Clinical trials: Periapical Periodontitis
Apical Periodontitis
Evaluation of Different Root Canal Irrigation Techniques
This clinical study aims to evaluate the effect of different root canal irrigation techniques on postoperative pain levels and periapical healing in premolar and molar teeth diagnosed with apical periodontitis (Periapical Index…
- Trial name
- NCT07106320
- Testing
- VDW Ultra Ultrasonic Irrigation Activation, EDDY Sonic Irrigation Activation, Conventional Needle Irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 162 people
- Sponsor
- Medipol University
Periapical Diseases, Periapical Periodontitis
Effect of Targeted Endodontic Microsurgery on Quality of Life and Healing on Mandibular Molars
Targeted endodontic microsurgery represents precise and advanced approach to resolving persisting chronic periapical periodontitis after non- surgical root canal treatment.
- Conditions
- Periapical Diseases, Periapical Periodontitis, Periapical Cyst, Periapical Granuloma
- Trial name
- NCT06643676
- Testing
- Targeted Endodontic Microsurgery Using 3d Printed surgical guide using the patient's CBCT data, Conventional Endodontic Microsurgery with a free hand procedure using bur and CBCT analysis
- Where
- India
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Bacterial Infections
Effect of Passive Ultrasonic Irrigation on Bacteria That Persist After Root Canal Preparation
This study aims to evaluate the effectiveness of ultrasonic irrigation in improving root canal disinfection after chemomechanical procedures.
- Trial name
- NCT05100433
- Testing
- Ultrasonic irrigation
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo
Irreversible Pulpitis With Apical Periodontitis
Full Pulpotomy in Permanent Teeth With Irreversible Pulpitis and Apical Periodontitis
This study will evaluate whether full pulpotomy can successfully treat mature permanent teeth with irreversible pulp inflammation and a periapical lesion.
- Trial name
- NCT07768852
- Testing
- Full pulpotomy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
Pain
Incidence of Flare-ups and Apical Healing After Single-visit or Two-visits Treatment.
Aim to compare Incidence of flare-ups and apical healing after single-visit or two-visits treatment of teeth with necrotic pulp and apical periodontitis after a two-year control period.
- Trial name
- FlareUp (NCT02815189)
- Testing
- Ibuprofen for post operative pain, Acetaminophen 325 mg for Flare up
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Baja California
Apical Periodontitis
Comparison of Sonic and Ultrasonic Activation on Healing of Apical Periodontitis
The goal of this clinical trial is to learn whether two different irrigation activation methods - passive ultrasonic irrigation (PUI) and sonic activation - help periapical healing in root canal treatments of single-rooted teeth…
- Trial name
- SONIC-ULTRA (NCT07249450)
- Testing
- Sonic Activation Irrigation, Passive Ultrasonic Irrigation (PUI), Conventional Needle Irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Hilal Çuhadar Beşiroğlu
Apical Periodontitis
E. Faecalis Prevalence in Primary and Secondary Endodontic Infections: a Pre-post Microbial Analysis Following Chemo-mechanical Preparation
Post-treatment apical periodontitis is a fairly prevalent condition frequently caused by a persistent endodontic infection due to failure of the endodontic treatment.
- Trial name
- NCT04637659
- Testing
- Root Canal Treatment
- Where
- Italy
- Volunteers
- 72 people
- Sponsor
- University of Siena
Chronic Apical Periodontitis
A Cone Beam Computed Tomographic Evaluation of Healing of Apicomarginal Defects Using Autologous Platelet Aggregates
This study will evaluate the effect of PRF (platelet rich fibrin) on the healing of apicomarginal defects. Healing of the defects will be assessed 2 dimensionaly by periapical radiograph and 3 dimensionaly using CBCT.
- Trial name
- NCT04389346
- Testing
- Periapical surgery using autologous platelet aggregate, Periapical surgery without autologous platelet aggregate
- Where
- India
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Pulp Necrosis, Apical Periodontitis
Comparing Amla (Emblica Officinalis) and 3% Sodium Hypochlorite Against Enterococcus Faecalis in Root Canal Treatment.
Bacteria inside the root canal are a major cause of tooth infections. If they are not completely removed, the infection may continue even after root canal treatment.
- Trial name
- NCT07688005
- Testing
- Sodium Hypochlorite 3% Solution, Emblica officinalis Solution
- Where
- Pakistan
- Volunteers
- 66 people
- Sponsor
- Postgraduate Medical Institute, Lahore
Post Endodontic Pain, Periapical Healing
Comparative Evaluation of Endodontic Instrumentation Kinematics and Cryotherapy on Post-endodontic Pain and Periapical Healing
TITLE : Comparative evaluation of two different endodontic instrumentation kinematics and cryotherapy on post endodontic pain and periapical healing in teeth with asymptomatic apical periodontitis - A double blind, prospective…
- Trial name
- NCT07500870
- Testing
- rotary instrumentation kinematics, reciprocating instrumentation kinematics
- Where
- India
- Volunteers
- 60 people
- Sponsor
- All India Institute of Medical Sciences
Persistent Apical Periodontitis
Effect Of Different Sodium Hypochlorite Concentrations On Intracanal Substance P, CGRP And Opiorphin Levels And Postoperative Pain During Root Canal Retreatment
This randomized clinical study aims to evaluate the effect of different sodium hypochlorite concentrations (1%, 2.5%, and 5.25%) used during root canal retreatment on intracanal levels of Substance P, CGRP, and Opiorphin, as well…
- Trial name
- NaOCl-NPP (NCT07453576)
- Testing
- Sodium Hypochlorite 1% Irrigation, Sodium Hypochlorite 2.5% Irrigation, Sodium Hypochlorite 5% Irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- KEZBAN MELTEM ÇOLAK
Apical Periodontitis
Effect of Sodium Hypochlorite Concentration on Success of Non-surgical Root Canal Treatment
.There is no general agreement regarding the optimal concentration of sodium hypochlorite to be used in endodontic treatment.Therefore, this study aims to evaluate the effect of sodium hypochlorite concentration on the success of…
- Trial name
- NCT03288467
- Testing
- Root canal treatment with 5% NaOCl, Root canal treatment with 1% NaOCl
- Volunteers
- 90 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Symptomatic Periapical Periodontitis
Effect of Preoperative Amoxicillin/Clavulanic Acid Combination on Postoperative Endodontic Pain
The aim of this prospective, randomized, placebo controlled study is to evaluate the effect of a single preoperative dose of amoxicillin/clavulanic acid combination on post-operative pain and swelling in adult patient with…
- Trial name
- NCT03033147
- Testing
- Amoxicillin/Clavulanate Potassium 875 mg-125 mg oral tablet
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Cairo University
Dentoalveolar Abscess
Systemic and Local Antimicrobials in the Management of Dental Abscess in Children
Dental infections originating in the teeth are routinely managed systemically with a course of oral antibiotics, while severe forms are managed with intravenous antibiotics.
- Trial name
- NCT03761264
- Testing
- Odontopaste®, Pulpdent, Amoxicillin
- Where
- Malaysia
- Volunteers
- 55 people
- Sponsor
- University of Malaya
Apical Periodontitis, Pain
One vs Two Visits Root Canal Treatments in Infected Teeth
The primary aim of the study is to compare the outcome of one vs two visits endodontics (root canal treatments) performed in general dental practice of infected (necrotic) teeth, one and four years after treatment.
- Conditions
- Apical Periodontitis, Pain, Tooth Loss, Dental Pulp Necrosis
- Trial name
- NCT04605445
- Testing
- 1 visit root canal treatment (endodontics), 2 visits root canal treatment (endodontics)
- Where
- 7 sites in Sweden
- Volunteers
- 1,000 people
- Sponsor
- Malmö University
Periapical Periodontitis
Encapsulated Mesenchymal Stem Cells for Dental Pulp Regeneration.
To compare the dental survival in a period of one year of mature permanent teeth with apical lesion following the administration of encapsulated Mesenchymal Stem Cells under a regenerative endodontic procedure and a conventional…
- Trial name
- RanoKure (NCT03102879)
- Testing
- Regenerative Endodontic Procedure, Conventional Root Canal Treatment
- Where
- Chile
- Volunteers
- 36 people
- Sponsor
- Universidad de los Andes, Chile
Chronic Apical Periodontitis, Dental Implantation
Topical Melatonin for Immediate Implants in Chronically Infected Extraction Sockets
The purpose of this study is to evaluate the effect of topical 2% melatonin gel on implant stability and osseointegration of immediate implants placed in chronically infected extraction sockets.
- Conditions
- Chronic Apical Periodontitis, Dental Implantation, Infected Extraction Socket
- Trial name
- NCT07829393
- Testing
- Topical Melatonin, Control
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Periapical Abscess
"Is Antibiotic Therapy Necessary for Patients Undergoing Extraction of Teeth With Abscess?"
This is a triple-blind randomized controlled trial conducted at the Department of Oral and Maxillofacial Surgery, Subbaiah Institute of Dental Sciences, Shimoga.
- Trial name
- NCT07694531
- Testing
- Amoxicillin 500mg
- Where
- India
- Volunteers
- 176 people
- Sponsor
- Subbaiah Institute of Dental Sciences
Postoperative Pain
Effects of Photobiomodulation on Postoperative Pain After Primary Endodontic Therapy in Molars With Symptomatic Apical Periodontitis
The purpose of this study is to evaluate the effects of photobiomodulation (PBM) on postoperative pain after endodontic treatment in mandibular molar teeth diagnosed with symptomatic apical periodontitis.
- Trial name
- NCT05032612
- Testing
- PBM Therapy
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- The University of Texas Health Science Center, Houston
Non Vital Teeth, Persistent Symptomatic Apical Periodontitis
To Evaluate and Compare the Effect of Orthograde and Retrograde MTA Root End Filling After Periapical Surgery in Posteriors
To evaluate and compare the effect of orthograde and retrograde MTA root end filling on clinical, 2D and 3D radiographic success and quality of life after periapical surgery in posteriors- A Randomised Control Trial
- Trial name
- NCT07808424
- Testing
- Endodontic Micro-Surgery
- Where
- India
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak