Clinical trials: Periodontal Inflammation
Sensitive Gum, Gum Inflammation
Usage Test on a New Cosmetic Product: Mouthwash
The goal of this clinical trial is to learn if a new mouthwash can help soothing oral mucosa in adult patients with sensitive gums.
- Trial name
- NCT06808711
- Testing
- Buccocéan mouthwash, Marketed mouthwash
- Where
- France
- Volunteers
- 50 people
- Sponsor
- YSLab
Gingival Inflammation, Dental Plaque Accumulation
Evaluation of the Anti-plaque Effect of a Bioflavonoid-based Antiseptic Mouthwash
This study evaluates the antiplaque efficacy of a bioflavonoid-based mouthwash compared to a positive control (0.12% chlorhexidine mouthwash).
- Trial name
- NCT07824388
- Testing
- Bioflavonoid mouthwash, Chlorhexidine 0.12% mouthwash
- Where
- Spain
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Barcelona
Periodontitis, Diagnose Disease
Serum and Saliva Sirtuin 6, Lipoxin A4, Caspase8 Levels in Correlation With Periodontal Status in Severe Periodontitis
It has been stated that Sirtuin-6 (SIRT6) play a important role in regulation of inflammation, energy metabolism, homeostasis and apoptosis, and SIRT6 may be assosiciated with many diseases.
- Trial name
- NCT05417061
- Testing
- Saliva and serum sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Rheumatoid Arthritis, Periodontal Disease
Periodontal Inflammation and Immunity in Preclinical Rheumatoid Arthritis
The purpose of this study is to evaluate the association of Rheumatoid Arthritis (RA)-related antibodies and periodontal inflammation in subjects at-risk for Rheumatoid Arthritis.
- Trial name
- NCT02794012
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Periodontal Diseases, Wound Heal
Hyaluronic Acid and Polynucleotides for Supra-bony Defects
The goal of this pilot study is to describe the early wound healing molecular events and the vascularization pattern associated with the treatment of supra-bony defects with access flap alone or in association with a combined…
- Conditions
- Periodontal Diseases, Wound Heal, Periodontal Inflammation, Periodontal Pocket
- Trial name
- NCT06309719
- Testing
- Periodontal Access Flap (AF) + Combined Formulation of Hyaluronic acid and Polydeoxyribonucleotides (PNHA), Periodontal Access Flap (AF)
- Where
- 2 sites in United Kingdom
- Volunteers
- 24 people
- Sponsor
- Queen Mary University of London
SRP, Minocycline HCl Microspheres
Systemic Markers of Inflammation: 9- and 12-Month Follow-Up Post Non-Surgical Periodontal Therapy
The primary goal of this study is to determine the amount of three systemic markers of inflammation: 1) Hemoglobin A1c (Hgb A1c, 2) High Sensitivity C-Reactive Protein (hsCRP), and 3) Haptoglobin (Hp) at 9 and 12 month follow-up…
- Conditions
- SRP, Minocycline HCl Microspheres, Biomarkers
- Trial name
- NCT04312542
- Testing
- Measurement of Biomarkers
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Minnesota
Gingivitis, Periodontitis
Circadian Clock Gene Expression in Periodontal Disease
This observational study aims to investigate whether periodontal inflammation is associated with alterations in the expression of circadian clock-related genes and proteins in gingival tissues.
- Trial name
- PERIOCLOCK (NCT07452783)
- Testing
- Gingival Tissue Biopsy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Inonu University
Stress, Psychological, Periodontal Diseases
Effect of Stress on Periodontal Therapy (NPT)
Aim of this study: is to evaluate the influence of stress level on the response of non surgical periodontal therapy in patients affected by severe periodontitis divided into "Medium/High stress level" or "Low stress level" based…
- Conditions
- Stress, Psychological, Periodontal Diseases, Periodontitis, Non Surgical Periodontal Therapy
- Trial name
- NCT04739475
- Testing
- Non Surgical Periodontal Therapy
- Where
- Italy
- Volunteers
- 89 people
- Sponsor
- University of Turin, Italy
Periodontal Disease
Power Toothbrush Use in Nursing Homes to Eliminate Mouth and Body Inflammation
The purpose of this study is to investigate whether brushing the teeth of nursing home residents with a power toothbrush as compared with standard care typically provided in nursing homes, will increase caregiver compliance with…
- Trial name
- NCT01639183
- Testing
- Rotating-oscillating Power Toothbrush, Standard Care
- Where
- Canada
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Gingivitis
Dose-Response Study of Iocide Oral Rinse
The purpose of this study is to explore the dose-response relationship of Iocide oral rinse in a clinical trial of gingivitis. Approximately sixty (60) otherwise healthy subjects having gingivitis will be randomized into the…
- Trial name
- NCT01103102
- Testing
- Iocide Oral Rinse
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Biomedical Development Corporation
Bacteremia, Infective Endocarditis
Reducing Risk for Infective Endocarditis
This clinical trial is studying if bacteria found in a participant's bloodstream after brushing their teeth can be prevented with a dental cleaning and more education on how to best brush and care for their teeth.
- Trial name
- PIE-B (NCT05721781)
- Testing
- Oral Hygiene instruction, Dental Cleaning
- Where
- 6 sites in United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Periodontal Pocket, Periodontitis
Multicenter Study on the Use of a Collagen-based Hydrogel for the Treatment of 153 Periodontal Pockets in 38 Adults With Generalized Stage III Periodontitis
This is a prospective, observational, multicenter study designed to evaluate the real-world efficacy and safety of H42®, a collagen hydrogel, in the treatment of periodontal pockets.
- Trial name
- NCT07592377
- Testing
- H42® Collagen Hydrogel for the non-surgical treatment of periodontal pockets
- Where
- 2 sites in Italy
- Volunteers
- 38 people
- Sponsor
- Bioteck S.p.A.
Acne Vulgaris, Gingivitis and Periodontal Diseases
Retinoic Acid Therapy and Regulation of Salivary and Serum IL-1β, IL-8 and MCP-1 Levels
This prospective cohort study analysed the effects of systemic retinoic acid use on periodontal status, salivary flow rate (SFR), and salivary and serum levels of interleukin (IL)-1β, IL-8 and monocyte chemoattractant protein…
- Conditions
- Acne Vulgaris, Gingivitis and Periodontal Diseases, Saliva Collection, Inflammation Biomarkers
- Trial name
- NCT06879795
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Medipol University
Wound Healing and Prevention, Oral Inflammation
Impact of Nd:YAG Laser Photobiostimulation on Healing of Gingiva
The intervention in this study is to determine whether multiple applications of photobiostimulation with Nd-YAG laser improve wound healing following tooth extraction and alveolar ridge preservation.
- Conditions
- Wound Healing and Prevention, Oral Inflammation, Photobiomodulation, Post-operative Pain Management
- Trial name
- NCT07095556
- Testing
- Low-level laser therapy
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Failure of Dental Implant Due to Infection, Infection
Regenerative Surgical Treatment of Peri-implantitis
The purpose of the study is to evaluate if surgical treatment of peri-implantitis with enamel matrix derivative (Emdogain®, EMD) will have an additional effect on the healing outcome, changes in the peri-implant microflora and on…
- Conditions
- Failure of Dental Implant Due to Infection, Infection, Inflammation, Peri-implantitis
- Trial name
- NCT02500654
- Testing
- Emdogain®, Surgery alone
- Where
- Sweden
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Catrine Isehed
Periodontitis, Periodontal Inflammation
GCF Annexin-A1, Carbonic Anhydrase-1, and Elongation Factor-1 Gamma Levels in Periodontitis
The study aimed to investigate gingival crevicular fluid (GCF) levels of possible novel biomarkers Annexin-A1 (ANX A1), Carbonic anhydrase- 1 (CA I), and Elongation Factor-1 Gamma (EF1-Ɣ) in health along with different…
- Trial name
- NCT05680441
- Testing
- Peirodontal clinical measurements and gingival crevicular fluid sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Dokuz Eylul University
Polycystic Ovary Syndrome, Inflammation Gum
Endocan Levels at Polycystic Ovary Syndrome and Periodontal Inflammation
Periodontal diseases are chronic inflammatory disease occurred by the interaction between pathogenic microorganism and the host defense.
- Conditions
- Polycystic Ovary Syndrome, Inflammation Gum, Cytokines
- Trial name
- NCT03264846
- Testing
- Collection of Serum and Saliva Samples
- Where
- Turkey (Türkiye)
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Ebru Saglam
Periodontitis, Dental Implants
Marginal Bone Level Around Dental Implants in Periodontitis Patients
This study evaluates and compares marginal bone level changes around dental implants with two different surface characteristics in patients with a history of periodontitis.
- Conditions
- Periodontitis, Dental Implants, Marginal Bone Loss, Periodontal Probing Depth
- Trial name
- (MBL) (NCT07608523)
- Testing
- SLA Dental Implant, Plasma Spraying Dental Implant
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Faculty of Dental Medicine for Girls
Periodontitis, Acute-Phase Response
Relationship Between LRG and Periodontal Disease
This study aimed to investigate gingival crevicular fluid (GCF) and serum levels of LRG, interleukin (IL)-6 and tumor necrosis factor (TNF)-α in patients with periodontitis before and after non-surgical periodontal treatment.
- Conditions
- Periodontitis, Acute-Phase Response, Inflammation
- Trial name
- NCT04383561
- Testing
- Non-surgical periodontal treatment, Oral hygiene instructions
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Plaque Accumulation, Gingival Inflammation
Triphila Mouthwash Effect as Anti-plaque and Anti-gingivitis in Children
The study aim to to assess the antiplaque and antigingivitis efficacy of Triphala mouthwash versus chlorhexidine mouthwash among children.
- Trial name
- NCT07016659
- Testing
- 0.12% Chlorhexidine Mouthwash ( Hexitol ), Triphila mouthwash
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Cairo University