Clinical trials: Perinatal Morbidity
Maternal Death, Neonatal Death
Evaluating the Effects of SMS Text Messaging Support System Among Frontline Health Workers in Ghana
Introduction Maternal and neonatal mortality continue to be to be prominent public health issues in sub Saharan Africa including Ghana, with slow progress made towards attainment of Millennium Development Goals (MDG) 4 \& 5.
- Conditions
- Maternal Death, Neonatal Death, Postpartum Haemorrhage, Pre-eclampsia
- Trial name
- Accelerate (NCT02468310)
- Testing
- Maternal and neonatal emergency protocols
- Where
- Ghana
- Volunteers
- 65,831 people, healthy volunteers welcome
- Sponsor
- Hannah Brown Amoakoh
Infectious Disease, Neoplasms
AnovaOS Network Powered Patient Registry
The objective of this study is the development, implementation and management of a registry of patient data that captures clinically meaningful, real-world, data on the diagnosis, nature, course of infection, treatment(s) and…
- Conditions
- Infectious Disease, Neoplasms, Diseases of the Blood and Blood-Forming Organs and Certain Disorders Involving the Immune Mechanism (D50-D89), Endocrine, Nutritional and Metabolic Diseases (E00-E89)
- Trial name
- NCT05013944
- Where
- United States
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Anova Enterprises, Inc
Hypertension, Pregnancy-Induced, Hypertension
Wearables to Define Postpartum Blood Pressure Trajectories and Facilitate Evidence-based Monitoring Guidelines
To better understand postpartum blood pressure changes, the investigators are proposing a study to monitor blood pressure after delivery in 100 patients who the investigators expect to have normal blood pressure (i.e.
- Conditions
- Hypertension, Pregnancy-Induced, Hypertension, Postpartum Preeclampsia, Postpartum Complication
- Trial name
- NCT06576544
- Testing
- BP Watch
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of California, San Diego
Hypothermia, Morbidity
Perinatal Hypothermia, Risk Factors and Long-Term Consequences in Guinea-Bissau, Westafrica
Low body temperature (hypothermia (HT)) at birth contributes to infant mortality in low-income countries. A study from Guinéa-Bissau indicates that HT results in an increased mortality rate, which persist at least two months…
- Conditions
- Hypothermia, Morbidity, Mortality
- Trial name
- NCT00429000
- Testing
- thermospot
- Where
- Guinea-Bissau
- Volunteers
- 788 people, healthy volunteers welcome
- Sponsor
- Bandim Health Project
Maternal Sepsis During Labor, Hemorrhage, Postpartum
Scaling Up an Integrated Approach to Improve Delivery Care in North Guatemala With Stepped Wedge Design
"¡Que Vivan las Madres!: Venga a tener su parto al CAP" (QVLM) is a guatemalan quasi-experimental study that has been performed from January 2014 to January 2017 by the Epidemiological Research Center in Sexual and Reproductive…
- Conditions
- Maternal Sepsis During Labor, Hemorrhage, Postpartum, Eclampsia; Complicating Pregnancy, Pre-Eclampsia
- Trial name
- QVLM (NCT03151070)
- Testing
- QVLM Intervention package
- Volunteers
- 32,000 people
- Sponsor
- Hospital San Juan de Dios Guatemala
Perinatal Mortality, Neonatal Morbidities
Machine Learning From Fetal Flow Waveforms to Predict Adverse Perinatal Outcomes
The aim of this study is to get a proof of concept for using a computational model of fetal haemodynamics, combined with machine learning based on Doppler patterns of the fetal cardiovascular, cerebral and placental flows, to…
- Trial name
- NCT03398551
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Maternal Death, Neonatal Death
Integrated Community Engagement and Audit Systems
The goal of this implementation research project is to determine the feasibility of establishing and implementing an acceptable and robust audit system with community representation at secondary health facilities to improve…
- Conditions
- Maternal Death, Neonatal Death, Stillbirth
- Trial name
- NCT05640050
- Testing
- Audit Implementation
- Where
- Pakistan
- Volunteers
- 1,000 people
- Sponsor
- Aga Khan University
Perinatal, Morbidity
Doula Model of Care
The goal of this randomized controlled intervention trial is to determine if an integrated partnership between a birth worker/community support organization and the Hospital of the University of Pennsylvania (HUP), will improve…
- Conditions
- Perinatal, Morbidity, Mental Health
- Trial name
- NCT06915259
- Testing
- Doula Model of Care
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Sepsis, Umbilical Cord
Perinatal Handwashing Intervention in Bangladesh
The purpose of this study is to determine if an intensive handwashing intervention administered to primiparous women during their pregnancy can increase maternal handwashing with soap at critical times.
- Conditions
- Sepsis, Umbilical Cord, Infection
- Trial name
- NCT01309321
- Testing
- Perinatal Handwashing Promotion, Neonatal Health Promotion
- Where
- Bangladesh
- Volunteers
- 400 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Vaginal Bleeding During Pregnancy
Tranexamic Acid in Pregnancies With Vaginal Bleeding
Tranexamic acid has been proposed and used for prevention and management of antepartum and postpartum hemorrhage.
- Trial name
- NCT03632824
- Testing
- Tranexamic Acid
- Where
- Iraq
- Volunteers
- 139 people
- Sponsor
- Hawler Medical University
Brain Injuries, Congenital Heart Disease
Protecting Brains and Saving Futures - the PBSF Protocol
Background: Multiple neonatal disorders are associated with risks of neurological injury. Thus, management of these infants should involve a coordinated approach to permit early diagnosis with improved clinical care.
- Conditions
- Brain Injuries, Congenital Heart Disease, Newborn Morbidity, Intraventricular Hemorrhage
- Trial name
- PBSF (NCT03786497)
- Where
- 2 sites in Brazil
- Volunteers
- 2,268 people
- Sponsor
- Protecting Brains Saving Futures
Anesthesia, Perinatal Morbidity
General Anesthesia for Cesarean Section, Maternal and Perinatal Outcomes
To evaluate the maternal and perinatal outcomes that occur in obstetric patients undergoing cesarean section surgery under general anesthesia at the Fray Antonio Alcalde Civil Hospital of Guadalajara.
- Conditions
- Anesthesia, Perinatal Morbidity, Maternal-Fetal Relations
- Trial name
- NCT06160583
- Where
- Mexico
- Volunteers
- 5,000 people
- Sponsor
- Hospital Civil de Guadalajara
covid19 Infection, Pregnancy Complications
Covid-19 in Pregnancy: a French Population-based Cohort of Women and Newborns
The purpose of this study is to characterize the incidence and clinical features of the maternal COVID 19 infection, as well as the associated morbidity of the mother and the child, in the French context
- Conditions
- covid19 Infection, Pregnancy Complications, Neonatal Complications
- Trial name
- Coropreg (NCT04463758)
- Testing
- An auto-questionnaire comprising three psychometric scales
- Where
- France
- Volunteers
- 6,015 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Fetal Growth Retardation, High-Risk Pregnancy
Routine Ultrasound Screening in the Third Trimester
Late intrauterine growth restriction is infrequently diagnosed with an overall sensitivity of 40 % in low-risk pregnancies. In addition, late intrauterine growth restriction may be associated with intrauterine death and poor…
- Trial name
- RECRET (NCT01594463)
- Testing
- ultrasound examination
- Where
- France
- Volunteers
- 3,760 people
- Sponsor
- University Hospital, Rouen
External Causes of Morbidity and Mortality, Stillbirth
Linking Facility-based Mortality Audits With Community Engagement in Gilgit-Baltistan, Pakistan
Pakistan is one of the countries in South Asia where neonatal mortality rates remain stagnant. Babies born in Pakistan encounter the highest risk of dying; of every 1,000 babies born, 46 die before the end of their first month…
- Conditions
- External Causes of Morbidity and Mortality, Stillbirth, Neonatal Death
- Trial name
- NCT03904706
- Testing
- Audits only, Audits with community feedback
- Where
- Pakistan
- Volunteers
- 1,871 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Fetal Heart Rate Abnormalities, Respiratory Depression
Safer Births - Reducing Perinatal Mortality
Safer Births is a research and development collaboration to establish new knowledge and new innovative products to better equip and increase competence of health workers for safer births and increased newborn survival worldwide.
- Conditions
- Fetal Heart Rate Abnormalities, Respiratory Depression, Birth Asphyxia, Neonatal Resuscitation
- Trial name
- NCT01869582
- Testing
- Fetoscope, Fetal heart rate, Upright Resuscitator, Resuscitation, Doppler, Fetal heart rate
- Where
- 2 sites in Tanzania
- Volunteers
- 20,000 people
- Sponsor
- Helse Stavanger HF
Neonatal SEPSIS, Perinatal Mortality
Outcomes in Spontaneous and ART Twin Pregnancies
During the last decades, assisted reproductive technique has been transformed from a miracle to real and has become widely used for treatment human infertility. this was associated with increased the rate of twin pregnancies
- Conditions
- Neonatal SEPSIS, Perinatal Mortality, Maternal Morbidity
- Trial name
- NCT03590483
- Where
- Iraq
- Volunteers
- 200 people
- Sponsor
- Hawler Medical University
Maternal Complication of Pregnancy, Newborn Morbidity
Scaling up Evidence Based MNCH Interventions : A Quasi Experimental Study Umeed e Nau (UeN) Project
The Umeed-e-Nau (UeN) initiative aims to support the introduction, scale up, and further piloting of high quality and high impact interventions to improve Maternal, Newborn And Child Health (MNCH)in Pakistan by harnessing the…
- Conditions
- Maternal Complication of Pregnancy, Newborn Morbidity, Perinatal Problems
- Trial name
- UeN (NCT04184544)
- Testing
- Improving of quality of care at health facility and outreach level
- Where
- Pakistan
- Volunteers
- 5,000,000 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Respiratory Distress Syndrome in Premature Infant, Patent Ductus Arteriosus After Premature Birth
Combined Lung Ultrasounds and Transthoracic Electrical Bioimpedance in Preterm Infants With Respiratory Distress.
Respiratory distress syndrome (RDS) is among the most common complications of preterm birth, and typically becomes manifested soon after birth.
- Conditions
- Respiratory Distress Syndrome in Premature Infant, Patent Ductus Arteriosus After Premature Birth, Perinatal Morbidity
- Trial name
- NCT04359134
- Where
- 2 sites in Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Morbidity;Perinatal, Pregnancy Complications
Postpartum Outcomes in BC
For every case of maternal death, many more women experience life-threatening complications during pregnancy and childbirth. Yet, severe maternal morbidity (SMM) cases are often overlooked post-delivery.
- Conditions
- Morbidity;Perinatal, Pregnancy Complications, Pregnancy Related
- Trial name
- NCT05461183
- Testing
- Retrospective database analysis
- Volunteers
- 15,000 people
- Sponsor
- University of British Columbia