance in Diabetes
This is a double-blind randomized clinical trial. Both patients and the podiatrist that will evaluate and monitor study patients will be blinded to electrical stimulation application.
- Trial name
- NCT02337218
- Testing
- SENSUS Pain Management System
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Texas Southwestern Medical Center
Neuropathy Autonomic, Cardiac Autonomic Neuropathy
Diabetic Neuropathy Rapid Screening Test in Turkish Patients With Type 2 Diabetes: Sudoscan
Neuropathy is a frequently observed complication occurring in 60-70% of diabetic patients throughout their lives. In addition, neuropathy is a severe disease that progresses insidiously; its diagnosis can be delayed due to the…
- Conditions
- Neuropathy Autonomic, Cardiac Autonomic Neuropathy, Type2Diabetes, Diabetic Neuropathy Peripheral
- Trial name
- NCT05299918
- Volunteers
- 437 people
- Sponsor
- Istanbul University
Painful Diabetic Neuropathy
Trazodone in Painful Diabetic Neuropathy
The aim of the study is to collect preliminary information on the effect of low doses of trazodone on pain intensity in patients with painful diabetic neuropathy and to evaluate the neuropathic pain symptoms, anxiety, sleep…
- Trial name
- NCT03202979
- Testing
- Trazodone 20 mg, Trazodone 10 mg
- Where
- 20 sites in Czechia, Hungary and 1 more
- Volunteers
- 142 people
- Sponsor
- Aziende Chimiche Riunite Angelini Francesco S.p.A
Diabetic Foot Ulcer (DFU)
Evaluating the Efficacy of FoundationDRS Solo in Addition to Standard of Care for the Treatment of Non-healing Diabetic Foot Ulcers
The goal of this clinical trial is to learn if using FoundationDRS Solo improves healing of chronic, non-healing foot ulcers in diabetic patients.
- Trial name
- NCT07290673
- Testing
- FoundationDRS Solo, Standard of Care
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Samaritan Biologics
Nephropathy, Hypoxia
Acute Effects of SGLT2 Inhibition on Renal Oxygenation and Autonomic Function in Type 1 Diabetes
Background: Inhibiting the sodium-glucose cotransporter-2 (SGLT2) has been observed to reduce risk of cardiovascular events and kidney failure in type 2 diabetes.
- Conditions
- Nephropathy, Hypoxia, Mitochondrial Alteration, Type 1 Diabetes
- Trial name
- Astronaut (NCT04193566)
- Testing
- Forxiga
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Steno Diabetes Center Copenhagen
Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
Prevalence and Risk Evaluation of Diabetic Complications of the Foot in A Large Canadian Population
The study aims to assess foot complications among patients with diabetes in Canada, using patient data collected during diabetes foot assessments performed by the LMC Chiropody Team between February 27, 2018 and April 17, 2019.
- Conditions
- Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1, Foot Deformities, Onychauxis
- Trial name
- PEDAL (NCT04327622)
- Where
- Canada
- Volunteers
- 5,084 people
- Sponsor
- LMC Diabetes & Endocrinology Ltd.
Type 2 Diabetes, Microvascular Function
The Effect of Pyridoxamine Supplementation on Microvascular Function in Type 2 Diabetes
Patients with type 2 diabetes have an increased risk of developing vascular complications. Microvascular dysfunction might be caused by the increased production of methylglyoxal under hyperglycaemic conditions.
- Conditions
- Type 2 Diabetes, Microvascular Function, Retinopathy, Diabetic, Nephropathy, Diabetic
- Trial name
- PYRAMID (NCT06376240)
- Testing
- Pyridoxamine 300mg per day
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Maastricht University Medical Center
Diabetic Neuropathy
Study of DA-9801 to Treat Diabetic Neuropathy
To evaluate the effectiveness of DA-9801 at 300mg, 600mg, 900mg and placebo, in reducing pain in subjects with diabetic neuropathic pain compared to their baseline values.
- Trial name
- NCT01822925
- Testing
- DA-9801 300mg, DA-9801 600mg, DA-9801 900mg
- Where
- 14 sites in United States
- Volunteers
- 128 people
- Sponsor
- NeuroBo Pharmaceuticals Inc.
Diabetic Neuropathy, Postural Balance
Additional Effects of Neural Mobilization on Pain, Balance and Quality of Life in Diabetic Neuropathy
Diabetic Peripheral Neuropathy (DPN) is a common complication of diabetes, affecting up to 50% of patients and causing pain, numbness, and balance impairments, which increase the risk of falls, ulcers, and reduced quality of…
- Conditions
- Diabetic Neuropathy, Postural Balance, Pain
- Trial name
- NCT07210203
- Testing
- Neural mobilization with Balance training with conventional physical Therapy, Balance Training only with conventional physical therapy
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Foundation University Islamabad
Painful Diabetic Peripheral Neuropathy (PDPN)
Cryoneurolysis for Painful Diabetic Neuropathy of the Foot
The study is a single-center, randomized, participant- and observer-masked, human-subjects, post-market clinical pilot study to investigate the use of ultrasound-guided percutaneous cryoneurolysis to treat diabetic neuropathy of…
- Trial name
- NCT06646731
- Testing
- cryoneurolysis
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Diego
Diabetic Peripheral Neuropathy
Ankle Proprioceptive Training In Patients With Diabetic Peripheral Neuropathy
Diabetes being a very prevalent condition results in various complications including neuropathy, which can impair various functional outcomes in patients including balance.
- Trial name
- NCT05848180
- Testing
- Ankle proprioceptive training (APT), Balance training (BT)
- Where
- Pakistan
- Volunteers
- 62 people
- Sponsor
- Riphah International University
Charcot Neuroarthropathy
Contact Cast Versus Posterior Slab as Offloading Modality for Charcot Neuroarthropathy
Charcot neuroarthropathy (CN) is a condition in diabetic patients characterized by foot swelling, redness, and a temperature difference exceeding 2˚C compared to the other foot.
- Trial name
- NCT06573554
- Testing
- Total Contact Cast, Posterior Slab
- Where
- India
- Volunteers
- 80 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Type 2 Diabetes
Effect of Arginine on Microcirculation in Patients With Diabetes
Patients with diabetes have dysfunction of the lining of the arteries which lead to impaired circulation in the small blood vessels. This is thought to be secondary to reduced chemicals in the blood viz: nitric oxide.
- Trial name
- NCT00902616
- Testing
- L-arginine
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Tameside Hospital NHS Foundation Trust
Small Fiber Neuropathy, Diabetic Neuropathies
Skin Biopsy in the Diagnosis of Small Fiber Neuropathy in Chinese Patients With Diabetes
To detect small fiber neuropathy in patients with possible or established diabetic peripheral neuropathy (DPN) by skin biopsy and explore clinical characteristics and pathological features in Chinese patients with diabetes.
- Conditions
- Small Fiber Neuropathy, Diabetic Neuropathies, Diabetes Mellitus
- Trial name
- NCT04071535
- Testing
- sudoscan、nerve conduction tests
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Diabetic Peripheral Neuropathic Pain (DPN), Diabetic Neuropathies
Cannabidiol for the Treatment of Diabetic Peripheral Neuropathy: Pilot Study
The "Cannabidiol for the Treatment of Diabetic Peripheral Neuropathy: Pilot study (CBD-DPN1)" is a double-blinded, placebo-controlled, crossover pilot study evaluating the efficacy of Cannabidiol (CBD) and full-spectrum CBD…
- Trial name
- CBD-DPN1 (NCT07298408)
- Testing
- Cannabidiol (CBD) oral solution, Full-Spectrum CBD hemp extract oral solution
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Florida A&M University
Diabetic Neuropathy
The Balance Control Mechanism of DPN Patients
This study will evaluate the balance ability of DPN (diabetic peripheral neuropathy)patients, which will help us to understand the relationship between peripheral and central nervous system, in order to early diagnosis and…
- Trial name
- NCT02606747
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Geheng Yuan
Diabetic Nephropathy, Diabetic Retinopathy
Anti-Nephropathic Effects of Chronic Intermittent Intravenous Insulin Therapy (CIIIT)
Investigators with the goal of optimizing glycemic and blood pressure control saw type 1 diabetic patients weekly. A control group received 3-4 subcutaneous insulin injections per day; an intravenous insulin pulsed infusion group…
- Trial name
- NCT00594152
- Testing
- CIIIT
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Joslin Diabetes Center
Painful Peripheral Diabetic Neuropathy
Nociceptive Pain Fiber Response
This study is designed to evaluate the effectiveness of the Provant Therapy System in improving localized nerve growth and skin perfusion in subjects with painful peripheral diabetic neuropathy of the foot.
- Trial name
- NCT02696070
- Testing
- Provant Therapy System
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Regenesis Biomedical, Inc.
Diabetes Mellitus, Diabetic Neuropathies
Enhancing Diabetic Foot Education by Viewing Personal Plantar Pressures
The purpose of this study is to examine the effectiveness of a novel patient education strategy, compared to a standard diabetic foot education.
- Conditions
- Diabetes Mellitus, Diabetic Neuropathies, Foot Complications
- Trial name
- DFE (NCT01941719)
- Testing
- Enhanced foot care education, Standard Foot Care Education
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Temple University