Clinical trials: Periapical Periodontitis
Apical Periodontitis
Comparison of Sonic and Ultrasonic Activation on Healing of Apical Periodontitis
The goal of this clinical trial is to learn whether two different irrigation activation methods - passive ultrasonic irrigation (PUI) and sonic activation - help periapical healing in root canal treatments of single-rooted teeth…
- Trial name
- SONIC-ULTRA (NCT07249450)
- Testing
- Sonic Activation Irrigation, Passive Ultrasonic Irrigation (PUI), Conventional Needle Irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Hilal Çuhadar Beşiroğlu
Periapical Periodontitis
Comparison of Frequency of Calcium Hydroxide Mixed With 0.2% Chlorhexidine Versus Saline as Intracanal Medicament in Periapical Periodontitis-A Randomized Controlled Trial
This randomized controlled trial aims to compare the effectiveness of calcium hydroxide mixed with 0.2% chlorhexidine digluconate versus calcium hydroxide mixed with saline as intracanal medicaments in reducing postoperative pain…
- Trial name
- NCT07252258
- Testing
- Calcium Hydroxide + Normal Saline, Calcium Hydroxide + 0.2% Chlorhexidine Digluconate
- Where
- Pakistan
- Volunteers
- 80 people
- Sponsor
- Aqsa Afzal
Periapical Periodontitis, Dental Pulp Necrosis
Influence of Maintaining Apical Patency on Post-Endodontic Pain in Molars
This randomized controlled trial will investigate if maintaining apical patency-a technique where a small file is gently moved past the root's end during cleaning-affects pain after a root canal.
- Trial name
- IMAP-Pain (NCT07239752)
- Testing
- Patency Group, Standard Root Canal Instrumentation
- Volunteers
- 48 people
- Sponsor
- College of Physicians and Surgeons Pakistan
Root Canal Treatment, Intracanal Medicament
The Success of Root Canal Treatments Performed Using Two Different Intracanal Medicaments
Previously untreated, asymptomatic, single-rooted maxillary anterior teeth with periapical lesions <5 mm, no fractures, resorption, calcification, or recent antibiotic use will performed two-visit root canal treatment.
- Conditions
- Root Canal Treatment, Intracanal Medicament, Post Operative Pain, Apical Periodontitis
- Trial name
- NCT07210177
- Testing
- Bio-C Temp Intracanal Medication, Metapaste Intracanal Medication
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ege University
Chronic Apical Periodontitis, Necrosis of Pulp
Using Platelet-rich Fibrin in Regenerative Endodontic Treatment in Mature Permanent Teeth
This study aims to evaluate the antibacterial effects of injectable platelet-rich fibrin (i-PRF) in vitro, and to assess the clinical and radiographic outcomes of using advanced platelet-rich fibrin (A-PRF+) and i-PRF in…
- Conditions
- Chronic Apical Periodontitis, Necrosis of Pulp, Acute Apical Periodontitis of Pulpal Origin, Periapical Abscess
- Trial name
- NCT07192289
- Testing
- Using advanced platelet-rich fibrin (A-PRF+) or injectable platelet-rich fibrin (i-PRF) in regenerative endodontic treatment in mature permanent teeth.
- Where
- Vietnam
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Apical Periodontitis, Oxidative Stress
Effect of Ozone Use in Intracanal Irrigation on Oxidative Stress Level in Teeth With Asymptomatic Apical Periodontitis
This clinical study aims to investigate the oxidative stress-related effects of ozone irrigation in patients with asymptomatic apical periodontitis undergoing root canal treatment.
- Trial name
- NCT07171762
- Testing
- Ozonytron XP, Physiological saline solution (0.9% NaCl)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- KEZBAN MELTEM ÇOLAK
Apical Periodontitis
To Evaluate Periapical Healing Post Full Pulpotomy in Teeth With and Without Apical Periodontitis
This clinical study aims to evaluate the periapical and clinical healing outcomes of full pulpotomy using MTA in mandibular permanent molars diagnosed with symptomatic irreversible pulpitis.
- Trial name
- NCT07179835
- Testing
- Full pulpotomy in adults ≥18 years with restorable mandibular first or second molars diagnosed with irreversible pulpitis, with or without apical periodontitis.
- Where
- India
- Volunteers
- 128 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Apical Periodontitis, Postoperative Pain
The Effect of Using Octenidine Hydrochloride as a Final Irrigation Solution on Teeth With Asymptomatic Apical Periodontitis on Postoperative Pain and Treatment Success: A Prospective Randomized Clinical Study
This single-centre, randomized, parallel-group clinical trial compared two commonly used final irrigants in single-visit root canal treatment: octenidine dihydrochloride (OCT) and chlorhexidine (CHX).
- Trial name
- NCT07173725
- Testing
- Octenidine dihydrochloride 0.1%, Chlorhexidine 2%
- Where
- Turkey (Türkiye)
- Volunteers
- 142 people
- Sponsor
- Bezmialem Vakif University
Apical Periodontitis
Evaluation of Periapical Healing Following Endodontic Microsurgery With Leukocyte and Platelet Rich Fibrin (L-PRF)
The purpose of the study is to evaluate peri-radicular healing after root-end surgery using Leukocyte and Platelet Rich Fibrin. The study population includes patients diagnosed with persistent periapical pathology and scheduled…
- Trial name
- NCT06545084
- Testing
- Leukocyte and Platelet Rich Fibrin
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Apical Periodontitis
Effectiveness of GentleWave on the Healing of Apical Periodontitis: A Prospective Cohort Study
The purpose of this 12-month prospective cohort study is to evaluate post-operatory pain, patient satisfaction, and treatment outcomes (i.e., healing) when the newly-developed, 510k FDA-approved multisonic energy GentleWAve…
- Trial name
- NCT04966169
- Testing
- GentleWave System
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Iowa
Apical Periodontitis, Periapical Lesion
Evaluation of Different Root Canal Obturation Techniques
The aim of this clinical study is to evaluate the effect of root canal filling, which is the last stage of root canal treatment (RCT), on the post-operative pain level on single rooted permanent teeth with wide lesions with…
- Trial name
- NCT07106307
- Testing
- Bioceramic Sealer, Warm Vertical Compaction, Epoxy Resin-Based Sealer
- Where
- Turkey (Türkiye)
- Volunteers
- 168 people
- Sponsor
- Medipol University
Apical Periodontitis
Evaluation of Different Root Canal Irrigation Techniques
This clinical study aims to evaluate the effect of different root canal irrigation techniques on postoperative pain levels and periapical healing in premolar and molar teeth diagnosed with apical periodontitis (Periapical Index…
- Trial name
- NCT07106320
- Testing
- VDW Ultra Ultrasonic Irrigation Activation, EDDY Sonic Irrigation Activation, Conventional Needle Irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 162 people
- Sponsor
- Medipol University
Apical Periodontitis, Necrotic Pulps
A Comparative Evaluation of the Degree of Pain and MMP-9 Expression Following Instrumentation of Necrotic Pulps With Apical Periodontitis in One or Two Visits
This randomized clinical trial compares postoperative pain and MMP-9 levels after root canal treatment of necrotic teeth with apical periodontitis, using either single-visit or two-visit instrumentation.
- Conditions
- Apical Periodontitis, Necrotic Pulps, Single Rooted Teeth
- Trial name
- NCT07101003
- Testing
- single visit instrumentation, multiple visit instrumentation
- Volunteers
- 28 people
- Sponsor
- Marwa Hisham Mohamed Salah Eldin
Intracanal Dressing, Apical Periodontitis
Effect of Bio-C Temp Versus Calcium Ydroxide as Intracanal Dressings on Postoperative Pain Intensity and Periapical MMP-9 Level in Patients With Necrotic Pulp
To compare the effect of Bio-C Temp Bioceramic intracanal dressing versus calcium hydroxide as intracanal medicaments on: Intensity of postoperative pain levels of MMP -9 in Periapical Fluids.
- Conditions
- Intracanal Dressing, Apical Periodontitis, Calcium Hydroxide, Biomarkers
- Trial name
- NCT07101029
- Testing
- Bio-C Temp Intracanal Medication, Calcium Hydroxide Intracanal medication
- Volunteers
- 30 people
- Sponsor
- Cairo University
Irreversible Pulpitis, Apical Periodontitis
Healing Outcomes Following Hydraulic Condensation With a Bioactive Bioceramic Sealer in Root Canal Treatment
This prospective clinical study aimed to evaluate the healing outcomes after root canal treatment using a bioceramic sealer called BioRoot RCS in combination with a technique known as hydraulic condensation.
- Trial name
- HEAL-BR (NCT07075354)
- Testing
- Hydraulic Condensation Root Canal Obturation with BioRoot RCS
- Where
- Bulgaria
- Volunteers
- 66 people
- Sponsor
- Plovdiv Medical University
Irreversible Pulpitis, Apical Periodontitis
Bite Force Measurements
ABSTRACT: Acute dental pain from untreated decay often drives patients to emergency rooms (ERs), where the lack of definitive dental treatment results in nearly 75% of these patients receiving analgesics, predominantly opioids.
- Conditions
- Irreversible Pulpitis, Apical Periodontitis, Pulpal Necrosis
- Trial name
- NCT06843525
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Rutgers, The State University of New Jersey
Apical Periodontitis, Dental Pulp Necrosis
Chitosan Irrigation in Premolar Root Canal Therapy (Randomized Trial)
The goal of this clinical trial is to learn which of three common root-canal rinsing (irrigation) methods removes bacteria most effectively in adult patients who need root-canal treatment.
- Conditions
- Apical Periodontitis, Dental Pulp Necrosis, Root Canal Infection
- Trial name
- CHITO-PRE RCT (NCT07048028)
- Testing
- Chitosan Low Molecular Weight (20-200 Mpa.S), Sodium Hypochlorite, EDTA chelating agents
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- ESRA DAĞCI
Periapical Periodontitis
Effect of Simvastatin Versus Calcium Hydroxide Intracanal Medications on Post-operative Pain and Interleukin 6 and 8
Comparing the effect of Simvastatin versus calcium hydroxide used as an intracanal medicament on Post-operative Pain and Total amount of IL-6 and IL-8 in Periapical Fluids of lower premolars in patients with Symptomatic Apical…
- Trial name
- NCT05525013
- Testing
- Simvastatin Powder, Calcium Hydroxide
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pulpitis, Periapical Lesions
Success of Endodontic Treatment With Different Obturation Techniques and Sealer Cements
The present study aims to compare the radiographic success of endodontic treatment using Orstavik's criteria between two sealers: AH Plus (Dentsply DeTrey, Konstanz, Germany) and Neosealer Flo (Avalon Biomed, Bradenton, Florida…
- Conditions
- Pulpitis, Periapical Lesions, Periapical Periodontitis, Periapical Pathology
- Trial name
- NCT07019298
- Testing
- AH Plus (Dentsply Sirona, Charlotte, NC, USA), NeoSealer Flo, Continuous Wave Condensation
- Where
- Spain
- Volunteers
- 270 people
- Sponsor
- University of Siena
Periapical Periodontitis, Pulpitis
Postoperative Pain Evaluation After Obturation With Different Sealers
This study aims to evaluate the incidence and intensity of postoperative pain in patients undergoing root canal treatment on teeth diagnosed with pulpitis, pulp necrosis, or with previous endodontic treatment.
- Conditions
- Periapical Periodontitis, Pulpitis, Necorsis
- Trial name
- NCT07018284
- Testing
- AH Plus (Dentsply Sirona, Charlotte, NC, USA), NeoSealer Flo, Continuous Wave Condensation
- Where
- Spain
- Volunteers
- 270 people
- Sponsor
- University of Siena