Clinical trials: Peripheral Diabetic Neuropathy
Skin Cancer, Skin Diseases
Multi-modal Quantitative Imaging of the Skin
This clinical trial is about evaluating the suitability of multi-modal imaging technology, which covers virtually the entire body, to evaluate the possibility of screening and early detection of disease.
- Conditions
- Skin Cancer, Skin Diseases, Atopic Dermatitis, Psoriasis
- Trial name
- DermaFlow (NCT06989216)
- Where
- 3 sites in Sweden
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- HJN Sverige AB/Neko Health
Diabetes Mellitus, Peripheral Neuropathy
Diabetes Peripheral Neuropathy and Small-fibre Nerve Damage: A Comparative Study
The purpose of this study is to investigate whether patients with diabetes-related peripheral neuropathic pain also have non-recognized damage to the intestine caused by autonomic neuropathy.
- Conditions
- Diabetes Mellitus, Peripheral Neuropathy, Small Fibre Neuropathy, Autonomic Neuropathy
- Trial name
- NCT01160887
- Where
- Norway
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Diabetic Peripheral Neuropathy, Fibromyalgia
Pharmacokinetics of Two Formulation of Pregabalin
A Randomized, Single-Dose, Parallel-Group Study to Evaluate the Pharmacokinetic Profiles of Two Formulations of Pregabalin after Oral Administration in Healthy Volunteers under Fasting Conditions
- Conditions
- Diabetic Peripheral Neuropathy, Fibromyalgia, Partial Seizure Disorder
- Trial name
- NCT03712475
- Testing
- Pregabalin
- Where
- Taiwan
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Yung Shin Pharm. Ind. Co., Ltd.
Diabetic Neuropathies, Diabetic Neuropathy Peripheral
A Study Evaluating Drug-Drug Interaction (DDI) Between HSK16149 Capsules and Metformin Hydrochloride Tablets
This study is a single-center, open, single-arm study, conducted in healthy Chinese populations, and plans to enroll 22 healthy adult subjects (the ratio of either sex is not less than 1/3).
- Trial name
- NCT04841720
- Testing
- HSK16149, Metformin Hydrochloride tablet, HSK16149+Metformin（phase 3）
- Where
- China
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Diabetes
Effects of Electromagnetic Therapy Versus Laser Therapy on Peripheral Diabetic Neuropathy
This study are to: Evaluate effect of magnetic therapy on peripheral neuropathy in diabetic patients. Evaluate effect of laser therapy on peripheral neuropathy in diabetic patients.
- Trial name
- NCT03049605
- Testing
- Magnetic therapy, laser therapy, Only medical treatment
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Imam Abdulrahman Bin Faisal University
Diabetic Autonomic Neuropathy, Gastrointestinal Motility Disorder
Gastrointestinal Motility Among Diabetes Patients
Gastrointestinal (GI) symptoms including vomiting, nausea, abdominal pain, constipation or chronic diarrhea affect a large number of patients with diabetes mellitus (DM).
- Conditions
- Diabetic Autonomic Neuropathy, Gastrointestinal Motility Disorder, Diabetes Mellitus, Change of Transit or Circulation
- Trial name
- NCT02573519
- Testing
- 11C Donepezil PET/CT scan, 3D-Transit, 3D-Transit during treatment with Pyridostigmine
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Nephropathy, Hypoxia
Acute Effects of SGLT2 Inhibition on Renal Oxygenation and Autonomic Function in Type 1 Diabetes
Background: Inhibiting the sodium-glucose cotransporter-2 (SGLT2) has been observed to reduce risk of cardiovascular events and kidney failure in type 2 diabetes.
- Conditions
- Nephropathy, Hypoxia, Mitochondrial Alteration, Type 1 Diabetes
- Trial name
- Astronaut (NCT04193566)
- Testing
- Forxiga
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Steno Diabetes Center Copenhagen
Small Fiber Neuropathy, Diabetic Neuropathies
Skin Biopsy in the Diagnosis of Small Fiber Neuropathy in Chinese Patients With Diabetes
To detect small fiber neuropathy in patients with possible or established diabetic peripheral neuropathy (DPN) by skin biopsy and explore clinical characteristics and pathological features in Chinese patients with diabetes.
- Conditions
- Small Fiber Neuropathy, Diabetic Neuropathies, Diabetes Mellitus
- Trial name
- NCT04071535
- Testing
- sudoscan、nerve conduction tests
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Painful Peripheral Diabetic Neuropathy
Nociceptive Pain Fiber Response
This study is designed to evaluate the effectiveness of the Provant Therapy System in improving localized nerve growth and skin perfusion in subjects with painful peripheral diabetic neuropathy of the foot.
- Trial name
- NCT02696070
- Testing
- Provant Therapy System
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Regenesis Biomedical, Inc.
Diabetic Foot, Diabetes
Predictors of Skin Temperature, Plantar Pressure and Ulceration in Diabetic Foot Patients.
Diabetes is a chronic disease with increasing prevalence worldwide with a high burden to individuals and the society and it is expected to be the 7th leading cause of death in 2030.
- Trial name
- NCT03254095
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Universidade do Porto
Diabetic Neuropathies, Diabetes Mellitus
The Effect of Sensorial Biodex Balance Balance System Exercises in Diabetic Neuropathy
This study examined the effects of balance exercises performed with the Biodex Balance System (BBS) on nerve conduction, sensory symptoms, and muscle strength in patients with diabetes-related neuropathy.
- Conditions
- Diabetic Neuropathies, Diabetes Mellitus, Exercise Training
- Trial name
- NCT05255497
- Testing
- Biodex Balance Exercise System
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Duygu AKTAR REYHANIOGLU
Small Fiber Neuropathy, Diabetic Neuropathies
Diabetic Small Fiber Neuropathy: Clinical, Electrophysiological and Neurosonographic Study
The aim of work is to study the clinical, electrodiagnostic and neurosonographic characteristics of diabetic patients with small fiber neuropathy in the Egyptian population, and to evaluate both the diagnostic and the prognostic…
- Conditions
- Small Fiber Neuropathy, Diabetic Neuropathies, Autonomic Neuropathy, Diabetic Peripheral Neuropathy
- Trial name
- NCT05993871
- Testing
- Clinical Evaluation/Questionnaires, Nerve Conduction Study, Small fiber electrodiagnostic tests
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Tanta University
Diabetes Type 2, Diabetic Neuropathies
High vs Low Dose Vitamin D in Patients With Diabetic Peripheral Neuropathy
Aim. To assess the effect of different doses of vitamin D supplementation on peripheral neuropathy in patients with type 2 diabetes mellitus (T2DM).
- Conditions
- Diabetes Type 2, Diabetic Neuropathies, Vitamin D Deficiency
- Trial name
- NCT04377399
- Testing
- Vitamin D
- Where
- Russia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Diabetic Neuropathy
NIR- and Multifrequent Impedance Spectroscopy on the Skin in Type 1 Diabetes
The aim of the study is to examine the suitability to detect diabetic neuropathy using NIR and impedance.
- Trial name
- NIR (NCT01707979)
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Lise Tarnow
Diabetic Neuropathy Peripheral, Small Vessel Disease of Diabetes Mellitus
Microcirculatory Vasomotor Changes in Type 2 Diabetes With Peripheral Neuropathy
Microcirculatory flow is subject to cyclic changes under the influence of heart rate, respiration, myogenic activity, neurogenic factors and endothelial factors.
- Conditions
- Diabetic Neuropathy Peripheral, Small Vessel Disease of Diabetes Mellitus, Vasodilation, Vasoconstriction
- Trial name
- NEUROMICRO (NCT03847779)
- Testing
- "Rest", "Exercise", "Foot lowering"
- Where
- France
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- University of Avignon
Type 2 Diabetes, Osteoporosis
Impact of Screening and Multicomponent Exercise on Fall Rates, Fractures, and Cardiovascular Health in Diabetes
The DIACTIVE study is a randomized controlled trial with a 5- year follow-up designed to evaluate the impact of comprehensive screening and multicomponent interventions on fall prevention, bone health, nerve function and…
- Conditions
- Type 2 Diabetes, Osteoporosis, Diabetic Neuropathies, Fall Prevention
- Trial name
- DiaACTIVE (NCT06745544)
- Testing
- Rhythm- and Multitask-Based Activity (RYMA) and Activities of Daily Living (ADL)
- Where
- Denmark
- Volunteers
- 490 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Diabetes Mellitus, Diabetes Complications
Comparison of Resin Salve and Octenidine in Patients With Neuropathic Diabetic Foot Ulcers
Prevalence of diabetic foot ulcers are reported to be 15% in patients who suffer from diabetes and ulcerations are present in 84% of all diabetes-related amputations.
- Conditions
- Diabetes Mellitus, Diabetes Complications, Diabetic Neuropathies, Wound Infection
- Trial name
- NCT02169167
- Testing
- Resin salve treatment, Octenidine treatment
- Where
- Poland
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Janne J. Jokinen
Diabetic Peripheral Neuropathy
Strength And Balance Training on Diabetic Peripheral Neuropathy
A Randomized Control Trial was conducted on 20 participants, equally allocated in strength plus balance and aerobic group from February-2020 until December-2020.Participants were selected according to inclusion and exclusion…
- Trial name
- NCT04807452
- Testing
- Strength and balance training, Aerobics training
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Diabetes Type 1, Proteomics
Proteomic Analysis in Paediatric Diabetes Type 1 (PAPD)
The aim of the present study is to investigate a targeted proteomic analysis in plasma of children - of Greek origin- with type 1 diabetes (DT1) and its correlation with the electrophysiological findings that accompany diabetic…
- Conditions
- Diabetes Type 1, Proteomics, Diabetic Peripheral Neuropathy
- Trial name
- PAPD (NCT04257877)
- Testing
- Blood sampling
- Where
- Greece
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Chronic Pain, Acute Pain
Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA
This study relies on the use of a smartphone application (SOMA) that the investigators developed for tracking daily mood, pain, and activity status in acute pain, chronic pain, and healthy controls over four months.The primary…
- Conditions
- Chronic Pain, Acute Pain, Post Operative Pain, Fibromyalgia, Primary
- Trial name
- NCT05754190
- Testing
- SOMA pain manager smartphone application
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Brown University