Clinical trials: Peripheral Arterial Disease
Peripheral Arterial Disease, Vascular Diseases, Peripheral
The Role of microRNA-210 in Regulating Oxidative Stress in Patients With PAD
MicroRNA-210 (miR-210) can be a potential therapeutic target of patients with peripheral artery disease (PAD). Recent evidence suggests the role of miR-210 and oxidative stress in the pathophysiology of PAD and its association…
- Conditions
- Peripheral Arterial Disease, Vascular Diseases, Peripheral, Arterial Occlusive Diseases, Atherosclerosis
- Trial name
- NCT04089943
- Testing
- Revascularization operation, Control group
- Where
- 2 sites in United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- University of West Florida
PAD - Peripheral Arterial Disease
Non-invasive MSOT Examination of Muscle Oxygenation in Athletes and PAD Patients
The aim of the study is to present the quantitative differences in oxygenated hemoglobin in different cohorts. This clinical study evaluates whether there is a correlation between measurements using multispectral optoacoustic…
- Trial name
- NCT07347535
- Testing
- MSOT - Multispectral optoacustic tomography, CPET
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital Erlangen
Peripheral Artery Disease (PAD)
Using Near-Infrared Light to Better Understand Peripheral Artery Disease
The goal of this study is to better understand how blood flows and how oxygen is utilized in the lower limbs of people who suffer from peripheral artery disease.
- Trial name
- NCT07313410
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington
Peripheral Arterial Disease
Creatine Use and Muscle Stretching in Peripheral Artery Disease
To utilize near-infrared spectroscopy to investigate if the research device, which induces muscle stretching, and creatine loading impact submaximal exercise performance in aged and PAD patients.
- Trial name
- NCT04471792
- Testing
- Creatine monohydrate, Cellulose
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Florida State University
Peripheral Artery Disease (D058729), Oxidative Stress (D018384)
Improving Exercise Rehabilitation Efficacy Outcomes Veterans Peripheral Artery Disease
Physical activity is the most beneficial and cost-effective treatment for Veterans with PAD, however, issues with oxygen delivery and utilization dramatically impair exercise compliance.
- Conditions
- Peripheral Artery Disease (D058729), Oxidative Stress (D018384), Inflammation (D007249)
- Trial name
- NCT05648630
- Testing
- PB125, Exercise Rehabilitation
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Atherosclerotic Cardiovascular Disease, Cardiovascular Diseases
Immunomodulatory Effects of PCSK9 Inhibition
Cardiovascular disease (CVD) represents the leading cause of death worldwide. While medications, such as statins, significantly reduce atherosclerotic CVD (ASCVD) risk by lowering low density lipoprotein levels, they may also…
- Conditions
- Atherosclerotic Cardiovascular Disease, Cardiovascular Diseases, Atherosclerosis, Arterial Inflammation
- Trial name
- INSPIRAR (NCT05720156)
- Testing
- 99mTc-tilmanocept SPECT/CT scanning
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
PAD - Peripheral Arterial Disease
Observational Study of Risk Factors for Peripheral Artery Disease in Bathroom Scale Withings Body Cardio Users
Withings Body Cardio is capable to measure PWV in the right and left lower limbs. The hypothesis of this study is a significant difference in PWV between the right and left lower limbs measured by the device may be the sign of…
- Trial name
- OBAOMI (NCT07082517)
- Testing
- Percentage analysis
- Where
- France
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Withings
Peripheral Arterial Disease
Feasibility Study to Evaluate Therapeutic Ultrasound (TUS) to Acutely Increase the Perfusion in Peripheral Arterial Disease (PAD)
This study is evaluating whether a therapeutic ultrasound device can improve symptoms in the leg of peripheral arterial disease (PAD) patients 65 years of age and over.
- Trial name
- Waltz (NCT05888740)
- Testing
- VibratoSleeve Therapeutic Ultrasound Device
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Vibrato Medical, Inc.
Peripheral Arterial Disease
Exoskeleton Variability Optimization
Exoskeletons, wearable devices that assist with walking, can improve mobility in clinical populations. With exoskeletons, it is crucial to optimize the assistance profile.
- Trial name
- NCT04338815
- Testing
- Exoskeleton Optimization, Endurance Evaluation
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Arterial Stiffness, Magnetic Field Exposure
Assessing Impacts of Static Magnetic Fields on Peripheral Pulses and Skin Blood Flow
The purpose of this research study is to investigate and determine the effects of static magnetic fields produced by a small magnet on peripheral pulses and skin blood flow.
- Conditions
- Arterial Stiffness, Magnetic Field Exposure, Peripheral Arterial Disease
- Trial name
- NCT04539704
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Nova Southeastern University
Peripheral Arterial Disease
Foot Reflexology and Pain and Ankle Brachial Index and Walking Impairement
This randomized controlled study aimed to determine the effect of foot reflexology on pain, walking impairement and ankle brachial index level in patients with peripheral artery disease
- Trial name
- NCT06001203
- Testing
- Reflexology
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Baskent University
Skin Cancer, Skin Diseases
Multi-modal Quantitative Imaging of the Skin
This clinical trial is about evaluating the suitability of multi-modal imaging technology, which covers virtually the entire body, to evaluate the possibility of screening and early detection of disease.
- Conditions
- Skin Cancer, Skin Diseases, Atopic Dermatitis, Psoriasis
- Trial name
- DermaFlow (NCT06989216)
- Where
- 3 sites in Sweden
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- HJN Sverige AB/Neko Health
Diabetes Mellitus, Type 2, Diabetic Foot
Non-invasive Imaging for In-vivo Quantification of Skin Composition and Structure
The goal of this clinical investigation is to explore a non-invasive technology for measuring the microcirculatory structure, composition and function in patients from a primary care population. The main aims are: 1.
- Conditions
- Diabetes Mellitus, Type 2, Diabetic Foot, Peripheral Arterial Disease, Skin Cancer
- Trial name
- Spectrum1 (NCT06976073)
- Where
- 3 sites in Sweden
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- HJN Sverige AB/Neko Health
Peripheral Artery Disease, Critical Limb Ischemia
Imaging-Guided Vessel Sizing in the Tibial Arteries
This study aims to investigate the utilization of intravascular imaging in treatment of tibial vessels in peripheral artery disease and critical limb ischemia (CLI).
- Trial name
- iVEST (NCT04748965)
- Testing
- Digital Subtraction Angiography
- Where
- 3 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Peripheral Artery Disease, Femoropopliteal Stenosis
Histological Segmentation of the Superficial Femoral Artery From Microscan to CT Using Artificial Intelligence
The femoropopliteal artery segment (FPAS) is one of the longest arteries in the human body, undergoing torsion, compression, flexion and extension due to lower limb movements.
- Trial name
- CTPred (NCT06260488)
- Testing
- Endovascular surgery
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Peripheral Artery Disease
FlowMet-R Blood Flow Measurement for the Diagnosis of Peripheral Artery Disease and Critical Limb Ischemia
Non-randomized, multi-center, longitudinal study of healthy subjects and subjects with PAD who are scheduled for ABI, TBI, and either Duplex Ultrasound or Angiographic assessments in a vascular clinic.
- Trial name
- NCT04120610
- Testing
- FlowMet-R, ABI, TBI
- Where
- 5 sites in United States
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Medtronic Endovascular
Death, Carotid Artery Disease
NOR-SYS: The Norwegian Stroke in the Young Study
NOR-SYS is a clinical research program about young ischemic stroke patients from 15 to 60 years. Patients, partners and the couple´s adult children who are at least 18 years old, are all invited to ultrasound examinations due to…
- Conditions
- Death, Carotid Artery Disease, Cardiovascular Disease, Peripheral Artery Disease
- Trial name
- NOR-SYS (NCT01597453)
- Testing
- Lifestyle counseling
- Where
- Norway
- Volunteers
- 1,062 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Intermittent Claudication
Bioequivalence Study of PMR Compared to Cilostazol IR Tablets in Healthy Volunteers
The study is designed to evaluate the bioequivalence and the within-subject variability between the test formulation of extended-release tablet of cilostazol (PMR) administered once daily and the reference formulation of…
- Trial name
- NCT05191862
- Testing
- Cilostazol 100 mg, PMR 135 mg
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Genovate Biotechnology Co., Ltd.,
Atrial Fibrillation, Coronary Heart Disease
EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality
Health inequality and genetic disparity are a significant issue in the United Kingdom (UK). This study focuses on diseases that are associated with significant morbidity and mortality in the UK, and specifically examines the…
- Conditions
- Atrial Fibrillation, Coronary Heart Disease, Cardiovascular Diseases, Heart Failure
- Trial name
- EMPOWER (NCT03987633)
- Where
- United Kingdom
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- Future Genetics Limited
Peripheral Arterial Occlusive Disease, Critical Limb Ischemia
Safety, Tolerability, and Biodistribution of [89Zr]Zr-DFO-APAC in Subjects With PAOD/CLI and Healthy Volunteers (Acronyms: 89Zr = Zirconium-89, DFO = Desferrioxamine, APAC = AntiPlatelet AntiCoagulant, PET/CT = Positron Emission Tomography/Computed Tomography)
The goal of this Phase 0 clinical trial is to evaluate safety and biodistribution of [89Zr]Zr-DFO-APAC in patients with peripheral arterial occlusive disease / critical limb ischemia (PAOD/CLI) and healthy volunteers.
- Trial name
- CHASE (NCT06204237)
- Testing
- [89Zr]Zr-DFO-APAC, PET/CT scan
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Aplagon Oy