Clinical trials: Perinatal
Pregnancy Related
Well-Mama Community Doula Navigator Study
This study will develop and test an intervention, called the Well-Mama intervention, which includes the use of a checklist by Community Doula Navigators to support pregnant women.
- Trial name
- NCT05179369
- Testing
- Standard Care with Well-Mama Intervention
- Where
- 2 sites in United States
- Volunteers
- 576 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Perinatal Arterial Ischemic Stroke, Perinatal Asphyxia
Intranasal Stem Cells to Treat Perinatal Brain Injury to Combat Cerebral Palsy
Hypoxic-ischemic brain injury (HIBI) is a leading cause of death and lifelong disability in near-term and term infants, most often caused by perinatal arterial ischemic stroke (PAIS, incidence approximately 1:5000 live births) or…
- Conditions
- Perinatal Arterial Ischemic Stroke, Perinatal Asphyxia, Hypoxic-Ischemic Brain Injury, PAIS
- Trial name
- iSTOP-CP (NCT07831746)
- Testing
- MSC, marrow
- Volunteers
- 162 people
- Sponsor
- UMC Utrecht
Depression, Depression, Postpartum
Randomized Controlled Trial of the Alma Peer Mentoring Program for Pregnant Women Experiencing Depression
Women have double the odds of getting depressed as men and commonly experience depression during the childbearing and early parenting years. Many new and expectant mothers who experience depression never receive help.
- Trial name
- NCT02883686
- Testing
- Alma
- Where
- 2 sites in United States
- Volunteers
- 27 people
- Sponsor
- University of Colorado, Boulder
Perinatal Death, Perinatal Grief
Simulation of Perinatal Grief. (SPG)
A proposal for teaching innovation is proposed with the topic of "perinatal grief" very little studied and taught in degrees such as medicine, nursing and psychology, with scientific evidence demonstrating a knowledge deficit on…
- Conditions
- Perinatal Death, Perinatal Grief, Teaching Innovation
- Trial name
- NCT06169423
- Testing
- Educative intervention
- Where
- Spain
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Universitat Jaume I
Depression, Postpartum Depression
Personalized Integrated Chronotherapy for Perinatal Depression
Perinatal depression and anxiety are common, serious, and frequently overlapping disorders that increase morbidity and mortality in new mothers (including suicide) and result in poor infant/child outcomes.
- Conditions
- Depression, Postpartum Depression, Prenatal Disorder, Circadian Dysregulation
- Trial name
- NCT04364646
- Testing
- Personalized Integrated Chronotherapy
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- Rhode Island Hospital
Postnatal Depression, Genetic Predisposition
Sequence Variations of Genes in the Estrogen Pathway and Perinatal Depression
To elucidate the disease pathway of perinatal depression by identifying genetic variants which could play a role in predisposing to the condition and/or lead to better understanding of the pathogenesis of the condition.
- Trial name
- NCT02373709
- Where
- Singapore
- Volunteers
- 750 people
- Sponsor
- KK Women's and Children's Hospital
Postpartum Depression, Postpartum Anxiety
The SUPPORT Study: Effectiveness and Usability of a Web-Enabled Resource for Postpartum Mental Health
The SUPPORT Study aims to evaluate the effectiveness and usability of postpartumcare.ca, a web-enabled resource for postpartum depression (PPD) and postpartum anxiety (PPA), created based on the input of birthing parents in…
- Conditions
- Postpartum Depression, Postpartum Anxiety, Postnatal Depression, Perinatal Disorder
- Trial name
- SUPPORT (NCT05382884)
- Testing
- Postpartumcare.ca (Web-Enabled Intervention)
- Where
- Canada
- Volunteers
- 103 people
- Sponsor
- University of British Columbia
Human Immunodeficiency Virus, Perinatal Depression
Adaptation of the Friendship Bench Intervention for HIV-infected Perinatal Women in Lilongwe
In many sub-Saharan African countries, the scale-up of lifelong antiretroviral treatment (ART) to all pregnant and breastfeeding women under Option B+ has the potential to radically improve maternal health and reduce…
- Trial name
- Periscope (NCT04143009)
- Testing
- Enhanced Friendship Bench, Enhanced Standard Care (Control), Adapted Friendship Bench
- Where
- 3 sites in Malawi
- Volunteers
- 92 people
- Sponsor
- University of North Carolina, Chapel Hill
Postpartum Depression, Pregnancy Related
Clinical Pilates and Prenatal Education on Perinatal Depressive Symptoms
This study evaluated whether a combined program of supervised Clinical Pilates Exercise and structured Prenatal Education, added to routine antenatal care, reduces perinatal depressive symptoms compared with routine antenatal…
- Conditions
- Postpartum Depression, Pregnancy Related, Low Back Pain, Labor Pain
- Trial name
- CPE-PE (NCT07647809)
- Testing
- Clinical Pilates Exercise, Prenatal Education
- Where
- Turkey (Türkiye)
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Perinatal Depression, Post Partum Depression
Accelerated TMS for Perinatal Depression
We are studying a treatment for depression called accelerated Transcranial Magnetic Stimulation (TMS) among pregnant and postpartum individuals.
- Conditions
- Perinatal Depression, Post Partum Depression, Major Depressive Disorder
- Trial name
- PAiNT (NCT06968390)
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Brigham and Women's Hospital
Pregnancy, Living in an Isolated Area
Optimizing Access to Care During Pregnancy in Rural Areas in a Perinatal Health Network
Pregnant women who live in rural area have fewer prenatal consultations. It has been demonstrated that maternal and neonatal morbidity and mortality increase if time travel to a maternity ward is longer than 30 min.
- Trial name
- OPTI'SOINS (NCT04823104)
- Testing
- Home visitation
- Where
- France
- Volunteers
- 105 people
- Sponsor
- University Hospital, Clermont-Ferrand
Pre-Eclampsia, Premature Birth
PREPARE, Prematurity Reduction by Pre-eclampsia Care
Investigators will test a novel system of integrated care, to promote the use of the WORLD HEALTH ORGANIZATION Guidelines for the management of pre-eclampsia and initiate the use of a structured risk assessment strategy to reduce…
- Trial name
- PREPARE (NCT03073317)
- Testing
- FullPIERS and sFlit/PLGF (Soluble fms-Like Tyrosine Kinase-1-to-Placental Growth Factor Ratio)
- Where
- 8 sites in Brazil
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- Instituto Fernandes Figueira
Perinatal Hypoxia, Dopamine
Measuring Brain Activity of School Age Children
This observational study will investigate whether differences in birth events and oxygen levels during the newborn period affects the brain activity of children during the middle childhood years.
- Conditions
- Perinatal Hypoxia, Dopamine, Neurobehavioral Manifestations
- Trial name
- NCT03407729
- Testing
- Magnetic Resonance Imaging, Cognitive Performance Testing
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Asthma, Dermatitis, Atopic
Impact in Off-spring of Mothers After Perinatal Daily Intake of a Probiotic
A probiotic (Lactobacillus rhamnosus GG) supplement to pregnant women the last four weeks of pregnancy and three months after birth is expected to give a 40% reduction in risk of atopic sensitisation and allergic disease at two…
- Conditions
- Asthma, Dermatitis, Atopic, Rhinitis, Allergic, Perennial
- Trial name
- NCT00159523
- Testing
- Probiotic
- Where
- Norway
- Volunteers
- 416 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Perinatal Outcomes, Social Determinants of Health (SDOH)
Rhode Island Community-based Maternal Support Services
The purpose of this project is to improve perinatal health outcomes in Rhode Island by bringing together the hospital, community health workers (CHWs), doulas, and community-based organizations to build a service delivery model…
- Conditions
- Perinatal Outcomes, Social Determinants of Health (SDOH), Health Disparity, Minority and Vulnerable Populations, Pregnancy
- Trial name
- RICOMSS (NCT07446374)
- Testing
- Perinatal health screening, Support services
- Where
- 7 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Perinatal Anxiety
Cognitive Behavioural Group Therapy for Perinatal Anxiety
This study evaluated the effectiveness of a 6-week, group-based, cognitive behavioural therapy (CGBT) program for women with anxiety disorders (with or without comorbid depressive symptoms) during pregnancy or early postpartum.
- Trial name
- CBT-PA (NCT02850523)
- Testing
- Cognitive Behavioural Therapy for Perinatal Anxiety
- Where
- Canada
- Volunteers
- 86 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Hand Washing Behavior, Hand Cleansing Behavior
Waterless Hand Cleansing With Chlorhexidine During the Perinatal Period
Background (brief): 1. Burden: Neonatal death still unacceptably high in low income countries. The common causes of neonatal death are pneumonia, sepsis and omphalitis.
- Conditions
- Hand Washing Behavior, Hand Cleansing Behavior, Chlorhexidine, Neonatal Period
- Trial name
- NCT01955317
- Testing
- Hand cleansing with chlorhexidine, Mother and neonatal health counselling
- Where
- Bangladesh
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Infant, Extremely Premature, Brain Injuries
Safeguarding the Brain of Our Smallest Infants Phase III
the SafeBoosC-III trial investigates the benefit and harms of treatment based on near-infrared spectroscopy monitoring compared with treatment as usual.
- Conditions
- Infant, Extremely Premature, Brain Injuries, Death, Brain, Death; Neonatal
- Trial name
- SafeBoosC (NCT03770741)
- Testing
- Modify cardio-respiratory support to avoid cerebral hypoxia, Treatment as usual
- Where
- Denmark
- Volunteers
- 1,601 people
- Sponsor
- Gorm Greisen
Pregnancy
Cluster-randomized Trial Measuring Integration of Professional Midwives and Obstetric Nurses in Rural Clinics in Mexico
Rates and causes of maternal mortality in Mexico have dropped only slightly; thus, reaching the internationally established Millennium Development Milestones (MDM) is still a distant goal.
- Trial name
- NCT01477541
- Testing
- PM/ON integration
- Volunteers
- 27 people
- Sponsor
- Instituto Nacional de Salud Publica, Mexico
Pregnancy, Maternal Health
Wired Mothers - Use of Mobile Phones to Improve Maternal and Neonatal Health in Zanzibar
Reducing maternal and newborn mortality remains a global challenge. Because obstetric complications cannot be predicted, skilled attendance at the time of delivery and access to emergency obstetric care remain the most effective…
- Conditions
- Pregnancy, Maternal Health, Newborn Death, Health Behavior
- Trial name
- NCT01821222
- Testing
- Wired mothers
- Where
- Tanzania
- Volunteers
- 2,550 people
- Sponsor
- University of Copenhagen