Clinical trials: Periodontal Inflammation
DENT IMPLANTS, LASER
Clinical and Microbiologic Outcomes of aPDT in the Non-surgical Treatment of Implant Inflammation
The purpose of this study is to compare clinical outcomes (change in bleeding sites (BOP) and probing depth reduction (PPD) after mechanical debridement of implant surfaces at sites exhibiting plaque induced inflammation with or…
- Trial name
- NCT04187053
- Testing
- Conventional mechanical therapy, Saline, Methylene Blue
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- The University of Texas Health Science Center, Houston
Moderate to Advanced Chronic Periodontitis
Local Minocycline to Reduce Future Inflammation and Bone Loss in Periodontal Maintenance Patients
The purpose of this study is to determine the effect of local application of minocycline microspheres on the periodontal inflammation and bone loss prevention in patients diagnosed with moderate-severe chronic periodontitis…
- Trial name
- NCT01647282
- Testing
- locally-applied minocycline HCl (1 mg), scaling and root planing (Sc/RP)
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of Nebraska
Gingival Inflammation and Bleeding, Dental Plaque
Clinical Efficacy Evaluation of Three Dentifrices
Clinical study to evaluate and compare the efficacy of two baking soda containing dentifrices, containing 20% and 35% baking soda, to a non-baking soda dentifrice for their ability to reduce gingivitis and plaque following…
- Trial name
- NCT03988374
- Testing
- Dentifrices
- Where
- Canada
- Volunteers
- 319 people
- Sponsor
- Church & Dwight Company, Inc.
Plaque, Gingivitis
A Clinical Trial to Test the Effect of Marketed Mouth Rinses on Decreasing Plaque and Gum Inflammation
The reduction of existing plaque and gum inflammation will be evaluated using two marketed mouth rinses along with tooth brushing after 21 days of use compared to a placebo mouth rinse.
- Trial name
- NCT02233998
- Testing
- Mouth Rinse 1, Mouth Rinse 2, Mouth Rinse 3
- Where
- Canada
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Gingival Inflammation, Plaque
The Effectiveness of Brushing and Flossing Sequence on Control of Plaque and Gingival Inflammation
This study evaluates the effectiveness of brushing and flossing sequence in the control of dental plaque and gingival inflammation.
- Conditions
- Gingival Inflammation, Plaque, Gingival Bleeding, Plaque Control
- Trial name
- RCT (NCT03989427)
- Testing
- Brushing first and Flossing later (BF), Flossing first and Brushing later (FB)
- Where
- Malaysia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Melaka Manipal Medical College
Gingival Inflammation
Safety and Preliminary Efficacy of Lipoxin Analog BLXA4-ME Oral Rinse for the Treatment of Gingivitis
The primary objective is to evaluate the safety of an investigational compound, BLXA4-ME, topically applied as a daily oral rinse in adults with gingivitis.
- Trial name
- BLXA4 (NCT02342691)
- Testing
- BLXA4
- Where
- United States
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- The Forsyth Institute
SRP, Minocycline HCl Microspheres
Scaling and Root Planing (SRP) With and Without Minocycline HCl Microspheres, 1 mg
The primary goal of this study is to investigate the qualitative and quantitative effects of scaling and root planing (SRP) with and without minocycline HCL microspheres, 1 mg on periodontal pathogens and overall bacterial load.
- Conditions
- SRP, Minocycline HCl Microspheres, Biomarkers
- Trial name
- NCT03762915
- Testing
- minocycline HCl microspheres
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Periodontitis, Gingivitis
The Effects of DHA on Periodontitis
The purpose of this study is to determine whether docosahexaenoic acid (DHA) is effective in the treatment of periodontitis in adults.
- Conditions
- Periodontitis, Gingivitis, Inflammation
- Trial name
- DAP (NCT01976806)
- Testing
- Aspirin, Docosahexaenoic acid
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Gingivitis
Dose-dependent Anti-inflammatory Effects of Vitamin D in a Human Gingivitis Model
The burden of chronic gingivitis and periodontitis in the US is disproportionately high among Non-Hispanic Blacks compared to Non-Hispanic Whites.
- Trial name
- NCT00779909
- Testing
- vitamin D3
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Boston University
Gingival Inflammation
Efficacy of Eco-Friendly Toothpaste Tablets Versus Conventional Toothpaste Using PI and GI Index
Objectives: To assess the change in gingival index (GI) and plaque index (PI) when comparing the use of toothpaste tablets to conventional toothpaste.
- Trial name
- NCT05805865
- Testing
- Toothpaste Tablet, Conventional Toothpaste
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Gingivitis, Periodontitis
Efficacy of ClōSYS® Sensitive Fluoride Toothpaste and ClōSYS® Sensitive Rinse Regimen on MGI, PI and BOP
90-day, self-controlled, longitudinal, non-blinded clinical trial which will measure changes in clinical parameters in participants with gingivitis and Stage I or II periodontitis who apply ClōSYS® Sensitive Fluoride Toothpaste…
- Trial name
- NCT05258721
- Testing
- ClōSYS® Sensitive Fluoride Toothpaste, ClōSYS® Sensitive Rinse
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Rowpar Pharmaceuticals, Inc.
Gingivitis
Evaluate Inflammation Caused by Gingivitis in Adults
The purpose of this study is to compare the anti-inflammatory efficacy of a dentifrice
- Trial name
- NCT00941668
- Testing
- Triclosan/Copolymer/fluoride toothpaste, sodium monofluorophosphate toothpaste
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive