Clinical trials: Periodontitis, Adult, open to volunteers
Edentulous Mouth, Periodontal Diseases
Changes in Microbial Status From Dentate, Edentulous and After Dental Implant Placement
The objectives of this study are to analyze the oral microbiome modulations occurring during the transition from partial (with some residual teeth) to full edentulous (without remaining teeth) status and implant placement in…
- Conditions
- Edentulous Mouth, Periodontal Diseases, Periodontitis, Adult, Microbial Colonization
- Trial name
- NCT06149585
- Testing
- Microbial Sampling
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Oral Disease, Cardiovascular Diseases
Oral Health in Adults: Social Gradients and Correlation With Cardiovascular Health
Non-communicable diseases (NCDs) are rising in prevalence because of aging, unhealthy diet and sedentary lifestyle, and common NCDs are caries and periodontitis (here oral diseases) and cardiovascular disease (CVD).
- Conditions
- Oral Disease, Cardiovascular Diseases, Diabetes
- Trial name
- HUSK (NCT05758467)
- Where
- Norway
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Oral Health Centre of Expertise in Western Norway
Chronic Periodontitis, Aggressive Periodontitis
B Cell Functions in Periodontitis
The inflammatory response involves many players from the immune response, including B lymphocytes. These cells are responsible for the synthesis of immunoglobulins in response to the presence of an antigen.
- Trial name
- LBPARO (NCT02833285)
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Periodontitis, Adult, Periodontitis (Stage 3)
Microbiological and Clinical Effects of Pre- and Probiotics in Non-Surgical Periodontal Therapy
Periodontitis is a prevalent chronic inflammatory disease driven by a dysbiotic oral biofilm and a dysregulated host immune response.
- Conditions
- Periodontitis, Adult, Periodontitis (Stage 3), Periodontitis Stage IV
- Trial name
- PROPARO (NCT07443410)
- Testing
- Non-surgical periodontal therapy (NSPT) and supportive periodontal therapy (SPT), Probiotic lozenge (Limosilactobacillus reuteri; GUM® PerioBalance®), Vitamin B12 drops (natural elements)
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Diabete Mellitus, Dyslipidaemia
Prevalence and Associated Factors of High BMI and Periodontitis in Thai Adults Aged Under 60 Years
Overweight and obesity, as well as periodontitis, are common public health problems with increasing prevalence. Both conditions may be linked through shared mechanisms involving chronic low-grade systemic inflammation.
- Conditions
- Diabete Mellitus, Dyslipidaemia, Chronic Kidney Disease, Psychiatric Disorder
- Trial name
- NCT07880717
- Testing
- Periodontal Examination, Questionnaire interview, Anthropometric measurements
- Where
- Thailand
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Periodontal Diseases
Non-surgical Treatment of Chronic Periodontitis With an Adjunctive Vitamin E and Coenzyme Q10 Supplementation
Non-surgical treatment of chronic periodontitis with vitamin E and coenzyme Q10 supplementation
- Trial name
- NCT06373848
- Testing
- Receive 30 mg of Coq10
- Where
- Iran
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Islamic Azad University, Sanandaj
Periodontis, Aggressive Periodontitis
Single-cell and Spatial Transcriptomic Profiling of Gingival Tissues in Aggressive and Chronic Periodontitis: Deciphering Cellular Heterogeneity and Inflammatory Microenvironment Features
The goal of this observational study is to investigate cellular heterogeneity and inflammatory microenvironment features in gingival tissues from patients with aggressive periodontitis compared to chronic periodontitis and…
- Trial name
- NCT07487272
- Where
- China
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Dental Implantation, Missing Teeth
The Effect Of Enamel Matrix Derivatives On Gingival Tissue Thickness
Scientists do research to answer important questions which might help change or improve the way we do things in the future. The investigators know that using Enamel Matrix Derivatives results in thicker gum tissues around teeth.
- Conditions
- Dental Implantation, Missing Teeth, Periodontitis, Adult, Mucositis
- Trial name
- NCT07053969
- Testing
- Enamel Matrix Derivative
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio