Clinical trials: Perinatal Stroke
Hemiparesis, Neonatal Stroke
Transcranial Magnetic Stimulation in Children With Stroke
This is a pilot study of repetitive transcranial magnetic stimulation (rTMS) to test tolerance and efficacy in children who have hemiparesis from acquired or presumed perinatal stroke.
- Conditions
- Hemiparesis, Neonatal Stroke, Ischemic Stroke, Hemorrhagic Stroke
- Trial name
- TMSCS (NCT01637129)
- Testing
- Transcranial Magnetic Stimulation
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- Nationwide Children's Hospital
Perinatal Stroke, Hemiparetic Cerebral Palsy
Creating an Engaging BCI/FES Therapy for Children With Perinatal Stroke Using Social Media
The goal of this trial is to evaluate the feasibility of a brain-computer interface controlled functional electrical stimulation (BCI-FES) social media integrated system for children with hemiparetic cerebral palsy .
- Trial name
- NCT07133347
- Testing
- Brain computer interface controlled functional electrical stimulation therapy integrated with social media
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of Calgary
Stroke, Cerebral Palsy
Modulation of Brain Plasticity After Perinatal Stroke
Newborn stroke is the leading cause of a common type of cerebral palsy (CP) that affects thousands of Canadian children and families.
- Trial name
- PLASTIC CHAMPS (NCT01189058)
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS), Constraint-induced movement therapy (CIMT)
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- University of Calgary
PAIS, Neonatal Stroke
Darbepoetin for Ischemic Neonatal Stroke to Augment Regeneration
The aim of the study is to perform a randomized double-blind placebo controlled prospective study in newborn infants with MRI confirmed Middle Cerebral Artery (MCA) Perinatal Arterial Ischemic Stroke (PAIS) with darbepoetin.
- Conditions
- PAIS, Neonatal Stroke, Perinatal Stroke
- Trial name
- DINOSAUR (NCT03171818)
- Testing
- Darbepoetin Alfa, Saline
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- UMC Utrecht
Seizures
Pilot Study of Bumetanide for Newborn Seizures
The main goal of the study is to obtain pharmacokinetic and safety data of bumetanide in newborns with refractory seizures. The overall hypothesis is that bumetanide, added to conventional antiepileptic (antiseizure) medications…
- Trial name
- NCT00830531
- Testing
- Bumetanide
- Where
- 4 sites in United States
- Volunteers
- 43 people
- Sponsor
- Soul, Janet , M.D.
Perinatal Stroke and Risk of Unilateral Cerebral Palsy, Early Parent-delivered Home-based Intervention
Spanish eTIPS for Early Therapy in Perinatal Stroke
This study adapts and evaluates the Spanish version of eTIPS, an early home-based therapy program for infants at risk of unilateral cerebral palsy after perinatal stroke.
- Conditions
- Perinatal Stroke and Risk of Unilateral Cerebral Palsy, Early Parent-delivered Home-based Intervention, Spanish Cross-cultural Adaptation of eTIPS
- Trial name
- eTIPS-ES (NCT07605988)
- Testing
- eTIPS, Usual Clinical Care
- Volunteers
- 20 people
- Sponsor
- University of Castilla-La Mancha
Cerebral Palsy
FES in Young Children With Perinatal Stroke
Every year about 1 out of every 1,600-5,000 infants has a stroke around the time of birth. Many of these children will have lifelong physical problems. For example, the arm muscles are often paralyzed.
- Trial name
- NCT02975180
- Testing
- FES, Conventional
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- University Health Network, Toronto
Orthopedic Disorder, Neurologic Disorder
Safety and Clinical Outcomes With Amniotic and Umbilical Cord Tissue Therapy for Numerous Medical Conditions
To determine the safety and efficacy of Amniotic and Umbilical Cord Tissue for the treatment of the following condition categories: Orthopedic, Neurologic, Urologic, Autoimmune, Renal, Cardiac and Pulmonary Conditions.
- Conditions
- Orthopedic Disorder, Neurologic Disorder, Urologic Diseases, Erectile Dysfunction
- Trial name
- NCT03899298
- Testing
- Amniotic and Umbilical Cord Tissue Procedure
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- R3 Stem Cell
Cerebral Palsy, Perinatal Stroke
Single-session tDCS in Cerebral Palsy
The goal of this study is to characterize individual responses to a single application of transcranial direct current stimulation (tDCS) in children with unilateral cerebral palsy (UCP), and to test which electrode configuration…
- Conditions
- Cerebral Palsy, Perinatal Stroke, Periventricular Leukomalacia
- Trial name
- NCT03635775
- Testing
- Active tDCS
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Perinatal Stroke, Hemiplegic Cerebral Palsy
Stimulation for Perinatal Stroke Optimizing Recovery Trajectories
Perinatal stroke causes lifelong neurological disability and most hemiparetic cerebral palsy (CP). With morbidity spanning diverse aspects of a child's life and lasting for decades, global impact is large, including 10000…
- Trial name
- SPORT (NCT03216837)
- Testing
- Cathodal transcranial direct current stimulation
- Where
- Canada
- Volunteers
- 89 people
- Sponsor
- University of Calgary
Abnormalities, Blood Coagulation Disorder
Study of Abnormal Blood Clotting in Children With Stroke
Effective treatment and prevention strategies for childhood stroke and porencephaly can only be developed once the causes are understood.
- Conditions
- Abnormalities, Blood Coagulation Disorder, Brain Disease, Cerebrovascular Accident
- Trial name
- NCT00001927
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Stroke
Early Intervention in Infants With Perinatal Stroke
This current study proposes to analyze the feasibility and effects of the two most used therapies, constraint-induced movement therapy and hand-arm bimanual intensive training, in very young infants (less than one year) with…
- Trial name
- NCT02720432
- Testing
- CIMT, HABIT, baby-massage
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- University Ghent
Perinatal Arterial Ischemic Stroke, Neonatal Stroke
Perinatal Arterial Stroke Treated With Stromal Cells Intranasally
This study will assess safety and feasibility of bone marrow-derived allogeneic MSCs, administered by the nasal route, in neonates who suffered from PAIS.
- Trial name
- PASSIoN (NCT03356821)
- Testing
- Mesenchymal Stem Cells
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht