Clinical trials: Perinatal
Postpartum Depression, Pregnancy
Mindfulness-Based Cognitive Therapy for the Prevention of Perinatal Depressive Relapse/Recurrence
Pregnant women with histories of depression are at high risk of depressive relapse/recurrence during the perinatal period, and options for relapse/recurrence prevention are limited.
- Conditions
- Postpartum Depression, Pregnancy, Depression
- Trial name
- NCT02387424
- Testing
- MBCT-PD, OAR
- Where
- 4 sites in United States
- Volunteers
- 86 people
- Sponsor
- University of Colorado, Boulder
HIV-1
Interventions to Decrease the Risk of Mother-to-Child Transmission of HIV in India
This study, conducted in Tamil Nadu, India, was initiated in response to the developing epidemic of HIV/AIDS in India. It is divided into two stages, as follows: Stage I All women registered in the pregnancy clinics at the…
- Trial name
- NCT00341796
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Depression
MOMCare: Culturally Relevant Treatment Services for Perinatal Depression
The study will evaluate the effectiveness of a culturally relevant, multi-component intervention for antenatal depression. The intervention includes an engagement session, and the woman's choice of brief interpersonal…
- Trial name
- MOMCare (NCT01045655)
- Testing
- MOMCare
- Where
- United States
- Volunteers
- 168 people
- Sponsor
- University of Washington
Maternal Death, Neonatal Death
Integrated Community Engagement and Audit Systems
The goal of this implementation research project is to determine the feasibility of establishing and implementing an acceptable and robust audit system with community representation at secondary health facilities to improve…
- Conditions
- Maternal Death, Neonatal Death, Stillbirth
- Trial name
- NCT05640050
- Testing
- Audit Implementation
- Where
- Pakistan
- Volunteers
- 1,000 people
- Sponsor
- Aga Khan University
Chronic Hypertension Complicating Pregnancy, Pre-Eclampsia
Chronic Hypertension and Acetyl Salicylic Acid in Pregnancy
A randomized clinical trial to assess the efficiency of acetylsalicylic acid (aspirin) 150 mg/day started before 20 weeks of gestation in the prevention on maternal and fœtal complications in pregnant women with chronic…
- Conditions
- Chronic Hypertension Complicating Pregnancy, Pre-Eclampsia, Intrauterine Growth Restriction, Aspirin
- Trial name
- CHASAP (NCT04356326)
- Testing
- Aspirin 150 mg
- Where
- 20 sites in France
- Volunteers
- 500 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Hypoxia Ischemia, Cerebral, Hypoxia-Ischemia, Brain
Functional Imaging of Baby Brains
Infants are at risk of developing motor and cognitive neurodevelopmental disabilities as a sequelae to hypoxic-ischemic brain injury during the perinatal period.
- Conditions
- Hypoxia Ischemia, Cerebral, Hypoxia-Ischemia, Brain, Hypoxia Neonatal, Hypoxic-Ischemic Encephalopathy
- Trial name
- FIBB (NCT05514665)
- Testing
- Diffuse Optical Tomography
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Hamilton Health Sciences Corporation
Fetal Growth Restriction (FGR), Preeclampsia
Association of Assisted Reproductive Technologies Parameters With the Perinatal Outcome
The goal of this prospective cohort study is to examine how different parameters of assisted reproductive technologies (ART) are associated with the perinatal outcome in individuals with singleton or multiple gestations.
- Conditions
- Fetal Growth Restriction (FGR), Preeclampsia, Stillbirth, Placenta Previa
- Trial name
- NCT06918236
- Where
- 6 sites in Bulgaria, Greece and 1 more
- Volunteers
- 12,084 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Hypoxic Ischaemic Encephalopathy
Neuroprotective Effects of Hypothermia Combined With Inhaled Xenon Following Perinatal Asphyxia
This is a randomised controlled trial in newborn infants with perinatal asphyxial encephalopathy assessing whether a combination of hypothermia and inhaled xenon preserve cerebral metabolism and structure.
- Trial name
- TOBYXe (NCT00934700)
- Testing
- Xenon gas
- Where
- United Kingdom
- Volunteers
- 92 people
- Sponsor
- Imperial College London
Cesarean Section Rates
Reducing Cesarean Section Rates and Enhancing Vaginal Delivery in Greece: a Stepped-Wedge Randomized Controlled Trial
It is becoming increasingly apparent that there is an urgent need to systematically investigate the rising cesarean section (CS) rates in Greece and develop interventions to substantially reduce these rates.
- Trial name
- ENGAGE (NCT04504500)
- Testing
- HSOG guidelines application, Interactive workshops and courses, Feedback through follow-up meetings
- Where
- Greece
- Volunteers
- 6,029 people, healthy volunteers welcome
- Sponsor
- Hellenic Society of Obstetrics and Gynecology
Perinatal Stroke
Baby Brain Recovery Study
This study will be a longitudinal multiple-visit observational study, done to identify possible bioindicators of recovery and repair of motor corticospinal pathways which may be targeted by future interventions in infants with…
- Trial name
- NCT05013736
- Testing
- Magnetic Resonance Imaging, Behavioral Assessments, Non invasive Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of Wisconsin, Madison
Intrapartum Fetal Monitoring
Evaluating a Two Stage Intrapartum Fetal Assessment in India
An intrapartum fetal monitoring training programme (on intermittent auscultation and cardiotocography) will be delivered at Government Medical College (GMC) to all relevant staff.
- Trial name
- NCT04084353
- Testing
- Intrapartum fetal monitoring training and quality improvement project
- Where
- United Kingdom
- Volunteers
- 6,682 people
- Sponsor
- University of Liverpool
Syphilis
Modernizing Perinatal Syphilis Testing
The purpose of this study is to determine the testing performance of real-time quantitative polymerase chain reaction and transcription mediated amplification by comparing test performance of these novel molecular tests to…
- Trial name
- NCT06082453
- Testing
- Quantitative polymerase chain reaction (qPCR) assay for detection of Treponema pallidum, Aptima Treponema pallidum transcription-mediated amplification (TMA) assay for detection of Treponema pallidum, Center for Disease Control (CDC) Sexually Transmitted Infections (STI) 2021 Treatment Guidelines for diagnosis of syphilis
- Where
- 9 sites in United States
- Volunteers
- 924 people
- Sponsor
- The University of Texas Health Science Center, Houston
Communication, Multidisciplinary
The Effect of Communication Training on the Communication Skills of the Students
Patient safety, which is an important concept in terms of providing effective and high-quality health care, is defined as "preventing health care errors and eliminating or reducing patient damage caused by health care errors".
- Trial name
- NCT05187598
- Testing
- Effective communication training in perinatal patient safety
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Antenatal Care
Lack of Antenatal Care in Primiparas
Antenatal care is a key strategy for reducing maternal and neonatal morbidity and mortality rate because adequate utilization of antenatal health care services is associated with improved maternal and neonatal health outcomes.
- Trial name
- ANC (NCT02663765)
- Where
- Egypt
- Volunteers
- 512 people
- Sponsor
- Assiut University
Major Depressive Disorder
IPT for Major Depression Following Perinatal Loss: Healing After Loss (HeAL)
This study tests the efficacy of interpersonal psychotherapy (IPT) for major depression following perinatal loss (early and late fetal death and early neonatal death) in a sample of 274 women in Flint and Detroit, Michigan.
- Trial name
- HeAL (NCT04629599)
- Testing
- Interpersonal psychotherapy for major depression following perinatal loss, Coping with Depression
- Where
- United States
- Volunteers
- 199 people
- Sponsor
- Michigan State University
Hernias, Diaphragmatic, Congenital, Hernia; Diaphragm Defect, Congenital
Physiological-based Cord Clamping in Congenital Diaphragmatic Hernia
Pulmonary hypertension is a major determinant of postnatal survival in infants with a congenital diaphragmatic hernia (CDH). The current care during the perinatal stabilisation period in infants born with this rare birth defect…
- Conditions
- Hernias, Diaphragmatic, Congenital, Hernia; Diaphragm Defect, Congenital, Pulmonary Hypertension
- Trial name
- PinC (NCT04373902)
- Testing
- Physiological-based cord clamping
- Where
- 9 sites in Australia, Austria and 5 more
- Volunteers
- 144 people
- Sponsor
- Erasmus Medical Center
Asphyxia Neonatorum
Biomarkers And Neurological Outcome in Neonates 2
Follow-up of participants of BANON1 study at age of at least 2 years. BANON1 (ClinicalTrials.gov ID: NCT03357250): Validation of biomarkers based on 24 months neuro-developmental outcome data in a human population for their…
- Trial name
- BANON2 (NCT04714775)
- Where
- 13 sites in Germany, Turkey (Türkiye)
- Volunteers
- 500 people
- Sponsor
- InfanDx AG
Perinatal Depression, Postpartum Depression
Development, Feasibility and Acceptability of Fathers and Babies (FAB): A Pilot Study
During this project the investigators will develop and pilot test a companion intervention for fathers (Fathers and Babies-FAB), to supplement the Mothers and Babies Course (MB) that provides stress and mood management tools for…
- Conditions
- Perinatal Depression, Postpartum Depression, Depression
- Trial name
- NCT03427528
- Testing
- Fathers and Babies (FAB), MB 1-on-1 plus TXT
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Arterial Ischemic Stroke (AIS) in Children
Umbilical Cord Blood in the Treatment of Stroke in Children.
The specific aims of this study are: 1. To determine if Human Umbilical Cord Blood (hUCB) infusion is safe in children with perinatal arterial ischemic stroke (AIS). 2.
- Trial name
- Pedi Stroke (NCT01700166)
- Testing
- Autologous Human Cord Blood derived Stem Cell injection
- Where
- United States
- Sponsor
- Aryn Knight
Pregnancy, Birth Weight
Prenatal Multi-micronutrient Supplementation and Pregnancy Outcome
Prenatal maternal micronutrient supplementation has been suggested as a means to reduce the proportion of low birth weight babies in low-income countries.
- Trial name
- NCT00168688
- Testing
- multi micronutrient supplement, MN1, MN2
- Where
- Guinea-Bissau
- Volunteers
- 2,100 people, healthy volunteers welcome
- Sponsor
- Bandim Health Project