Clinical trials: Periodontal Inflammation
Plaque, Gingivitis
A Clinical Trial to Test the Effect of Marketed Mouth Rinses on Decreasing Plaque and Gum Inflammation
The reduction of existing plaque and gum inflammation will be evaluated using two marketed mouth rinses along with tooth brushing after 21 days of use compared to a placebo mouth rinse.
- Trial name
- NCT02233998
- Testing
- Mouth Rinse 1, Mouth Rinse 2, Mouth Rinse 3
- Where
- Canada
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Transgender Individuals
Effects of Gender-Affirming Hormone Therapy on Cardiovascular, Metabolic, and Mental Health Outcomes in Transgender Adults.
The objective of this observational study is to examine the impact of gender-affirming hormone therapy (GAHT) on mood in transgender individuals and to explore its potential association with early atherosclerotic processes.
- Trial name
- NCT07394400
- Where
- Spain
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Milagros Rocha Barajas
Periodontal Diseases
Amelogenins and Systemic Inflammation After Periodontal Surgical Therapy
The aim of this study is to compare surgical treatment of periodontal infrabony defects with and without the adjunct of an enemal matrix derivative (EMD) in terms of acute-phase responses, in systemic healthy patients.
- Trial name
- PERIOEMD-1 (NCT03590093)
- Testing
- Periodontal surgery, EMD application
- Where
- Italy
- Volunteers
- 38 people
- Sponsor
- University of Pisa
Periodontitis, Diabetes Mellitus, Type 2
Effect of Periodontal Treatment on Adipokine Levels
The present study aimed to determine the effect of non-surgical periodontal treatment (NSPT) on serum and salivary adipokine and interleukin-1β levels in periodontitis patients with or without type 2 Diabetes Mellitus (T2DM).
- Trial name
- NCT06225154
- Testing
- Non-surgical periodontal treatment
- Where
- 2 sites in Finland, Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Marmara University
Periodontitis, Inflammation
Calcium-vitamin D & Periodontal Therapy for Improving Metabolic and Inflammatory Profile Among Pregnant Women
The improvement of maternal and child health remains a key issue in global health. Production and improved accessibility of healthy and nutrient-rich milk-based products could potentially tackle health and nutrition inequalities…
- Trial name
- IMPROVE (NCT03148483)
- Testing
- Early PT, Delayed PT, Fortified Milk
- Where
- Brazil
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Westminster
Inflammation Gum, Cardiac Surgery
Impact of Teeth Extraction on Inflammation Marker's Levels in Patients Who Undergoing Cardiac Surgery
The aim of this study is to examine effects of dental treatments, surgical (extractions) and non-surgical procedures (non-surgical periodontal therapy), on serum levels for PCR, WBCs and PCT in patients needing a dental…
- Trial name
- NCT04626011
- Testing
- Tooth extractions
- Where
- Italy
- Volunteers
- 38 people
- Sponsor
- University of Trieste
Periodontitis, Gingivitis
GFI-1 and Periodontal Disease
Gum disease, including gingivitis and its more advanced form, periodontitis, is a common condition that damages the tissues supporting the teeth.
- Trial name
- NCT07758374
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Inonu University
Inflammation, Periodontal Disease
Advanced Oxidation Protein Product and Monocyte Chemoattractant Protein-1 in Periodontal Disease
This study investigates the levels of advanced oxidation protein product and monocyte chemoattractant protein-1 in gingival crevicular fluid in periodontal disease and health.
- Trial name
- NCT02848378
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Tooth Abrasion, Gingival Recessions
The Effect of Retraction Cord on the Surrounding Periodontal Tissues in Restorative Treatment
The goal of this clinical trial is to learn whether a retraction cord affects gum health when used during tooth restoration procedures.
- Conditions
- Tooth Abrasion, Gingival Recessions, Non-Carious Cervical Lesions (NCCLs), Periodontal Health
- Trial name
- NCT07734935
- Testing
- Gingival Retraction Cord, Composite Resin Restorative, Universal Adhesive - G-Premio Bond
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people
- Sponsor
- Istanbul University
Gingival Inflammation
Investigation of the Interplay Between Local Oral Inflammation, Microbiota and Systemic Immune Responses.
This is a clinical research study designed to measure changes in inflammation and the oral microbiome during a phase of good oral hygiene and the absence of oral hygiene.
- Trial name
- ILIMSIR (NCT06966492)
- Testing
- Stannous Fluoride Toothpaste (SnF)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Post Operative Pain, Inflammation
The Effect of Intra Oral Cryotherapy in Patients With Symptomatic Apical Periodontitis
The participants were divided into two groups: Group I (cryotherapy) (n =10) after the completion of the mechanical preparation intra oral cryotherapy was applied.
- Trial name
- NCT06082479
- Testing
- intraoral cryotherapy,ice gel
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Coronary Stenosis, Periodontal Diseases
Periodontal Disease, Inflammation and Acute Coronary Syndromes
Recent studies have shown that the systemic inflammation caused by periodontal disease (PD) can determine important changes in the coronary arteries, favoring atherosclerosis progression and development of acute coronary…
- Conditions
- Coronary Stenosis, Periodontal Diseases, Acute Coronary Syndrome, Non-ST Elevation Myocardial Infarction
- Trial name
- ATHERODENT (NCT03395041)
- Testing
- cardiac imaging tests
- Where
- Romania
- Volunteers
- 149 people
- Sponsor
- Cardio Med Medical Center
Periodontal Diseases Inflammation
Evaluation of Nucleotide-Binding Oligomerization Domain-Containing Protein (NOD) 1 and NOD 2
The host immune response to microorganisms is primarily recognized by pattern recognition receptors (PRRs), including toll-like receptors and nucleotide-binding oligomeric domain (NOD) receptors (NLRs).
- Trial name
- NCT07160894
- Testing
- Saliva and Serum sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Medipol University
Wound Heal
Periodontal Inflammation and Wound Healing in Multiple Extractions
Four participants requiring multiple dental extractions will be recruited for this study. Two participants will be 21-50 years old, two participants will be 65-80 years old.
- Trial name
- NCT06185114
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Nebraska
Gingivitis, Periodontitis
Is Professional Tooth Cleaning Necessary for Managing Gingivitis (Gingival Inflammation) if Subjects Use Intelligent Toothbrushes?
Periodontitis is highly prevalent and develops from plaque-induced gingivitis. Managing gingivitis is key to preventing periodontitis and its complications.
- Trial name
- NCT07549347
- Testing
- Optimal oral care regimen, Periodontal Treatment
- Where
- China
- Volunteers
- 92 people
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Periodontal Disease, Periodontitis (Stage 3)
Evaluation of the Potential Effects of LRP5 and Tph1 in the Pathogenesis of Periodontal Disease Individuals With Stage III Grade B Periodontitis
Objectives: The aim of this study was to determine the changes in LRP5 and TPH1 levels in serum and saliva samples due to periodontal inflammation and to evaluate the relationship between these values and clinical periodontal…
- Conditions
- Periodontal Disease, Periodontitis (Stage 3), Periodontitis Stage III
- Trial name
- NCT06933797
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ankara University
Periodontal Disease
Periodontal Disease and Circulatory Microbial Components
The goal of this project is to study the immune activity of certain proteins present in the blood of patients with severe periodontal disease. Periodontal disease (gum disease) is the major cause of tooth loss among adults.
- Trial name
- CirCo (NCT01154855)
- Testing
- Prophylaxis ; Gross debridement for diseased patients
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Gingival Inflammation
Gingival Irritation Due to Bleaching Tray Design in an At-home Bleaching Treatment
The primary aim of this study is to assess whether the design of the bleaching tray used in at-home bleaching treatment is directly correlated with the risk of gingival irritation.
- Trial name
- NCT06371664
- Testing
- Conventional Tray (1 mm), Extended Tray (3 mm)
- Where
- Spain
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Santiago de Compostela
Gingival Inflammation
Lactobacillus Reuteri Strains for Gingivitis Reduction
The aim of the present study was to investigate the potential beneficial effects in volunteer young adults of orally administered L. reuteri (DSM 17938 and ATCC PTA 5289) on gingival inflammation.
- Trial name
- NCT06234839
- Testing
- L. reuteri (DSM 17938 and ATCC PTA 5289) in form of oral tablets
- Where
- Mexico
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de San Luis Potosí
Periodontitis, Obesity (Body Mass Index >30 kg/m2)
Obesity and Clinical and Cytokine Responses to Periodontal Therapy
This prospective controlled clinical study included 80 participants allocated into four groups according to body mass index (BMI) and periodontal status: obese periodontitis, normal-weight periodontitis, obese periodontally…
- Trial name
- NCT07869277
- Testing
- Scaling and Root Planing (SRP)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Emine Çifcibaşı